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The map label for this gene is argF [H]

Identifier: 37681103

GI number: 37681103

Start: 2978566

End: 2979570

Strand: Direct

Name: argF [H]

Synonym: VV2919

Alternate gene names: 37681103

Gene position: 2978566-2979570 (Clockwise)

Preceding gene: 37681102

Following gene: 37681104

Centisome position: 88.79

GC content: 48.56

Gene sequence:

>1005_bases
ATGGCATTTAATCTCCGGAATCGCAACTTCCTCAAGTTGTTGGACTTCTCGACAAAAGAGATCCAGTTTTTGATCGATCT
GTCTGCTGATCTAAAGAAAGCCAAATACGCTGGCACTGAGCAGAAGAAACTACTGGGCAAAAACATTGCATTGATCTTTG
AGAAAGCGTCAACTCGTACCCGATGTGCTTTTGAAGTCGCCGCCTTTGATCAAGGCGCACAAGTCACCTATATCGGCCCT
TCTGGATCGCAAATTGGTGATAAAGAGTCGATGAAAGACACTGCGCGAGTGTTGGGTCGCATGTACGATGGCATTCAATA
TCGTGGCTTTGGTCAAGCGATCGTCGAAGAGCTCGGTGCTTTCGCTGGCGTCCCGGTATGGAATGGCTTAACCGACGAAT
TTCATCCCACACAAATTCTTGCTGACTTCCTCACCATGCTTGAACACAGCCAAGGCAAAGCACTTGCCGACATTCAATTC
GCCTACCTTGGTGATGCGCGTAATAACGTCGGCAATTCGTTGATGGTGGGTGCAGCCAAAATGGGCATGGATATTAGCCT
TGTTGGCCCGCAAGCTTACTGGCCCGATGAAGAACTCGTGACCGCCTGCCAAGCCATTGCCAAACAAACCGGTGGCAAGA
TTACCCTGACTGAAAATGTCGCAGAAGGGGTACAAGGCTGTGATTTCCTCTATACCGACGTTTGGGTCTCCATGGGTGAA
TCACCAGAGGCTTGGGATGAGCGCGTGGCCTTGATGAAGCCTTATCAAGTCAATACGAACGTCCTCAAGCAAACTGGCAA
TCCGAATGTCAAATTTATGCATTGCCTACCGGCTTTCCACAACGACGAAACCACCATTGGCAAACAAGTGGCTGACAAGT
TTGGCATGAAAGGCTTGGAAGTGACCGAAGAAGTGTTTGAATCCGAGCACTCGATTGTGTTTGATGAAGCCGAAAATCGC
ATGCACACCATCAAAGCCGTAATGGTCGCAACTTTAGGTAGTTAA

Upstream 100 bases:

>100_bases
AAGTTGGCTTTTTTATGCTTAATTTTAAAATAATTATTCACAAAAGTAGCATTTCTATGTTTTACTAGTGCCATGACGAT
GGATAAATAAGGAACGAGTC

Downstream 100 bases:

>100_bases
TCGATTACATTTCGGACCTAAAGCTTGATGTAATCGCTTGCGCTCGCTTTTCTTATGCGTATAATGCTCGGCAATTTGTC
CGAGGGTTGGTAAATAACAA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAFNLRNRNFLKLLDFSTKEIQFLIDLSADLKKAKYAGTEQKKLLGKNIALIFEKASTRTRCAFEVAAFDQGAQVTYIGP
SGSQIGDKESMKDTARVLGRMYDGIQYRGFGQAIVEELGAFAGVPVWNGLTDEFHPTQILADFLTMLEHSQGKALADIQF
AYLGDARNNVGNSLMVGAAKMGMDISLVGPQAYWPDEELVTACQAIAKQTGGKITLTENVAEGVQGCDFLYTDVWVSMGE
SPEAWDERVALMKPYQVNTNVLKQTGNPNVKFMHCLPAFHNDETTIGKQVADKFGMKGLEVTEEVFESEHSIVFDEAENR
MHTIKAVMVATLGS

Sequences:

>Translated_334_residues
MAFNLRNRNFLKLLDFSTKEIQFLIDLSADLKKAKYAGTEQKKLLGKNIALIFEKASTRTRCAFEVAAFDQGAQVTYIGP
SGSQIGDKESMKDTARVLGRMYDGIQYRGFGQAIVEELGAFAGVPVWNGLTDEFHPTQILADFLTMLEHSQGKALADIQF
AYLGDARNNVGNSLMVGAAKMGMDISLVGPQAYWPDEELVTACQAIAKQTGGKITLTENVAEGVQGCDFLYTDVWVSMGE
SPEAWDERVALMKPYQVNTNVLKQTGNPNVKFMHCLPAFHNDETTIGKQVADKFGMKGLEVTEEVFESEHSIVFDEAENR
MHTIKAVMVATLGS
>Mature_333_residues
AFNLRNRNFLKLLDFSTKEIQFLIDLSADLKKAKYAGTEQKKLLGKNIALIFEKASTRTRCAFEVAAFDQGAQVTYIGPS
GSQIGDKESMKDTARVLGRMYDGIQYRGFGQAIVEELGAFAGVPVWNGLTDEFHPTQILADFLTMLEHSQGKALADIQFA
YLGDARNNVGNSLMVGAAKMGMDISLVGPQAYWPDEELVTACQAIAKQTGGKITLTENVAEGVQGCDFLYTDVWVSMGES
PEAWDERVALMKPYQVNTNVLKQTGNPNVKFMHCLPAFHNDETTIGKQVADKFGMKGLEVTEEVFESEHSIVFDEAENRM
HTIKAVMVATLGS

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=329, Percent_Identity=37.6899696048632, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1790703, Length=327, Percent_Identity=67.5840978593272, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786469, Length=331, Percent_Identity=66.1631419939577, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI48994908, Length=378, Percent_Identity=24.3386243386243, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322373, Length=328, Percent_Identity=32.9268292682927, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 36790; Mature: 36659

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNLRNRNFLKLLDFSTKEIQFLIDLSADLKKAKYAGTEQKKLLGKNIALIFEKASTRT
CCCCCCCCCEEEEECCCCCCEEEEEECCHHHHHHHCCCCHHHHHHCCCEEEEEECCCCCC
RCAFEVAAFDQGAQVTYIGPSGSQIGDKESMKDTARVLGRMYDGIQYRGFGQAIVEELGA
CEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHH
FAGVPVWNGLTDEFHPTQILADFLTMLEHSQGKALADIQFAYLGDARNNVGNSLMVGAAK
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEEEHHH
MGMDISLVGPQAYWPDEELVTACQAIAKQTGGKITLTENVAEGVQGCDFLYTDVWVSMGE
HCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCHHHHHHHHHHCCC
SPEAWDERVALMKPYQVNTNVLKQTGNPNVKFMHCLPAFHNDETTIGKQVADKFGMKGLE
CCCHHHHHHHHCCCEECCHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHH
VTEEVFESEHSIVFDEAENRMHTIKAVMVATLGS
HHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFNLRNRNFLKLLDFSTKEIQFLIDLSADLKKAKYAGTEQKKLLGKNIALIFEKASTRT
CCCCCCCCEEEEECCCCCCEEEEEECCHHHHHHHCCCCHHHHHHCCCEEEEEECCCCCC
RCAFEVAAFDQGAQVTYIGPSGSQIGDKESMKDTARVLGRMYDGIQYRGFGQAIVEELGA
CEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHH
FAGVPVWNGLTDEFHPTQILADFLTMLEHSQGKALADIQFAYLGDARNNVGNSLMVGAAK
HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEEEHHH
MGMDISLVGPQAYWPDEELVTACQAIAKQTGGKITLTENVAEGVQGCDFLYTDVWVSMGE
HCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCHHHHHHHHHHCCC
SPEAWDERVALMKPYQVNTNVLKQTGNPNVKFMHCLPAFHNDETTIGKQVADKFGMKGLE
CCCHHHHHHHHCCCEECCHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCHH
VTEEVFESEHSIVFDEAENRMHTIKAVMVATLGS
HHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA