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The map label for this gene is csd [H]

Identifier: 37679642

GI number: 37679642

Start: 1492942

End: 1494186

Strand: Direct

Name: csd [H]

Synonym: VV1458

Alternate gene names: 37679642

Gene position: 1492942-1494186 (Clockwise)

Preceding gene: 37679641

Following gene: 37679644

Centisome position: 44.51

GC content: 49.4

Gene sequence:

>1245_bases
ATGAATTGGTCGCCTAATCAAGTTCGAGCGCAGTTTCCTGCGTTGGCACAGTATCATAACCAAAGACCAGTAACGTTTTT
TGACGGGCCGGGCGGATCTCAAGTGCCGCAATCAGTGTTGGATGCCATGGTCGGCTACCTCGGGCATTTTAACTCGAACT
TAGGCGGGCACTATTTTTCCAGTCACAAGACGGTTGAGGTAATGAAGCAAGCGCGCCAATCTGCGCAAGCATTACTCAAT
GCGCCATCGCAAGACAATATTGTCTTCGGTGCGAATATGACCTCTTTGACGTTTCAGTTAAGTCGAGCCATTAGCCGAGA
TTGGCAGGCGGGGGATGAAGTCATTGTCACCGCGTTGGATCATTATTCCAATGTCTCGAGCTGGGAGCAGGCAGCAGAAG
ACAAAGGCGTGACGGTTCACCAAGTGCGGGTGAATCCTGAAGATTGCACCTTGGATATGGAACACTTTAAACAGTTGCTC
AGTGCTCGCACAAAATTAGTGGCCGTCACCTTTGCGTCGAATACAACGGGCACCATTGTTGATATTGCGTCAGTGGTGAA
GTTAGCTCGAAGTGTGGGCGCTTTGGTGTATGTCGATGCGGTGCACTATTTGCCGCACCACTTAGTGGATGTGCAAGCCT
TGGATTGCGACTTTCTTGCCTGCTCGGCATACAAGTTTTTTGGCCCTCATGTCGGCATTGCTTATGTCGCTTCTCCATGG
TTAGAGACACTGCGTCCTTATAAAGTGGAGCCCGCCACGAACATTGGGCCGGGCCGTTTTGAAACAGGTACGCAAAGCTT
TGAAGGCTTAGCAGGTGTGTCTGCGGCCATAGAGTACCTCGCTCAATTTGGAGAAGAAGGTGCCAGTTTGCGCCAGCGAC
TAGAGCAAAGTTACGCGCTTTATGCTCAACATGAGCAAACATTAAGTCAGCATTTCTTGCAGCGTTTGTCGGCACTGGAT
GGGATTACGTTATACGGCATCAACGACGCATCAAGTGATAAACGTACCCCGACATTTGCGATAACAGTGGAGGGCTATTC
TCCAGAGTTTATTGCAAAAACATTGGGTGAGCACAACATCTGTGTCTGGAATGGCCACTTTTATGCCCTTGGCCTAATTC
GGCAATTAGGGTTGGAGTTCAGCGGCGGAGTGATTCGGATTGGTTGCATGCATTACAACACGGTCGAAGAGGTCGACTTG
TTGTTTAATGTTTTGGAGAGTATTGTCGATCAACCGAGTGCATAG

Upstream 100 bases:

>100_bases
GACAGCAAGTTGTGGCACAACGCCAAACCCATTCGCGCTATTGAACAAGAACGAGAAGGTCATATGGATGTGTTTGTGTT
GACGGCAAAAGGAATGGCAC

Downstream 100 bases:

>100_bases
TAAGGAAAGAGCCAGCGAATGCTGGCTCTTTTGTCTCATTAGGCTTCAAATTCCACTTCATAAGAGGTGAATTTGCGAAC
ATTAATCACGCCCGTATCCA

Product: selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MNWSPNQVRAQFPALAQYHNQRPVTFFDGPGGSQVPQSVLDAMVGYLGHFNSNLGGHYFSSHKTVEVMKQARQSAQALLN
APSQDNIVFGANMTSLTFQLSRAISRDWQAGDEVIVTALDHYSNVSSWEQAAEDKGVTVHQVRVNPEDCTLDMEHFKQLL
SARTKLVAVTFASNTTGTIVDIASVVKLARSVGALVYVDAVHYLPHHLVDVQALDCDFLACSAYKFFGPHVGIAYVASPW
LETLRPYKVEPATNIGPGRFETGTQSFEGLAGVSAAIEYLAQFGEEGASLRQRLEQSYALYAQHEQTLSQHFLQRLSALD
GITLYGINDASSDKRTPTFAITVEGYSPEFIAKTLGEHNICVWNGHFYALGLIRQLGLEFSGGVIRIGCMHYNTVEEVDL
LFNVLESIVDQPSA

Sequences:

>Translated_414_residues
MNWSPNQVRAQFPALAQYHNQRPVTFFDGPGGSQVPQSVLDAMVGYLGHFNSNLGGHYFSSHKTVEVMKQARQSAQALLN
APSQDNIVFGANMTSLTFQLSRAISRDWQAGDEVIVTALDHYSNVSSWEQAAEDKGVTVHQVRVNPEDCTLDMEHFKQLL
SARTKLVAVTFASNTTGTIVDIASVVKLARSVGALVYVDAVHYLPHHLVDVQALDCDFLACSAYKFFGPHVGIAYVASPW
LETLRPYKVEPATNIGPGRFETGTQSFEGLAGVSAAIEYLAQFGEEGASLRQRLEQSYALYAQHEQTLSQHFLQRLSALD
GITLYGINDASSDKRTPTFAITVEGYSPEFIAKTLGEHNICVWNGHFYALGLIRQLGLEFSGGVIRIGCMHYNTVEEVDL
LFNVLESIVDQPSA
>Mature_414_residues
MNWSPNQVRAQFPALAQYHNQRPVTFFDGPGGSQVPQSVLDAMVGYLGHFNSNLGGHYFSSHKTVEVMKQARQSAQALLN
APSQDNIVFGANMTSLTFQLSRAISRDWQAGDEVIVTALDHYSNVSSWEQAAEDKGVTVHQVRVNPEDCTLDMEHFKQLL
SARTKLVAVTFASNTTGTIVDIASVVKLARSVGALVYVDAVHYLPHHLVDVQALDCDFLACSAYKFFGPHVGIAYVASPW
LETLRPYKVEPATNIGPGRFETGTQSFEGLAGVSAAIEYLAQFGEEGASLRQRLEQSYALYAQHEQTLSQHFLQRLSALD
GITLYGINDASSDKRTPTFAITVEGYSPEFIAKTLGEHNICVWNGHFYALGLIRQLGLEFSGGVIRIGCMHYNTVEEVDL
LFNVLESIVDQPSA

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787970, Length=429, Percent_Identity=30.5361305361305, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789175, Length=429, Percent_Identity=28.4382284382284, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25143064, Length=217, Percent_Identity=26.2672811059908, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319831, Length=403, Percent_Identity=23.3250620347395, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129463, Length=392, Percent_Identity=24.7448979591837, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45510; Mature: 45510

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWSPNQVRAQFPALAQYHNQRPVTFFDGPGGSQVPQSVLDAMVGYLGHFNSNLGGHYFS
CCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
SHKTVEVMKQARQSAQALLNAPSQDNIVFGANMTSLTFQLSRAISRDWQAGDEVIVTALD
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEHH
HYSNVSSWEQAAEDKGVTVHQVRVNPEDCTLDMEHFKQLLSARTKLVAVTFASNTTGTIV
HHCCHHHHHHHHHCCCCEEEEEEECCCCCEECHHHHHHHHHCCCEEEEEEEECCCCCHHH
DIASVVKLARSVGALVYVDAVHYLPHHLVDVQALDCDFLACSAYKFFGPHVGIAYVASPW
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHEHEECCCCHHHHHHHHHHCCCCHHHHHHHHH
LETLRPYKVEPATNIGPGRFETGTQSFEGLAGVSAAIEYLAQFGEEGASLRQRLEQSYAL
HHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YAQHEQTLSQHFLQRLSALDGITLYGINDASSDKRTPTFAITVEGYSPEFIAKTLGEHNI
HHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCE
CVWNGHFYALGLIRQLGLEFSGGVIRIGCMHYNTVEEVDLLFNVLESIVDQPSA
EEECCHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNWSPNQVRAQFPALAQYHNQRPVTFFDGPGGSQVPQSVLDAMVGYLGHFNSNLGGHYFS
CCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
SHKTVEVMKQARQSAQALLNAPSQDNIVFGANMTSLTFQLSRAISRDWQAGDEVIVTALD
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEHH
HYSNVSSWEQAAEDKGVTVHQVRVNPEDCTLDMEHFKQLLSARTKLVAVTFASNTTGTIV
HHCCHHHHHHHHHCCCCEEEEEEECCCCCEECHHHHHHHHHCCCEEEEEEEECCCCCHHH
DIASVVKLARSVGALVYVDAVHYLPHHLVDVQALDCDFLACSAYKFFGPHVGIAYVASPW
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHEHEECCCCHHHHHHHHHHCCCCHHHHHHHHH
LETLRPYKVEPATNIGPGRFETGTQSFEGLAGVSAAIEYLAQFGEEGASLRQRLEQSYAL
HHHCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
YAQHEQTLSQHFLQRLSALDGITLYGINDASSDKRTPTFAITVEGYSPEFIAKTLGEHNI
HHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCE
CVWNGHFYALGLIRQLGLEFSGGVIRIGCMHYNTVEEVDLLFNVLESIVDQPSA
EEECCHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]