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The map label for this gene is zwf [H]

Identifier: 37679789

GI number: 37679789

Start: 1650475

End: 1652055

Strand: Direct

Name: zwf [H]

Synonym: VV1605

Alternate gene names: 37679789

Gene position: 1650475-1652055 (Clockwise)

Preceding gene: 37679788

Following gene: 37679790

Centisome position: 49.2

GC content: 46.74

Gene sequence:

>1581_bases
GTGTCACTGATAGGGTGGGCTCATCCTTTAAGCCGTATCCAGGCACACAACAAGTACCTCGTTTTTAAGGGAAAGATGAT
GGTAATACCAGAAAACAGCAGCATCGTAATTTTTGGTGCTTCAGGTGATTTAACATATCGCAAGTTGATCCCTGCTTTAT
ACCACCTCTACGCAAGTAAGCAGCTACCAGAAAACTTTGCTATTTTAGGTGTCAGCCGCACTGAATACAGCGATGAATCT
TATCGCGAAAAGTTAAAGCGCTCTCTTCAGGAAATGGAGAAAACGGAACCAGCTATTCTGGATTCATTTATCGACCATCT
TCACTATCAAGCCATCAACACGTCAGACACACAAGACTACGCGAAGTTGGTTGTACGTTTAGACGAATTGGCCGCTCAAT
ACCAGTTCGAACAACGTAATACACTGTTTTATCTTGCCACACCGCCAAGCCTTTACAGTGTCATTCCTTCAAGCCTTGCT
CATCACGGTCTTAACAGTGAAGAGGATGGTTGGAAACGGCTGATCATTGAAAAACCGTTTGGTTATGATTTGGCTTCGGC
ACGTCAGCTCGACAAAGAAATACACGATTGCTTCCAAGAGCATCAGATCTATCGCATCGACCACTACCTTGGAAAAGAGA
CCGTGCAAAACTTACTTGTTTTCCGTTTCTCTAACGCCATGTTTGAACCTCTGTGGAACCGCAACTTCATTGATTATGTG
GAAATCACAGGTGCCGAATTCCTTGGCGTGGAAGAGCGTGGCGGTTATTACGACGGCTCCGGCGCTGTGCGCGATATGTT
CCAAAACCATCTACTGCAAGTATTGGCAATGGTGGGCATGGAACCGCCTGCACAAATTAATGCCGATTCCATGCGTGATG
AAGTAGTGAAAGTTCTGCAGTGTTTAAAACCGCTTGAGGAAGATGATCTGCGTAACAACCTAGTTTTGGGTCAATACACA
GCATCAGACGTGCGCGGACAACATCTGCTTGGCTACCGTGAAGAAAACGGCGTAGCGGACGATTCTCGTACTGAGACTTA
CATTGGTCTTAAAGCGTACATCAATAACTGGCGTTGGAATGGCGTGCCATTCTACGTGCGCACGGGTAAGCGTCTTCCAA
CTCGCGTAACAGAAGTGGTTATCCACTTCAAACAAACACCGCATCCGGTATTTGGCCAAAACGCCCCAGAAAACAAACTG
ATCATTCGTATTCAGCCTGATGAAGGCATTCAAATGAGCTTCGGTTTGAAAGAACCTGGTGCAGGCTTTAAAGCGAAAGA
AGTGAAGATGAACTTCCATTATGCTTCGTTGCAAGAGACGCAAATGCTGACCGCCTATGAGCGTCTGCTTCTTGATGCGT
TAAACGGCGATGCAACGCTGTTTGCTCGCAGCGATGCGGTCGAAGCGTGTTGGAAATACGTTCAACCTATCCTCGATTTC
AAACAAGATCCACAAGCACTCTTTGGTTATGCCTGCGGCACTTGGGGGCCAAAAGAGTCAGACGATTTGCTGCAGCGTGA
CGATCGCGCGTGGCGTTTCCCATGCAAAAACCTAACAGATACGGACTACTGCGAACTATGA

Upstream 100 bases:

>100_bases
CCCCGTGTCGGGCAAATCATTCTTATTACCAACCCACACTCACTGTTTTGTAAGGTTTTGTCTATTAGTGGAATAGGCAG
GGCCGATTATCAATTTTTAG

Downstream 100 bases:

>100_bases
TCAATCACAAGATCTACCAAACAGCAGAGCAGGTAGTAGAAAGCCTAGCAAACGACATGAAAGCGTTTAGCGAAATGGGC
CGACCTGTTCATATCTCACT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSLIGWAHPLSRIQAHNKYLVFKGKMMVIPENSSIVIFGASGDLTYRKLIPALYHLYASKQLPENFAILGVSRTEYSDES
YREKLKRSLQEMEKTEPAILDSFIDHLHYQAINTSDTQDYAKLVVRLDELAAQYQFEQRNTLFYLATPPSLYSVIPSSLA
HHGLNSEEDGWKRLIIEKPFGYDLASARQLDKEIHDCFQEHQIYRIDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYV
EITGAEFLGVEERGGYYDGSGAVRDMFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQCLKPLEEDDLRNNLVLGQYT
ASDVRGQHLLGYREENGVADDSRTETYIGLKAYINNWRWNGVPFYVRTGKRLPTRVTEVVIHFKQTPHPVFGQNAPENKL
IIRIQPDEGIQMSFGLKEPGAGFKAKEVKMNFHYASLQETQMLTAYERLLLDALNGDATLFARSDAVEACWKYVQPILDF
KQDPQALFGYACGTWGPKESDDLLQRDDRAWRFPCKNLTDTDYCEL

Sequences:

>Translated_526_residues
MSLIGWAHPLSRIQAHNKYLVFKGKMMVIPENSSIVIFGASGDLTYRKLIPALYHLYASKQLPENFAILGVSRTEYSDES
YREKLKRSLQEMEKTEPAILDSFIDHLHYQAINTSDTQDYAKLVVRLDELAAQYQFEQRNTLFYLATPPSLYSVIPSSLA
HHGLNSEEDGWKRLIIEKPFGYDLASARQLDKEIHDCFQEHQIYRIDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYV
EITGAEFLGVEERGGYYDGSGAVRDMFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQCLKPLEEDDLRNNLVLGQYT
ASDVRGQHLLGYREENGVADDSRTETYIGLKAYINNWRWNGVPFYVRTGKRLPTRVTEVVIHFKQTPHPVFGQNAPENKL
IIRIQPDEGIQMSFGLKEPGAGFKAKEVKMNFHYASLQETQMLTAYERLLLDALNGDATLFARSDAVEACWKYVQPILDF
KQDPQALFGYACGTWGPKESDDLLQRDDRAWRFPCKNLTDTDYCEL
>Mature_525_residues
SLIGWAHPLSRIQAHNKYLVFKGKMMVIPENSSIVIFGASGDLTYRKLIPALYHLYASKQLPENFAILGVSRTEYSDESY
REKLKRSLQEMEKTEPAILDSFIDHLHYQAINTSDTQDYAKLVVRLDELAAQYQFEQRNTLFYLATPPSLYSVIPSSLAH
HGLNSEEDGWKRLIIEKPFGYDLASARQLDKEIHDCFQEHQIYRIDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYVE
ITGAEFLGVEERGGYYDGSGAVRDMFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQCLKPLEEDDLRNNLVLGQYTA
SDVRGQHLLGYREENGVADDSRTETYIGLKAYINNWRWNGVPFYVRTGKRLPTRVTEVVIHFKQTPHPVFGQNAPENKLI
IRIQPDEGIQMSFGLKEPGAGFKAKEVKMNFHYASLQETQMLTAYERLLLDALNGDATLFARSDAVEACWKYVQPILDFK
QDPQALFGYACGTWGPKESDDLLQRDDRAWRFPCKNLTDTDYCEL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=502, Percent_Identity=38.0478087649402, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI108773793, Length=489, Percent_Identity=38.241308793456, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI52145310, Length=363, Percent_Identity=31.6804407713499, Blast_Score=169, Evalue=7e-42,
Organism=Escherichia coli, GI1788158, Length=486, Percent_Identity=41.7695473251029, Blast_Score=396, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17538218, Length=476, Percent_Identity=37.8151260504202, Blast_Score=339, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=36.7768595041322, Blast_Score=303, Evalue=6e-83,
Organism=Drosophila melanogaster, GI24643350, Length=488, Percent_Identity=37.9098360655738, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24643352, Length=488, Percent_Identity=37.9098360655738, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI221513548, Length=473, Percent_Identity=30.8668076109937, Blast_Score=220, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 60460; Mature: 60329

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIGWAHPLSRIQAHNKYLVFKGKMMVIPENSSIVIFGASGDLTYRKLIPALYHLYASK
CCCCCHHHHHHHHHCCCCEEEEECEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHH
QLPENFAILGVSRTEYSDESYREKLKRSLQEMEKTEPAILDSFIDHLHYQAINTSDTQDY
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHH
AKLVVRLDELAAQYQFEQRNTLFYLATPPSLYSVIPSSLAHHGLNSEEDGWKRLIIEKPF
HHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
GYDLASARQLDKEIHDCFQEHQIYRIDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYV
CCCHHHHHHHHHHHHHHHHHCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
EITGAEFLGVEERGGYYDGSGAVRDMFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQ
EECCCCEECCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
CLKPLEEDDLRNNLVLGQYTASDVRGQHLLGYREENGVADDSRTETYIGLKAYINNWRWN
HHCCCCHHHHHCCEEEEECCHHHCCCCHHCCCCCCCCCCCCCCCCEEEEHHHHHCCCCCC
GVPFYVRTGKRLPTRVTEVVIHFKQTPHPVFGQNAPENKLIIRIQPDEGIQMSFGLKEPG
CEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCC
AGFKAKEVKMNFHYASLQETQMLTAYERLLLDALNGDATLFARSDAVEACWKYVQPILDF
CCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCC
KQDPQALFGYACGTWGPKESDDLLQRDDRAWRFPCKNLTDTDYCEL
CCCHHHHHHHHCCCCCCCCCHHHHHCCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SLIGWAHPLSRIQAHNKYLVFKGKMMVIPENSSIVIFGASGDLTYRKLIPALYHLYASK
CCCCHHHHHHHHHCCCCEEEEECEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHH
QLPENFAILGVSRTEYSDESYREKLKRSLQEMEKTEPAILDSFIDHLHYQAINTSDTQDY
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHH
AKLVVRLDELAAQYQFEQRNTLFYLATPPSLYSVIPSSLAHHGLNSEEDGWKRLIIEKPF
HHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
GYDLASARQLDKEIHDCFQEHQIYRIDHYLGKETVQNLLVFRFSNAMFEPLWNRNFIDYV
CCCHHHHHHHHHHHHHHHHHCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
EITGAEFLGVEERGGYYDGSGAVRDMFQNHLLQVLAMVGMEPPAQINADSMRDEVVKVLQ
EECCCCEECCCCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
CLKPLEEDDLRNNLVLGQYTASDVRGQHLLGYREENGVADDSRTETYIGLKAYINNWRWN
HHCCCCHHHHHCCEEEEECCHHHCCCCHHCCCCCCCCCCCCCCCCEEEEHHHHHCCCCCC
GVPFYVRTGKRLPTRVTEVVIHFKQTPHPVFGQNAPENKLIIRIQPDEGIQMSFGLKEPG
CEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCC
AGFKAKEVKMNFHYASLQETQMLTAYERLLLDALNGDATLFARSDAVEACWKYVQPILDF
CCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCC
KQDPQALFGYACGTWGPKESDDLLQRDDRAWRFPCKNLTDTDYCEL
CCCHHHHHHHHCCCCCCCCCHHHHHCCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]