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The map label for this gene is ydiD [C]

Identifier: 37678678

GI number: 37678678

Start: 478501

End: 480351

Strand: Direct

Name: ydiD [C]

Synonym: VV0494

Alternate gene names: 37678678

Gene position: 478501-480351 (Clockwise)

Preceding gene: 161486664

Following gene: 37678679

Centisome position: 14.26

GC content: 46.41

Gene sequence:

>1851_bases
GTGCCCGCAAATAGAGCTTACATGTGTAAGCCAAAGGTAAGAGACATGGCCAATTTAGATTTTCACATCGTAAAACGAAT
TCGTAAGCAGATTGCACAAGGTGCGGAGCGAGTTGCGCTCAAGCATAAAGTTGGTGCAGTTTGGCAAGGTATTAGCTGGA
AGCAATTTGGTCAGCAAATTGATGAATTATCCCTAGCGTTGCTTGCGCAGGGCATTGAAGTCCAAGATAAGATCGCTATC
TTTTCTAATAACATGCCGCAGTGGACGGTGGCCGATTTTGCGGCCCTACAATTACGTGCAGTCACGGTCCCGATTTATCC
AACCAATACGGCAGCTCAAGCGGCTTATATTCTGCAAAATGCCGACGTTAAAGTTCTGTTTGTGGGTGAACAGCCACAAT
TTGACGCCGCAGTGAAAATTTTCGATGAGTGTGAGCAACTGAACCTGATTGTCGCCATGTCAGACGATATTGATTTAGGC
GAACATCACTTTGCTATCCATTGGAAAGCATTCATTCAACAAGGTCAACAAGAGGCTCGTGCTGAGCTCGAACGACGTTT
AGAACAGGCAAATTTTGAGGATTTGCTGACGCTAATCTATACCTCTGGCACCACGGGGCAGCCGAAAGGGGTGATGTTAG
ATTATTCCAACATTGCCGCTCAATTAGAGGGGCATGATCGACGCTTAAGCCTGACAGAAAACGACGTTTCGCTTTGTTTC
TTGCCGTTATCACACGTTTTTGAGCGCGCTTGGACCTTTTACGTTCTGTATAAAGGCGGTACGAACTGTTATTTGCAAGA
TACCATGCAAGTTCGTGACGCTCTGAGTGATATCAAGCCAACAGTGATGTGTGCCGTGCCGCGCTTTTACGAGAAGATCT
TCTCTGCCATCCATGAGAAAGTCTCTCGTGCGCCGCTGATGCGCAAAATCATGTTTACCTGGGCGGTGAACATGGGCGCG
AAGATGTCCGTGTGTCACCAAGAAGGTCGCCAGCCTTCATTGATGCTGAAAAAAGCCCATGCGTTGGCGGATAAGCTGGT
GTTGTCAAAACTGCGTGCCCTGCTGGGAGGCAACATCAACTTTATGCCATGTGGTGGTGCAAAATTGGATGAAACCATTG
GTCGTTTCTTCCATGCGATTGGTATCAACGTGAAGCTGGGCTACGGCATGACCGAAACCACAGCAACGATTTCATGCTGG
GATGACAAGTGCTTTAACCCCGATTCTATCGGCATGTCGATGCCGGGCGCACAAGTAAAGATTGGCGAAAACAACGAAAT
TTTGGTTCGTGGTCCGATGGTGATGCGTGGTTACTACAAGCTCCCAGAAGAAACGGAGAAAACGTTTGATGAACACGGTT
TCCTCAAAACGGGCGATGCGGGTCATATTGATGAGCACGGCAACCTATTCATTACCGACCGTATCAAAGAGCTGATGAAA
ACGTCTGGAGGCAAATACATTGCCCCGCAGATGATTGAAGGTGCGATTGGTAAAGATCATTTCATTGAGCAAATCGCGGT
GATTGCCGATACACGCAAATTCGTTTCAGCTTTGATTGTGCCTTGTTTTGACTCCTTGGAAGAGTACGCCAAAGAGCTCA
ATATTAAGTATCACGATCGCGTTGAATTGATTAAGCATCACCAAGTCGTGGAAATGCTGGAGAAGCGCGTTAACGATCTG
CAGAAAGAGCTGGCGAAATTTGAACAAGTGAAGAAGTTCAAGTTGCTACCAAAAGCATTTTCTATGGATGAAGGTGAGTT
GACGCCAACGCAGAAATTGCGCCGTAAGGTGATTAACGACAAGTACCAAGACGAAATCGAAGAAATGTATTCAGAAAAGA
AAGAAAAATAA

Upstream 100 bases:

>100_bases
GGCCATGAGGGCATTTTTTTATCTTGTTATTGATGATTCTCTCTAATTGAGCATAAGTTTGACCCTCATCAGTTGCGTTT
TTTGTTCCCACCGCTACACT

Downstream 100 bases:

>100_bases
GCTTTTCTGTCGAACATTGACGTCACATTTATCCTTGATGAACCTCACTGAGTGTGAAACGCCAGTGAGGTTTTTCCGTC
TTTGACGCCTGTAGGCAGGC

Product: long-chain acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MPANRAYMCKPKVRDMANLDFHIVKRIRKQIAQGAERVALKHKVGAVWQGISWKQFGQQIDELSLALLAQGIEVQDKIAI
FSNNMPQWTVADFAALQLRAVTVPIYPTNTAAQAAYILQNADVKVLFVGEQPQFDAAVKIFDECEQLNLIVAMSDDIDLG
EHHFAIHWKAFIQQGQQEARAELERRLEQANFEDLLTLIYTSGTTGQPKGVMLDYSNIAAQLEGHDRRLSLTENDVSLCF
LPLSHVFERAWTFYVLYKGGTNCYLQDTMQVRDALSDIKPTVMCAVPRFYEKIFSAIHEKVSRAPLMRKIMFTWAVNMGA
KMSVCHQEGRQPSLMLKKAHALADKLVLSKLRALLGGNINFMPCGGAKLDETIGRFFHAIGINVKLGYGMTETTATISCW
DDKCFNPDSIGMSMPGAQVKIGENNEILVRGPMVMRGYYKLPEETEKTFDEHGFLKTGDAGHIDEHGNLFITDRIKELMK
TSGGKYIAPQMIEGAIGKDHFIEQIAVIADTRKFVSALIVPCFDSLEEYAKELNIKYHDRVELIKHHQVVEMLEKRVNDL
QKELAKFEQVKKFKLLPKAFSMDEGELTPTQKLRRKVINDKYQDEIEEMYSEKKEK

Sequences:

>Translated_616_residues
MPANRAYMCKPKVRDMANLDFHIVKRIRKQIAQGAERVALKHKVGAVWQGISWKQFGQQIDELSLALLAQGIEVQDKIAI
FSNNMPQWTVADFAALQLRAVTVPIYPTNTAAQAAYILQNADVKVLFVGEQPQFDAAVKIFDECEQLNLIVAMSDDIDLG
EHHFAIHWKAFIQQGQQEARAELERRLEQANFEDLLTLIYTSGTTGQPKGVMLDYSNIAAQLEGHDRRLSLTENDVSLCF
LPLSHVFERAWTFYVLYKGGTNCYLQDTMQVRDALSDIKPTVMCAVPRFYEKIFSAIHEKVSRAPLMRKIMFTWAVNMGA
KMSVCHQEGRQPSLMLKKAHALADKLVLSKLRALLGGNINFMPCGGAKLDETIGRFFHAIGINVKLGYGMTETTATISCW
DDKCFNPDSIGMSMPGAQVKIGENNEILVRGPMVMRGYYKLPEETEKTFDEHGFLKTGDAGHIDEHGNLFITDRIKELMK
TSGGKYIAPQMIEGAIGKDHFIEQIAVIADTRKFVSALIVPCFDSLEEYAKELNIKYHDRVELIKHHQVVEMLEKRVNDL
QKELAKFEQVKKFKLLPKAFSMDEGELTPTQKLRRKVINDKYQDEIEEMYSEKKEK
>Mature_615_residues
PANRAYMCKPKVRDMANLDFHIVKRIRKQIAQGAERVALKHKVGAVWQGISWKQFGQQIDELSLALLAQGIEVQDKIAIF
SNNMPQWTVADFAALQLRAVTVPIYPTNTAAQAAYILQNADVKVLFVGEQPQFDAAVKIFDECEQLNLIVAMSDDIDLGE
HHFAIHWKAFIQQGQQEARAELERRLEQANFEDLLTLIYTSGTTGQPKGVMLDYSNIAAQLEGHDRRLSLTENDVSLCFL
PLSHVFERAWTFYVLYKGGTNCYLQDTMQVRDALSDIKPTVMCAVPRFYEKIFSAIHEKVSRAPLMRKIMFTWAVNMGAK
MSVCHQEGRQPSLMLKKAHALADKLVLSKLRALLGGNINFMPCGGAKLDETIGRFFHAIGINVKLGYGMTETTATISCWD
DKCFNPDSIGMSMPGAQVKIGENNEILVRGPMVMRGYYKLPEETEKTFDEHGFLKTGDAGHIDEHGNLFITDRIKELMKT
SGGKYIAPQMIEGAIGKDHFIEQIAVIADTRKFVSALIVPCFDSLEEYAKELNIKYHDRVELIKHHQVVEMLEKRVNDLQ
KELAKFEQVKKFKLLPKAFSMDEGELTPTQKLRRKVINDKYQDEIEEMYSEKKEK

Specific function: Unknown

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI27477105, Length=635, Percent_Identity=27.244094488189, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI42794756, Length=594, Percent_Identity=29.4612794612795, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI42794760, Length=594, Percent_Identity=29.4612794612795, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI42794758, Length=594, Percent_Identity=29.4612794612795, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI40807491, Length=606, Percent_Identity=28.5478547854785, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI57165412, Length=594, Percent_Identity=28.7878787878788, Blast_Score=219, Evalue=9e-57,
Organism=Homo sapiens, GI83745141, Length=613, Percent_Identity=26.1011419249592, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI57165410, Length=594, Percent_Identity=28.7878787878788, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI42794754, Length=586, Percent_Identity=28.4982935153584, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI42794752, Length=586, Percent_Identity=28.4982935153584, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI12669909, Length=605, Percent_Identity=23.9669421487603, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI4758332, Length=605, Percent_Identity=23.9669421487603, Blast_Score=162, Evalue=8e-40,
Organism=Escherichia coli, GI145693145, Length=464, Percent_Identity=25.4310344827586, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788107, Length=485, Percent_Identity=23.7113402061856, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786810, Length=461, Percent_Identity=22.9934924078091, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17556552, Length=614, Percent_Identity=28.5016286644951, Blast_Score=239, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17541856, Length=597, Percent_Identity=30.6532663316583, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17510401, Length=598, Percent_Identity=27.9264214046823, Blast_Score=209, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI193204819, Length=633, Percent_Identity=29.0679304897314, Blast_Score=196, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17553312, Length=622, Percent_Identity=25.7234726688103, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17564090, Length=545, Percent_Identity=26.7889908256881, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI25147511, Length=642, Percent_Identity=24.4548286604361, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17558820, Length=537, Percent_Identity=24.5810055865922, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=326, Percent_Identity=27.3006134969325, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17559526, Length=342, Percent_Identity=28.0701754385965, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32563687, Length=477, Percent_Identity=23.6897274633124, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI133901848, Length=215, Percent_Identity=28.8372093023256, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=346, Percent_Identity=24.8554913294798, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6324893, Length=447, Percent_Identity=29.082774049217, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320852, Length=584, Percent_Identity=25.6849315068493, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322182, Length=465, Percent_Identity=28.8172043010753, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323903, Length=602, Percent_Identity=25.9136212624585, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281366413, Length=591, Percent_Identity=30.9644670050761, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24666501, Length=591, Percent_Identity=30.9644670050761, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24666497, Length=591, Percent_Identity=30.9644670050761, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI17933690, Length=625, Percent_Identity=25.92, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI19921316, Length=620, Percent_Identity=27.5806451612903, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI62471689, Length=592, Percent_Identity=27.7027027027027, Blast_Score=186, Evalue=6e-47,
Organism=Drosophila melanogaster, GI62471679, Length=592, Percent_Identity=27.7027027027027, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI62471683, Length=592, Percent_Identity=27.7027027027027, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI62471685, Length=592, Percent_Identity=27.7027027027027, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24586636, Length=592, Percent_Identity=27.7027027027027, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI62471681, Length=592, Percent_Identity=27.7027027027027, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI62471687, Length=592, Percent_Identity=27.7027027027027, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24586634, Length=592, Percent_Identity=27.7027027027027, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI22026970, Length=592, Percent_Identity=27.7027027027027, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI21355181, Length=535, Percent_Identity=24.6728971962617, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24653035, Length=190, Percent_Identity=33.1578947368421, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24648260, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356947, Length=220, Percent_Identity=26.3636363636364, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281365686, Length=204, Percent_Identity=29.9019607843137, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076582, Length=190, Percent_Identity=32.6315789473684, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358303, Length=207, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 69908; Mature: 69777

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPANRAYMCKPKVRDMANLDFHIVKRIRKQIAQGAERVALKHKVGAVWQGISWKQFGQQI
CCCCCCEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DELSLALLAQGIEVQDKIAIFSNNMPQWTVADFAALQLRAVTVPIYPTNTAAQAAYILQN
HHHHHHHHHCCCCHHHEEEEEECCCCCCHHHHHHHEEEEEEEEEEECCCHHHHHHHHEEC
ADVKVLFVGEQPQFDAAVKIFDECEQLNLIVAMSDDIDLGEHHFAIHWKAFIQQGQQEAR
CCEEEEEECCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCCEEEEHHHHHHHHCHHHHH
AELERRLEQANFEDLLTLIYTSGTTGQPKGVMLDYSNIAAQLEGHDRRLSLTENDVSLCF
HHHHHHHHHCCHHHHHHHHEECCCCCCCCCEEEEHHHHHHHCCCCCCEEEEECCCCEEEE
LPLSHVFERAWTFYVLYKGGTNCYLQDTMQVRDALSDIKPTVMCAVPRFYEKIFSAIHEK
EEHHHHHHHHEEEEEEEECCCCEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
VSRAPLMRKIMFTWAVNMGAKMSVCHQEGRQPSLMLKKAHALADKLVLSKLRALLGGNIN
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
FMPCGGAKLDETIGRFFHAIGINVKLGYGMTETTATISCWDDKCFNPDSIGMSMPGAQVK
EEECCCCHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEE
IGENNEILVRGPMVMRGYYKLPEETEKTFDEHGFLKTGDAGHIDEHGNLFITDRIKELMK
ECCCCEEEEECCCEECCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHHHHH
TSGGKYIAPQMIEGAIGKDHFIEQIAVIADTRKFVSALIVPCFDSLEEYAKELNIKYHDR
CCCCCEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VELIKHHQVVEMLEKRVNDLQKELAKFEQVKKFKLLPKAFSMDEGELTPTQKLRRKVIND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHCC
KYQDEIEEMYSEKKEK
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PANRAYMCKPKVRDMANLDFHIVKRIRKQIAQGAERVALKHKVGAVWQGISWKQFGQQI
CCCCCEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DELSLALLAQGIEVQDKIAIFSNNMPQWTVADFAALQLRAVTVPIYPTNTAAQAAYILQN
HHHHHHHHHCCCCHHHEEEEEECCCCCCHHHHHHHEEEEEEEEEEECCCHHHHHHHHEEC
ADVKVLFVGEQPQFDAAVKIFDECEQLNLIVAMSDDIDLGEHHFAIHWKAFIQQGQQEAR
CCEEEEEECCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCCCEEEEHHHHHHHHCHHHHH
AELERRLEQANFEDLLTLIYTSGTTGQPKGVMLDYSNIAAQLEGHDRRLSLTENDVSLCF
HHHHHHHHHCCHHHHHHHHEECCCCCCCCCEEEEHHHHHHHCCCCCCEEEEECCCCEEEE
LPLSHVFERAWTFYVLYKGGTNCYLQDTMQVRDALSDIKPTVMCAVPRFYEKIFSAIHEK
EEHHHHHHHHEEEEEEEECCCCEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHH
VSRAPLMRKIMFTWAVNMGAKMSVCHQEGRQPSLMLKKAHALADKLVLSKLRALLGGNIN
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
FMPCGGAKLDETIGRFFHAIGINVKLGYGMTETTATISCWDDKCFNPDSIGMSMPGAQVK
EEECCCCHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEE
IGENNEILVRGPMVMRGYYKLPEETEKTFDEHGFLKTGDAGHIDEHGNLFITDRIKELMK
ECCCCEEEEECCCEECCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCEEEHHHHHHHHH
TSGGKYIAPQMIEGAIGKDHFIEQIAVIADTRKFVSALIVPCFDSLEEYAKELNIKYHDR
CCCCCEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VELIKHHQVVEMLEKRVNDLQKELAKFEQVKKFKLLPKAFSMDEGELTPTQKLRRKVIND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHCC
KYQDEIEEMYSEKKEK
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]