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The map label for this gene is neuC [H]

Identifier: 37678495

GI number: 37678495

Start: 320339

End: 321517

Strand: Direct

Name: neuC [H]

Synonym: VV0311

Alternate gene names: 37678495

Gene position: 320339-321517 (Clockwise)

Preceding gene: 37678494

Following gene: 37678496

Centisome position: 9.55

GC content: 47.92

Gene sequence:

>1179_bases
ATGAGCGTAAATCAGAAAAAAGTCGCCGTTTTTACCGGAACAAGAGCAGAGTATGGTCTGCTCTTTTGGCTTTTAAAAGA
CATCCAAGCCGATCCTGTTCTTCAACTTCAATTGCTGGTTTCTGGTATGCATCTATCGCCTGAGTTCGGCGAAACCTATC
AGCAAATTGAGCGAGATGGTTTTCATATCGACGAAAAAATCGAAATCCTGCTTTCCTCAGATTCAGCGGTAGGCACAGCC
AAAAGCATGGGGCTGGGCGTATTGGGGTTTGCGGATGCTTTGGCAAGGCTTAAACCAGACGTACTGGTGATTCTTGGCGA
TCGTTTTGAAGCTTTGGCCGCGGCACAAACGGCCATGATTCTGCGTCTTCCAGTGATTCATTTACATGGTGGGGAAATTA
CCGAGGGCGCGTATGACGACGCCATTCGTCATGCGATCACCAAGTTGAGTTATTTGCATGGCACCTCGACCGAAGCGTAT
CGTCAGCGTGTGATCCAGCTAGGGGAAGCGCCAGAGCGCGTGAAAAATATCGGCGCTATTGGGCTTGACCACCTTAAACG
CGCTCAGTTCTTGGATGTGCCGGCTCTGGCTCAATCACTCAACTTCCCTTTGACTCAGCCGTACTTCTTGGTGACCTACC
ATCCCGTTACCTTGGGTGAAGAAGCACCAGAAACCAGTTTTCAAGCGTTACTGGATGCACTGGATTCGTATCCTGAGCAT
CAAATTATCCTCACTTATCCGAATGCCGATGATGGTGGACGTCGTATCATCCCAATGCTTGAAGCGTATGCTGCGGCAAA
TCCCCAGCGTGTGCTTGCTATTCCTTCTTTAGGGCAAGTGCGTTATCTCAGCGCGGTGAAACATGCTAGCGTTGTGATTG
GCAACTCTTCCAGTGGCATTATTGAAGTGCCTGCTTTTGATGTACCGACGGTGAATATTGGTGTGCGTCAGCAAGGGCGT
TTGGCCGCAAAAAGTGTCTTGCATTGCCGGGCATCTAAAGAAGAGATTGAACAAGCAATTCAAACTGCCATTACCATAGG
TTATAAGGCTGACGGTGAAGTGATCGATAATCCTTATGGCCAAGGTGATAGCAGTGCGCAAGTGATTGCAATGATAAAAT
CACTTCATTTTGAACCTTGTAAGTCATTCTATGACTTACCCTTTGAACCGATTGAGTGA

Upstream 100 bases:

>100_bases
AACAAGCCCTACGTGGGGATTTGACCCATTCAGAGTTCATTGAAGCACACTTGATTAACTTACCGAGTACGCCGGTTGGC
GCTTAGGTGAGGGAGCGAGC

Downstream 100 bases:

>100_bases
GGCAGCATGACTCTAATCATTGCAGAAGCGGGTGTAAACCATAATGGCGACGAAGCACTGGCGTTTAAACTCGTCGACGC
TGCGCATCAAGCTGGTGCCG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSVNQKKVAVFTGTRAEYGLLFWLLKDIQADPVLQLQLLVSGMHLSPEFGETYQQIERDGFHIDEKIEILLSSDSAVGTA
KSMGLGVLGFADALARLKPDVLVILGDRFEALAAAQTAMILRLPVIHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEAY
RQRVIQLGEAPERVKNIGAIGLDHLKRAQFLDVPALAQSLNFPLTQPYFLVTYHPVTLGEEAPETSFQALLDALDSYPEH
QIILTYPNADDGGRRIIPMLEAYAAANPQRVLAIPSLGQVRYLSAVKHASVVIGNSSSGIIEVPAFDVPTVNIGVRQQGR
LAAKSVLHCRASKEEIEQAIQTAITIGYKADGEVIDNPYGQGDSSAQVIAMIKSLHFEPCKSFYDLPFEPIE

Sequences:

>Translated_392_residues
MSVNQKKVAVFTGTRAEYGLLFWLLKDIQADPVLQLQLLVSGMHLSPEFGETYQQIERDGFHIDEKIEILLSSDSAVGTA
KSMGLGVLGFADALARLKPDVLVILGDRFEALAAAQTAMILRLPVIHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEAY
RQRVIQLGEAPERVKNIGAIGLDHLKRAQFLDVPALAQSLNFPLTQPYFLVTYHPVTLGEEAPETSFQALLDALDSYPEH
QIILTYPNADDGGRRIIPMLEAYAAANPQRVLAIPSLGQVRYLSAVKHASVVIGNSSSGIIEVPAFDVPTVNIGVRQQGR
LAAKSVLHCRASKEEIEQAIQTAITIGYKADGEVIDNPYGQGDSSAQVIAMIKSLHFEPCKSFYDLPFEPIE
>Mature_391_residues
SVNQKKVAVFTGTRAEYGLLFWLLKDIQADPVLQLQLLVSGMHLSPEFGETYQQIERDGFHIDEKIEILLSSDSAVGTAK
SMGLGVLGFADALARLKPDVLVILGDRFEALAAAQTAMILRLPVIHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEAYR
QRVIQLGEAPERVKNIGAIGLDHLKRAQFLDVPALAQSLNFPLTQPYFLVTYHPVTLGEEAPETSFQALLDALDSYPEHQ
IILTYPNADDGGRRIIPMLEAYAAANPQRVLAIPSLGQVRYLSAVKHASVVIGNSSSGIIEVPAFDVPTVNIGVRQQGRL
AAKSVLHCRASKEEIEQAIQTAITIGYKADGEVIDNPYGQGDSSAQVIAMIKSLHFEPCKSFYDLPFEPIE

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI190014632, Length=391, Percent_Identity=31.2020460358056, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI298566312, Length=391, Percent_Identity=31.2020460358056, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI4885285, Length=391, Percent_Identity=31.2020460358056, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI298566325, Length=355, Percent_Identity=30.1408450704225, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI298566315, Length=137, Percent_Identity=36.4963503649635, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 42795; Mature: 42663

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNQKKVAVFTGTRAEYGLLFWLLKDIQADPVLQLQLLVSGMHLSPEFGETYQQIERDG
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHCC
FHIDEKIEILLSSDSAVGTAKSMGLGVLGFADALARLKPDVLVILGDRFEALAAAQTAMI
CCCCCEEEEEEECCCCCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
LRLPVIHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEAYRQRVIQLGEAPERVKNIGAI
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCCCC
GLDHLKRAQFLDVPALAQSLNFPLTQPYFLVTYHPVTLGEEAPETSFQALLDALDSYPEH
CHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEECCEECCCCCCCHHHHHHHHHHHCCCCC
QIILTYPNADDGGRRIIPMLEAYAAANPQRVLAIPSLGQVRYLSAVKHASVVIGNSSSGI
EEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCEEEEECCCCCE
IEVPAFDVPTVNIGVRQQGRLAAKSVLHCRASKEEIEQAIQTAITIGYKADGEVIDNPYG
EECCCCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCCCCCCCC
QGDSSAQVIAMIKSLHFEPCKSFYDLPFEPIE
CCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SVNQKKVAVFTGTRAEYGLLFWLLKDIQADPVLQLQLLVSGMHLSPEFGETYQQIERDG
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHCC
FHIDEKIEILLSSDSAVGTAKSMGLGVLGFADALARLKPDVLVILGDRFEALAAAQTAMI
CCCCCEEEEEEECCCCCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
LRLPVIHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEAYRQRVIQLGEAPERVKNIGAI
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHCCCC
GLDHLKRAQFLDVPALAQSLNFPLTQPYFLVTYHPVTLGEEAPETSFQALLDALDSYPEH
CHHHHHHHHHCCHHHHHHHCCCCCCCCEEEEEECCEECCCCCCCHHHHHHHHHHHCCCCC
QIILTYPNADDGGRRIIPMLEAYAAANPQRVLAIPSLGQVRYLSAVKHASVVIGNSSSGI
EEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCEEEEECCCCCE
IEVPAFDVPTVNIGVRQQGRLAAKSVLHCRASKEEIEQAIQTAITIGYKADGEVIDNPYG
EECCCCCCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCCCCCCCCC
QGDSSAQVIAMIKSLHFEPCKSFYDLPFEPIE
CCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]