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The map label for this gene is ilvC [H]

Identifier: 37678219

GI number: 37678219

Start: 39308

End: 40792

Strand: Direct

Name: ilvC [H]

Synonym: VV0035

Alternate gene names: 37678219

Gene position: 39308-40792 (Clockwise)

Preceding gene: 37678217

Following gene: 37678224

Centisome position: 1.17

GC content: 46.46

Gene sequence:

>1485_bases
ATGGCGAACTATTTCAATACTTTGAACCTTCGTGAGCAACTAGACCAATTGGGTCGTTGTCGTTTTATGGATCGCAGTGA
ATTCGCTACAGAGGCGGATTACCTTAAGGGTAAAAAAGTCGTCATCGTAGGTTGTGGTGCGCAAGGCCTAAACCAAGGTC
TAAACATGCGTGACTCAGGTCTTGATGTTGCTTACGCACTACGTCAAGCCGCGATTGATGAGCAGCGTCAATCATACAAA
AATGCTAAAGAGAACGGTTTTGAAGTGGGTAGTTATGAAACGCTGATCCCTCAAGCTGATCTTGTTGTTAACTTGACACC
AGATAAACAGCACACCAATGTGGTTGAAACCGTAATGCCCCTAATGAAAGAAGGCGCGGCTCTTGGCTACTCACACGGTT
TTAACGTTGTTGAAGAAGGCATGCAAATCCGTAAAGATCTAACGGTTGTTATGGTGGCGCCTAAGTGTCCCGGTACAGAA
GTTCGTGAAGAATACAAACGTGGCTTTGGTGTTCCTACATTGATTGCTGTTCACCCAGAGAACGATCCAAAAGGTGAGGG
TTGGGACATTGCGAAAGCTTGGGCGGCTGCGACTGGTGGTCATCGTGCGGGTTGTCTTGAGTCTTCTTTTGTTGCTGAAG
TGAAATCAGACTTGATGGGTGAGCAAACCATTCTATGTGGCATGCTTCAAGCTGGTTCTATCGTATGTTACGAGAAGATG
GTTGCGGAAGGTATTGACCCAGGTTACGCAGGTAAGTTACTGCAGTACGGTTGGGAAACCATTACCGAAGCACTGAAGTT
CGGTGGTATCACACATATGATGGACCGTCTATCAAACCCAGCGAAGATCAAAGCATTTGAGCTTTCTGAAGAGCTAAAGG
ATCTGATGCGTCCTCTGTACAACAAACACATGGACGACATTATCTCAGGTCACTTCTCTAGCACTATGATGGCTGACTGG
GCGAATGATGATGCGAATCTGCTAGGCTGGCGCGCTGAAACGGGTGAAACGGCGTTCGAAAATTACCCATCAACGGATGT
TGAAATCTCTGAGCAAGAGTACTTTGACAACGGTATCTTAATGGTTGCAATGGTTCGTGCTGGCGTTGAACTGGCGTTTG
AAGCAATGACGGCCTCTGGCATTATTGACGAATCGGCTTACTACGAGTCGCTGCATGAGTTACCACTTATTGCCAACACA
ATTGCACGTAAGCGTCTATACGAGATGAACGTGGTTATCTCAGACACAGCGGAATATGGTAACTACCTGTTTGCTAATGT
GGCAACACCGCTACTTCGTGAGAAGTTTATGCCTTCGGTAGGGACAGATGTGATTGGTAAGGGGTTAGGTGAAACTTCTA
ATCAAGTTGATAACGCGACACTCATTGCCGTAAATGAGACTATCCGCAATCACCCTGTTGAGTACATCGGTGAAGAGCTG
CGTGGTTACATGACTGACATGAAACGTATCGCTGTTGGTGGCTAA

Upstream 100 bases:

>100_bases
TGTGAATATATCACTTTGAGCAACTTAAAGTCTGTTTTAGTATGAATTCATTCGGTGAGTAACCACCGACCGTGATGGAT
GAATTTTAAGGAGAGCCCTG

Downstream 100 bases:

>100_bases
GTATCGCCTTTCCACCTATTCTCATTCTAGTGTCTAGAAAAGGGCGCTAACAAAACTCCAGGCAGACTGGGGTGATAAAT
ACAAAAGAAAACACAACATG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MANYFNTLNLREQLDQLGRCRFMDRSEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRQAAIDEQRQSYK
NAKENGFEVGSYETLIPQADLVVNLTPDKQHTNVVETVMPLMKEGAALGYSHGFNVVEEGMQIRKDLTVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAATGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
VAEGIDPGYAGKLLQYGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADW
ANDDANLLGWRAETGETAFENYPSTDVEISEQEYFDNGILMVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPSVGTDVIGKGLGETSNQVDNATLIAVNETIRNHPVEYIGEEL
RGYMTDMKRIAVGG

Sequences:

>Translated_494_residues
MANYFNTLNLREQLDQLGRCRFMDRSEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRQAAIDEQRQSYK
NAKENGFEVGSYETLIPQADLVVNLTPDKQHTNVVETVMPLMKEGAALGYSHGFNVVEEGMQIRKDLTVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAATGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
VAEGIDPGYAGKLLQYGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADW
ANDDANLLGWRAETGETAFENYPSTDVEISEQEYFDNGILMVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPSVGTDVIGKGLGETSNQVDNATLIAVNETIRNHPVEYIGEEL
RGYMTDMKRIAVGG
>Mature_493_residues
ANYFNTLNLREQLDQLGRCRFMDRSEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSGLDVAYALRQAAIDEQRQSYKN
AKENGFEVGSYETLIPQADLVVNLTPDKQHTNVVETVMPLMKEGAALGYSHGFNVVEEGMQIRKDLTVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAATGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKMV
AEGIDPGYAGKLLQYGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLYNKHMDDIISGHFSSTMMADWA
NDDANLLGWRAETGETAFENYPSTDVEISEQEYFDNGILMVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTI
ARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPSVGTDVIGKGLGETSNQVDNATLIAVNETIRNHPVEYIGEELR
GYMTDMKRIAVGG

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=494, Percent_Identity=76.1133603238866, Blast_Score=765, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=287, Percent_Identity=29.9651567944251, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54541; Mature: 54409

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLNLREQLDQLGRCRFMDRSEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSG
CCCCHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LDVAYALRQAAIDEQRQSYKNAKENGFEVGSYETLIPQADLVVNLTPDKQHTNVVETVMP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCEEEEECCCCHHHHHHHHHHH
LMKEGAALGYSHGFNVVEEGMQIRKDLTVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGWDIAKAWAAATGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
VAEGIDPGYAGKLLQYGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLY
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
NKHMDDIISGHFSSTMMADWANDDANLLGWRAETGETAFENYPSTDVEISEQEYFDNGIL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHCCCCCCCEECHHHHHCCCHH
MVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANVATPLLREKFMPSVGTDVIGKGLGETSNQVDNATLIAVNETIRNHPVEYIGEEL
CEEHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHH
RGYMTDMKRIAVGG
HHHHHHHHHHHCCC
>Mature Secondary Structure 
ANYFNTLNLREQLDQLGRCRFMDRSEFATEADYLKGKKVVIVGCGAQGLNQGLNMRDSG
CCCHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LDVAYALRQAAIDEQRQSYKNAKENGFEVGSYETLIPQADLVVNLTPDKQHTNVVETVMP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCEEEEECCCCHHHHHHHHHHH
LMKEGAALGYSHGFNVVEEGMQIRKDLTVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGWDIAKAWAAATGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
CCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
VAEGIDPGYAGKLLQYGWETITEALKFGGITHMMDRLSNPAKIKAFELSEELKDLMRPLY
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHH
NKHMDDIISGHFSSTMMADWANDDANLLGWRAETGETAFENYPSTDVEISEQEYFDNGIL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHCCCCCCCEECHHHHHCCCHH
MVAMVRAGVELAFEAMTASGIIDESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANVATPLLREKFMPSVGTDVIGKGLGETSNQVDNATLIAVNETIRNHPVEYIGEEL
CEEHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHHH
RGYMTDMKRIAVGG
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA