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The map label for this gene is hutC [H]

Identifier: 37680132

GI number: 37680132

Start: 1936414

End: 1937121

Strand: Direct

Name: hutC [H]

Synonym: VV1948

Alternate gene names: 37680132

Gene position: 1936414-1937121 (Clockwise)

Preceding gene: 37680130

Following gene: 37680133

Centisome position: 57.73

GC content: 47.6

Gene sequence:

>708_bases
ATGCCATCACCGCTGTATATTCAGATCAAACAGTTCATTGAAACAAAAATCGACAGTGGCGAGTGGCACATCGGCTTTAA
GATCGCAACTGAGCTAGAGCTGACCGAGCAATTTGGCGTCAGCCGCATGACCGTCAATAAAGCCATTCGCGATTTGGTCA
ATGAGGGGAAATTGCAAAGGCGACCACGTTTAGGCACGTTTGTCTGTGATAAACCAGAAAAGGCAGAATCTCCACTGCTC
GATGTCCGTAACATTGCCGAAGAAGTGGTCAATCGCGGCAAGACGCATCACAGCAAAGTCATTCAACAGTTGGTCCTCAA
AGCGGATGATACGATTGCAACCAAACTCGGTGTAATGCTAGGAACCAAAGTGTTCTACAGTGAAATTATTCACTACGAGG
ATAAGGAGCCTATCCAGCTCGAGTTGCGCTGGGTTAATAGCCTCTATGCACCCCGCTATTTGCAACAAGATTTCACCCAA
ATGACCCCCAACCAGTATCTTTCGGAGAACTGCCCTTTGAGTGCGATGGAACATACGGTTGAAGCCATCATGCCCGATAC
CCGTATTCGCCAAGAGCTCAACATGAAAGTCAATGAACCTTGTCTGCTGCTCAACCGTCGTACTTGGAGTGAAGACAAAC
TCGTCAGCACCGCACTGCTGTATCATCCGGGTAATCGCTACAAGCTGAGCTCTAAGATTTTGTTGTAA

Upstream 100 bases:

>100_bases
CCTCGCTCGTAACAATGTGTTTCACCACAAAATGCGGCGATGAAGTTGCTTTTTCAACGTTAATTACGCACTATTTGTAT
AGTCAATAAGAGGAAAGATT

Downstream 100 bases:

>100_bases
TTTAGAGTATCACACTTCGATTTGATCACATTTCAGCAACATTCACCTTGTCACAACGGTTATTTTCTCCTATTTATTTG
TATATACATTTAGTCAATAC

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MPSPLYIQIKQFIETKIDSGEWHIGFKIATELELTEQFGVSRMTVNKAIRDLVNEGKLQRRPRLGTFVCDKPEKAESPLL
DVRNIAEEVVNRGKTHHSKVIQQLVLKADDTIATKLGVMLGTKVFYSEIIHYEDKEPIQLELRWVNSLYAPRYLQQDFTQ
MTPNQYLSENCPLSAMEHTVEAIMPDTRIRQELNMKVNEPCLLLNRRTWSEDKLVSTALLYHPGNRYKLSSKILL

Sequences:

>Translated_235_residues
MPSPLYIQIKQFIETKIDSGEWHIGFKIATELELTEQFGVSRMTVNKAIRDLVNEGKLQRRPRLGTFVCDKPEKAESPLL
DVRNIAEEVVNRGKTHHSKVIQQLVLKADDTIATKLGVMLGTKVFYSEIIHYEDKEPIQLELRWVNSLYAPRYLQQDFTQ
MTPNQYLSENCPLSAMEHTVEAIMPDTRIRQELNMKVNEPCLLLNRRTWSEDKLVSTALLYHPGNRYKLSSKILL
>Mature_234_residues
PSPLYIQIKQFIETKIDSGEWHIGFKIATELELTEQFGVSRMTVNKAIRDLVNEGKLQRRPRLGTFVCDKPEKAESPLLD
VRNIAEEVVNRGKTHHSKVIQQLVLKADDTIATKLGVMLGTKVFYSEIIHYEDKEPIQLELRWVNSLYAPRYLQQDFTQM
TPNQYLSENCPLSAMEHTVEAIMPDTRIRQELNMKVNEPCLLLNRRTWSEDKLVSTALLYHPGNRYKLSSKILL

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=230, Percent_Identity=30, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1788418, Length=207, Percent_Identity=28.0193236714976, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786950, Length=205, Percent_Identity=29.2682926829268, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790118, Length=232, Percent_Identity=21.551724137931, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27212; Mature: 27081

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPLYIQIKQFIETKIDSGEWHIGFKIATELELTEQFGVSRMTVNKAIRDLVNEGKLQR
CCCCCEEHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCHHC
RPRLGTFVCDKPEKAESPLLDVRNIAEEVVNRGKTHHSKVIQQLVLKADDTIATKLGVML
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
GTKVFYSEIIHYEDKEPIQLELRWVNSLYAPRYLQQDFTQMTPNQYLSENCPLSAMEHTV
HHHHHHHHHHHCCCCCCEEEEEEEHHHHHCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHH
EAIMPDTRIRQELNMKVNEPCLLLNRRTWSEDKLVSTALLYHPGNRYKLSSKILL
HHHCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHEECCCCCEEECCCCCC
>Mature Secondary Structure 
PSPLYIQIKQFIETKIDSGEWHIGFKIATELELTEQFGVSRMTVNKAIRDLVNEGKLQR
CCCCEEHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHCCHHHHHHHHHHHHHHCCCHHC
RPRLGTFVCDKPEKAESPLLDVRNIAEEVVNRGKTHHSKVIQQLVLKADDTIATKLGVML
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
GTKVFYSEIIHYEDKEPIQLELRWVNSLYAPRYLQQDFTQMTPNQYLSENCPLSAMEHTV
HHHHHHHHHHHCCCCCCEEEEEEEHHHHHCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHH
EAIMPDTRIRQELNMKVNEPCLLLNRRTWSEDKLVSTALLYHPGNRYKLSSKILL
HHHCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHEECCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]