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The map label for this gene is phoR

Identifier: 37678908

GI number: 37678908

Start: 727533

End: 728831

Strand: Direct

Name: phoR

Synonym: VV0724

Alternate gene names: 37678908

Gene position: 727533-728831 (Clockwise)

Preceding gene: 37678907

Following gene: 37678909

Centisome position: 21.69

GC content: 47.34

Gene sequence:

>1299_bases
GTGGTTGAAAGATTAACTTGGAAAAAGCTGGCATGGGAGCTGGCTTTTTTTTACACCCCCTGGGTAATTGTTGGGTGGAT
ATTCGGCTATATGCCGTGGCTGCTTTTGGTGGCGACGGCTTTGCAGCTTGGTTGGCATTTACACAATCAGGTACGTTTGT
CTGCGTGGCTCTGGGATGAAAAGCGTTTAACGCCGCCATCGGGCAGTGGTAATTGGGAATCGCTGTTTAATGGCCTTTAT
CGCTTGCAGCAAAGACAGCGACGCAAGCGTAAAGAGCTGACGAATTTGATCCGTCGTTTTCGCAATGGTGCAGAATCGTT
GCCGGATGCGGTTGTGGTGTTTCGTGCGGAGGGCAACATTGTTTGGTGTAACAAGCTGGCGCAACATCTATTAGGTTTCC
ATTGGCCTGAAGATTCTGGTCAGCCTATTTCTAATCTTCTTCGCACTCCTGATTTTATTAAATATCTCTCTGGTAATGAT
TTTTCTGAACCGTTGGAAATGAGCTCGCCGCTAAACGTTGAACGTACGCTGGAACTGCGTATTGTTCCTTATACTGAAGG
TGAGCACTTGATGGTGGTGCGTGACGTGACGCAGTTGAAACAGCTAGAAGGCATGCGTCGAAACTTTTTTGCTAATGTTT
CCCATGAGTTACGTACGCCAATGACAGTGCTTCAGGGTTATCTCGAAATGACCGAAGATCCGGACATGTTGGTTGGCCCC
ATGTGGGGCAAAGCCCATCGTGTGATGACGGAACAGCTGAATCGCATGAACAGCTTAGTGAATCAGTTGTTAACCTTATC
CAAGATCGAAGCATCGCCAATCCATGAGTTGGATGAAGTGGTTGATGTGCCAGCCATGCTGGAAGTGCTAGAGAAAGAAG
CGGTAAGTTTGAGTGGTGATAATCAGCACGCCATCTCTTTTCAAGTGGATAAAGCGCTCAAAGTCTATGCCGATGAAGAT
CAACTGCGCAGTGCTATTTCGAACCTAGTATACAATGCCGTGAAGTACACACCTGCTGGTGCAAACGTACAGGTTCGCTG
GTATCGCAATAGCAAGGGTGCTTGCCTAGAAGTGGAAGACAGTGGTGATGGTATTGAACCGCAACATATCCATCGTCTGA
CAGAGCGTTTTTATCGCGTTGACAAAGCACGCTCTCGTGACACCGGGGGCAGTGGTTTAGGTCTGGCGATTGTAAAACAT
GCTTTGACTCATCACGACACTCATTTGGATATCCAAAGTAAAGTGGGCAGTGGCAGTAAGTTTTCATTTGTTTTACCGGC
AAAATTGGTGGCGAAATGA

Upstream 100 bases:

>100_bases
AAGCGCTAGAAGATGCAGGGCATGATAAACTGATTCAAACAGTGCGAGGCGCGGGCTATCGTTTCTCAACGAAAGCGTAA
ATACCATGTCGGAGTCGTGA

Downstream 100 bases:

>100_bases
AACGATGGTGGTTGAGTTTATTGTTGATGGGGGGAATAAGTGCGAGTGCTCAGGCATTGGATACACCATTGCAACCTTAT
AAAAAAATCCCCGGTGTTTC

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MVERLTWKKLAWELAFFYTPWVIVGWIFGYMPWLLLVATALQLGWHLHNQVRLSAWLWDEKRLTPPSGSGNWESLFNGLY
RLQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRAEGNIVWCNKLAQHLLGFHWPEDSGQPISNLLRTPDFIKYLSGND
FSEPLEMSSPLNVERTLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMLVGP
MWGKAHRVMTEQLNRMNSLVNQLLTLSKIEASPIHELDEVVDVPAMLEVLEKEAVSLSGDNQHAISFQVDKALKVYADED
QLRSAISNLVYNAVKYTPAGANVQVRWYRNSKGACLEVEDSGDGIEPQHIHRLTERFYRVDKARSRDTGGSGLGLAIVKH
ALTHHDTHLDIQSKVGSGSKFSFVLPAKLVAK

Sequences:

>Translated_432_residues
MVERLTWKKLAWELAFFYTPWVIVGWIFGYMPWLLLVATALQLGWHLHNQVRLSAWLWDEKRLTPPSGSGNWESLFNGLY
RLQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRAEGNIVWCNKLAQHLLGFHWPEDSGQPISNLLRTPDFIKYLSGND
FSEPLEMSSPLNVERTLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMLVGP
MWGKAHRVMTEQLNRMNSLVNQLLTLSKIEASPIHELDEVVDVPAMLEVLEKEAVSLSGDNQHAISFQVDKALKVYADED
QLRSAISNLVYNAVKYTPAGANVQVRWYRNSKGACLEVEDSGDGIEPQHIHRLTERFYRVDKARSRDTGGSGLGLAIVKH
ALTHHDTHLDIQSKVGSGSKFSFVLPAKLVAK
>Mature_432_residues
MVERLTWKKLAWELAFFYTPWVIVGWIFGYMPWLLLVATALQLGWHLHNQVRLSAWLWDEKRLTPPSGSGNWESLFNGLY
RLQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRAEGNIVWCNKLAQHLLGFHWPEDSGQPISNLLRTPDFIKYLSGND
FSEPLEMSSPLNVERTLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMLVGP
MWGKAHRVMTEQLNRMNSLVNQLLTLSKIEASPIHELDEVVDVPAMLEVLEKEAVSLSGDNQHAISFQVDKALKVYADED
QLRSAISNLVYNAVKYTPAGANVQVRWYRNSKGACLEVEDSGDGIEPQHIHRLTERFYRVDKARSRDTGGSGLGLAIVKH
ALTHHDTHLDIQSKVGSGSKFSFVLPAKLVAK

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=433, Percent_Identity=60.0461893764434, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1788393, Length=251, Percent_Identity=29.4820717131474, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786783, Length=273, Percent_Identity=31.8681318681319, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788549, Length=365, Percent_Identity=24.9315068493151, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=30.1801801801802, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1788713, Length=405, Percent_Identity=23.7037037037037, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=28.2608695652174, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994928, Length=275, Percent_Identity=27.6363636363636, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI145693157, Length=341, Percent_Identity=25.2199413489736, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=26.5217391304348, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789808, Length=249, Percent_Identity=28.5140562248996, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790551, Length=219, Percent_Identity=29.6803652968037, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786912, Length=232, Percent_Identity=28.8793103448276, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788279, Length=261, Percent_Identity=26.4367816091954, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789403, Length=231, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=226, Percent_Identity=27.8761061946903, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=193, Percent_Identity=29.5336787564767, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49418; Mature: 49418

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVERLTWKKLAWELAFFYTPWVIVGWIFGYMPWLLLVATALQLGWHLHNQVRLSAWLWDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
KRLTPPSGSGNWESLFNGLYRLQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRAEGNI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCCE
VWCNKLAQHLLGFHWPEDSGQPISNLLRTPDFIKYLSGNDFSEPLEMSSPLNVERTLELR
EEHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
IVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMLVGP
EEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCCCCCEEEEC
MWGKAHRVMTEQLNRMNSLVNQLLTLSKIEASPIHELDEVVDVPAMLEVLEKEAVSLSGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCC
NQHAISFQVDKALKVYADEDQLRSAISNLVYNAVKYTPAGANVQVRWYRNSKGACLEVED
CCEEEEEEECCHHHEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEC
SGDGIEPQHIHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDTHLDIQSKVGSGSK
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHCCCCCC
FSFVLPAKLVAK
EEEECCHHHHCC
>Mature Secondary Structure
MVERLTWKKLAWELAFFYTPWVIVGWIFGYMPWLLLVATALQLGWHLHNQVRLSAWLWDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
KRLTPPSGSGNWESLFNGLYRLQQRQRRKRKELTNLIRRFRNGAESLPDAVVVFRAEGNI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEECCCCE
VWCNKLAQHLLGFHWPEDSGQPISNLLRTPDFIKYLSGNDFSEPLEMSSPLNVERTLELR
EEHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
IVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMLVGP
EEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHCCCCCCEEEEC
MWGKAHRVMTEQLNRMNSLVNQLLTLSKIEASPIHELDEVVDVPAMLEVLEKEAVSLSGD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCC
NQHAISFQVDKALKVYADEDQLRSAISNLVYNAVKYTPAGANVQVRWYRNSKGACLEVED
CCEEEEEEECCHHHEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEC
SGDGIEPQHIHRLTERFYRVDKARSRDTGGSGLGLAIVKHALTHHDTHLDIQSKVGSGSK
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHCCCCCC
FSFVLPAKLVAK
EEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]