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The map label for this gene is mlc [H]

Identifier: 37679474

GI number: 37679474

Start: 1310984

End: 1312291

Strand: Direct

Name: mlc [H]

Synonym: VV1290

Alternate gene names: 37679474

Gene position: 1310984-1312291 (Clockwise)

Preceding gene: 37679472

Following gene: 37679475

Centisome position: 39.08

GC content: 46.18

Gene sequence:

>1308_bases
GTGATGCTGGTCACGGGGATTTATCAATTCACTTCACAATTACTTCGCAAAGTAAAAAAATTGCTCCGTTATAGAATGTT
GGAGTGCAAGATGTACATGGCTCAACCGGGCCATATTGATCATATCAAACAGGTCAATGCTGGTCGTGTATACAAACTAA
TTGACCTTAAGGGTCCAATCTCTCGAATCGATTTGTCAAAAGAAAGCGAGCTGGCACCGGCGAGTATTACGAAAATTACC
CGTGAGTTGATAGAAGCACATCTTGTGCACGAAACTACCGTGCAAGAAGCGATTAGCCGAGGAAGACCAGCGGTCGGCCT
TCAAGTGAATAATGCTGGATGGCAATTTCTTTCGATGCGACTTGGACGAGGTTATCTCACCATTGCACTCCATGAATTGG
GTGGTGAAGTCCTGATCGATACAAAAATCGATATCCACGAAAGGGATCAAGATGACGTTCTTGCTCGACTCCTACACGAA
ATCGAAGAATTTTTCCAAACCTATGCCGATCAACTGGATCGTGTAACCAGTATCGCGATTACGTTGCCTGGCTTAGTCAA
TTCAGAACAAGGCATTGTGCTGCAAATGCCGCATTACAATGTTGAAAACCTCGCTCTCGGTCCAGAGATTTACAAAGCGA
CTGGGCTACCGGTTTTCATCGCCAATGACACACGAGCTTGGGCTTTGGCGGAAAAGCTATTTGGTCACTCTCAAGGTAAC
GAAAACTCGGTTCTTATTTCGATCCACCATGGTTTAGGTGCGGGTATCATACTTGATGGACGGGTATTGCAGGGCCGTCA
CGGGAACATTGGCGAATTAGGCCATATCCAGATCGATCCACAAGGCAAACTTTGCCACTGTGGCAACAGAGGGTGCCTTG
AAACGGTCGCAAGTTCTAAAGCCATTCGTGAAGAGGTAATGGAACGCATTGCTAATGGAGAGTCGTCCATTCTCGAAGAG
CTGGAAGATGTCACGATTGAAAGCATTTGTGAGGCTGCAGCGAATGGAGATGCATTAGCTGTGGATGTCATTGAGAAACT
CGGCCGTTATCTTGGCTCGGCGATTGCGATTGTCATCAACTTATTTAACCCAGAAAAAGTGCTGATCGGCGGTGTAATCA
ACCAAGCGAAGGAAGTTCTCTATCCGGCTATTCGACGCTGCATTGAAGAGCAAAGCTTGCCTGTTTATCACCAAGATCTT
GAACTGGTGGAATCGCGTTTCTATAAACAGGCAACCATGCCAGGGGCTGCATTGATTAAGCAGGCTCTTTACGATGGCTT
GCTATTAATGAAAGTGGTCGAAGGTTAA

Upstream 100 bases:

>100_bases
TTCAGAAATTTTTTCAAGAAAAATAAGTTTGAGGTGATGCGATGTGTCGCCGACTAAATGATGGATATTTGATTCGATAC
ACAAACATTCATGTTTATAC

Downstream 100 bases:

>100_bases
ATCCCAACTCGCGGCAAACCTGGATCTTCTCCAGGTTTTGTTTTATTCGGCCTTGAAATCAGTGACCTGCCTATCTCAAT
TGCCCCTCATCAATTGATCT

Product: transcriptional regulator

Products: NA

Alternate protein names: Making large colonies protein [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MMLVTGIYQFTSQLLRKVKKLLRYRMLECKMYMAQPGHIDHIKQVNAGRVYKLIDLKGPISRIDLSKESELAPASITKIT
RELIEAHLVHETTVQEAISRGRPAVGLQVNNAGWQFLSMRLGRGYLTIALHELGGEVLIDTKIDIHERDQDDVLARLLHE
IEEFFQTYADQLDRVTSIAITLPGLVNSEQGIVLQMPHYNVENLALGPEIYKATGLPVFIANDTRAWALAEKLFGHSQGN
ENSVLISIHHGLGAGIILDGRVLQGRHGNIGELGHIQIDPQGKLCHCGNRGCLETVASSKAIREEVMERIANGESSILEE
LEDVTIESICEAAANGDALAVDVIEKLGRYLGSAIAIVINLFNPEKVLIGGVINQAKEVLYPAIRRCIEEQSLPVYHQDL
ELVESRFYKQATMPGAALIKQALYDGLLLMKVVEG

Sequences:

>Translated_435_residues
MMLVTGIYQFTSQLLRKVKKLLRYRMLECKMYMAQPGHIDHIKQVNAGRVYKLIDLKGPISRIDLSKESELAPASITKIT
RELIEAHLVHETTVQEAISRGRPAVGLQVNNAGWQFLSMRLGRGYLTIALHELGGEVLIDTKIDIHERDQDDVLARLLHE
IEEFFQTYADQLDRVTSIAITLPGLVNSEQGIVLQMPHYNVENLALGPEIYKATGLPVFIANDTRAWALAEKLFGHSQGN
ENSVLISIHHGLGAGIILDGRVLQGRHGNIGELGHIQIDPQGKLCHCGNRGCLETVASSKAIREEVMERIANGESSILEE
LEDVTIESICEAAANGDALAVDVIEKLGRYLGSAIAIVINLFNPEKVLIGGVINQAKEVLYPAIRRCIEEQSLPVYHQDL
ELVESRFYKQATMPGAALIKQALYDGLLLMKVVEG
>Mature_435_residues
MMLVTGIYQFTSQLLRKVKKLLRYRMLECKMYMAQPGHIDHIKQVNAGRVYKLIDLKGPISRIDLSKESELAPASITKIT
RELIEAHLVHETTVQEAISRGRPAVGLQVNNAGWQFLSMRLGRGYLTIALHELGGEVLIDTKIDIHERDQDDVLARLLHE
IEEFFQTYADQLDRVTSIAITLPGLVNSEQGIVLQMPHYNVENLALGPEIYKATGLPVFIANDTRAWALAEKLFGHSQGN
ENSVLISIHHGLGAGIILDGRVLQGRHGNIGELGHIQIDPQGKLCHCGNRGCLETVASSKAIREEVMERIANGESSILEE
LEDVTIESICEAAANGDALAVDVIEKLGRYLGSAIAIVINLFNPEKVLIGGVINQAKEVLYPAIRRCIEEQSLPVYHQDL
ELVESRFYKQATMPGAALIKQALYDGLLLMKVVEG

Specific function: Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI190014632, Length=206, Percent_Identity=31.0679611650485, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI298566325, Length=206, Percent_Identity=31.0679611650485, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI298566315, Length=206, Percent_Identity=31.0679611650485, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4885285, Length=206, Percent_Identity=31.0679611650485, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1787878, Length=402, Percent_Identity=46.5174129353234, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1786891, Length=401, Percent_Identity=43.8902743142145, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI87082127, Length=217, Percent_Identity=24.8847926267281, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790522, Length=205, Percent_Identity=26.3414634146341, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082230, Length=227, Percent_Identity=27.7533039647577, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 48143; Mature: 48143

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLVTGIYQFTSQLLRKVKKLLRYRMLECKMYMAQPGHIDHIKQVNAGRVYKLIDLKGPI
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCCCH
SRIDLSKESELAPASITKITRELIEAHLVHETTVQEAISRGRPAVGLQVNNAGWQFLSMR
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
LGRGYLTIALHELGGEVLIDTKIDIHERDQDDVLARLLHEIEEFFQTYADQLDRVTSIAI
HCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
TLPGLVNSEQGIVLQMPHYNVENLALGPEIYKATGLPVFIANDTRAWALAEKLFGHSQGN
ECCCCCCCCCCEEEECCCCCCCCEECCCHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCC
ENSVLISIHHGLGAGIILDGRVLQGRHGNIGELGHIQIDPQGKLCHCGNRGCLETVASSK
CCEEEEEEECCCCCCEEECCEEECCCCCCCCCCCEEEECCCCCEEECCCCHHHHHHHHHH
AIREEVMERIANGESSILEELEDVTIESICEAAANGDALAVDVIEKLGRYLGSAIAIVIN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHEE
LFNPEKVLIGGVINQAKEVLYPAIRRCIEEQSLPVYHQDLELVESRFYKQATMPGAALIK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
QALYDGLLLMKVVEG
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MMLVTGIYQFTSQLLRKVKKLLRYRMLECKMYMAQPGHIDHIKQVNAGRVYKLIDLKGPI
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCCCH
SRIDLSKESELAPASITKITRELIEAHLVHETTVQEAISRGRPAVGLQVNNAGWQFLSMR
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
LGRGYLTIALHELGGEVLIDTKIDIHERDQDDVLARLLHEIEEFFQTYADQLDRVTSIAI
HCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
TLPGLVNSEQGIVLQMPHYNVENLALGPEIYKATGLPVFIANDTRAWALAEKLFGHSQGN
ECCCCCCCCCCEEEECCCCCCCCEECCCHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCC
ENSVLISIHHGLGAGIILDGRVLQGRHGNIGELGHIQIDPQGKLCHCGNRGCLETVASSK
CCEEEEEEECCCCCCEEECCEEECCCCCCCCCCCEEEECCCCCEEECCCCHHHHHHHHHH
AIREEVMERIANGESSILEELEDVTIESICEAAANGDALAVDVIEKLGRYLGSAIAIVIN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHEE
LFNPEKVLIGGVINQAKEVLYPAIRRCIEEQSLPVYHQDLELVESRFYKQATMPGAALIK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
QALYDGLLLMKVVEG
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7766024; 9097039; 9278503 [H]