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The map label for this gene is lysC [H]

Identifier: 229047210

GI number: 229047210

Start: 3028081

End: 3029430

Strand: Direct

Name: lysC [H]

Synonym: VV2959

Alternate gene names: 229047210

Gene position: 3028081-3029430 (Clockwise)

Preceding gene: 37681141

Following gene: 37681145

Centisome position: 90.27

GC content: 49.11

Gene sequence:

>1350_bases
GTGAGCGCATTGAATGTAGCGAAATTTGGTGGAACAAGTGTTGCAAACTTTGAGGCAATGAGTCGTTGCTCGGCCATTAT
TGAAAACAATCCAGAGACACGCTTAGTGGTAAGCAGTGCATGCTCTGGCGTCACTAACCTATTGGTAGAGTTGGCCAATG
GTGTTCAATCACAAGAAAGACGCGCTGAACTTCTAGCCCAATTGGCTGAAATTCATGACGCGATTCTCAATCAATTGGAA
GATGCAACAGAAGCGGCGGCGGAAGTGTATGCCATTCTCGATACCATCACTAGCCTTGCTGAAGCCGCATCGATTCAAGC
CAGCAATAAACTCACCGACCACTTGGTCGCATGTGGTGAGTTGATGTCGACTCATATTCTGGCCCAGTTGATGCGTGAGC
GTGGAGTCAACGCGGTGCGATTTGATATTCGAGAAGTCCTACGCACAGATGACAACTTTGGCCGCGCAGAACCTGACGTG
GCGAAAATTGCAGAGCTGGCGCAAGAGAAGCTTTTACCACTTTGCCGCGATTACGTGGTAGTAACTCAAGGCTTCATCGG
CTCGGATGAGGAAGGTAATACCACCACCTTAGGCCGTGGTGGCAGTGATTACAGTGCGGCTTTGATTGCCGAAGGCGTTA
AAGCAAGTGGCCTCGAGATTTGGACCGATGTTCCAGGGATCTACACCACTGATCCTCGCATTGCGGCGAAAGCAGCGCCA
ATTCCAGAAATCAGCTTTGCAGAAGCGTCTGAAATGGCTAACTTTGGTGCCAAAATTCTGCACCCATCAACGCTCGTTCC
AGCCCTTCGTCACGACATTCCAGTTTTTGTCGGATCGTCAAAAGAGCCAGAAAAAGGCGGTACTTGGATTCGCCACGAAG
CACAAAGCTCGCCGCTTTTCCGTGCACTGGCACTGCGTTGCAATCAGACTATGGTCACCTTACGCAGTGCGAAAATGTTC
CATGCGTACGGCTTCTTAGCCAAAGTATTTGAAATTCTCGCAAAACACAAAATCTCCGTGGATTTGATCACAACCTCAGA
GATCAGCGTTTCCCTCACTCTAGACAAAACGGACACTTCTGGTGGTGCACCTGAAGTGCCACAGGCCGCGCGAGAGGAGC
TTGAAGAGCTATGCACTGTTGAAGTCGAGCACAACCTTTGTCTGGTGGCCTTGATCGGCAATCATATGGAGACGAAGGGT
TACGCTAAAGAAGTCTTCAGCACCTTAGGGGATTTCAATTTGCGTATGATCTGTTACGGGGCAAGTGATCACAACCTTTG
CTTCTTAGTCGATGCACACGATTCTAAGAGCGTGATCCAAAAACTTCATCAAGATCTTTTTGAACGCTAA

Upstream 100 bases:

>100_bases
TGACCTCTCTAAACTGCTCTGCCCCTTTCCTCACCAAAACAAACATCGGATGTTGGATTACCAACGGTTAATATTTTTCG
GAAGTCGTGGGAGAAATGCC

Downstream 100 bases:

>100_bases
ACATCGTTTCAAGATCACATCGATCCAAAGAGAAAAGGTCACATCGCAGTGACCTTTTCGTTTGCTCAACGCTGGCTAGT
ATCAGCCATTAATATTAGGA

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSALNVAKFGGTSVANFEAMSRCSAIIENNPETRLVVSSACSGVTNLLVELANGVQSQERRAELLAQLAEIHDAILNQLE
DATEAAAEVYAILDTITSLAEAASIQASNKLTDHLVACGELMSTHILAQLMRERGVNAVRFDIREVLRTDDNFGRAEPDV
AKIAELAQEKLLPLCRDYVVVTQGFIGSDEEGNTTTLGRGGSDYSAALIAEGVKASGLEIWTDVPGIYTTDPRIAAKAAP
IPEISFAEASEMANFGAKILHPSTLVPALRHDIPVFVGSSKEPEKGGTWIRHEAQSSPLFRALALRCNQTMVTLRSAKMF
HAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTSGGAPEVPQAAREELEELCTVEVEHNLCLVALIGNHMETKG
YAKEVFSTLGDFNLRMICYGASDHNLCFLVDAHDSKSVIQKLHQDLFER

Sequences:

>Translated_449_residues
MSALNVAKFGGTSVANFEAMSRCSAIIENNPETRLVVSSACSGVTNLLVELANGVQSQERRAELLAQLAEIHDAILNQLE
DATEAAAEVYAILDTITSLAEAASIQASNKLTDHLVACGELMSTHILAQLMRERGVNAVRFDIREVLRTDDNFGRAEPDV
AKIAELAQEKLLPLCRDYVVVTQGFIGSDEEGNTTTLGRGGSDYSAALIAEGVKASGLEIWTDVPGIYTTDPRIAAKAAP
IPEISFAEASEMANFGAKILHPSTLVPALRHDIPVFVGSSKEPEKGGTWIRHEAQSSPLFRALALRCNQTMVTLRSAKMF
HAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTSGGAPEVPQAAREELEELCTVEVEHNLCLVALIGNHMETKG
YAKEVFSTLGDFNLRMICYGASDHNLCFLVDAHDSKSVIQKLHQDLFER
>Mature_448_residues
SALNVAKFGGTSVANFEAMSRCSAIIENNPETRLVVSSACSGVTNLLVELANGVQSQERRAELLAQLAEIHDAILNQLED
ATEAAAEVYAILDTITSLAEAASIQASNKLTDHLVACGELMSTHILAQLMRERGVNAVRFDIREVLRTDDNFGRAEPDVA
KIAELAQEKLLPLCRDYVVVTQGFIGSDEEGNTTTLGRGGSDYSAALIAEGVKASGLEIWTDVPGIYTTDPRIAAKAAPI
PEISFAEASEMANFGAKILHPSTLVPALRHDIPVFVGSSKEPEKGGTWIRHEAQSSPLFRALALRCNQTMVTLRSAKMFH
AYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTSGGAPEVPQAAREELEELCTVEVEHNLCLVALIGNHMETKGY
AKEVFSTLGDFNLRMICYGASDHNLCFLVDAHDSKSVIQKLHQDLFER

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=450, Percent_Identity=57.5555555555556, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1786183, Length=467, Percent_Identity=31.2633832976445, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1790376, Length=288, Percent_Identity=31.9444444444444, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320893, Length=496, Percent_Identity=28.8306451612903, Blast_Score=166, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 48642; Mature: 48511

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALNVAKFGGTSVANFEAMSRCSAIIENNPETRLVVSSACSGVTNLLVELANGVQSQER
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHH
RAELLAQLAEIHDAILNQLEDATEAAAEVYAILDTITSLAEAASIQASNKLTDHLVACGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMSTHILAQLMRERGVNAVRFDIREVLRTDDNFGRAEPDVAKIAELAQEKLLPLCRDYVV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VTQGFIGSDEEGNTTTLGRGGSDYSAALIAEGVKASGLEIWTDVPGIYTTDPRIAAKAAP
HHCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCEEEECCCCCEECCCCHHHCCCC
IPEISFAEASEMANFGAKILHPSTLVPALRHDIPVFVGSSKEPEKGGTWIRHEAQSSPLF
CCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEECCCCCCCCCCCEEEECCCCCHHH
RALALRCNQTMVTLRSAKMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEECCCCC
GGAPEVPQAAREELEELCTVEVEHNLCLVALIGNHMETKGYAKEVFSTLGDFNLRMICYG
CCCCCCCHHHHHHHHHHHEEEECCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEE
ASDHNLCFLVDAHDSKSVIQKLHQDLFER
CCCCCEEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SALNVAKFGGTSVANFEAMSRCSAIIENNPETRLVVSSACSGVTNLLVELANGVQSQER
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHH
RAELLAQLAEIHDAILNQLEDATEAAAEVYAILDTITSLAEAASIQASNKLTDHLVACGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMSTHILAQLMRERGVNAVRFDIREVLRTDDNFGRAEPDVAKIAELAQEKLLPLCRDYVV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VTQGFIGSDEEGNTTTLGRGGSDYSAALIAEGVKASGLEIWTDVPGIYTTDPRIAAKAAP
HHCCCCCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCEEEECCCCCEECCCCHHHCCCC
IPEISFAEASEMANFGAKILHPSTLVPALRHDIPVFVGSSKEPEKGGTWIRHEAQSSPLF
CCCCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEECCCCCCCCCCCEEEECCCCCHHH
RALALRCNQTMVTLRSAKMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEECCCCC
GGAPEVPQAAREELEELCTVEVEHNLCLVALIGNHMETKGYAKEVFSTLGDFNLRMICYG
CCCCCCCHHHHHHHHHHHEEEECCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEE
ASDHNLCFLVDAHDSKSVIQKLHQDLFER
CCCCCEEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]