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The map label for this gene is gor [H]

Identifier: 37523770

GI number: 37523770

Start: 4399194

End: 4400546

Strand: Reverse

Name: gor [H]

Synonym: gll4201

Alternate gene names: 37523770

Gene position: 4400546-4399194 (Counterclockwise)

Preceding gene: 37523772

Following gene: 37523769

Centisome position: 94.45

GC content: 65.78

Gene sequence:

>1353_bases
ATGCAAAAGCACTATGACCTGGTGGTTCTGGGCACTGGCGTGGCCGGTTCCTCCGTCGCCAAACGCTGCCGAGAAGCCGG
CTGGAAGGTCGCTGTTGTCGATTCGCGGCCCTTCGGCGGCACTTGCGCCCTGCGCGGCTGCACGCCCAAAAAAGTGCTCG
TTCAAGCCGGGGAACTGCTCGATCGGTGGCGGCACCTTGCGGGCAAGGGCCTGCGTGCCGAGGAGGCCCGCATCGATTGG
CCGGAGTTGATGCGCTTCAAGCGTTCGCTCATCGAGCCTTTGCCGGCCGCGCGCGAGGCGGAGTACGCCGAGGCGGGCAT
CGAGTCCTACCACGGCGTGGCCCGATTCGTCGGGGCGACCGCGCTTGAGGTGGAGGGCGCCCACCTGCAGGGAGAAAAGG
TGCTCATCGCCACCGGGTCGCGGCCGGCCACCCTCGGCATCGAAGGGGAAGAGCACCTTGCGAGCTCGGACGATTTTCTG
GAACTGGGCACGTTGCCGCGGCGCATTGTGTTTGTGGGCGGCGGCTATATTTCGATGGAATTTGCCCACCTCGCCGCCCG
CGCTGGTTCCCAGGTGCACGTTTTGCACCAGGACGAACGCCCGTTGGCCCCGTTCGATCCCGATCTGGTGGATCGGCTCA
TCGAAGCGACGCGGGAACTGGGTGCGCTATGCCTGTGCCACAAGGTCAAGGCGATCGAAAAAACCGCCCAGGGCTTGCTG
GTGCACACCGACGGCGACGGCGGCCCCTACGCGGCGGACTTGGTCGTGCACGGCGCGAGCCGCGTCCCAAACGTCGAGGC
GCTGGATCTCGACGGGGCGGGCGTCGAAGCCGGCAAAAAAGGCATCAAAGTGAACGCCCACCTGCAAAGCGTCTCCAACC
CGGCGGTGTACGCAGCCGGAGATGTAGCCGACGCCCCCGGTCCGCAGTTGACCCCGGTGGCCGGCCTGCACGCCGAGACG
GTTGCCGAGAACCTGTTGAAGGGCAACACCCGCTCCCTTGAACAAGCCGTCTTTGCCAGCACAGTGTTCACAGTGCCTGC
CCTGGCGGGGGTGGGTTTGCTGGAGGAGCAGGCGCAGGCGCAGGGGCTTCACTACCGCGTGCTGCAGGCCGACCACCGCG
ATCGGCTCGCCGTCCGCTCCCTTGCCGCTCCCTACGCAGCCCACAAAATCCTGGTCGAGGAGCCGGGCGGACGTATTTTG
GGGGCCCATCTGCTCGGCCCCTTTGCCACCGAGATCATCAATGTCTTCGCCCTGGCCATCCAGGCGCAAGTCGACATCGA
CCAACTGCGGGCCACCCACTTTGCCTACCCAACCGGCAGCTCCGAGATTTTTGCGATGCTCTCAAAAGGCTGA

Upstream 100 bases:

>100_bases
AGCACGGCCCTTTTACTCCCCGTTTGGGTTCCCCCCGCGGGTAGAACCGGCTGCAGCGGTTTCGCGGGAAGCTAAAGGGC
GGATGCGAGCGGACCCTTGT

Downstream 100 bases:

>100_bases
ACCGGACTACTGTCGCAACTCAATCCGACTGCAGAGCGCTTGCTGACCCCTGAGAGCTCCCTCTGCAGTACACCCGTCAA
CTGAAATGCCGCCACGGTCC

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MQKHYDLVVLGTGVAGSSVAKRCREAGWKVAVVDSRPFGGTCALRGCTPKKVLVQAGELLDRWRHLAGKGLRAEEARIDW
PELMRFKRSLIEPLPAAREAEYAEAGIESYHGVARFVGATALEVEGAHLQGEKVLIATGSRPATLGIEGEEHLASSDDFL
ELGTLPRRIVFVGGGYISMEFAHLAARAGSQVHVLHQDERPLAPFDPDLVDRLIEATRELGALCLCHKVKAIEKTAQGLL
VHTDGDGGPYAADLVVHGASRVPNVEALDLDGAGVEAGKKGIKVNAHLQSVSNPAVYAAGDVADAPGPQLTPVAGLHAET
VAENLLKGNTRSLEQAVFASTVFTVPALAGVGLLEEQAQAQGLHYRVLQADHRDRLAVRSLAAPYAAHKILVEEPGGRIL
GAHLLGPFATEIINVFALAIQAQVDIDQLRATHFAYPTGSSEIFAMLSKG

Sequences:

>Translated_450_residues
MQKHYDLVVLGTGVAGSSVAKRCREAGWKVAVVDSRPFGGTCALRGCTPKKVLVQAGELLDRWRHLAGKGLRAEEARIDW
PELMRFKRSLIEPLPAAREAEYAEAGIESYHGVARFVGATALEVEGAHLQGEKVLIATGSRPATLGIEGEEHLASSDDFL
ELGTLPRRIVFVGGGYISMEFAHLAARAGSQVHVLHQDERPLAPFDPDLVDRLIEATRELGALCLCHKVKAIEKTAQGLL
VHTDGDGGPYAADLVVHGASRVPNVEALDLDGAGVEAGKKGIKVNAHLQSVSNPAVYAAGDVADAPGPQLTPVAGLHAET
VAENLLKGNTRSLEQAVFASTVFTVPALAGVGLLEEQAQAQGLHYRVLQADHRDRLAVRSLAAPYAAHKILVEEPGGRIL
GAHLLGPFATEIINVFALAIQAQVDIDQLRATHFAYPTGSSEIFAMLSKG
>Mature_450_residues
MQKHYDLVVLGTGVAGSSVAKRCREAGWKVAVVDSRPFGGTCALRGCTPKKVLVQAGELLDRWRHLAGKGLRAEEARIDW
PELMRFKRSLIEPLPAAREAEYAEAGIESYHGVARFVGATALEVEGAHLQGEKVLIATGSRPATLGIEGEEHLASSDDFL
ELGTLPRRIVFVGGGYISMEFAHLAARAGSQVHVLHQDERPLAPFDPDLVDRLIEATRELGALCLCHKVKAIEKTAQGLL
VHTDGDGGPYAADLVVHGASRVPNVEALDLDGAGVEAGKKGIKVNAHLQSVSNPAVYAAGDVADAPGPQLTPVAGLHAET
VAENLLKGNTRSLEQAVFASTVFTVPALAGVGLLEEQAQAQGLHYRVLQADHRDRLAVRSLAAPYAAHKILVEEPGGRIL
GAHLLGPFATEIINVFALAIQAQVDIDQLRATHFAYPTGSSEIFAMLSKG

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=27.7056277056277, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=28.4210526315789, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI91199540, Length=451, Percent_Identity=25.9423503325942, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI33519430, Length=437, Percent_Identity=28.3752860411899, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI33519428, Length=437, Percent_Identity=28.3752860411899, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI33519426, Length=437, Percent_Identity=28.3752860411899, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI148277071, Length=437, Percent_Identity=28.3752860411899, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI148277065, Length=437, Percent_Identity=28.3752860411899, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI291045266, Length=483, Percent_Identity=27.536231884058, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI291045268, Length=478, Percent_Identity=25.9414225941423, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1789915, Length=462, Percent_Identity=29.6536796536797, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=29.7539149888143, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082354, Length=451, Percent_Identity=27.2727272727273, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=28.0087527352298, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=29.3501048218029, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=30, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=30, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=25.219298245614, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=26.0869565217391, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6325166, Length=477, Percent_Identity=26.8343815513627, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=25.4859611231102, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=24.1014799154334, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=30.0847457627119, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24640553, Length=466, Percent_Identity=29.8283261802575, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24640549, Length=466, Percent_Identity=29.8283261802575, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24640551, Length=466, Percent_Identity=29.8283261802575, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21358499, Length=456, Percent_Identity=26.5350877192982, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 47808; Mature: 47808

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKHYDLVVLGTGVAGSSVAKRCREAGWKVAVVDSRPFGGTCALRGCTPKKVLVQAGELL
CCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHH
DRWRHLAGKGLRAEEARIDWPELMRFKRSLIEPLPAAREAEYAEAGIESYHGVARFVGAT
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCE
ALEVEGAHLQGEKVLIATGSRPATLGIEGEEHLASSDDFLELGTLPRRIVFVGGGYISME
EEEEECCEECCCEEEEEECCCCEEEECCCHHHCCCCCCCEECCCCCEEEEEEECCEEEHH
FAHLAARAGSQVHVLHQDERPLAPFDPDLVDRLIEATRELGALCLCHKVKAIEKTAQGLL
HHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VHTDGDGGPYAADLVVHGASRVPNVEALDLDGAGVEAGKKGIKVNAHLQSVSNPAVYAAG
EEECCCCCCEEEHEEEECCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHCCCCCCEEEEC
DVADAPGPQLTPVAGLHAETVAENLLKGNTRSLEQAVFASTVFTVPALAGVGLLEEQAQA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QGLHYRVLQADHRDRLAVRSLAAPYAAHKILVEEPGGRILGAHLLGPFATEIINVFALAI
CCCEEEEECCCCHHHHHHHHHHCCHHHCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHH
QAQVDIDQLRATHFAYPTGSSEIFAMLSKG
HHCCCHHHHHHHHEECCCCCHHHHEEECCC
>Mature Secondary Structure
MQKHYDLVVLGTGVAGSSVAKRCREAGWKVAVVDSRPFGGTCALRGCTPKKVLVQAGELL
CCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHH
DRWRHLAGKGLRAEEARIDWPELMRFKRSLIEPLPAAREAEYAEAGIESYHGVARFVGAT
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCE
ALEVEGAHLQGEKVLIATGSRPATLGIEGEEHLASSDDFLELGTLPRRIVFVGGGYISME
EEEEECCEECCCEEEEEECCCCEEEECCCHHHCCCCCCCEECCCCCEEEEEEECCEEEHH
FAHLAARAGSQVHVLHQDERPLAPFDPDLVDRLIEATRELGALCLCHKVKAIEKTAQGLL
HHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VHTDGDGGPYAADLVVHGASRVPNVEALDLDGAGVEAGKKGIKVNAHLQSVSNPAVYAAG
EEECCCCCCEEEHEEEECCCCCCCCEEEECCCCCCCCCCCCCEEEEEHHCCCCCCEEEEC
DVADAPGPQLTPVAGLHAETVAENLLKGNTRSLEQAVFASTVFTVPALAGVGLLEEQAQA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QGLHYRVLQADHRDRLAVRSLAAPYAAHKILVEEPGGRILGAHLLGPFATEIINVFALAI
CCCEEEEECCCCHHHHHHHHHHCCHHHCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHH
QAQVDIDQLRATHFAYPTGSSEIFAMLSKG
HHCCCHHHHHHHHEECCCCCHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]