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The map label for this gene is tmk

Identifier: 37679464

GI number: 37679464

Start: 1300236

End: 1300874

Strand: Direct

Name: tmk

Synonym: VV1280

Alternate gene names: 37679464

Gene position: 1300236-1300874 (Clockwise)

Preceding gene: 37679463

Following gene: 37679465

Centisome position: 38.76

GC content: 48.2

Gene sequence:

>639_bases
ATGAAGCAAGCAAAATTTATCGTCATTGAAGGTTTAGAAGGCGCAGGGAAAAGCACGGCAATTCAAACGGTTTTGGACAC
ATTACGCCAAGCAGGGATTAATGAGATTGCACAAACGCGTGAACCGGGTGGCACACCTTTGGCGGAAAAGATGCGAGCTC
TGGTGAAGGAAGAGCATCCTGGCGAGCATTTGCATGACATGACGGAGCTGCTACTGCTCTACGCGGCACGAGTTCAGTTA
GTTGAGAATGTCATTAAGCCTGCGCTACACGAAGGAAAGTGGGTGGTGGGTGATCGTCATGATCTTTCTTCCCAAGCGTA
CCAAGGCGGTGGTCGTCAAATTGATGCGACACTAATGAAAAATCTGCGTGACACGGCATTAGGAGAGTTTAAGCCAGCCT
TTACTCTGTATATGGATATCGATCCTAAAGTGGGCTTGGAGAGAGCGAGAGGGCGAGGAGAGCTCGATCGCATCGAAAAA
ATGGACATCAGCTTTTTCGAAAGAACACGTCAGCGTTATTTGGAGTTAGCGAAGAGCGATGCGTCTATCGTTACGATTAA
CGCAGAGCAAAGCATTGAGCAGGTCGCAAACGACATTCGATCTGCGCTCAACCTTTGGCTAGAACAGTTACAGGATTAA

Upstream 100 bases:

>100_bases
TTTACTTTGTCGCTAGCGGTAAGGGTGGGCATGTGTTCTCAAAAACATTAGCTGAACATAATAGAGCAGTAAGAGCATAT
CTGCGGGAATTGAAGAAAAG

Downstream 100 bases:

>100_bases
GGTTTTGACACACTATCCTTGGTTAGCATCGACATGGCAAGGGCTGCAGTCCGCCATGTCGGCACAGCGGTTACCTGGTG
CCATCTTGTTGCAATCTGAC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKQAKFIVIEGLEGAGKSTAIQTVLDTLRQAGINEIAQTREPGGTPLAEKMRALVKEEHPGEHLHDMTELLLLYAARVQL
VENVIKPALHEGKWVVGDRHDLSSQAYQGGGRQIDATLMKNLRDTALGEFKPAFTLYMDIDPKVGLERARGRGELDRIEK
MDISFFERTRQRYLELAKSDASIVTINAEQSIEQVANDIRSALNLWLEQLQD

Sequences:

>Translated_212_residues
MKQAKFIVIEGLEGAGKSTAIQTVLDTLRQAGINEIAQTREPGGTPLAEKMRALVKEEHPGEHLHDMTELLLLYAARVQL
VENVIKPALHEGKWVVGDRHDLSSQAYQGGGRQIDATLMKNLRDTALGEFKPAFTLYMDIDPKVGLERARGRGELDRIEK
MDISFFERTRQRYLELAKSDASIVTINAEQSIEQVANDIRSALNLWLEQLQD
>Mature_212_residues
MKQAKFIVIEGLEGAGKSTAIQTVLDTLRQAGINEIAQTREPGGTPLAEKMRALVKEEHPGEHLHDMTELLLLYAARVQL
VENVIKPALHEGKWVVGDRHDLSSQAYQGGGRQIDATLMKNLRDTALGEFKPAFTLYMDIDPKVGLERARGRGELDRIEK
MDISFFERTRQRYLELAKSDASIVTINAEQSIEQVANDIRSALNLWLEQLQD

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=210, Percent_Identity=58.5714285714286, Blast_Score=249, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_VIBVU (Q8D8H5)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_761802.1
- ProteinModelPortal:   Q8D8H5
- SMR:   Q8D8H5
- GeneID:   1179832
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_3002
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   VVUL216895:VV1_3002-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23792; Mature: 23792

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAKFIVIEGLEGAGKSTAIQTVLDTLRQAGINEIAQTREPGGTPLAEKMRALVKEEHP
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHCCCC
GEHLHDMTELLLLYAARVQLVENVIKPALHEGKWVVGDRHDLSSQAYQGGGRQIDATLMK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCEEHHHHHH
NLRDTALGEFKPAFTLYMDIDPKVGLERARGRGELDRIEKMDISFFERTRQRYLELAKSD
HHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
ASIVTINAEQSIEQVANDIRSALNLWLEQLQD
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQAKFIVIEGLEGAGKSTAIQTVLDTLRQAGINEIAQTREPGGTPLAEKMRALVKEEHP
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHCCCC
GEHLHDMTELLLLYAARVQLVENVIKPALHEGKWVVGDRHDLSSQAYQGGGRQIDATLMK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCEEHHHHHH
NLRDTALGEFKPAFTLYMDIDPKVGLERARGRGELDRIEKMDISFFERTRQRYLELAKSD
HHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
ASIVTINAEQSIEQVANDIRSALNLWLEQLQD
CCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA