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The map label for this gene is gltT [H]

Identifier: 37679010

GI number: 37679010

Start: 829340

End: 830620

Strand: Direct

Name: gltT [H]

Synonym: VV0826

Alternate gene names: 37679010

Gene position: 829340-830620 (Clockwise)

Preceding gene: 37679009

Following gene: 37679011

Centisome position: 24.72

GC content: 48.17

Gene sequence:

>1281_bases
ATGGATAAATCACTTTCAAGTAAGATTTTTGTAGGCTTGTTTGCTGGTCTACTTATCGGTACTGCTATTCAGTATCTCTT
TAGTGGCGTTGCTATCTTTGATACTTATTTGCTGGGTGCCGCAGAGGGCGCTGGTGGTATGTTTGTATCGCTAATCAAGC
TGCTGGTTGTGCCACTTGTTTATGTTTCGATTGTGTGTGGCATTGTTGACCTAAAAGACATTACTGCGTTTGGTCGCCTT
GGTGGTAAAACTTTTGCGCTTTACATTATCAATACCATTATTGCGATTGCGGCAGCGCTGACGGTTGGTCTTATCTTCCA
ACCAGGGGCGGATGCACATCTTGCGGGTACCATTTCAGAAACGGTAAAACTGACCACAACGGAAACACCGGATATCTTTT
CGTTGGTAGTGAACATTGTGCCAAGCAACCCAGTGCAAGCTTTCGCCAATGGTGACATGCTGCAAATCATCTTTATGGCG
ATTTTGACCGGTTTGGCAATCCAAGCGCTGGATTCTCGTGGTGGTCCTGCTATCCGTACTTTCAAGATGGCCAATGAGAT
CATGATGAAACTGGTTGGCCTTGTGATGAGCCTTGCGCCTTACGGTGTGTTTGCTCTGATGATTCAACTTGGAGCGACTT
TGGATGCCAACACGCTGATGTCGGTTGCGGGCTATGTCGCGTTAGTTGTGGCCATGCTGGTATTTTGGATCTTCTTCTTC
TACCCAATAGTAGTGGGCATTACTACTGGGATCACACCCAAGGCATTTTTGCGTGCGACTCGTGAGCAGATCTTGTTCTC
GTTATCGACCGCGAGCTCGAATGCAACCATCCCTGTGACCATGAGAACCCTGACTGAGAAGCTTAATGTATCTAAGTCTG
TGGCTGGTTTTGGTGTGCCACTGGGCGCGACCATGAACATGTCAGGCGTGTCTATTTACATTGCGTTGGCGACCATGTTT
GTGGCAAACGCATTTGGCCAGCCAATTAACACGGCAGACATCTTTACACTGGGCTTGACGATTCTTTTGCTTTCAATTGG
TGCCGGTGGCGTACCTGGCGGTGGCGTAGTGATGGTGGGTGTACTGCTTCATCAACTTGGTTTGCCACCTGAAGGCCTTG
CTATTATTGCCGCGGTAGACCGTATCAATGATATGTTCTGTACTTCGTCTAACGTAGTAGGCGATACCGCGGTGAATACC
ATCGTTGCGAAATCTGAAGGGGAAATTGGTGTGGAAGCGGACGAAGCGCAAACAGCGCCTTCAACCACAGCGAATGCGTA
A

Upstream 100 bases:

>100_bases
TTTGTAATTCAAGTGTGTATTATGTGCGAACTCCGTCTTAAATATAGGCGGTTTTAACTACAAAACCATAAATTACAAAC
ACAACATTCTGGAGTGAAGG

Downstream 100 bases:

>100_bases
GCACACTTTTTCTGCGAAACAAAAGCGAAGCCTAGCGGCTTCGCTTTTTTTGTACTTTGAAATGATGCCCCCTCTTTTGC
TCATTGAGTACATCAAGCGT

Product: sodium/glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MDKSLSSKIFVGLFAGLLIGTAIQYLFSGVAIFDTYLLGAAEGAGGMFVSLIKLLVVPLVYVSIVCGIVDLKDITAFGRL
GGKTFALYIINTIIAIAAALTVGLIFQPGADAHLAGTISETVKLTTTETPDIFSLVVNIVPSNPVQAFANGDMLQIIFMA
ILTGLAIQALDSRGGPAIRTFKMANEIMMKLVGLVMSLAPYGVFALMIQLGATLDANTLMSVAGYVALVVAMLVFWIFFF
YPIVVGITTGITPKAFLRATREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVPLGATMNMSGVSIYIALATMF
VANAFGQPINTADIFTLGLTILLLSIGAGGVPGGGVVMVGVLLHQLGLPPEGLAIIAAVDRINDMFCTSSNVVGDTAVNT
IVAKSEGEIGVEADEAQTAPSTTANA

Sequences:

>Translated_426_residues
MDKSLSSKIFVGLFAGLLIGTAIQYLFSGVAIFDTYLLGAAEGAGGMFVSLIKLLVVPLVYVSIVCGIVDLKDITAFGRL
GGKTFALYIINTIIAIAAALTVGLIFQPGADAHLAGTISETVKLTTTETPDIFSLVVNIVPSNPVQAFANGDMLQIIFMA
ILTGLAIQALDSRGGPAIRTFKMANEIMMKLVGLVMSLAPYGVFALMIQLGATLDANTLMSVAGYVALVVAMLVFWIFFF
YPIVVGITTGITPKAFLRATREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVPLGATMNMSGVSIYIALATMF
VANAFGQPINTADIFTLGLTILLLSIGAGGVPGGGVVMVGVLLHQLGLPPEGLAIIAAVDRINDMFCTSSNVVGDTAVNT
IVAKSEGEIGVEADEAQTAPSTTANA
>Mature_426_residues
MDKSLSSKIFVGLFAGLLIGTAIQYLFSGVAIFDTYLLGAAEGAGGMFVSLIKLLVVPLVYVSIVCGIVDLKDITAFGRL
GGKTFALYIINTIIAIAAALTVGLIFQPGADAHLAGTISETVKLTTTETPDIFSLVVNIVPSNPVQAFANGDMLQIIFMA
ILTGLAIQALDSRGGPAIRTFKMANEIMMKLVGLVMSLAPYGVFALMIQLGATLDANTLMSVAGYVALVVAMLVFWIFFF
YPIVVGITTGITPKAFLRATREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVPLGATMNMSGVSIYIALATMF
VANAFGQPINTADIFTLGLTILLLSIGAGGVPGGGVVMVGVLLHQLGLPPEGLAIIAAVDRINDMFCTSSNVVGDTAVNT
IVAKSEGEIGVEADEAQTAPSTTANA

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=408, Percent_Identity=29.1666666666667, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI21314632, Length=400, Percent_Identity=30, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI194239697, Length=425, Percent_Identity=26.5882352941176, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4827012, Length=284, Percent_Identity=30.9859154929577, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI169790839, Length=413, Percent_Identity=27.1186440677966, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI5032093, Length=383, Percent_Identity=30.8093994778068, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI66773030, Length=399, Percent_Identity=26.8170426065163, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI223468566, Length=284, Percent_Identity=31.3380281690141, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI223468564, Length=256, Percent_Identity=31.640625, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI262359914, Length=372, Percent_Identity=25.8064516129032, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI301601644, Length=140, Percent_Identity=37.1428571428571, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1790514, Length=416, Percent_Identity=33.1730769230769, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789947, Length=372, Percent_Identity=29.5698924731183, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1788024, Length=401, Percent_Identity=27.6807980049875, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789473, Length=288, Percent_Identity=29.1666666666667, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71983106, Length=398, Percent_Identity=29.1457286432161, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=398, Percent_Identity=29.1457286432161, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=384, Percent_Identity=30.2083333333333, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71996953, Length=409, Percent_Identity=26.161369193154, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=401, Percent_Identity=26.1845386533666, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193206505, Length=391, Percent_Identity=26.0869565217391, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=393, Percent_Identity=26.7175572519084, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24583025, Length=421, Percent_Identity=25.6532066508314, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17137668, Length=421, Percent_Identity=25.6532066508314, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24583023, Length=421, Percent_Identity=25.6532066508314, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360481, Length=449, Percent_Identity=24.0534521158129, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281360483, Length=449, Percent_Identity=24.0534521158129, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137666, Length=449, Percent_Identity=24.0534521158129, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44206; Mature: 44206

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCC
>Mature Secondary Structure
MDKSLSSKIFVGLFAGLLIGTAIQYLFSGVAIFDTYLLGAAEGAGGMFVSLIKLLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
YVSIVCGIVDLKDITAFGRLGGKTFALYIINTIIAIAAALTVGLIFQPGADAHLAGTISE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHCCHHH
TVKLTTTETPDIFSLVVNIVPSNPVQAFANGDMLQIIFMAILTGLAIQALDSRGGPAIRT
CEEEEECCCCHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHH
FKMANEIMMKLVGLVMSLAPYGVFALMIQLGATLDANTLMSVAGYVALVVAMLVFWIFFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YPIVVGITTGITPKAFLRATREQILFSLSTASSNATIPVTMRTLTEKLNVSKSVAGFGVP
HHHHHHHHCCCCHHHHHHHHHHHHHHHEEECCCCCEEEEEHHHHHHHHCCHHHHHCCCCC
LGATMNMSGVSIYIALATMFVANAFGQPINTADIFTLGLTILLLSIGAGGVPGGGVVMVG
CCCEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VLLHQLGLPPEGLAIIAAVDRINDMFCTSSNVVGDTAVNTIVAKSEGEIGVEADEAQTAP
HHHHHHCCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCCCCCCCCCCCCC
STTANA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]