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The map label for this gene is gyrA [H]

Identifier: 38232651

GI number: 38232651

Start: 8792

End: 11362

Strand: Direct

Name: gyrA [H]

Synonym: DIP0009

Alternate gene names: 38232651

Gene position: 8792-11362 (Clockwise)

Preceding gene: 38232647

Following gene: 38232652

Centisome position: 0.35

GC content: 61.07

Gene sequence:

>2571_bases
ATGAGCGACGATCTTCTCGGTGGTGACGGCTACGACCGCGTCCACCCGATCGACCTCAACGAGGAGATGGAGACCAGCTA
CATCGATTATGCGATGTCGGTCATCGTCGGCCGTGCTTTGCCTGAGGTCCGTGACGGACTCAAGCCAGTGCACCGCCGCA
TCCTCTACGCGATGTACGACTCCGGCTACCGCCCCGACCGCAGCTACGTAAAGTCTGCGCGCCCAGTCTCAGACACCATG
GGCCAGTTCCACCCCCACGGCGACTCCGCAATTTACGACACCTTGGTGCGCCTCGCCCAAGACTGGAACATGCGGTACCC
CATGGTCGACGGCCAGGGTAACTTCGGCTCCCGCGGCAACGACGGCCCCGCAGCTATGCGTTACACCGAGTGTCGCCTGA
CCCCATTGGCTATGGAGATGGTTCGCGACATTCGCGAGAACACCGTGGACTTCTCCCCGAACTACGACGGCAAGACCCAA
GAACCAGACGTATTGCCATCGCGCGTTCCTAACCTGCTGATGAACGGCTCCAACGGTATTGCCGTCGGTATGGCCACCAA
CATCCCGCCGCATAACCTGCGCGAACTTGGCGACGCCATCTTCTGGCTGCTAGACAACCCCGAAGCAGACGAAGCGTCGG
CGCTGGAAGCCTGCATGAAGTATGTCAAGGGCCCCGATTTCCCCACCGCGGGCCAGATCGTCGGCTCCCAAGGCATTAAC
GACGCCTACACCACCGGCCGCGGCTCCATCCGCATGCGCGGTGTCACTTCCATCGAGGAAGAAGGCAACCGTCAGATCAT
CGTGATCACCGAGCTGCCCTATCAGGTCAACCCGGACAACATGATCTCCAACATTGCGGAGCAGGTTCGCGACGGCAAAC
TCGCGGGCATCTCCAAGATCGAGGACGAATCCTCCGACCGCGTGGGCATGCGCATCGTGGTCACCCTCAAGCGTGACGCT
GTGCCGCGCGTGGTACTCAACAACCTGTACAAGCACTCCCAGCTGCAAACCAACTTCGGTGCGAACATGCTGTCCATCGT
GGATGGTGTGCCACGCACCCTGCGTCTCGACCAGATGCTGCGCCACTATGTGACGCACCAGATCGAAGTGATCGTGCGCC
GCACGCAGTACCGCCTCGACGAGGCGGAAAAGCGCGCCCATATCTTGCGTGGTTTGGTCAAAGCCCTCGACATGCTCGAC
GAGGTCATCGCCTTAATCCGTCGTTCGCCAACCGTCGACATCGCCCGCACCGGCCTGATGGAACTGCTCACTGTCGACGA
AATCCAAGCAGACGCCATCCTGGCTATGCAGCTGCGTCGCCTAGCTGCCCTCGAGCGTCAAAAGATCGTCGACGAACTTG
CCGAGATCGAACTGGAAATCGCCGACTACAAGGACATTCTGGCCCGCCCAGAGCGTCAGCGCGCTATCGTGCGTGACGAG
CTTGCGGAGATCGTCGATAAGTATGGCGACGACCGCCGCACCCAAATCATCGCCGCAACTGGCGATGTCACCGAAGAAGA
CCTCATCGCCCGCGAGAACGTGGTAGTCACCATCACCTCCACCGGCTACGCCAAACGCACCAAAGTGGACGCCTACAAGT
CCCAGCGACGCGGCGGCAAGGGCGTACGCGGCGCCGAGCTCAAACAAGACGACGTGGTCCGCCACTTCTTTGTCAGCTCC
ACCCACGACTGGATCCTGTTCTTCACCAACTTTGGTCGCGTCTACCGACTCAAAGCCTACGAACTACCAGAAGCATCGCG
CACCGCCCGCGGCCAGCACGTGGCCAACCTGCTGGAATTCCAGCCGGAAGAGCGCATCGCCCAGGTCATTCAAATCCAGT
CCTACGAGGATGCCCCCTACCTCGTACTGGCAACCGCGCAGGGTCGTGTGAAGAAGTCCCGCCTCTCCGACTACGAGTCC
AACCGCTCCGGCGGACTTATCGCCATCAACCTCAACGAAGGCGACAAGCTCATCGGCGCAGCACTATGCGACAACGACGA
CGACCTGCTGCTCGTCTCCGAAGAAGGCCAGTCGATTCGCTTCAACGCCAACGACGACCAACTGCGCCCCATGGGCCGTG
CTACCGCAGGCGTGAAGGGTATGCGCTTCAAGGGCGACGACCAACTGCTGGCAATGACAGTGGTCAAGCCGGATGCATTC
TTGCTGGTAGCTACCTCCGGCGGCTACGGTAAGCGCACCTCCTTGGATGAATACTCACCACAGGGACGCGGCGGCCAGGG
CGTGCTTACCTTCAAGTACACGCCAAAGCGTGGCAAGCTCATCGCCGCAGTTGTTGTTGACGAAGACGACGAGATCCTAG
CTATCACCTCCGCTGGCGGCGTTATCCGCACCGTAGTGAACCAGATCCGCCCGTCGTCACGCGCCACCATGGGCGTGCGC
CTCGTCAACCTCGAAGATGGCGTCGAACTGCTCGCCATCGACCGCAACGTGGAAGGCGAAGGCGAAGAAGCCGCCGAAGC
CGTAGCCACCGGAGCTGTCGACGGCCCCGCCGAACGCGGCAAGCAAACCGAAGTTGACCTCGGCATAGATAACGCCGACG
AGGAGGCCTAA

Upstream 100 bases:

>100_bases
TATCAATCTGATACCAAAAATGCTTGGATGTGGCGTTAGAAGCTAGAATAGAGGGGTTATTGCCTACATACTCGATGAAT
CTTATAGAAAAAGGTGACAT

Downstream 100 bases:

>100_bases
TGGCAACACGCGACGTGATCATTACCCGAGTAGCACCAGGCAGTGCGTTTAAAACCGCACTCTCCCTGTCGCTGATCGGA
CTTATCTCATGGCTGATCTG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 856; Mature: 855

Protein sequence:

>856_residues
MSDDLLGGDGYDRVHPIDLNEEMETSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMYDSGYRPDRSYVKSARPVSDTM
GQFHPHGDSAIYDTLVRLAQDWNMRYPMVDGQGNFGSRGNDGPAAMRYTECRLTPLAMEMVRDIRENTVDFSPNYDGKTQ
EPDVLPSRVPNLLMNGSNGIAVGMATNIPPHNLRELGDAIFWLLDNPEADEASALEACMKYVKGPDFPTAGQIVGSQGIN
DAYTTGRGSIRMRGVTSIEEEGNRQIIVITELPYQVNPDNMISNIAEQVRDGKLAGISKIEDESSDRVGMRIVVTLKRDA
VPRVVLNNLYKHSQLQTNFGANMLSIVDGVPRTLRLDQMLRHYVTHQIEVIVRRTQYRLDEAEKRAHILRGLVKALDMLD
EVIALIRRSPTVDIARTGLMELLTVDEIQADAILAMQLRRLAALERQKIVDELAEIELEIADYKDILARPERQRAIVRDE
LAEIVDKYGDDRRTQIIAATGDVTEEDLIARENVVVTITSTGYAKRTKVDAYKSQRRGGKGVRGAELKQDDVVRHFFVSS
THDWILFFTNFGRVYRLKAYELPEASRTARGQHVANLLEFQPEERIAQVIQIQSYEDAPYLVLATAQGRVKKSRLSDYES
NRSGGLIAINLNEGDKLIGAALCDNDDDLLLVSEEGQSIRFNANDDQLRPMGRATAGVKGMRFKGDDQLLAMTVVKPDAF
LLVATSGGYGKRTSLDEYSPQGRGGQGVLTFKYTPKRGKLIAAVVVDEDDEILAITSAGGVIRTVVNQIRPSSRATMGVR
LVNLEDGVELLAIDRNVEGEGEEAAEAVATGAVDGPAERGKQTEVDLGIDNADEEA

Sequences:

>Translated_856_residues
MSDDLLGGDGYDRVHPIDLNEEMETSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMYDSGYRPDRSYVKSARPVSDTM
GQFHPHGDSAIYDTLVRLAQDWNMRYPMVDGQGNFGSRGNDGPAAMRYTECRLTPLAMEMVRDIRENTVDFSPNYDGKTQ
EPDVLPSRVPNLLMNGSNGIAVGMATNIPPHNLRELGDAIFWLLDNPEADEASALEACMKYVKGPDFPTAGQIVGSQGIN
DAYTTGRGSIRMRGVTSIEEEGNRQIIVITELPYQVNPDNMISNIAEQVRDGKLAGISKIEDESSDRVGMRIVVTLKRDA
VPRVVLNNLYKHSQLQTNFGANMLSIVDGVPRTLRLDQMLRHYVTHQIEVIVRRTQYRLDEAEKRAHILRGLVKALDMLD
EVIALIRRSPTVDIARTGLMELLTVDEIQADAILAMQLRRLAALERQKIVDELAEIELEIADYKDILARPERQRAIVRDE
LAEIVDKYGDDRRTQIIAATGDVTEEDLIARENVVVTITSTGYAKRTKVDAYKSQRRGGKGVRGAELKQDDVVRHFFVSS
THDWILFFTNFGRVYRLKAYELPEASRTARGQHVANLLEFQPEERIAQVIQIQSYEDAPYLVLATAQGRVKKSRLSDYES
NRSGGLIAINLNEGDKLIGAALCDNDDDLLLVSEEGQSIRFNANDDQLRPMGRATAGVKGMRFKGDDQLLAMTVVKPDAF
LLVATSGGYGKRTSLDEYSPQGRGGQGVLTFKYTPKRGKLIAAVVVDEDDEILAITSAGGVIRTVVNQIRPSSRATMGVR
LVNLEDGVELLAIDRNVEGEGEEAAEAVATGAVDGPAERGKQTEVDLGIDNADEEA
>Mature_855_residues
SDDLLGGDGYDRVHPIDLNEEMETSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMYDSGYRPDRSYVKSARPVSDTMG
QFHPHGDSAIYDTLVRLAQDWNMRYPMVDGQGNFGSRGNDGPAAMRYTECRLTPLAMEMVRDIRENTVDFSPNYDGKTQE
PDVLPSRVPNLLMNGSNGIAVGMATNIPPHNLRELGDAIFWLLDNPEADEASALEACMKYVKGPDFPTAGQIVGSQGIND
AYTTGRGSIRMRGVTSIEEEGNRQIIVITELPYQVNPDNMISNIAEQVRDGKLAGISKIEDESSDRVGMRIVVTLKRDAV
PRVVLNNLYKHSQLQTNFGANMLSIVDGVPRTLRLDQMLRHYVTHQIEVIVRRTQYRLDEAEKRAHILRGLVKALDMLDE
VIALIRRSPTVDIARTGLMELLTVDEIQADAILAMQLRRLAALERQKIVDELAEIELEIADYKDILARPERQRAIVRDEL
AEIVDKYGDDRRTQIIAATGDVTEEDLIARENVVVTITSTGYAKRTKVDAYKSQRRGGKGVRGAELKQDDVVRHFFVSST
HDWILFFTNFGRVYRLKAYELPEASRTARGQHVANLLEFQPEERIAQVIQIQSYEDAPYLVLATAQGRVKKSRLSDYESN
RSGGLIAINLNEGDKLIGAALCDNDDDLLLVSEEGQSIRFNANDDQLRPMGRATAGVKGMRFKGDDQLLAMTVVKPDAFL
LVATSGGYGKRTSLDEYSPQGRGGQGVLTFKYTPKRGKLIAAVVVDEDDEILAITSAGGVIRTVVNQIRPSSRATMGVRL
VNLEDGVELLAIDRNVEGEGEEAAEAVATGAVDGPAERGKQTEVDLGIDNADEEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=339, Percent_Identity=26.2536873156342, Blast_Score=81, Evalue=5e-15,
Organism=Homo sapiens, GI19913408, Length=332, Percent_Identity=25.3012048192771, Blast_Score=80, Evalue=9e-15,
Organism=Escherichia coli, GI1788562, Length=878, Percent_Identity=43.3940774487472, Blast_Score=725, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=727, Percent_Identity=34.1127922971114, Blast_Score=388, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=169, Percent_Identity=31.9526627218935, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=310, Percent_Identity=26.7741935483871, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17136538, Length=370, Percent_Identity=24.3243243243243, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94912; Mature: 94781

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDLLGGDGYDRVHPIDLNEEMETSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMYD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
SGYRPDRSYVKSARPVSDTMGQFHPHGDSAIYDTLVRLAQDWNMRYPMVDGQGNFGSRGN
CCCCCCHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCC
DGPAAMRYTECRLTPLAMEMVRDIRENTVDFSPNYDGKTQEPDVLPSRVPNLLMNGSNGI
CCCCCEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCHHEECCCCCE
AVGMATNIPPHNLRELGDAIFWLLDNPEADEASALEACMKYVKGPDFPTAGQIVGSQGIN
EEEEECCCCCHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCC
DAYTTGRGSIRMRGVTSIEEEGNRQIIVITELPYQVNPDNMISNIAEQVRDGKLAGISKI
CCCCCCCCCEEEECCCCHHHCCCCEEEEEEECCCEECHHHHHHHHHHHHHCCCCCCCHHC
EDESSDRVGMRIVVTLKRDAVPRVVLNNLYKHSQLQTNFGANMLSIVDGVPRTLRLDQML
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHH
RHYVTHQIEVIVRRTQYRLDEAEKRAHILRGLVKALDMLDEVIALIRRSPTVDIARTGLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ELLTVDEIQADAILAMQLRRLAALERQKIVDELAEIELEIADYKDILARPERQRAIVRDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHCCCHHHHHHHHHH
LAEIVDKYGDDRRTQIIAATGDVTEEDLIARENVVVTITSTGYAKRTKVDAYKSQRRGGK
HHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCC
GVRGAELKQDDVVRHFFVSSTHDWILFFTNFGRVYRLKAYELPEASRTARGQHVANLLEF
CCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHC
QPEERIAQVIQIQSYEDAPYLVLATAQGRVKKSRLSDYESNRSGGLIAINLNEGDKLIGA
CCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCEEEE
ALCDNDDDLLLVSEEGQSIRFNANDDQLRPMGRATAGVKGMRFKGDDQLLAMTVVKPDAF
EECCCCCCEEEECCCCCEEEECCCCCCCCCCCHHHCCCCCCEECCCCCEEEEEEECCCEE
LLVATSGGYGKRTSLDEYSPQGRGGQGVLTFKYTPKRGKLIAAVVVDEDDEILAITSAGG
EEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEECCCH
VIRTVVNQIRPSSRATMGVRLVNLEDGVELLAIDRNVEGEGEEAAEAVATGAVDGPAERG
HHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHCC
KQTEVDLGIDNADEEA
CCEEEEECCCCCCCCC
>Mature Secondary Structure 
SDDLLGGDGYDRVHPIDLNEEMETSYIDYAMSVIVGRALPEVRDGLKPVHRRILYAMYD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
SGYRPDRSYVKSARPVSDTMGQFHPHGDSAIYDTLVRLAQDWNMRYPMVDGQGNFGSRGN
CCCCCCHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCC
DGPAAMRYTECRLTPLAMEMVRDIRENTVDFSPNYDGKTQEPDVLPSRVPNLLMNGSNGI
CCCCCEEEEHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCHHEECCCCCE
AVGMATNIPPHNLRELGDAIFWLLDNPEADEASALEACMKYVKGPDFPTAGQIVGSQGIN
EEEEECCCCCHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCC
DAYTTGRGSIRMRGVTSIEEEGNRQIIVITELPYQVNPDNMISNIAEQVRDGKLAGISKI
CCCCCCCCCEEEECCCCHHHCCCCEEEEEEECCCEECHHHHHHHHHHHHHCCCCCCCHHC
EDESSDRVGMRIVVTLKRDAVPRVVLNNLYKHSQLQTNFGANMLSIVDGVPRTLRLDQML
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHH
RHYVTHQIEVIVRRTQYRLDEAEKRAHILRGLVKALDMLDEVIALIRRSPTVDIARTGLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ELLTVDEIQADAILAMQLRRLAALERQKIVDELAEIELEIADYKDILARPERQRAIVRDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHCCCHHHHHHHHHH
LAEIVDKYGDDRRTQIIAATGDVTEEDLIARENVVVTITSTGYAKRTKVDAYKSQRRGGK
HHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCC
GVRGAELKQDDVVRHFFVSSTHDWILFFTNFGRVYRLKAYELPEASRTARGQHVANLLEF
CCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHC
QPEERIAQVIQIQSYEDAPYLVLATAQGRVKKSRLSDYESNRSGGLIAINLNEGDKLIGA
CCHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCEEEE
ALCDNDDDLLLVSEEGQSIRFNANDDQLRPMGRATAGVKGMRFKGDDQLLAMTVVKPDAF
EECCCCCCEEEECCCCCEEEECCCCCCCCCCCHHHCCCCCCEECCCCCEEEEEEECCCEE
LLVATSGGYGKRTSLDEYSPQGRGGQGVLTFKYTPKRGKLIAAVVVDEDDEILAITSAGG
EEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEECCCH
VIRTVVNQIRPSSRATMGVRLVNLEDGVELLAIDRNVEGEGEEAAEAVATGAVDGPAERG
HHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHCC
KQTEVDLGIDNADEEA
CCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8878580 [H]