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The map label for this gene is dapL

Identifier: 37523677

GI number: 37523677

Start: 4303583

End: 4304761

Strand: Direct

Name: dapL

Synonym: glr4108

Alternate gene names: 37523677

Gene position: 4303583-4304761 (Clockwise)

Preceding gene: 37523676

Following gene: 37523678

Centisome position: 92.37

GC content: 63.44

Gene sequence:

>1179_bases
ATGAAGACTGCCGCCCGCCTCGATCGCATCCCGCCTTATCTGTTTGCCGAAATCGACCGCCGCCGCGACGAGGCCGTCGC
CCGCGGCGTGGACATCATCAACATGGGCATCGGCGACCCGGACAAACCCACCCCCCCGGTGGTACTGGAGGCGATGCACG
CGGCCATCGACGACCCCTCCACCCACAACTACCCGCCCTACAAGGGCACCAAAGCTTATCGGGAAGCGGCGGCGGCCTGG
TTCGAGCGGCGCTTCGGCGTGGGCGGCTTCCACCCGGATACGGAGGTGATTTCTTCGATCGGCTCCAAAGAAGCGATCCA
CAACACGTTCTTGGCCTTCGTCGATCCGGGCGATTACACCCTCATCCCCGATCCGGCCTACCCGGTCTACCGCACCTCGA
CGATTTTTGCCGGGGGCGAATTTTTTGCGATGCCGCTATTGCCCGAAAACCAGCTTCTGCCGGATCTGGAGGCGGTGCCC
GAGACAGTGGCCCGCAAGGCGAAACTGCTGTGGCTCAACTACCCCAACAACCCCACCGGAGCGGTCGCCTCGCTCGAATT
TTTTGAAAAAGTCGTCCACTTTGCCAAAAAGCACGACATTCTCGTGTGCCACGACAACGCCTACAGCGAGATGGCCTACG
ACGGCTACAAACCGCCCAGCATTCTGCAGGTGCCTGGCGCCCGCGATGTCGCCATCGAATTTTTGTCGTGCTCGAAGGCC
TACAACATGACCGGCTGGCGCGTCGGCTTCGTGATCGGCAACCGGACGGGCATCGCCGGGCTCGGCCAGGTGAAGACCAA
CATCGACTCAGGCGTGTTCAAGGCTATCCAGCAGGCGGCGATTGCCGCCTTCGGCCTCGACGACGAGCGGCTGCACGCAC
TGATGGCCGTCTACCAGAACCGCCGCAACATCATCGTCGAGGGCCTGCGCTCGCTCGGCTGGCCCCTCGAAGCCCCCAAA
GCCACCCTTTATGTCTGGGCGCCCATCCCAAAATCCTTCGGCTCGTCGGTCGAATTTGTAGGGGCATTGCTCGATAAGTG
CGGGATCATCGTCCCGCCGGGCAACGGCTACGGCGAGCACGGAGAGGGCTTCTTCCGGATCGCCCTCACGGTTCCCGACG
AGCGCATGCGCGAGGCGATCGGCCGCATGGAGGCCGCCGGGATCCGCTTCGAGGGCTAG

Upstream 100 bases:

>100_bases
GCGCCACCGCGACAGCCAGGAGTTGGCCCATGCCCTGGCGCCCTTTGCCCTGGGTTGAGCGACTCGGTACAATAGCGCAG
TCCGTTTGCCGTTGGTGCCC

Downstream 100 bases:

>100_bases
ACTGGAGGCAAGACGAGCGGTCCGGTCATGGTACAGACGATTCAGGCCCAGAATCTGCGACTTGTGGACCTCCAGCAGCG
CTTCGGTCTGCACTGGATTG

Product: LL-diaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKTAARLDRIPPYLFAEIDRRRDEAVARGVDIINMGIGDPDKPTPPVVLEAMHAAIDDPSTHNYPPYKGTKAYREAAAAW
FERRFGVGGFHPDTEVISSIGSKEAIHNTFLAFVDPGDYTLIPDPAYPVYRTSTIFAGGEFFAMPLLPENQLLPDLEAVP
ETVARKAKLLWLNYPNNPTGAVASLEFFEKVVHFAKKHDILVCHDNAYSEMAYDGYKPPSILQVPGARDVAIEFLSCSKA
YNMTGWRVGFVIGNRTGIAGLGQVKTNIDSGVFKAIQQAAIAAFGLDDERLHALMAVYQNRRNIIVEGLRSLGWPLEAPK
ATLYVWAPIPKSFGSSVEFVGALLDKCGIIVPPGNGYGEHGEGFFRIALTVPDERMREAIGRMEAAGIRFEG

Sequences:

>Translated_392_residues
MKTAARLDRIPPYLFAEIDRRRDEAVARGVDIINMGIGDPDKPTPPVVLEAMHAAIDDPSTHNYPPYKGTKAYREAAAAW
FERRFGVGGFHPDTEVISSIGSKEAIHNTFLAFVDPGDYTLIPDPAYPVYRTSTIFAGGEFFAMPLLPENQLLPDLEAVP
ETVARKAKLLWLNYPNNPTGAVASLEFFEKVVHFAKKHDILVCHDNAYSEMAYDGYKPPSILQVPGARDVAIEFLSCSKA
YNMTGWRVGFVIGNRTGIAGLGQVKTNIDSGVFKAIQQAAIAAFGLDDERLHALMAVYQNRRNIIVEGLRSLGWPLEAPK
ATLYVWAPIPKSFGSSVEFVGALLDKCGIIVPPGNGYGEHGEGFFRIALTVPDERMREAIGRMEAAGIRFEG
>Mature_392_residues
MKTAARLDRIPPYLFAEIDRRRDEAVARGVDIINMGIGDPDKPTPPVVLEAMHAAIDDPSTHNYPPYKGTKAYREAAAAW
FERRFGVGGFHPDTEVISSIGSKEAIHNTFLAFVDPGDYTLIPDPAYPVYRTSTIFAGGEFFAMPLLPENQLLPDLEAVP
ETVARKAKLLWLNYPNNPTGAVASLEFFEKVVHFAKKHDILVCHDNAYSEMAYDGYKPPSILQVPGARDVAIEFLSCSKA
YNMTGWRVGFVIGNRTGIAGLGQVKTNIDSGVFKAIQQAAIAAFGLDDERLHALMAVYQNRRNIIVEGLRSLGWPLEAPK
ATLYVWAPIPKSFGSSVEFVGALLDKCGIIVPPGNGYGEHGEGFFRIALTVPDERMREAIGRMEAAGIRFEG

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily

Homologues:

Organism=Homo sapiens, GI95147551, Length=317, Percent_Identity=29.3375394321767, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI169881279, Length=317, Percent_Identity=29.3375394321767, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI4507369, Length=385, Percent_Identity=25.974025974026, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI56713256, Length=300, Percent_Identity=26.3333333333333, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI56713254, Length=300, Percent_Identity=26.3333333333333, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI169881281, Length=244, Percent_Identity=27.4590163934426, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1788722, Length=382, Percent_Identity=41.3612565445026, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1786816, Length=336, Percent_Identity=27.6785714285714, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788627, Length=232, Percent_Identity=26.7241379310345, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994476, Length=274, Percent_Identity=27.7372262773723, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71994472, Length=274, Percent_Identity=27.7372262773723, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17567663, Length=381, Percent_Identity=25.1968503937008, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17567369, Length=264, Percent_Identity=25.7575757575758, Blast_Score=98, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6322401, Length=390, Percent_Identity=21.2820512820513, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28573069, Length=390, Percent_Identity=23.8461538461538, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24646114, Length=390, Percent_Identity=23.8461538461538, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28573067, Length=390, Percent_Identity=23.8461538461538, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28573065, Length=390, Percent_Identity=23.8461538461538, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI18859735, Length=377, Percent_Identity=23.0769230769231, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPAT_GLOVI (Q7NDX4)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_927054.1
- HSSP:   Q16773
- ProteinModelPortal:   Q7NDX4
- GeneID:   2602511
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr4108
- NMPDR:   fig|251221.1.peg.4108
- HOGENOM:   HBG645860
- OMA:   YSEIAFD
- ProtClustDB:   PRK09276
- BioCyc:   GVIO251221:GLR4108-MONOMER
- HAMAP:   MF_01642
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.83

Molecular weight: Translated: 43043; Mature: 43043

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 38-38 BINDING 64-64 BINDING 127-127 BINDING 177-177 BINDING 177-177 BINDING 205-205 BINDING 208-208 BINDING 236-236 BINDING 238-238 BINDING 247-247 BINDING 366-366

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAARLDRIPPYLFAEIDRRRDEAVARGVDIINMGIGDPDKPTPPVVLEAMHAAIDDPS
CCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCC
THNYPPYKGTKAYREAAAAWFERRFGVGGFHPDTEVISSIGSKEAIHNTFLAFVDPGDYT
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHEEEEEECCCCEE
LIPDPAYPVYRTSTIFAGGEFFAMPLLPENQLLPDLEAVPETVARKAKLLWLNYPNNPTG
ECCCCCCCCEECEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCCC
AVASLEFFEKVVHFAKKHDILVCHDNAYSEMAYDGYKPPSILQVPGARDVAIEFLSCSKA
HHHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHH
YNMTGWRVGFVIGNRTGIAGLGQVKTNIDSGVFKAIQQAAIAAFGLDDERLHALMAVYQN
CCCCCEEEEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
RRNIIVEGLRSLGWPLEAPKATLYVWAPIPKSFGSSVEFVGALLDKCGIIVPPGNGYGEH
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHCCHHHHHHHHHHHCCEEECCCCCCCCC
GEGFFRIALTVPDERMREAIGRMEAAGIRFEG
CCCEEEEEEECCHHHHHHHHHHHHHCCCEECC
>Mature Secondary Structure
MKTAARLDRIPPYLFAEIDRRRDEAVARGVDIINMGIGDPDKPTPPVVLEAMHAAIDDPS
CCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCC
THNYPPYKGTKAYREAAAAWFERRFGVGGFHPDTEVISSIGSKEAIHNTFLAFVDPGDYT
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHEEEEEECCCCEE
LIPDPAYPVYRTSTIFAGGEFFAMPLLPENQLLPDLEAVPETVARKAKLLWLNYPNNPTG
ECCCCCCCCEECEEEEECCCEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEEECCCCCCC
AVASLEFFEKVVHFAKKHDILVCHDNAYSEMAYDGYKPPSILQVPGARDVAIEFLSCSKA
HHHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHH
YNMTGWRVGFVIGNRTGIAGLGQVKTNIDSGVFKAIQQAAIAAFGLDDERLHALMAVYQN
CCCCCEEEEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHC
RRNIIVEGLRSLGWPLEAPKATLYVWAPIPKSFGSSVEFVGALLDKCGIIVPPGNGYGEH
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHCCHHHHHHHHHHHCCEEECCCCCCCCC
GEGFFRIALTVPDERMREAIGRMEAAGIRFEG
CCCEEEEEEECCHHHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292