Click here to switch to the map view.

The map label for this gene is hemB [H]

Identifier: 37523927

GI number: 37523927

Start: 4593663

End: 4594646

Strand: Direct

Name: hemB [H]

Synonym: gvip565

Alternate gene names: 37523927

Gene position: 4593663-4594646 (Clockwise)

Preceding gene: 37523926

Following gene: 37523929

Centisome position: 98.6

GC content: 64.53

Gene sequence:

>984_bases
ATGTTTCCGTCTGTTCGCCCGCGCCGATTGCGCACGACGCCCACCCTGCGCCGGATGGTGCGCGAAAACCATCTGCACCC
CGAAGATCTGGTCAGCCCCATCTTCGTGGTGCCGGGATCGGGCTTTGCCCGCGAGGTCTCCTCGATGCCCGGCGTCTTTC
AGCTGTCGGTGGACAAGGCCGTGGAGGAGGCGCGCGAAGTGTGGGATCTGGGCGTCCCCTCGGTGATTCTTTTTGGCATC
CCCGAGCAAAAGGACGCCGGGGCCACAGGCGCCTGGCACGACCACGGCATTGTCCAGGAAGCAACGACTGCTATCAAAGC
GGCCCTGCCGGAGCTGGTGGTGATGGCCGATACCTGCCTGTGCGAGTACACCAACCACGGCCACTGCGGCGTCATCGAGT
TGAGCGACACGATTGGCCATGTCCTCAACGATCCGACCCTCGAAATTTTGGGCAAGACCGCCGTCGCCCAGGCGCGCGCC
GGGGCGGATCTGATCGCCCCTTCCGGGATGATGGACGGCATGGTGCGGGCCATCCGCACGGCCCTCGACGAAGCGGGCTT
CACCGACACGCCGATTCTTTCTTACGCGGCCAAGTACGCCTCCGCCTACTACGGTCCTTTTCGGGACGCCGCCGAATCGA
CCCCTCAATTTGGCGATCGGCGCACCTACCAGATGGACCCGGCCAACAGCCGCGAGGCGCTCAAAGAAATTGCCCTCGAC
ATCGCCGAGGGCGCCGACATGCTGATGGTCAAACCGGCCCTGGCCTACCTGGACATCCTGCACCGCGTCAAAGCGGCGAC
CCACCTGCCGGTAGCCGCCTACAACGTTTCAGGCGAGTACGCGATGGTCAAAGCCGCCGCTCTCAACGGTTGGATCGACG
AGGAACGGGTGGTGATGGAGACGCTGATGTCGATGAAACGCGCCGGGGCGGACCTGATCTTGACCTACCACGCCAAGGAC
GCCGCCCGCTGGCTTGGAGCCTGA

Upstream 100 bases:

>100_bases
GAATAGCCGCCGACACCGATGGGATCCCTTCCCCGTACCGGCGCCTGCTAACGTGGTAGGCGCCGTTCTTTGTCCAACGC
ACCAGGGGAGGAGGCCCGCC

Downstream 100 bases:

>100_bases
TCCCCACCTCGTGGGCGGATCACCCGCCTACATACTGCTGCAGGATCTGCTTGCGCTTGCTGCGCCGCAGCTTGCGCAGC
GCTTCCGATTCGATTTGCCG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MFPSVRPRRLRTTPTLRRMVRENHLHPEDLVSPIFVVPGSGFAREVSSMPGVFQLSVDKAVEEAREVWDLGVPSVILFGI
PEQKDAGATGAWHDHGIVQEATTAIKAALPELVVMADTCLCEYTNHGHCGVIELSDTIGHVLNDPTLEILGKTAVAQARA
GADLIAPSGMMDGMVRAIRTALDEAGFTDTPILSYAAKYASAYYGPFRDAAESTPQFGDRRTYQMDPANSREALKEIALD
IAEGADMLMVKPALAYLDILHRVKAATHLPVAAYNVSGEYAMVKAAALNGWIDEERVVMETLMSMKRAGADLILTYHAKD
AARWLGA

Sequences:

>Translated_327_residues
MFPSVRPRRLRTTPTLRRMVRENHLHPEDLVSPIFVVPGSGFAREVSSMPGVFQLSVDKAVEEAREVWDLGVPSVILFGI
PEQKDAGATGAWHDHGIVQEATTAIKAALPELVVMADTCLCEYTNHGHCGVIELSDTIGHVLNDPTLEILGKTAVAQARA
GADLIAPSGMMDGMVRAIRTALDEAGFTDTPILSYAAKYASAYYGPFRDAAESTPQFGDRRTYQMDPANSREALKEIALD
IAEGADMLMVKPALAYLDILHRVKAATHLPVAAYNVSGEYAMVKAAALNGWIDEERVVMETLMSMKRAGADLILTYHAKD
AARWLGA
>Mature_327_residues
MFPSVRPRRLRTTPTLRRMVRENHLHPEDLVSPIFVVPGSGFAREVSSMPGVFQLSVDKAVEEAREVWDLGVPSVILFGI
PEQKDAGATGAWHDHGIVQEATTAIKAALPELVVMADTCLCEYTNHGHCGVIELSDTIGHVLNDPTLEILGKTAVAQARA
GADLIAPSGMMDGMVRAIRTALDEAGFTDTPILSYAAKYASAYYGPFRDAAESTPQFGDRRTYQMDPANSREALKEIALD
IAEGADMLMVKPALAYLDILHRVKAATHLPVAAYNVSGEYAMVKAAALNGWIDEERVVMETLMSMKRAGADLILTYHAKD
AARWLGA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=305, Percent_Identity=40.9836065573771, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI87081728, Length=318, Percent_Identity=53.7735849056604, Blast_Score=319, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6321398, Length=317, Percent_Identity=40.3785488958991, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI21358291, Length=308, Percent_Identity=40.5844155844156, Blast_Score=231, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35503; Mature: 35503

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPSVRPRRLRTTPTLRRMVRENHLHPEDLVSPIFVVPGSGFAREVSSMPGVFQLSVDKA
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCEEEECCCCHHHHHHCCCCEEEEHHHHH
VEEAREVWDLGVPSVILFGIPEQKDAGATGAWHDHGIVQEATTAIKAALPELVVMADTCL
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CEYTNHGHCGVIELSDTIGHVLNDPTLEILGKTAVAQARAGADLIAPSGMMDGMVRAIRT
HHCCCCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ALDEAGFTDTPILSYAAKYASAYYGPFRDAAESTPQFGDRRTYQMDPANSREALKEIALD
HHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHH
IAEGADMLMVKPALAYLDILHRVKAATHLPVAAYNVSGEYAMVKAAALNGWIDEERVVME
HHCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
TLMSMKRAGADLILTYHAKDAARWLGA
HHHHHHHCCCCEEEEEECHHHHHHHCC
>Mature Secondary Structure
MFPSVRPRRLRTTPTLRRMVRENHLHPEDLVSPIFVVPGSGFAREVSSMPGVFQLSVDKA
CCCCCCCCCCCCCHHHHHHHHHCCCCHHHHCCCEEEECCCCHHHHHHCCCCEEEEHHHHH
VEEAREVWDLGVPSVILFGIPEQKDAGATGAWHDHGIVQEATTAIKAALPELVVMADTCL
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CEYTNHGHCGVIELSDTIGHVLNDPTLEILGKTAVAQARAGADLIAPSGMMDGMVRAIRT
HHCCCCCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ALDEAGFTDTPILSYAAKYASAYYGPFRDAAESTPQFGDRRTYQMDPANSREALKEIALD
HHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHH
IAEGADMLMVKPALAYLDILHRVKAATHLPVAAYNVSGEYAMVKAAALNGWIDEERVVME
HHCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
TLMSMKRAGADLILTYHAKDAARWLGA
HHHHHHHCCCCEEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]