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The map label for this gene is phoP [H]

Identifier: 37523731

GI number: 37523731

Start: 4360707

End: 4361447

Strand: Reverse

Name: phoP [H]

Synonym: gll4162

Alternate gene names: 37523731

Gene position: 4361447-4360707 (Counterclockwise)

Preceding gene: 37523737

Following gene: 37523730

Centisome position: 93.61

GC content: 61.13

Gene sequence:

>741_bases
ATGCCACGTGTGCTTGTCATAGACGACGACCCTGCAATTCTGGAACTTGTCGCTTTCAACCTGGAGATGTCCGGGTACGA
GGTGCTTGAGGCACCGGACGGGCACAAGGGCCAGGCGTTCGCTCTGCAGATGCTGCCGGATCTGATTGTGCTCGATTTGA
TGCTGCCGCAGGTCGACGGTCTAACCATCTGTCAGCGTCTGCGCCGCGACGAGCGCACCGCAGAGATTCCGATTTTGATG
CTTACGGCCCTCGGTCAGATCAAGGACAAAGTCGGCGGCTTCAACGCCGGGGCCGACGATTACATGACCAAGCCGTTCGA
GATCGAGGAGCTCCTGGTGCGGGTGCGGGCCTTGTTGCGGCGCACCGACCGGATGCCCCAGGCGGCACGCCACGCCGAGA
TCCTCTCGCTGGGACCTCTGACGCTCATTCCGGAGCGCTTCGAGTGCATCTGGTTCAACAAGCCCATTAAGCTCACCCAC
CTTGAATTTGAGCTGCTGCACTGCCTGTTGCAGCGGCACGGCCAGACCGTTTCTCCGAGCGAGATTCTGCGCGAAGTCTG
GGGGTACGACCCGGACGACGATATCGAGACTATCCGCGTGCACATCCGCCACCTGCGCACCAAGCTCGAACCGGATCCGC
GCCACCCGCAGTTCATCAAGACCGTCTACGGTGCCGGCTACTGCCTCGAGGTTCCCCAGGCTATCCAAGACGGCCAGATG
ATCCACCAGCCTGCGGAATAA

Upstream 100 bases:

>100_bases
TGAGTAATCGCTCCGCAGCGAAACGCGCTATAATAAGTATGATGCAGGCTGATTAAGTTAAGTTAAGAAAGATTCAAACA
TAAGACAACAAGGATTACGG

Downstream 100 bases:

>100_bases
ATTTGCGAGCGGCCTGCCGGTTTACCTGGGCTTGCGGTTGGATACACTGTTGAAGGCGTGGCGCCACCCGATGGGTGGCG
CCAGTCTTTAGTTTTTTTTT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MPRVLVIDDDPAILELVAFNLEMSGYEVLEAPDGHKGQAFALQMLPDLIVLDLMLPQVDGLTICQRLRRDERTAEIPILM
LTALGQIKDKVGGFNAGADDYMTKPFEIEELLVRVRALLRRTDRMPQAARHAEILSLGPLTLIPERFECIWFNKPIKLTH
LEFELLHCLLQRHGQTVSPSEILREVWGYDPDDDIETIRVHIRHLRTKLEPDPRHPQFIKTVYGAGYCLEVPQAIQDGQM
IHQPAE

Sequences:

>Translated_246_residues
MPRVLVIDDDPAILELVAFNLEMSGYEVLEAPDGHKGQAFALQMLPDLIVLDLMLPQVDGLTICQRLRRDERTAEIPILM
LTALGQIKDKVGGFNAGADDYMTKPFEIEELLVRVRALLRRTDRMPQAARHAEILSLGPLTLIPERFECIWFNKPIKLTH
LEFELLHCLLQRHGQTVSPSEILREVWGYDPDDDIETIRVHIRHLRTKLEPDPRHPQFIKTVYGAGYCLEVPQAIQDGQM
IHQPAE
>Mature_245_residues
PRVLVIDDDPAILELVAFNLEMSGYEVLEAPDGHKGQAFALQMLPDLIVLDLMLPQVDGLTICQRLRRDERTAEIPILML
TALGQIKDKVGGFNAGADDYMTKPFEIEELLVRVRALLRRTDRMPQAARHAEILSLGPLTLIPERFECIWFNKPIKLTHL
EFELLHCLLQRHGQTVSPSEILREVWGYDPDDDIETIRVHIRHLRTKLEPDPRHPQFIKTVYGAGYCLEVPQAIQDGQMI
HQPAE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=37.7777777777778, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=37.117903930131, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786784, Length=237, Percent_Identity=37.5527426160338, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=35.3711790393013, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=36.0869565217391, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1787375, Length=233, Percent_Identity=33.4763948497854, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1786911, Length=237, Percent_Identity=33.7552742616034, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=36.3247863247863, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=33.920704845815, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=34.1991341991342, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=31.4159292035398, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1790863, Length=242, Percent_Identity=28.5123966942149, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.8777292576419, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693140, Length=246, Percent_Identity=29.6747967479675, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=130, Percent_Identity=27.6923076923077, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789149, Length=108, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28109; Mature: 27978

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVLVIDDDPAILELVAFNLEMSGYEVLEAPDGHKGQAFALQMLPDLIVLDLMLPQVDG
CCEEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
LTICQRLRRDERTAEIPILMLTALGQIKDKVGGFNAGADDYMTKPFEIEELLVRVRALLR
HHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHH
RTDRMPQAARHAEILSLGPLTLIPERFECIWFNKPIKLTHLEFELLHCLLQRHGQTVSPS
HHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHCCCCCCHH
EILREVWGYDPDDDIETIRVHIRHLRTKLEPDPRHPQFIKTVYGAGYCLEVPQAIQDGQM
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEECCHHHHHCCCH
IHQPAE
HCCCCC
>Mature Secondary Structure 
PRVLVIDDDPAILELVAFNLEMSGYEVLEAPDGHKGQAFALQMLPDLIVLDLMLPQVDG
CEEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCH
LTICQRLRRDERTAEIPILMLTALGQIKDKVGGFNAGADDYMTKPFEIEELLVRVRALLR
HHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHH
RTDRMPQAARHAEILSLGPLTLIPERFECIWFNKPIKLTHLEFELLHCLLQRHGQTVSPS
HHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEHHHHHHHHHHHHHCCCCCCHH
EILREVWGYDPDDDIETIRVHIRHLRTKLEPDPRHPQFIKTVYGAGYCLEVPQAIQDGQM
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEECCHHHHHCCCH
IHQPAE
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]