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The map label for this gene is mltC [H]

Identifier: 37681070

GI number: 37681070

Start: 2936884

End: 2938023

Strand: Direct

Name: mltC [H]

Synonym: VV2886

Alternate gene names: 37681070

Gene position: 2936884-2938023 (Clockwise)

Preceding gene: 37681069

Following gene: 37681071

Centisome position: 87.55

GC content: 44.82

Gene sequence:

>1140_bases
ATGAAAAAGTTTGGGTATTTTTTAGCTGCATTGCTCTTAACCGGTTGTAGCCGCGAATTTATCGAAAACATCTATGACGT
CAATTACCAACCGACCAACCGCTTTGCTAAAAATCTCGCAGAGCTGCCAGGACAATTTGAAAAAGACACGGCTGCACTGG
ATGCTTTGATCAACAGCTTCTCAGGCAATATTGAAAAACGCTGGGGGAGCCGAGAAATAAAAATGGCAGGCAAAAGTAAC
TATGTGAAATACATAGACAATTACCTCAGCCGAGCCGATGTCAACTTTAGCAATGGCACCATCCTCATTGAGACGGTTTC
ACCCACAGAACCCAAACAGCACCTGAAAAATGCCATTATCACTACCTTGCTAACTCCAGATGATCCGGCCAATGTCGATC
TTTTCTCCTCCAAAGAGATCCGCTTGGAAGGGCAACCTTTTCTCTACAATCAAGTGTTGGATCAAGACAAACAAGCTATC
CAGTGGAGTTGGCGCGCCAATCGCTTTGCCGATTATCTGATCGCCAATAAACTCAAGACACGTACGGTTGATTTTAAGAA
AGCCTACTACGTTGAAATTCCCATGGTGGCAGACCACGTAGACAAACGCAGTTATAAATACGCCGATATCGTACGCCGCG
CCTCAACTAAGTACGATATTCCCGAAGATCTGATTTACGCCATCATCAAAACCGAAAGCAGCTTCAACCCCTATGCAGTG
AGCTGGGCCAACGCCTATGGTTTGATGCAAGTGGTGCCCAAAACGGCTGGGCGCGATGTGTTCAACTTGGTTAAAAATCG
CAGTGGCGAACCCAGTCCGGAATATCTCTTTAACCCAGAAAACAATATTGACACCGGAACGGCTTATTTTTATCTGTTGA
AAAATCGCTATCTAAAAGAGGTCAATCATCCAACATCTCTCGAATATTCGATGATTTCAGCCTACAACGGTGGCACAGGC
GGGGTACTCAATACCTTTAATCGCAATGATCGCAAGCGCGCAATGCGCGATCTCAACGCATTGCAACCCAATCAAGTGTA
TTGGGCATTAACCAAAAAACACCCCAATGCAGAAGCTCGCCGTTATTTGGAAAAAGTAACCAAGTTCAAGCAAGACTTTA
ATCAAGGACATTCTCTTTGA

Upstream 100 bases:

>100_bases
TACACACCACCGAGCAAATAATCTGGTTTTCTTCATGGTTAATCAATGACATCATAGCCAACGCTTTGGTGTCATTTTTT
TAGGTTTGAATAGGTAAACG

Downstream 100 bases:

>100_bases
TTACAAATGAATATTTTCTAAGCAAATGATCAATTTTTTACTTTTTTTGCAAAAAATCGGTTGACGAGGCAGGTAAAAAT
CCGTTTAATAGCGCTCCGTC

Product: soluble lytic murein transglycosylase

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKKFGYFLAALLLTGCSREFIENIYDVNYQPTNRFAKNLAELPGQFEKDTAALDALINSFSGNIEKRWGSREIKMAGKSN
YVKYIDNYLSRADVNFSNGTILIETVSPTEPKQHLKNAIITTLLTPDDPANVDLFSSKEIRLEGQPFLYNQVLDQDKQAI
QWSWRANRFADYLIANKLKTRTVDFKKAYYVEIPMVADHVDKRSYKYADIVRRASTKYDIPEDLIYAIIKTESSFNPYAV
SWANAYGLMQVVPKTAGRDVFNLVKNRSGEPSPEYLFNPENNIDTGTAYFYLLKNRYLKEVNHPTSLEYSMISAYNGGTG
GVLNTFNRNDRKRAMRDLNALQPNQVYWALTKKHPNAEARRYLEKVTKFKQDFNQGHSL

Sequences:

>Translated_379_residues
MKKFGYFLAALLLTGCSREFIENIYDVNYQPTNRFAKNLAELPGQFEKDTAALDALINSFSGNIEKRWGSREIKMAGKSN
YVKYIDNYLSRADVNFSNGTILIETVSPTEPKQHLKNAIITTLLTPDDPANVDLFSSKEIRLEGQPFLYNQVLDQDKQAI
QWSWRANRFADYLIANKLKTRTVDFKKAYYVEIPMVADHVDKRSYKYADIVRRASTKYDIPEDLIYAIIKTESSFNPYAV
SWANAYGLMQVVPKTAGRDVFNLVKNRSGEPSPEYLFNPENNIDTGTAYFYLLKNRYLKEVNHPTSLEYSMISAYNGGTG
GVLNTFNRNDRKRAMRDLNALQPNQVYWALTKKHPNAEARRYLEKVTKFKQDFNQGHSL
>Mature_379_residues
MKKFGYFLAALLLTGCSREFIENIYDVNYQPTNRFAKNLAELPGQFEKDTAALDALINSFSGNIEKRWGSREIKMAGKSN
YVKYIDNYLSRADVNFSNGTILIETVSPTEPKQHLKNAIITTLLTPDDPANVDLFSSKEIRLEGQPFLYNQVLDQDKQAI
QWSWRANRFADYLIANKLKTRTVDFKKAYYVEIPMVADHVDKRSYKYADIVRRASTKYDIPEDLIYAIIKTESSFNPYAV
SWANAYGLMQVVPKTAGRDVFNLVKNRSGEPSPEYLFNPENNIDTGTAYFYLLKNRYLKEVNHPTSLEYSMISAYNGGTG
GVLNTFNRNDRKRAMRDLNALQPNQVYWALTKKHPNAEARRYLEKVTKFKQDFNQGHSL

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=329, Percent_Identity=50.7598784194529, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI87081855, Length=179, Percent_Identity=36.3128491620112, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 43604; Mature: 43604

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFGYFLAALLLTGCSREFIENIYDVNYQPTNRFAKNLAELPGQFEKDTAALDALINSF
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SGNIEKRWGSREIKMAGKSNYVKYIDNYLSRADVNFSNGTILIETVSPTEPKQHLKNAII
CCCHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHH
TTLLTPDDPANVDLFSSKEIRLEGQPFLYNQVLDQDKQAIQWSWRANRFADYLIANKLKT
HEEECCCCCCCEEEECCCEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RTVDFKKAYYVEIPMVADHVDKRSYKYADIVRRASTKYDIPEDLIYAIIKTESSFNPYAV
CEEECCEEEEEECCHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEE
SWANAYGLMQVVPKTAGRDVFNLVKNRSGEPSPEYLFNPENNIDTGTAYFYLLKNRYLKE
EHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
VNHPTSLEYSMISAYNGGTGGVLNTFNRNDRKRAMRDLNALQPNQVYWALTKKHPNAEAR
CCCCCCCCCHHHEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
RYLEKVTKFKQDFNQGHSL
HHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKFGYFLAALLLTGCSREFIENIYDVNYQPTNRFAKNLAELPGQFEKDTAALDALINSF
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SGNIEKRWGSREIKMAGKSNYVKYIDNYLSRADVNFSNGTILIETVSPTEPKQHLKNAII
CCCHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHH
TTLLTPDDPANVDLFSSKEIRLEGQPFLYNQVLDQDKQAIQWSWRANRFADYLIANKLKT
HEEECCCCCCCEEEECCCEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RTVDFKKAYYVEIPMVADHVDKRSYKYADIVRRASTKYDIPEDLIYAIIKTESSFNPYAV
CEEECCEEEEEECCHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEE
SWANAYGLMQVVPKTAGRDVFNLVKNRSGEPSPEYLFNPENNIDTGTAYFYLLKNRYLKE
EHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHH
VNHPTSLEYSMISAYNGGTGGVLNTFNRNDRKRAMRDLNALQPNQVYWALTKKHPNAEAR
CCCCCCCCCHHHEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH
RYLEKVTKFKQDFNQGHSL
HHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]