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The map label for this gene is ilvG [H]

Identifier: 37681424

GI number: 37681424

Start: 3331178

End: 3332824

Strand: Direct

Name: ilvG [H]

Synonym: VV3240

Alternate gene names: 37681424

Gene position: 3331178-3332824 (Clockwise)

Preceding gene: 37681422

Following gene: 37681425

Centisome position: 99.3

GC content: 52.4

Gene sequence:

>1647_bases
ATGACAGGAGCAGAGTTAGTCGTTGCCGCATTAAAACAGCAAGGCATCAAAACCGTGTTTGGTTACCCTGGTGGTGCCAT
CATGCCAATCTACGATGCCTTGTATGACGGTGGTGTTGAACACATTTTGTGTCGTCATGAACAAGGGGCTGCGATGGCAG
CGATTGGGATGGCGCGAGCCACGCAGGATGTTGCGGTGTGTATGGCCACATCGGGTCCCGGAGCCACCAACCTTGTCACC
GGTTTAGCCGATGCCTTTCTTGATTCAGTGCCGTTAGTTGCCATCACCGGTCAGGTTGCCAGTTCTCATATCGGCACCGA
TGCATTCCAAGAAATGGATGTGATTGGTATGTCGCTATCGTGTACTAAACACAGTTACTTAGTGACCGACATCAACGAGC
TGGCCCCAACCTTGGCAGAAGCCTTTGAAGTGGCCAAAACCGGACGACCGGGCCCAGTGATTGTCGATATCGCCAAAGAC
GTCCAGCTTGCAAAAGCGCCTGTTGAATTGCTTCCTCCTTTTACGCCTCCAGCATTACCCCAAGTCAGCCAAGTTGATGT
GGCTCGAGCTCAAGCGCTTCTCGATCAATCCACCCGCCCGGTGTTATACGTCGGTGGTGGTGTGCAACTGGCTAAAGCGA
CCCATACGGTGCGCGAATTTTTACGCCTCAACCCGATGCCTGCCGTCAGCACCTTAAAAGGGTTAGGCACCATCGAACGT
CACGACCCTCACTATTTGGGCATGCTCGGCATGCATGGCACCAAAGCGGCCAACCTCGTGGTGCAAGAAGCGGATCTTTT
GCTGGTGGTAGGTGCACGTTTTGATGACCGTGTGACGGGCAAATTAGAAACCTTCGCCCCTCACGCCAAAGTGATCCACA
TTGATATCGACGCGGCAGAAATCAATAAACTGCGTCATGCCAACGCTCCGTTACGCGGCGATATCAATGTCATCCTGCCT
CAGTTAGAACTGACTCGTGATATTTCTCCTTGGGTTCATCACTGTGAAAGCTTACGCAGCGGCTTTAAGTGGCGTTACGA
CCACCCAGGAGAGCTCATCTATGCGCCGGGGTTGCTCAAGCAACTTTCCGATCTGATGCCGGACAACACCATCGTCTCCA
CCGACGTAGGCCAACACCAGATGTGGGCAGCGCAACACATTCAGCCACGCGAACCACAAAACTTCATCACCTCAGCGGGC
CTTGGCACCATGGGTTTTGGCTTGCCAGCGGCGATGGGCGCCGCAGTAGCAAGACCGGACGCACAATCGGTGCTGATCTC
TGGTGATGGCTCAATCATGATGAACATCCAAGAATTAGGCACGCTCAAGCGCCGCCAAATCCCAGTCAAAATCGTGTTGT
TGAACAACCAACGTCTTGGCATGGTGCGTCAGTGGCAATCGCTGTTCTTCGATGGTCGTCACAGTGAAACCATCCTTGAT
GACAACCCTGATTTTGTCATGTTGGCGAAAGCCTTCGATATTCCGGGCAAAACCATTACCAAGAAAGAAGAAGTGGAACC
GGCACTTAAAGAGATGCTCGCAAGCAAAACATCTTACTTGCTGCATGTGTTGATTGATGAAGAAGAAAATGTGTGGCCGC
TGGTACCGCCAGGTGCGTCAAACAGTGATATGTTGGAAAACACCTAG

Upstream 100 bases:

>100_bases
TTTTAGACAGTTCAGAAATGACGGGAAGTATGGGAGCGCACGCTATGTGCAAGATGTATGGAAACGGCTACAACCAAAAG
AGTAGCCAAGGAGGCCAACG

Downstream 100 bases:

>100_bases
GAGAGCCACTGATGGAACGTTATTTATTAGACATCAAAGCCGATGACAAACCCGTGCTGTTAGAGCGTGTTCTCCGTGTC
ATTCGCCACCGCGGCTTTGT

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MTGAELVVAALKQQGIKTVFGYPGGAIMPIYDALYDGGVEHILCRHEQGAAMAAIGMARATQDVAVCMATSGPGATNLVT
GLADAFLDSVPLVAITGQVASSHIGTDAFQEMDVIGMSLSCTKHSYLVTDINELAPTLAEAFEVAKTGRPGPVIVDIAKD
VQLAKAPVELLPPFTPPALPQVSQVDVARAQALLDQSTRPVLYVGGGVQLAKATHTVREFLRLNPMPAVSTLKGLGTIER
HDPHYLGMLGMHGTKAANLVVQEADLLLVVGARFDDRVTGKLETFAPHAKVIHIDIDAAEINKLRHANAPLRGDINVILP
QLELTRDISPWVHHCESLRSGFKWRYDHPGELIYAPGLLKQLSDLMPDNTIVSTDVGQHQMWAAQHIQPREPQNFITSAG
LGTMGFGLPAAMGAAVARPDAQSVLISGDGSIMMNIQELGTLKRRQIPVKIVLLNNQRLGMVRQWQSLFFDGRHSETILD
DNPDFVMLAKAFDIPGKTITKKEEVEPALKEMLASKTSYLLHVLIDEEENVWPLVPPGASNSDMLENT

Sequences:

>Translated_548_residues
MTGAELVVAALKQQGIKTVFGYPGGAIMPIYDALYDGGVEHILCRHEQGAAMAAIGMARATQDVAVCMATSGPGATNLVT
GLADAFLDSVPLVAITGQVASSHIGTDAFQEMDVIGMSLSCTKHSYLVTDINELAPTLAEAFEVAKTGRPGPVIVDIAKD
VQLAKAPVELLPPFTPPALPQVSQVDVARAQALLDQSTRPVLYVGGGVQLAKATHTVREFLRLNPMPAVSTLKGLGTIER
HDPHYLGMLGMHGTKAANLVVQEADLLLVVGARFDDRVTGKLETFAPHAKVIHIDIDAAEINKLRHANAPLRGDINVILP
QLELTRDISPWVHHCESLRSGFKWRYDHPGELIYAPGLLKQLSDLMPDNTIVSTDVGQHQMWAAQHIQPREPQNFITSAG
LGTMGFGLPAAMGAAVARPDAQSVLISGDGSIMMNIQELGTLKRRQIPVKIVLLNNQRLGMVRQWQSLFFDGRHSETILD
DNPDFVMLAKAFDIPGKTITKKEEVEPALKEMLASKTSYLLHVLIDEEENVWPLVPPGASNSDMLENT
>Mature_547_residues
TGAELVVAALKQQGIKTVFGYPGGAIMPIYDALYDGGVEHILCRHEQGAAMAAIGMARATQDVAVCMATSGPGATNLVTG
LADAFLDSVPLVAITGQVASSHIGTDAFQEMDVIGMSLSCTKHSYLVTDINELAPTLAEAFEVAKTGRPGPVIVDIAKDV
QLAKAPVELLPPFTPPALPQVSQVDVARAQALLDQSTRPVLYVGGGVQLAKATHTVREFLRLNPMPAVSTLKGLGTIERH
DPHYLGMLGMHGTKAANLVVQEADLLLVVGARFDDRVTGKLETFAPHAKVIHIDIDAAEINKLRHANAPLRGDINVILPQ
LELTRDISPWVHHCESLRSGFKWRYDHPGELIYAPGLLKQLSDLMPDNTIVSTDVGQHQMWAAQHIQPREPQNFITSAGL
GTMGFGLPAAMGAAVARPDAQSVLISGDGSIMMNIQELGTLKRRQIPVKIVLLNNQRLGMVRQWQSLFFDGRHSETILDD
NPDFVMLAKAFDIPGKTITKKEEVEPALKEMLASKTSYLLHVLIDEEENVWPLVPPGASNSDMLENT

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=554, Percent_Identity=24.5487364620939, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI21361361, Length=508, Percent_Identity=26.1811023622047, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1790104, Length=550, Percent_Identity=47.0909090909091, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI87081685, Length=566, Percent_Identity=42.9328621908127, Blast_Score=443, Evalue=1e-125,
Organism=Escherichia coli, GI1786717, Length=552, Percent_Identity=30.0724637681159, Blast_Score=252, Evalue=5e-68,
Organism=Escherichia coli, GI1787096, Length=546, Percent_Identity=29.8534798534799, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1788716, Length=545, Percent_Identity=26.9724770642202, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17531301, Length=481, Percent_Identity=28.6902286902287, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17531299, Length=481, Percent_Identity=28.6902286902287, Blast_Score=158, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17542570, Length=598, Percent_Identity=24.0802675585284, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323755, Length=569, Percent_Identity=42.3550087873462, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6320816, Length=481, Percent_Identity=24.5322245322245, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320123, Length=522, Percent_Identity=22.9885057471264, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323163, Length=491, Percent_Identity=22.1995926680244, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323073, Length=480, Percent_Identity=22.9166666666667, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI19922626, Length=541, Percent_Identity=25.6931608133087, Blast_Score=159, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59144; Mature: 59013

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGAELVVAALKQQGIKTVFGYPGGAIMPIYDALYDGGVEHILCRHEQGAAMAAIGMARA
CCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHHHC
TQDVAVCMATSGPGATNLVTGLADAFLDSVPLVAITGQVASSHIGTDAFQEMDVIGMSLS
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCHHHHHHHHHCEEEE
CTKHSYLVTDINELAPTLAEAFEVAKTGRPGPVIVDIAKDVQLAKAPVELLPPFTPPALP
CCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCHHHCCCCCCCCCC
QVSQVDVARAQALLDQSTRPVLYVGGGVQLAKATHTVREFLRLNPMPAVSTLKGLGTIER
CCHHHHHHHHHHHHCCCCCCEEEECCCEEEHHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
HDPHYLGMLGMHGTKAANLVVQEADLLLVVGARFDDRVTGKLETFAPHAKVIHIDIDAAE
CCCCEEEEECCCCCCHHHEEEEECCEEEEEECCCCCCCCCCHHHCCCCEEEEEEECCHHH
INKLRHANAPLRGDINVILPQLELTRDISPWVHHCESLRSGFKWRYDHPGELIYAPGLLK
HHHHHHCCCCCCCCCEEEECCHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCHHHH
QLSDLMPDNTIVSTDVGQHQMWAAQHIQPREPQNFITSAGLGTMGFGLPAAMGAAVARPD
HHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHCCCCHHCCCHHHHHHHHHCCCC
AQSVLISGDGSIMMNIQELGTLKRRQIPVKIVLLNNQRLGMVRQWQSLFFDGRHSETILD
CCEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEC
DNPDFVMLAKAFDIPGKTITKKEEVEPALKEMLASKTSYLLHVLIDEEENVWPLVPPGAS
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEECCCCCC
NSDMLENT
CCCCCCCC
>Mature Secondary Structure 
TGAELVVAALKQQGIKTVFGYPGGAIMPIYDALYDGGVEHILCRHEQGAAMAAIGMARA
CCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCHHHEEEECCCCCHHHHHHHHHC
TQDVAVCMATSGPGATNLVTGLADAFLDSVPLVAITGQVASSHIGTDAFQEMDVIGMSLS
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCHHHHHHHHHCEEEE
CTKHSYLVTDINELAPTLAEAFEVAKTGRPGPVIVDIAKDVQLAKAPVELLPPFTPPALP
CCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCHHHCCCCCCCCCC
QVSQVDVARAQALLDQSTRPVLYVGGGVQLAKATHTVREFLRLNPMPAVSTLKGLGTIER
CCHHHHHHHHHHHHCCCCCCEEEECCCEEEHHHHHHHHHHHHCCCCCHHHHHHHCCCCCC
HDPHYLGMLGMHGTKAANLVVQEADLLLVVGARFDDRVTGKLETFAPHAKVIHIDIDAAE
CCCCEEEEECCCCCCHHHEEEEECCEEEEEECCCCCCCCCCHHHCCCCEEEEEEECCHHH
INKLRHANAPLRGDINVILPQLELTRDISPWVHHCESLRSGFKWRYDHPGELIYAPGLLK
HHHHHHCCCCCCCCCEEEECCHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCHHHH
QLSDLMPDNTIVSTDVGQHQMWAAQHIQPREPQNFITSAGLGTMGFGLPAAMGAAVARPD
HHHHHCCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHCCCCHHCCCHHHHHHHHHCCCC
AQSVLISGDGSIMMNIQELGTLKRRQIPVKIVLLNNQRLGMVRQWQSLFFDGRHSETILD
CCEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEC
DNPDFVMLAKAFDIPGKTITKKEEVEPALKEMLASKTSYLLHVLIDEEENVWPLVPPGAS
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEECCCCCC
NSDMLENT
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]