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The map label for this gene is mtaD [H]

Identifier: 37681246

GI number: 37681246

Start: 3143191

End: 3144687

Strand: Direct

Name: mtaD [H]

Synonym: VV3062

Alternate gene names: 37681246

Gene position: 3143191-3144687 (Clockwise)

Preceding gene: 37681234

Following gene: 37681248

Centisome position: 93.7

GC content: 49.37

Gene sequence:

>1497_bases
ATGCAAACCGAGGAGCAAACGTTTGCAATTCATCATGAATCTCTTACTATCGCGGCAAACTATACCGATGCCTGTTCCAA
GGAAAATAGAATGCTGAAACGTAACGTAATTGCTGCTGCCATCGCAGGCATGAGCCTGTTTTCGTCCATGAGTTATGCCG
CACAACCCGCGGATCTCATGATCACCGATGCCATGATCCTCACCATGAACAAAGACAAAGTGGTGTATCAAAACGGCACT
GTAGTGGTAAAAGAGAACAAAATCATCGCGGTGGGTGATGCGGATGTGGCAAAGCAGTATCAAGCGAAACAAGTGCTTGA
TGTCGATGGGGATATCGTGATGCCGGGTTTAATCAACACGCACACGCATGTGTCGATGACGGTATTTCGCTCATTAGGTG
ACGATGTGCCTGACCGCCTGCATCGCTACATTTTCCCATTGGAAGCCAAACTGGTGTCACGCGATATGGTGCGCATCGGC
GCAAACTTGGGTAATGTTGAAATGCTCAAAGGTGGCGTAACGACCTACGCAGACATGTATTACTTCGAAGATGAAGTGGC
GAAAACGGTCGACCAAATTGGTATGCGCGCCGTGCTTGGCCAGAGTGTGATTCAGTTTCCTGTCGCCGATGCCAAAAACG
CCGACGAAGGCATTCAATACGCCCTGAACTTTATCGACCAATACCAAGATCACCCAAGAATTACCCCAGCGTTTGCACCG
CATGCGCCCTACACCAACACCACAGAAACGCTACAGAAAATCGCCAAACTCTCGCTAGAAAAAAACGTGCCTGTTTTGAT
TCACTTAGCCGAATCCACCCGTGAACAAGAAAAGATTGCTGAACGCGCAAATGGTTTATCGCCAGTGCAGTACATGCATC
AAATCGGCGCATTGAATGCCAACCTCGTCGGCGCTCACATGATTTTGGTCGACGACAAAGACATTGAGTTAGTGAAGCAG
GCCGATATGGGCGTGGCTCATAACATGAGTGCCAACATTAAGTCTGCCAAAGGCGTCGCCCCAGCCCTCAAGATGTACGA
CGAAAACGTGCGTATTGGTTTGGGTACCGATGGTCCAATGTCGGGCAACACGCTGAGCACCATTGATGAATTCAACCAAG
TGGCGAAAGTACACAAACTGGTCAATCACGATCGTGCAGCCATGCCACCACTCAAAGTGATCGATATGGCGACCATGGGC
GCAGCAAAAGCACTGCATATGGAAGATAAAATCGGTTCTCTTGAAGTCGGCAAACTGGCGGACATCATCGTTATCGATAC
CAAAGCGCCAAATATGGTCCCCGTTTACAACCCATACTCTGCTTTGGTTTACTCAGCCAACAGCGGCAATGTGCGCCATG
CCATTGTTGATGGCAAGCTGATCATGCAAGAGCGCCAAATCAACACGGTGAATGAGGAGCAAATTCGCCAAGAAGCACTG
GCCTTTACTGACATCGTCCGTAAAACCGTGCTCGACTCGGGCGAAGAGATTCGCTAA

Upstream 100 bases:

>100_bases
ACAGCCACGCGTCGCAGTTTCAGCAAATTAACACTTATTTTTCATAGTTTTTCATCATTCTTCTGATTCGTTTACATCTC
CGTGCCAAGATCACAGAAGT

Downstream 100 bases:

>100_bases
CTCCGCGACGTTCTGCAGCAACAGTGTGCTCTATCTTTGGATAGGGCATACTGGCAACGCCAGTTAGGCTTTTTGCAGCA
AGATCAGGAGCTCTGCGTTG

Product: cytosine deaminase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MQTEEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLMITDAMILTMNKDKVVYQNGT
VVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIG
ANLGNVEMLKGGVTTYADMYYFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERANGLSPVQYMHQIGALNANLVGAHMILVDDKDIELVKQ
ADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMG
AAKALHMEDKIGSLEVGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
AFTDIVRKTVLDSGEEIR

Sequences:

>Translated_498_residues
MQTEEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLMITDAMILTMNKDKVVYQNGT
VVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIG
ANLGNVEMLKGGVTTYADMYYFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERANGLSPVQYMHQIGALNANLVGAHMILVDDKDIELVKQ
ADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMG
AAKALHMEDKIGSLEVGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
AFTDIVRKTVLDSGEEIR
>Mature_498_residues
MQTEEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLMITDAMILTMNKDKVVYQNGT
VVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINTHTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIG
ANLGNVEMLKGGVTTYADMYYFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERANGLSPVQYMHQIGALNANLVGAHMILVDDKDIELVKQ
ADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPMSGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMG
AAKALHMEDKIGSLEVGKLADIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
AFTDIVRKTVLDSGEEIR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=379, Percent_Identity=23.7467018469657, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789249, Length=414, Percent_Identity=23.1884057971014, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319963, Length=335, Percent_Identity=26.865671641791, Blast_Score=119, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24643849, Length=435, Percent_Identity=25.0574712643678, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 54689; Mature: 54689

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTEEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLM
CCCCCCEEEEEECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
ITDAMILTMNKDKVVYQNGTVVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINT
EEEEEEEEECCCEEEEECCEEEEECCEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCC
HTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIGANLGNVEMLKGGVTTYADMY
CCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
YFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERANGLSPVQYMHQIGALNA
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
NLVGAHMILVDDKDIELVKQADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPM
CEEEEEEEEEECCCHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCC
SGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMGAAKALHMEDKIGSLEVGKLA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHEEHHCCCCCEECCCCE
DIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
EEEEEECCCCCEEEEECCCEEEEEECCCCCEEEEEECCEEEEEHHCCCCCCHHHHHHHHH
AFTDIVRKTVLDSGEEIR
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQTEEQTFAIHHESLTIAANYTDACSKENRMLKRNVIAAAIAGMSLFSSMSYAAQPADLM
CCCCCCEEEEEECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
ITDAMILTMNKDKVVYQNGTVVVKENKIIAVGDADVAKQYQAKQVLDVDGDIVMPGLINT
EEEEEEEEECCCEEEEECCEEEEECCEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCC
HTHVSMTVFRSLGDDVPDRLHRYIFPLEAKLVSRDMVRIGANLGNVEMLKGGVTTYADMY
CCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHH
YFEDEVAKTVDQIGMRAVLGQSVIQFPVADAKNADEGIQYALNFIDQYQDHPRITPAFAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
HAPYTNTTETLQKIAKLSLEKNVPVLIHLAESTREQEKIAERANGLSPVQYMHQIGALNA
CCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
NLVGAHMILVDDKDIELVKQADMGVAHNMSANIKSAKGVAPALKMYDENVRIGLGTDGPM
CEEEEEEEEEECCCHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCC
SGNTLSTIDEFNQVAKVHKLVNHDRAAMPPLKVIDMATMGAAKALHMEDKIGSLEVGKLA
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHEEHHCCCCCEECCCCE
DIIVIDTKAPNMVPVYNPYSALVYSANSGNVRHAIVDGKLIMQERQINTVNEEQIRQEAL
EEEEEECCCCCEEEEECCCEEEEEECCCCCEEEEEECCEEEEEHHCCCCCCHHHHHHHHH
AFTDIVRKTVLDSGEEIR
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA