Click here to switch to the map view.

The map label for this gene is ndk

Identifier: 37678947

GI number: 37678947

Start: 767295

End: 767720

Strand: Direct

Name: ndk

Synonym: VV0763

Alternate gene names: 37678947

Gene position: 767295-767720 (Clockwise)

Preceding gene: 37678946

Following gene: 37678948

Centisome position: 22.87

GC content: 47.18

Gene sequence:

>426_bases
ATGGCTCTAGAAAGAACATTTTCGATCATTAAGCCTGACGCTGTAGAACGCAACTTAATCGGTGAAATTTACCACCGCAT
TGAGAAGGCGGGATTACGCATCATCGCGGCAAAAATGGTGCATCTTAATGATGAACAAGCAAGTGGCTTTTACGCTGAGC
ACGAAGGAAAAGAATTTTTCCCAGCATTGAAAGAGTTCATGACTTCAGGACCCATCATGGTTCAGGTTCTAGAAGGCGAA
AATGCCATTGCACGTTACCGTGAATTGATGGGTAAAACCAACCCAGAAGAAGCAGCTTGTGGCACCATTCGCGCCGACTA
TGCACTGAGTATGCGTCACAACTCCGTTCACGGCAGTGACAGCCCAGCATCAGCAGCGCGTGAAATTGCTTTTTTCTTCC
CGGAGTCGGAAATCTGCCCTCGTTAA

Upstream 100 bases:

>100_bases
TCTGGCCAACCTGTTAGTGGAACAAGCGAATAAGTAATACTTCACAGCAGCCCTATTGGGCTGCTGACTATAACAACGAC
ATGAAATAAAGGGACACCTT

Downstream 100 bases:

>100_bases
GCGGTTTGAATAAGTAGACGAATTCCCAAGCCCAGCACGCAAGCTGGGCTTTTTCTGACTCAGGAAAAGTGTGGCGATAT
TTTAATCGTTTGGTTTTATT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MALERTFSIIKPDAVERNLIGEIYHRIEKAGLRIIAAKMVHLNDEQASGFYAEHEGKEFFPALKEFMTSGPIMVQVLEGE
NAIARYRELMGKTNPEEAACGTIRADYALSMRHNSVHGSDSPASAAREIAFFFPESEICPR

Sequences:

>Translated_141_residues
MALERTFSIIKPDAVERNLIGEIYHRIEKAGLRIIAAKMVHLNDEQASGFYAEHEGKEFFPALKEFMTSGPIMVQVLEGE
NAIARYRELMGKTNPEEAACGTIRADYALSMRHNSVHGSDSPASAAREIAFFFPESEICPR
>Mature_140_residues
ALERTFSIIKPDAVERNLIGEIYHRIEKAGLRIIAAKMVHLNDEQASGFYAEHEGKEFFPALKEFMTSGPIMVQVLEGEN
AIARYRELMGKTNPEEAACGTIRADYALSMRHNSVHGSDSPASAAREIAFFFPESEICPR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=41.9117647058824, Blast_Score=126, Evalue=6e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=41.6058394160584, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=41.6058394160584, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=41.6058394160584, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=41.6058394160584, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=42.2222222222222, Blast_Score=120, Evalue=4e-28,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=39.2592592592593, Blast_Score=116, Evalue=7e-27,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=39.2592592592593, Blast_Score=116, Evalue=7e-27,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=38.2352941176471, Blast_Score=113, Evalue=4e-26,
Organism=Homo sapiens, GI4505413, Length=141, Percent_Identity=39.0070921985816, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=41.304347826087, Blast_Score=99, Evalue=9e-22,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=39.568345323741, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=39.568345323741, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=34.0579710144928, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI30023828, Length=136, Percent_Identity=35.2941176470588, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=65.2482269503546, Blast_Score=198, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=41.4814814814815, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=44.8529411764706, Blast_Score=133, Evalue=9e-33,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=40.4411764705882, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=37.5, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15760; Mature: 15629

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALERTFSIIKPDAVERNLIGEIYHRIEKAGLRIIAAKMVHLNDEQASGFYAEHEGKEFF
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
PALKEFMTSGPIMVQVLEGENAIARYRELMGKTNPEEAACGTIRADYALSMRHNSVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCHHCCEEEEECCCCCCCCC
SPASAAREIAFFFPESEICPR
CHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ALERTFSIIKPDAVERNLIGEIYHRIEKAGLRIIAAKMVHLNDEQASGFYAEHEGKEFF
CCCHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
PALKEFMTSGPIMVQVLEGENAIARYRELMGKTNPEEAACGTIRADYALSMRHNSVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCHHCCEEEEECCCCCCCCC
SPASAAREIAFFFPESEICPR
CHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA