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The map label for this gene is gcp

Identifier: 37678749

GI number: 37678749

Start: 547265

End: 548284

Strand: Direct

Name: gcp

Synonym: VV0565

Alternate gene names: 37678749

Gene position: 547265-548284 (Clockwise)

Preceding gene: 37678743

Following gene: 37678750

Centisome position: 16.31

GC content: 49.8

Gene sequence:

>1020_bases
ATGCGCATTCTCGGCATTGAAACCTCCTGTGATGAAACAGGAATCGCCATTTATGACGATGAAAAAGGCCTACTGGCCCA
TAAATTATATAGCCAAATTAAACTGCATGCCGATTACGGCGGTGTCGTGCCTGAGCTCGCTTCTCGTGACCACGTGAAGA
AAACCATTCCTCTTATTAAAGAGGCGTTGAAAGAAGCCAATTTAACAGCAAAAGATATTGATGGTGTTGCTTACACAGCA
GGGCCAGGTTTGGTTGGGGCACTTTTGGTGGGGGCAACGATCGGTCGAAGCCTCGCTTACGCTTGGGGAGTGCCAGCCGT
TCCGGTTCATCATATGGAAGGTCACTTGCTCGCACCTATGCTTGAAGACAACCCACCGCCGTTTCCATTTGTAGCGGTAT
TGGTCTCGGGTGGTCACTCGATGATGGTGGAAGTGAAAGGCATTGGTGAGTACAAAATCCTAGGCGAATCCATTGATGAT
GCGGCGGGTGAAGCATTCGATAAGACGGCGAAGCTCATGGGCCTAGATTATCCAGGTGGTCCATTGCTGTCTAAATTGGC
CGAAAAAGGGACGCCGGGTCGCTTTAAGTTTCCGCGTCCGATGACCAATGTGCCCGGTTTGGACATGAGCTTCTCTGGTT
TGAAAACCTTTACCGCAAATACCATTGCGGCGAATGGTGATGATGAACAAACACGCGCCGATATTGCGTACGCTTTTGAA
GAGGCCGTGTGTGCCACATTGGCGATCAAATGTAAGCGCGCGCTAGAGCAAACGGGTATGAAACGTATTGTGATTGCGGG
TGGGGTGAGTGCCAACCGTCGTCTTCGTGCTGAGCTAGAAAAACTGGCGCACAAAGTGGGTGGGGATGTCTATTATCCAC
GTACCGAGTTTTGTACTGATAATGGTGCAATGATCGCGTATGCGGGCATGCAACGTTTGAAGAATAATGAAGTGTCAGAT
CTTGCGGTAGAGGCCCGACCTCGCTGGCCAATTGATCAATTGACGCCAGTGATGAAATAA

Upstream 100 bases:

>100_bases
CCTTTTGTCGATTATTGTCTGTACAAAATTTGTTTGTCTGGGCTGCGCGAGGTAATATGTCGGCAAATTTTCTATTAGCA
CTGAGCATACAGAGAAAACT

Downstream 100 bases:

>100_bases
ACTCAGTATAATCACGGTCGCTTAGGCGGCCGTTTTTTTAATTTGCTGCTTTGTATTCAACATGGAACTGAATGGCATCT
TGTGTTGCCTATGTTAGGTT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRILGIETSCDETGIAIYDDEKGLLAHKLYSQIKLHADYGGVVPELASRDHVKKTIPLIKEALKEANLTAKDIDGVAYTA
GPGLVGALLVGATIGRSLAYAWGVPAVPVHHMEGHLLAPMLEDNPPPFPFVAVLVSGGHSMMVEVKGIGEYKILGESIDD
AAGEAFDKTAKLMGLDYPGGPLLSKLAEKGTPGRFKFPRPMTNVPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFE
EAVCATLAIKCKRALEQTGMKRIVIAGGVSANRRLRAELEKLAHKVGGDVYYPRTEFCTDNGAMIAYAGMQRLKNNEVSD
LAVEARPRWPIDQLTPVMK

Sequences:

>Translated_339_residues
MRILGIETSCDETGIAIYDDEKGLLAHKLYSQIKLHADYGGVVPELASRDHVKKTIPLIKEALKEANLTAKDIDGVAYTA
GPGLVGALLVGATIGRSLAYAWGVPAVPVHHMEGHLLAPMLEDNPPPFPFVAVLVSGGHSMMVEVKGIGEYKILGESIDD
AAGEAFDKTAKLMGLDYPGGPLLSKLAEKGTPGRFKFPRPMTNVPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFE
EAVCATLAIKCKRALEQTGMKRIVIAGGVSANRRLRAELEKLAHKVGGDVYYPRTEFCTDNGAMIAYAGMQRLKNNEVSD
LAVEARPRWPIDQLTPVMK
>Mature_339_residues
MRILGIETSCDETGIAIYDDEKGLLAHKLYSQIKLHADYGGVVPELASRDHVKKTIPLIKEALKEANLTAKDIDGVAYTA
GPGLVGALLVGATIGRSLAYAWGVPAVPVHHMEGHLLAPMLEDNPPPFPFVAVLVSGGHSMMVEVKGIGEYKILGESIDD
AAGEAFDKTAKLMGLDYPGGPLLSKLAEKGTPGRFKFPRPMTNVPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFE
EAVCATLAIKCKRALEQTGMKRIVIAGGVSANRRLRAELEKLAHKVGGDVYYPRTEFCTDNGAMIAYAGMQRLKNNEVSD
LAVEARPRWPIDQLTPVMK

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=335, Percent_Identity=32.2388059701493, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI8923380, Length=335, Percent_Identity=31.3432835820896, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1789445, Length=334, Percent_Identity=77.5449101796407, Blast_Score=546, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17557464, Length=330, Percent_Identity=31.8181818181818, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI71995670, Length=346, Percent_Identity=32.3699421965318, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6320099, Length=371, Percent_Identity=32.6145552560647, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6322891, Length=343, Percent_Identity=28.2798833819242, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI20129063, Length=360, Percent_Identity=32.5, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI21357207, Length=330, Percent_Identity=31.5151515151515, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_VIBVU (Q8DEG4)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_759615.1
- ProteinModelPortal:   Q8DEG4
- SMR:   Q8DEG4
- GeneID:   1177577
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_0628
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   VVUL216895:VV1_0628-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36450; Mature: 36450

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILGIETSCDETGIAIYDDEKGLLAHKLYSQIKLHADYGGVVPELASRDHVKKTIPLIK
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
EALKEANLTAKDIDGVAYTAGPGLVGALLVGATIGRSLAYAWGVPAVPVHHMEGHLLAPM
HHHHHCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECHH
LEDNPPPFPFVAVLVSGGHSMMVEVKGIGEYKILGESIDDAAGEAFDKTAKLMGLDYPGG
HCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCC
PLLSKLAEKGTPGRFKFPRPMTNVPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFE
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCHHEECCEEECCCCCHHHHHHHHHHHH
EAVCATLAIKCKRALEQTGMKRIVIAGGVSANRRLRAELEKLAHKVGGDVYYPRTEFCTD
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEECCCHHEECC
NGAMIAYAGMQRLKNNEVSDLAVEARPRWPIDQLTPVMK
CCCEEEHHHHHHHCCCCCCCEEEECCCCCCHHHHCCCCC
>Mature Secondary Structure
MRILGIETSCDETGIAIYDDEKGLLAHKLYSQIKLHADYGGVVPELASRDHVKKTIPLIK
CEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
EALKEANLTAKDIDGVAYTAGPGLVGALLVGATIGRSLAYAWGVPAVPVHHMEGHLLAPM
HHHHHCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECHH
LEDNPPPFPFVAVLVSGGHSMMVEVKGIGEYKILGESIDDAAGEAFDKTAKLMGLDYPGG
HCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCC
PLLSKLAEKGTPGRFKFPRPMTNVPGLDMSFSGLKTFTANTIAANGDDEQTRADIAYAFE
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCHHEECCEEECCCCCHHHHHHHHHHHH
EAVCATLAIKCKRALEQTGMKRIVIAGGVSANRRLRAELEKLAHKVGGDVYYPRTEFCTD
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEECCCHHEECC
NGAMIAYAGMQRLKNNEVSDLAVEARPRWPIDQLTPVMK
CCCEEEHHHHHHHCCCCCCCEEEECCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA