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The map label for this gene is lysA [H]

Identifier: 37678270

GI number: 37678270

Start: 97173

End: 98426

Strand: Direct

Name: lysA [H]

Synonym: VV0086

Alternate gene names: 37678270

Gene position: 97173-98426 (Clockwise)

Preceding gene: 37678269

Following gene: 37678271

Centisome position: 2.9

GC content: 51.91

Gene sequence:

>1254_bases
TTGGATTATTTCAATTATCAGGACGATGGTCAGCTCTGGGCGGAAGAGGTTTCCTTAACCAGTCTGGCTGAGCAGTACGG
CACACCTCTGTATGTTTATTCGCGTGCGACGCTAGAGCGTCACTGGCATGCGTTTGACCGCTCGGTAGAAGGGCATCCTC
ACCTGGTTTGTTATGCGGTGAAAGCCAACTCGAACCTGGGGGTACTGAACACCTTGGCGCGATTAGGCTCTGGTTTTGAC
ATCGTATCCGGTGGTGAATTGGAGCGGGTGTTGGCCGCTGGCGGCGACCCACGTAAAGTGGTGTTCTCTGGTGTGGGCAA
AACCGAAGCGGAAATGCGCCGTGCGCTTGAACTCAACATCAAGTGTTTTAACGTCGAATCGGAACCTGAACTTGAGCGTT
TGAACCGCGTTGCGGGAGAGTTGGGTGTGAAAGCGCCAATCTCACTGCGCATTAACCCGGATGTGGATGCTCAAACCCAC
CCTTATATTTCAACGGGTCTGCGCGATAATAAATTTGGTATCGCCTTTGACCGTGCGCCAGCGGTATACCAATTTGCCCA
GAGCCTAGCAAACCTTAACGTCCAAGGTATCGACTGCCATATCGGCTCGCAGCTTACCGCGATTGAACCGTTTATCGATG
CGACTGATCGCTTGCTTGCTTTGATTGATGATTTGAAAGAGCAAGGCATCAACATTCGCCACCTTGATGTGGGTGGTGGT
CTTGGCGTGGTGTATCGTAACGAATTGCCACCACAGCCATCTGAATACGCCAAAGCGCTATTGGGCCGTTTAGAAAATCA
CCAAGATTTGGAACTGATTTTTGAACCAGGACGCGCGATCGCTGCGAACGCGGGCGTATTGCTGACCAAAGTTGAATTCC
TCAAGCACACAGAACACAAAAACTTTGCCATCATTGATGCGGCAATGAACGATTTGATGCGCCCTGCGCTGTACCAAGCG
TGGCAAGACATTGTGCCCGTTCAGCCTCGCCAAGGCGAAGCGGTGACTTATGATCTCGTGGGGCCAATTTGTGAAACGGG
AGACTTCCTCGGTAAAGACCGTTCACTGGTGTTGGCAGAGAACGATTTGCTAGCGGTTCGCAGTGCGGGCGCTTATGGCT
TTGTTATGTCGTCCAACTACAACACTCGTGCGCGTGCGGCGGAAGTGATGGTGGATGGCAAACAGCATTATCTGGTACGC
CAGCGCGAAGAATTGCGTAGCTTGTGGGAACTAGAACACATTCTTCCGGAGTAA

Upstream 100 bases:

>100_bases
GGGCGCTTTGTACATTCCAGATGACGCTCAACAATCTGAGCAATCACAGTAGGCATCGCAACTGATTTAGCAGTCGACCA
TATTATAAGGGAAGTGAATT

Downstream 100 bases:

>100_bases
CGAGCTTTTTATGCATTTCCATTTTTCTAAAATGCACGGTTTGGGTAACGACTTTATGGTGGTCGACTGCATTACTCAAA
ACGTTTACTTCTCTCAAGAG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDYFNYQDDGQLWAEEVSLTSLAEQYGTPLYVYSRATLERHWHAFDRSVEGHPHLVCYAVKANSNLGVLNTLARLGSGFD
IVSGGELERVLAAGGDPRKVVFSGVGKTEAEMRRALELNIKCFNVESEPELERLNRVAGELGVKAPISLRINPDVDAQTH
PYISTGLRDNKFGIAFDRAPAVYQFAQSLANLNVQGIDCHIGSQLTAIEPFIDATDRLLALIDDLKEQGINIRHLDVGGG
LGVVYRNELPPQPSEYAKALLGRLENHQDLELIFEPGRAIAANAGVLLTKVEFLKHTEHKNFAIIDAAMNDLMRPALYQA
WQDIVPVQPRQGEAVTYDLVGPICETGDFLGKDRSLVLAENDLLAVRSAGAYGFVMSSNYNTRARAAEVMVDGKQHYLVR
QREELRSLWELEHILPE

Sequences:

>Translated_417_residues
MDYFNYQDDGQLWAEEVSLTSLAEQYGTPLYVYSRATLERHWHAFDRSVEGHPHLVCYAVKANSNLGVLNTLARLGSGFD
IVSGGELERVLAAGGDPRKVVFSGVGKTEAEMRRALELNIKCFNVESEPELERLNRVAGELGVKAPISLRINPDVDAQTH
PYISTGLRDNKFGIAFDRAPAVYQFAQSLANLNVQGIDCHIGSQLTAIEPFIDATDRLLALIDDLKEQGINIRHLDVGGG
LGVVYRNELPPQPSEYAKALLGRLENHQDLELIFEPGRAIAANAGVLLTKVEFLKHTEHKNFAIIDAAMNDLMRPALYQA
WQDIVPVQPRQGEAVTYDLVGPICETGDFLGKDRSLVLAENDLLAVRSAGAYGFVMSSNYNTRARAAEVMVDGKQHYLVR
QREELRSLWELEHILPE
>Mature_417_residues
MDYFNYQDDGQLWAEEVSLTSLAEQYGTPLYVYSRATLERHWHAFDRSVEGHPHLVCYAVKANSNLGVLNTLARLGSGFD
IVSGGELERVLAAGGDPRKVVFSGVGKTEAEMRRALELNIKCFNVESEPELERLNRVAGELGVKAPISLRINPDVDAQTH
PYISTGLRDNKFGIAFDRAPAVYQFAQSLANLNVQGIDCHIGSQLTAIEPFIDATDRLLALIDDLKEQGINIRHLDVGGG
LGVVYRNELPPQPSEYAKALLGRLENHQDLELIFEPGRAIAANAGVLLTKVEFLKHTEHKNFAIIDAAMNDLMRPALYQA
WQDIVPVQPRQGEAVTYDLVGPICETGDFLGKDRSLVLAENDLLAVRSAGAYGFVMSSNYNTRARAAEVMVDGKQHYLVR
QREELRSLWELEHILPE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=236, Percent_Identity=27.9661016949153, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1789203, Length=429, Percent_Identity=30.5361305361305, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17562780, Length=361, Percent_Identity=24.3767313019391, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=236, Percent_Identity=27.1186440677966, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24586474, Length=400, Percent_Identity=24.5, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46307; Mature: 46307

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYFNYQDDGQLWAEEVSLTSLAEQYGTPLYVYSRATLERHWHAFDRSVEGHPHLVCYAV
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEE
KANSNLGVLNTLARLGSGFDIVSGGELERVLAAGGDPRKVVFSGVGKTEAEMRRALELNI
ECCCCCHHHHHHHHHCCCCEECCCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHEEEE
KCFNVESEPELERLNRVAGELGVKAPISLRINPDVDAQTHPYISTGLRDNKFGIAFDRAP
EEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCH
AVYQFAQSLANLNVQGIDCHIGSQLTAIEPFIDATDRLLALIDDLKEQGINIRHLDVGGG
HHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LGVVYRNELPPQPSEYAKALLGRLENHQDLELIFEPGRAIAANAGVLLTKVEFLKHTEHK
EEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHCCCC
NFAIIDAAMNDLMRPALYQAWQDIVPVQPRQGEAVTYDLVGPICETGDFLGKDRSLVLAE
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCEEEEEC
NDLLAVRSAGAYGFVMSSNYNTRARAAEVMVDGKQHYLVRQREELRSLWELEHILPE
CCEEEEECCCCEEEEEECCCCCHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYFNYQDDGQLWAEEVSLTSLAEQYGTPLYVYSRATLERHWHAFDRSVEGHPHLVCYAV
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEE
KANSNLGVLNTLARLGSGFDIVSGGELERVLAAGGDPRKVVFSGVGKTEAEMRRALELNI
ECCCCCHHHHHHHHHCCCCEECCCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHEEEE
KCFNVESEPELERLNRVAGELGVKAPISLRINPDVDAQTHPYISTGLRDNKFGIAFDRAP
EEEECCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCH
AVYQFAQSLANLNVQGIDCHIGSQLTAIEPFIDATDRLLALIDDLKEQGINIRHLDVGGG
HHHHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
LGVVYRNELPPQPSEYAKALLGRLENHQDLELIFEPGRAIAANAGVLLTKVEFLKHTEHK
EEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHCCCC
NFAIIDAAMNDLMRPALYQAWQDIVPVQPRQGEAVTYDLVGPICETGDFLGKDRSLVLAE
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHCCCCCCCCCEEEEEC
NDLLAVRSAGAYGFVMSSNYNTRARAAEVMVDGKQHYLVRQREELRSLWELEHILPE
CCEEEEECCCCEEEEEECCCCCHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]