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The map label for this gene is pepB [H]

Identifier: 37679662

GI number: 37679662

Start: 1514318

End: 1516117

Strand: Direct

Name: pepB [H]

Synonym: VV1478

Alternate gene names: 37679662

Gene position: 1514318-1516117 (Clockwise)

Preceding gene: 37679661

Following gene: 37679663

Centisome position: 45.14

GC content: 50.06

Gene sequence:

>1800_bases
ATGACCGCGCCAAGCTGGGATCTTTCTATTGCCTATGCAGATTTAACCGATGTTCGTATCGAACAAGATATCGAACTGAT
CGAGCAGTGCATCAAACTGCTCAATACACAAGCGTCACAGCGTGAAGTGGTGAGCGTGATGCAAAATGCCATCGTCACCC
GAGAAGCCGCAGGGCGTTTACTTTCGACGGTTTACACCTTTGCCAACTGTTATACCTCGGTGGATGTGACTCATCCTCAA
GCCAAAGCTTTGGTTGGACGTATGGCCAAGCTGAGTTCTGAAATGGAACAGGCATTTAGCCCATACCAACTGGCGCTAAT
GCACGCAGATGACGATTTCATCGCCGACGTTTTAGAGAGCAACAATCCCGATGTGGCTGGTCAGGTATTCTCCATTGCGC
AACTGCGCAAGCTGGCGGATCAAAGCTTGAGTGTGTCTGAGGAACAACTACTTTCTGCGATGCAGGTGGACGGGCGCGAT
GGTTGGGGCCGTCTCTACGACAACCTGACTGGCACCTTAAAAATCACCCTAGATGCTGAAGATGGCACACAAGAAACGCT
TGGATTTTCTCAAGCCGCCAGTTTGCTTTATGGGGCCGACTTCTCTCGTCAAGAACCCGCGTGGCGTGGGATTCAAAACG
CAATGGCAACACATCGTGAAACCTTTGCGGCAATTTTGAATGCGCTTTCTGGCTGGCGTTTAACCGAATACCAAAAGCGC
TCGCACCAACGCAATATCCACTTCTTAGAGCCAAGCCTTTATGAGAGCCGTATTGAGGCTCAGACCTTAGAAACCATGAT
CTCTGTGGCAAAGGAAAGTCGCTCGGTTGGCCAGAAGGCGGGGAAGCTAATGGCGCGTGTGCATGGCTTAGAGGCAATGA
AGCCTTGGAATCACTTGGCCGCAATGCCAGCGTTTGATGGCGAGGCCAAAGTGTATGGCTTTGATGAAGCGATTGAACTG
ATCCGCAATGCGTTTGCACAAGTCAACCCAGAGATGGCAAGCTTTGTTGACCTCATGGTGGAAAATGGCTGGATTGATGC
TGCGCCTTCGGAAAATAAACGCCTCGGTGCGTATTGCACTAAACTAGCGGCCACCCGTACACCGCTGGTGTTTATGACTT
GGTCGGGCAGCCGTTCGGATTTGCTGACTTTGGCCCATGAACTCGGGCACGCGTTCCACAACTGGGTGATGAAAGACATG
CCCCTTTGTCAAACGCGTTACCCAATGACGCTGGCAGAAACGGCGTCTATTTTTGCGGAGAACATTGTTCAGGATTACCT
GATTGCACAAGCGGTCACCGCTGAAGAGAAACTGGAAATGTTGTGGGAAGAGCTCTCTTCTGCTTACGCGCTCACCATCA
ATATTCCTGTGCGTTACGAATTTGAAAAAGCGTTCTATGAGCGTCGTGCCAGCGGTGAATTGTCGGCGGATGATATTTGC
CAGTTGATGAGTGAAACTTGGCAAGCGTGGTATGGCGATTCAATGTCAGAATCCGATCCCTATTTCTGGGCCAGCAAACT
TCATTTCTCGATTTCAGAAATCAGTTTCTACAACTACCCCTATTTGTTTGGTTACCTTTTCTCGAAAGGCATCTACGCTC
AGCGTGCGGCAAAGGGAGAGTCTTTCTATCGTGATTACGTCGCTTTGCTGCGAGATACAGGGGCGATGATGGCGGAAGAG
GTGGTCGCGCGGCATCTGCAAATGGATCTGACGCAAGCGGATTTCTGGCAACAGAGCATCGAACGTATCCGTGAAAAAGT
GGATGAATTTGAACAACTATTGGTGCAGATCGGAAAATAA

Upstream 100 bases:

>100_bases
GCAGTTTCCGACAGTCAAAATGATCGGGATGCCTCTCTCTATCAGGGAAGAACAGACGAATCATCCAGTCGATTAGTCAC
AGATTCATAAGGAACACAGA

Downstream 100 bases:

>100_bases
AATTCCGTGATCTTGTTATAATGGAAATGGTTAGGGATGTGGTAGAGTTCACTCCCTAACATACTGTTATTGTTTAAGAA
GTGTTCGGCGACGGTGATCT

Product: oligoendopeptidase F

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTAPSWDLSIAYADLTDVRIEQDIELIEQCIKLLNTQASQREVVSVMQNAIVTREAAGRLLSTVYTFANCYTSVDVTHPQ
AKALVGRMAKLSSEMEQAFSPYQLALMHADDDFIADVLESNNPDVAGQVFSIAQLRKLADQSLSVSEEQLLSAMQVDGRD
GWGRLYDNLTGTLKITLDAEDGTQETLGFSQAASLLYGADFSRQEPAWRGIQNAMATHRETFAAILNALSGWRLTEYQKR
SHQRNIHFLEPSLYESRIEAQTLETMISVAKESRSVGQKAGKLMARVHGLEAMKPWNHLAAMPAFDGEAKVYGFDEAIEL
IRNAFAQVNPEMASFVDLMVENGWIDAAPSENKRLGAYCTKLAATRTPLVFMTWSGSRSDLLTLAHELGHAFHNWVMKDM
PLCQTRYPMTLAETASIFAENIVQDYLIAQAVTAEEKLEMLWEELSSAYALTINIPVRYEFEKAFYERRASGELSADDIC
QLMSETWQAWYGDSMSESDPYFWASKLHFSISEISFYNYPYLFGYLFSKGIYAQRAAKGESFYRDYVALLRDTGAMMAEE
VVARHLQMDLTQADFWQQSIERIREKVDEFEQLLVQIGK

Sequences:

>Translated_599_residues
MTAPSWDLSIAYADLTDVRIEQDIELIEQCIKLLNTQASQREVVSVMQNAIVTREAAGRLLSTVYTFANCYTSVDVTHPQ
AKALVGRMAKLSSEMEQAFSPYQLALMHADDDFIADVLESNNPDVAGQVFSIAQLRKLADQSLSVSEEQLLSAMQVDGRD
GWGRLYDNLTGTLKITLDAEDGTQETLGFSQAASLLYGADFSRQEPAWRGIQNAMATHRETFAAILNALSGWRLTEYQKR
SHQRNIHFLEPSLYESRIEAQTLETMISVAKESRSVGQKAGKLMARVHGLEAMKPWNHLAAMPAFDGEAKVYGFDEAIEL
IRNAFAQVNPEMASFVDLMVENGWIDAAPSENKRLGAYCTKLAATRTPLVFMTWSGSRSDLLTLAHELGHAFHNWVMKDM
PLCQTRYPMTLAETASIFAENIVQDYLIAQAVTAEEKLEMLWEELSSAYALTINIPVRYEFEKAFYERRASGELSADDIC
QLMSETWQAWYGDSMSESDPYFWASKLHFSISEISFYNYPYLFGYLFSKGIYAQRAAKGESFYRDYVALLRDTGAMMAEE
VVARHLQMDLTQADFWQQSIERIREKVDEFEQLLVQIGK
>Mature_598_residues
TAPSWDLSIAYADLTDVRIEQDIELIEQCIKLLNTQASQREVVSVMQNAIVTREAAGRLLSTVYTFANCYTSVDVTHPQA
KALVGRMAKLSSEMEQAFSPYQLALMHADDDFIADVLESNNPDVAGQVFSIAQLRKLADQSLSVSEEQLLSAMQVDGRDG
WGRLYDNLTGTLKITLDAEDGTQETLGFSQAASLLYGADFSRQEPAWRGIQNAMATHRETFAAILNALSGWRLTEYQKRS
HQRNIHFLEPSLYESRIEAQTLETMISVAKESRSVGQKAGKLMARVHGLEAMKPWNHLAAMPAFDGEAKVYGFDEAIELI
RNAFAQVNPEMASFVDLMVENGWIDAAPSENKRLGAYCTKLAATRTPLVFMTWSGSRSDLLTLAHELGHAFHNWVMKDMP
LCQTRYPMTLAETASIFAENIVQDYLIAQAVTAEEKLEMLWEELSSAYALTINIPVRYEFEKAFYERRASGELSADDICQ
LMSETWQAWYGDSMSESDPYFWASKLHFSISEISFYNYPYLFGYLFSKGIYAQRAAKGESFYRDYVALLRDTGAMMAEEV
VARHLQMDLTQADFWQQSIERIREKVDEFEQLLVQIGK

Specific function: Has oligopeptidase activity and degrades a variety of small bioactive peptides, including bradykinin, neurotensin, and peptide fragments of substance P and adrenocorticotropin. Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)

COG id: COG1164

COG function: function code E; Oligoendopeptidase F

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567
- InterPro:   IPR004438
- InterPro:   IPR013647 [H]

Pfam domain/function: PF01432 Peptidase_M3; PF08439 Peptidase_M3_N [H]

EC number: NA

Molecular weight: Translated: 67693; Mature: 67562

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPSWDLSIAYADLTDVRIEQDIELIEQCIKLLNTQASQREVVSVMQNAIVTREAAGRL
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LSTVYTFANCYTSVDVTHPQAKALVGRMAKLSSEMEQAFSPYQLALMHADDDFIADVLES
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHC
NNPDVAGQVFSIAQLRKLADQSLSVSEEQLLSAMQVDGRDGWGRLYDNLTGTLKITLDAE
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEECC
DGTQETLGFSQAASLLYGADFSRQEPAWRGIQNAMATHRETFAAILNALSGWRLTEYQKR
CCCHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SHQRNIHFLEPSLYESRIEAQTLETMISVAKESRSVGQKAGKLMARVHGLEAMKPWNHLA
HHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AMPAFDGEAKVYGFDEAIELIRNAFAQVNPEMASFVDLMVENGWIDAAPSENKRLGAYCT
CCCCCCCCCEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KLAATRTPLVFMTWSGSRSDLLTLAHELGHAFHNWVMKDMPLCQTRYPMTLAETASIFAE
HHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHH
NIVQDYLIAQAVTAEEKLEMLWEELSSAYALTINIPVRYEFEKAFYERRASGELSADDIC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECEEEHHHHHHHHHHCCCCCCHHHHH
QLMSETWQAWYGDSMSESDPYFWASKLHFSISEISFYNYPYLFGYLFSKGIYAQRAAKGE
HHHHHHHHHHCCCCCCCCCCCEEHHHHEEEHHHHHHCCCHHHHHHHHHCCHHHHHHHCCH
SFYRDYVALLRDTGAMMAEEVVARHLQMDLTQADFWQQSIERIREKVDEFEQLLVQIGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAPSWDLSIAYADLTDVRIEQDIELIEQCIKLLNTQASQREVVSVMQNAIVTREAAGRL
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LSTVYTFANCYTSVDVTHPQAKALVGRMAKLSSEMEQAFSPYQLALMHADDDFIADVLES
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHC
NNPDVAGQVFSIAQLRKLADQSLSVSEEQLLSAMQVDGRDGWGRLYDNLTGTLKITLDAE
CCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEECC
DGTQETLGFSQAASLLYGADFSRQEPAWRGIQNAMATHRETFAAILNALSGWRLTEYQKR
CCCHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
SHQRNIHFLEPSLYESRIEAQTLETMISVAKESRSVGQKAGKLMARVHGLEAMKPWNHLA
HHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AMPAFDGEAKVYGFDEAIELIRNAFAQVNPEMASFVDLMVENGWIDAAPSENKRLGAYCT
CCCCCCCCCEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KLAATRTPLVFMTWSGSRSDLLTLAHELGHAFHNWVMKDMPLCQTRYPMTLAETASIFAE
HHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHH
NIVQDYLIAQAVTAEEKLEMLWEELSSAYALTINIPVRYEFEKAFYERRASGELSADDIC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECEEEHHHHHHHHHHCCCCCCHHHHH
QLMSETWQAWYGDSMSESDPYFWASKLHFSISEISFYNYPYLFGYLFSKGIYAQRAAKGE
HHHHHHHHHHCCCCCCCCCCCEEHHHHEEEHHHHHHCCCHHHHHHHHHCCHHHHHHHCCH
SFYRDYVALLRDTGAMMAEEVVARHLQMDLTQADFWQQSIERIREKVDEFEQLLVQIGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757883; 12354221 [H]