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The map label for this gene is cytR [H]

Identifier: 37681197

GI number: 37681197

Start: 3095049

End: 3096056

Strand: Direct

Name: cytR [H]

Synonym: VV3013

Alternate gene names: 37681197

Gene position: 3095049-3096056 (Clockwise)

Preceding gene: 37681196

Following gene: 37681198

Centisome position: 92.27

GC content: 50.69

Gene sequence:

>1008_bases
ATGGCGACAATGAAGGATGTTGCCCAGCTTGCAGGAGTTTCAACGGCAACGGTTTCGAGAGCGCTGATGAATCCAGACAA
AGTATCCGCCACAACGCGTAAGCGTGTGGAAGATGCGGTGTTGGAAGCTGGTTATTCCCCAAATTCGCTGGCACGCAATT
TACGCCGCAACGAGTCACGCACTATCGTCGCGATCGTTCCTGACATTTGTGATCCTTACTACACAGAGATCATTCGTGGC
ATTGAAGATGCCGCCATTGAACAGGGATATTTGGTTCTACTCGGTGACAGCGGCCAACAAAAGCGCCGTGAAAGCTCACT
CGTCAATCTCGTTTTTACCAAGCAAGCGGATGGTATGCTACTGCTTGGTACCGACTTACCGTTTGATGTGAGCAAGCCAG
AACAGAAAAATCTTCCTCCGATGGTCATGGCTTGCGAGTTCGCCCCCGATCTCGAACTGCCGACGGTTCATATCGATAAC
TTGACCTCAGCATTTGAAGCGGTGAACTACCTGACCCAATTGGGCCACAAACGCATCGCCCAAATTTCAGGGCCAAAATC
CGCAGCACTTTGTCAGTTTAGACAACAAGGCTATCAACAAGCTTTGCGCCGTGCAGGCATCACAATGAACCCACAATACT
GTGTTGAGTCTGAGTTCTCTTTTGAAGGTGGGGCGAAAGCGATCCGTCATCTGCTAGAAATGAATGACGCGCCAACCGCC
GTTTTCTGCCATTGTGACACCATGGCTATCGGGGCGATTCAAGAAGCGAAAAAATTGGGCTTCCGAGTACCCCAGGATCT
GTCGATTGTCGGCTTCGATGACATCCAGTTCGCCCAATATTGCGATCCTCCACTAACCACCATCTCACAACCACGCTATG
AGATTGGTCGTCAAGCGATGCTAATGATGTTAGAGCTGCTGAAAGGGCATGACATTCACAGTGGCTCACGCCTACTTGAA
ACCAAATTGGTGGTTCGTGGTAGCGCAGCGCCTCCGGGCTTACGCTAA

Upstream 100 bases:

>100_bases
ATTCAAATTAGAACGAGGCAACTCATAATTCGATTTTATTTTCCGAATCAGAACAATAACTAAACGTCATAATTGGCGAA
CATTTTGAGAGGGTTAGTAT

Downstream 100 bases:

>100_bases
AACCAAAACCAACCGGCAGCGAGGTTATTTGCAGCCTCGCTTCCTTTTCTGCGACGTTTCCCTGTTAACGCTTGGCATTC
TGCATTACCATAGCGGGCTA

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MATMKDVAQLAGVSTATVSRALMNPDKVSATTRKRVEDAVLEAGYSPNSLARNLRRNESRTIVAIVPDICDPYYTEIIRG
IEDAAIEQGYLVLLGDSGQQKRRESSLVNLVFTKQADGMLLLGTDLPFDVSKPEQKNLPPMVMACEFAPDLELPTVHIDN
LTSAFEAVNYLTQLGHKRIAQISGPKSAALCQFRQQGYQQALRRAGITMNPQYCVESEFSFEGGAKAIRHLLEMNDAPTA
VFCHCDTMAIGAIQEAKKLGFRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLELLKGHDIHSGSRLLE
TKLVVRGSAAPPGLR

Sequences:

>Translated_335_residues
MATMKDVAQLAGVSTATVSRALMNPDKVSATTRKRVEDAVLEAGYSPNSLARNLRRNESRTIVAIVPDICDPYYTEIIRG
IEDAAIEQGYLVLLGDSGQQKRRESSLVNLVFTKQADGMLLLGTDLPFDVSKPEQKNLPPMVMACEFAPDLELPTVHIDN
LTSAFEAVNYLTQLGHKRIAQISGPKSAALCQFRQQGYQQALRRAGITMNPQYCVESEFSFEGGAKAIRHLLEMNDAPTA
VFCHCDTMAIGAIQEAKKLGFRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLELLKGHDIHSGSRLLE
TKLVVRGSAAPPGLR
>Mature_334_residues
ATMKDVAQLAGVSTATVSRALMNPDKVSATTRKRVEDAVLEAGYSPNSLARNLRRNESRTIVAIVPDICDPYYTEIIRGI
EDAAIEQGYLVLLGDSGQQKRRESSLVNLVFTKQADGMLLLGTDLPFDVSKPEQKNLPPMVMACEFAPDLELPTVHIDNL
TSAFEAVNYLTQLGHKRIAQISGPKSAALCQFRQQGYQQALRRAGITMNPQYCVESEFSFEGGAKAIRHLLEMNDAPTAV
FCHCDTMAIGAIQEAKKLGFRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAMLMMLELLKGHDIHSGSRLLET
KLVVRGSAAPPGLR

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=327, Percent_Identity=62.9969418960245, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1790194, Length=333, Percent_Identity=38.1381381381381, Blast_Score=209, Evalue=1e-55,
Organism=Escherichia coli, GI1787948, Length=334, Percent_Identity=32.6347305389222, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789202, Length=334, Percent_Identity=31.437125748503, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1788474, Length=330, Percent_Identity=33.030303030303, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1789068, Length=338, Percent_Identity=31.0650887573964, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI48994940, Length=311, Percent_Identity=29.2604501607717, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787906, Length=332, Percent_Identity=28.6144578313253, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786540, Length=341, Percent_Identity=29.6187683284457, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787580, Length=316, Percent_Identity=26.8987341772152, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790715, Length=313, Percent_Identity=27.4760383386581, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1789456, Length=316, Percent_Identity=27.8481012658228, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1786268, Length=315, Percent_Identity=23.4920634920635, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790689, Length=314, Percent_Identity=25.796178343949, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36843; Mature: 36712

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMKDVAQLAGVSTATVSRALMNPDKVSATTRKRVEDAVLEAGYSPNSLARNLRRNESR
CCCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIVAIVPDICDPYYTEIIRGIEDAAIEQGYLVLLGDSGQQKRRESSLVNLVFTKQADGML
EEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHEEEEEEECCCCEE
LLGTDLPFDVSKPEQKNLPPMVMACEFAPDLELPTVHIDNLTSAFEAVNYLTQLGHKRIA
EEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
QISGPKSAALCQFRQQGYQQALRRAGITMNPQYCVESEFSFEGGAKAIRHLLEMNDAPTA
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCE
VFCHCDTMAIGAIQEAKKLGFRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAM
EEEECCHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHH
LMMLELLKGHDIHSGSRLLETKLVVRGSAAPPGLR
HHHHHHHCCCCCCCCCHHHHHHHEEECCCCCCCCC
>Mature Secondary Structure 
ATMKDVAQLAGVSTATVSRALMNPDKVSATTRKRVEDAVLEAGYSPNSLARNLRRNESR
CCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIVAIVPDICDPYYTEIIRGIEDAAIEQGYLVLLGDSGQQKRRESSLVNLVFTKQADGML
EEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHEEEEEEECCCCEE
LLGTDLPFDVSKPEQKNLPPMVMACEFAPDLELPTVHIDNLTSAFEAVNYLTQLGHKRIA
EEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
QISGPKSAALCQFRQQGYQQALRRAGITMNPQYCVESEFSFEGGAKAIRHLLEMNDAPTA
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCE
VFCHCDTMAIGAIQEAKKLGFRVPQDLSIVGFDDIQFAQYCDPPLTTISQPRYEIGRQAM
EEEECCHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHH
LMMLELLKGHDIHSGSRLLETKLVVRGSAAPPGLR
HHHHHHHCCCCCCCCCHHHHHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]