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The map label for this gene is yjcE [H]

Identifier: 37681145

GI number: 37681145

Start: 3033376

End: 3034710

Strand: Direct

Name: yjcE [H]

Synonym: VV2961

Alternate gene names: 37681145

Gene position: 3033376-3034710 (Clockwise)

Preceding gene: 229047210

Following gene: 37681154

Centisome position: 90.43

GC content: 44.42

Gene sequence:

>1335_bases
ATGTCGGTCTACTATACTCTCTGCTTTCTATCCGCTGCAGCAATGTTGATTGCTTTTGTAAACAGCAAGATAGGCAAAAT
GCAGACTACCATCGCGATTACCGCAGGTTCAATGGTGCTCTCATTACTTATTTTAATTGCTGGTCAGAACAACTGGTTCC
ACTTAACTGAAATCGCCACACAAACCATGTCGAGCATCGACTTTGAAGATTTCCTCCTCAAAGGTATTTTGGGCTTCTTA
TTGTTTGCCGGTGGTTTAGGTATCAAACTACCCAACCTTAAAGACCAAAAATGGGAAATTACCGTGTTGGCGCTAGGTGC
GACACTTTTCTCTACTTTCTTTATTGGTTTTGCTCTGTATGGCATTTGCCAGCTCATTGGTATTCAGTTTGATCTGATTT
ACTGCCTGCTTTTCGGTGCACTCATTTCACCGACCGACCCGATCGCCGTTTTGGCTATCGTGAAAAAACTCAAGGCACCT
CGTAGAATCTCAACGCAAATTGAAGGGGAATCACTATTCAATGATGGTTTTGGCCTTGTGATTTTTGTGACCTTGTTTAC
CATCGCATTTGGCCACGAAACACCCACGGTAGGCAGCGTTACCATGTTGTTTATCCAGGAAGCCATCGGCGGTATTTTGT
ATGGTTTCGCATTGGGGTTACTCTTCCATTATCTTATCTGTGCCACTGATGACCACTCAATGGAGCTACTACTCACCATT
GGCATCCCAACGGCAGGTTATGCTTTTGCAGAAGTGCTCCATGTTTCTGGTCCATTAGCAATGGTGGTCTCTGGCATTAT
GATTGGTAACTGGACACGATTCATCGGCTTCTCTAAAGAGAGTGAAGATCATCTCGATCATTTCTGGGAGCTCGTCGATG
AGTTTCTTAACGGTGTGCTTTTCCTTCTGATTGGTATGTCGATGTTGCTGTTTAAATTCCATCAAGAGGACTGGATTTTG
ATGGCCATCGCTATTCCACTGGTCTTAATCGCTCGTTACCTCAGCGTATTTTTGTCCTATATCGGCTTTAAACGCTTCCG
CCAATACAATCCATGGTCAATTAAAATCCTCACTTGGGGCGGGTTGCGCGGTGGTTTAGCCTTAGCGATGGCACTCTCAA
TTCCATCGGGTATCTGGGTTATTCCAGATAAGCTCATCGACGTGAAAGAGATTATTCTGGTGATGACCTACGCGGTGGTG
GTTTTTTCAATATTGGTTCAGGGTTCAACCATCACTCCAATGATCGAGAAAGCCAAACAATCAGAAGCTGAATTCGAAGC
GAAGCAAAGTTCGGTGACTGCTCCTGAAGGCAAGACAGAATCCATTTCATCATAA

Upstream 100 bases:

>100_bases
TTACAGCTCATTTGGACTAATTTACTAGGAAAAAGAGATTGCTATTTGCTCATCAAACGAGGAGAATTTCGTTCACAAAT
TGTTACAAATAGAGAACTGT

Downstream 100 bases:

>100_bases
TGATTAAGGGCCTTAGGGCCCTTTTTACTTCAGCCATTCATTAACAGTGGTGATATAACACAGTTCCGACCATGCGCTTT
TGCGTAATAGAGGCCTTCAT

Product: putative Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIATQTMSSIDFEDFLLKGILGFL
LFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALYGICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAP
RRISTQIEGESLFNDGFGLVIFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTI
GIPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVLFLLIGMSMLLFKFHQEDWIL
MAIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWGGLRGGLALAMALSIPSGIWVIPDKLIDVKEIILVMTYAVV
VFSILVQGSTITPMIEKAKQSEAEFEAKQSSVTAPEGKTESISS

Sequences:

>Translated_444_residues
MSVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIATQTMSSIDFEDFLLKGILGFL
LFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALYGICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAP
RRISTQIEGESLFNDGFGLVIFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTI
GIPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVLFLLIGMSMLLFKFHQEDWIL
MAIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWGGLRGGLALAMALSIPSGIWVIPDKLIDVKEIILVMTYAVV
VFSILVQGSTITPMIEKAKQSEAEFEAKQSSVTAPEGKTESISS
>Mature_443_residues
SVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIATQTMSSIDFEDFLLKGILGFLL
FAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALYGICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAPR
RISTQIEGESLFNDGFGLVIFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTIG
IPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVLFLLIGMSMLLFKFHQEDWILM
AIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWGGLRGGLALAMALSIPSGIWVIPDKLIDVKEIILVMTYAVVV
FSILVQGSTITPMIEKAKQSEAEFEAKQSSVTAPEGKTESISS

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=324, Percent_Identity=27.7777777777778, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI15529998, Length=339, Percent_Identity=27.4336283185841, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI27777632, Length=351, Percent_Identity=25.3561253561254, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI27734935, Length=356, Percent_Identity=24.438202247191, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI294997330, Length=445, Percent_Identity=22.0224719101124, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI110227626, Length=445, Percent_Identity=22.0224719101124, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI41872703, Length=377, Percent_Identity=25.4641909814324, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI5454070, Length=382, Percent_Identity=22.7748691099476, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI14211919, Length=409, Percent_Identity=24.2053789731051, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI194239733, Length=355, Percent_Identity=25.6338028169014, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4759144, Length=341, Percent_Identity=27.8592375366569, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790501, Length=358, Percent_Identity=27.6536312849162, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71999821, Length=402, Percent_Identity=24.8756218905473, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71999819, Length=402, Percent_Identity=24.8756218905473, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71999817, Length=402, Percent_Identity=24.8756218905473, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71987535, Length=344, Percent_Identity=25.5813953488372, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71987537, Length=344, Percent_Identity=25.5813953488372, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71990924, Length=368, Percent_Identity=24.4565217391304, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71990932, Length=368, Percent_Identity=24.4565217391304, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71980847, Length=367, Percent_Identity=25.0681198910082, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25150332, Length=324, Percent_Identity=24.3827160493827, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71993582, Length=336, Percent_Identity=27.0833333333333, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71993590, Length=336, Percent_Identity=27.0833333333333, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=300, Percent_Identity=24, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71992101, Length=300, Percent_Identity=24, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25147678, Length=296, Percent_Identity=25.3378378378378, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71987559, Length=336, Percent_Identity=22.6190476190476, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71987545, Length=336, Percent_Identity=22.6190476190476, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=344, Percent_Identity=25.5813953488372, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221473212, Length=350, Percent_Identity=26, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221473215, Length=350, Percent_Identity=26, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281364513, Length=350, Percent_Identity=26, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221473222, Length=350, Percent_Identity=26, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221510734, Length=339, Percent_Identity=25.3687315634218, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221510738, Length=339, Percent_Identity=25.3687315634218, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281360447, Length=411, Percent_Identity=24.5742092457421, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221510736, Length=334, Percent_Identity=25.4491017964072, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221510732, Length=334, Percent_Identity=25.4491017964072, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24585580, Length=339, Percent_Identity=25.3687315634218, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24585578, Length=339, Percent_Identity=25.3687315634218, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221510740, Length=339, Percent_Identity=25.3687315634218, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 48814; Mature: 48682

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIAT
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCEEHHHHHH
QTMSSIDFEDFLLKGILGFLLFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALY
HHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHH
GICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAPRRISTQIEGESLFNDGFGLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHCCCCHHH
IFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
GIPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVL
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FLLIGMSMLLFKFHQEDWILMAIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
GLRGGLALAMALSIPSGIWVIPDKLIDVKEIILVMTYAVVVFSILVQGSTITPMIEKAKQ
CCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
SEAEFEAKQSSVTAPEGKTESISS
HHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIAT
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCEEHHHHHH
QTMSSIDFEDFLLKGILGFLLFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALY
HHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHH
GICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAPRRISTQIEGESLFNDGFGLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHCCCCHHH
IFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
GIPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVL
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FLLIGMSMLLFKFHQEDWILMAIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
GLRGGLALAMALSIPSGIWVIPDKLIDVKEIILVMTYAVVVFSILVQGSTITPMIEKAKQ
CCCHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
SEAEFEAKQSSVTAPEGKTESISS
HHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]