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The map label for this gene is hmp [H]

Identifier: 37681248

GI number: 37681248

Start: 3145307

End: 3146491

Strand: Direct

Name: hmp [H]

Synonym: VV3064

Alternate gene names: 37681248

Gene position: 3145307-3146491 (Clockwise)

Preceding gene: 37681246

Following gene: 37681251

Centisome position: 93.76

GC content: 48.19

Gene sequence:

>1185_bases
ATGCTCAGCGAAAACACCATTAACATTGTAAAATCCACCGCCCCCCTGTTGGCCGAAACAGGACCAAAACTGACCGCCCA
TTTCTACCAACGTATGTTTGAGCACAACCCTGAACTCAAAGATATATTTAACATGAGCAACCAACGCAATGGTGACCAAC
GAGAAGCGTTGTTCAACGCCATCTGCGCCTACGCCAGCAACATTGACAATCTGCCTGCACTCTTAGGCGCAGTGGAAAAA
ATCGCTCACAAGCACTCCAGCTTTTTGATCACTGCCGATCAATATCAAATTGTCGGCAGTCACTTGCTAGCAACCATCGA
TGAACTTTTTTCTCCGGGGCAAGCCGTGCTCGATGCCTGGGCTGAAGCTTATGGTGTGCTGGCGAATGTCTTCATTCAGC
GAGAAGAGCAAATTTATCAAGCCAACCAATCACAAACCGGCGGCTGGCGTGGCTTGCGAGAGTTTGAACTGGTCGAAAAA
CAATACGAGAGTGCACACATCTGTAGCTTTGTCTTCAAGCCCGTGGATGGCGGCTCTGTCGTTAGCTTCAAACCAGGGCA
ATATTTAGGGATTTACATCAACGATGAGCAGTTTGAAAATCAAGAAATTCGCCAATACAGCTTGTCATCCTCTGTACGTC
CTGATTGCTATCGCATTTCGGTGAAACGTGAAGAAGGCGGCCGAGTCTCTAACTATCTGCACGATCATCTCGACGTTGGC
AGCAAAGTCAAACTCGCAGCGCCTGCCGGTGACTTTTTCCTTGATGCCGCGCCAACGGCACCAGTCGTGCTTATCTCTGC
GGGTGTCGGCCTCACGCCAACACTTTCTATGCTTGAAAGCCTCACCGAGCATCAAGCGCCGGTGACTTGGATTCATGCAA
CTGAAAATGGCCAACAACACGCATTTAAACAACACGTCAAACAATTGGTTGAAACGCATCCGCATTTCAATTCGTTAGTT
TGGTACAACCAACCAAACTCAGACGATAAAATCGGTGACGATTTCCAGTTCAGTGGATGGGTGAACCTGCATGAGATTGA
AACCGTCCTCAAACAGGCAGATGTACAAGTGTACTTCTGCGGCCCTGTTGGCTTTATGCAGTTTATCGCCAAACAATTGC
TTGAGATGGGAGTGCCTGAACAACAGTTCCATTACGAATGTTTTGGCCCACACAAAGTGGTTTAG

Upstream 100 bases:

>100_bases
AAACTTTTCTTGATTGAAAGATACATTTGAGATACAACTTTAAACATGCATTACAGATGCAACTTAAAATTAAACAAATA
ATCCTAATAGGAAGCCCGCT

Downstream 100 bases:

>100_bases
CATTAAAGTAGTTTAGTATTAGAGCGCGACAAGGTTCGTTGAACTCAACCACACAAGACACAAAAGCCCACCGAGTTGGT
GGGCTTTGGCATTCAAAGAG

Product: nitric oxide dioxygenase

Products: NA

Alternate protein names: Flavohemoglobin; Hemoglobin-like protein; Nitric oxide dioxygenase; NO oxygenase; NOD [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MLSENTINIVKSTAPLLAETGPKLTAHFYQRMFEHNPELKDIFNMSNQRNGDQREALFNAICAYASNIDNLPALLGAVEK
IAHKHSSFLITADQYQIVGSHLLATIDELFSPGQAVLDAWAEAYGVLANVFIQREEQIYQANQSQTGGWRGLREFELVEK
QYESAHICSFVFKPVDGGSVVSFKPGQYLGIYINDEQFENQEIRQYSLSSSVRPDCYRISVKREEGGRVSNYLHDHLDVG
SKVKLAAPAGDFFLDAAPTAPVVLISAGVGLTPTLSMLESLTEHQAPVTWIHATENGQQHAFKQHVKQLVETHPHFNSLV
WYNQPNSDDKIGDDFQFSGWVNLHEIETVLKQADVQVYFCGPVGFMQFIAKQLLEMGVPEQQFHYECFGPHKVV

Sequences:

>Translated_394_residues
MLSENTINIVKSTAPLLAETGPKLTAHFYQRMFEHNPELKDIFNMSNQRNGDQREALFNAICAYASNIDNLPALLGAVEK
IAHKHSSFLITADQYQIVGSHLLATIDELFSPGQAVLDAWAEAYGVLANVFIQREEQIYQANQSQTGGWRGLREFELVEK
QYESAHICSFVFKPVDGGSVVSFKPGQYLGIYINDEQFENQEIRQYSLSSSVRPDCYRISVKREEGGRVSNYLHDHLDVG
SKVKLAAPAGDFFLDAAPTAPVVLISAGVGLTPTLSMLESLTEHQAPVTWIHATENGQQHAFKQHVKQLVETHPHFNSLV
WYNQPNSDDKIGDDFQFSGWVNLHEIETVLKQADVQVYFCGPVGFMQFIAKQLLEMGVPEQQFHYECFGPHKVV
>Mature_394_residues
MLSENTINIVKSTAPLLAETGPKLTAHFYQRMFEHNPELKDIFNMSNQRNGDQREALFNAICAYASNIDNLPALLGAVEK
IAHKHSSFLITADQYQIVGSHLLATIDELFSPGQAVLDAWAEAYGVLANVFIQREEQIYQANQSQTGGWRGLREFELVEK
QYESAHICSFVFKPVDGGSVVSFKPGQYLGIYINDEQFENQEIRQYSLSSSVRPDCYRISVKREEGGRVSNYLHDHLDVG
SKVKLAAPAGDFFLDAAPTAPVVLISAGVGLTPTLSMLESLTEHQAPVTWIHATENGQQHAFKQHVKQLVETHPHFNSLV
WYNQPNSDDKIGDDFQFSGWVNLHEIETVLKQADVQVYFCGPVGFMQFIAKQLLEMGVPEQQFHYECFGPHKVV

Specific function: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a centra

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788903, Length=396, Percent_Identity=61.3636363636364, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1787658, Length=220, Percent_Identity=26.8181818181818, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788104, Length=242, Percent_Identity=26.0330578512397, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321673, Length=413, Percent_Identity=33.8983050847458, Blast_Score=218, Evalue=1e-57,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017927
- InterPro:   IPR001709
- InterPro:   IPR012292
- InterPro:   IPR009050
- InterPro:   IPR000971
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00042 Globin; PF00175 NAD_binding_1 [H]

EC number: =1.14.12.17 [H]

Molecular weight: Translated: 44233; Mature: 44233

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01033 GLOBIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSENTINIVKSTAPLLAETGPKLTAHFYQRMFEHNPELKDIFNMSNQRNGDQREALFNA
CCCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHH
ICAYASNIDNLPALLGAVEKIAHKHSSFLITADQYQIVGSHLLATIDELFSPGQAVLDAW
HHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHH
AEAYGVLANVFIQREEQIYQANQSQTGGWRGLREFELVEKQYESAHICSFVFKPVDGGSV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCE
VSFKPGQYLGIYINDEQFENQEIRQYSLSSSVRPDCYRISVKREEGGRVSNYLHDHLDVG
EEECCCCEEEEEECCCHHCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCC
SKVKLAAPAGDFFLDAAPTAPVVLISAGVGLTPTLSMLESLTEHQAPVTWIHATENGQQH
CEEEEECCCCCCEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
AFKQHVKQLVETHPHFNSLVWYNQPNSDDKIGDDFQFSGWVNLHEIETVLKQADVQVYFC
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCEEEEEE
GPVGFMQFIAKQLLEMGVPEQQFHYECFGPHKVV
CCHHHHHHHHHHHHHCCCCHHHCCEEECCCCCCC
>Mature Secondary Structure
MLSENTINIVKSTAPLLAETGPKLTAHFYQRMFEHNPELKDIFNMSNQRNGDQREALFNA
CCCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHH
ICAYASNIDNLPALLGAVEKIAHKHSSFLITADQYQIVGSHLLATIDELFSPGQAVLDAW
HHHHHCCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHH
AEAYGVLANVFIQREEQIYQANQSQTGGWRGLREFELVEKQYESAHICSFVFKPVDGGSV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCE
VSFKPGQYLGIYINDEQFENQEIRQYSLSSSVRPDCYRISVKREEGGRVSNYLHDHLDVG
EEECCCCEEEEEECCCHHCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCC
SKVKLAAPAGDFFLDAAPTAPVVLISAGVGLTPTLSMLESLTEHQAPVTWIHATENGQQH
CEEEEECCCCCCEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
AFKQHVKQLVETHPHFNSLVWYNQPNSDDKIGDDFQFSGWVNLHEIETVLKQADVQVYFC
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHCCEEEEEE
GPVGFMQFIAKQLLEMGVPEQQFHYECFGPHKVV
CCHHHHHHHHHHHHHCCCCHHHCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA