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The map label for this gene is mdtA [H]

Identifier: 37523556

GI number: 37523556

Start: 4189771

End: 4190991

Strand: Direct

Name: mdtA [H]

Synonym: glr3987

Alternate gene names: 37523556

Gene position: 4189771-4190991 (Clockwise)

Preceding gene: 37523555

Following gene: 37523557

Centisome position: 89.93

GC content: 64.46

Gene sequence:

>1221_bases
GTGAAGCACACAGGTCTGCAGTTTGCAACGGGTGTATTGCTGATAGCAACACTCGGCGGTTGCGGCGGCGGCGGCGAGAG
CCAGGCCCAGCAGGGACCGCCCCCCCAGGGTGTGCCTGTGCAGGTGGCGACGGTGAACTCCGCCACAGTCGTCGATTCGA
CCAATTATGTCGCCACGCTCATCTCGCGTCGGTCGGTCACGATGCAGCCGCGGGTGGCCGGGCAGGTGACCAATATCTAT
GTGCGCGCCGGTGCGGCGGTGGCCGCCGGCACGCCGCTCGTCCAGATCGACGCGCGCGAGCAGCAGGCCAACGTCTCCAG
CTTTGAGGCGGCCCAGCGCTCCGCCCGCGCCGAGCTCGACAGCGCCGAGCAGACGCTCAGGTCCAACCAGGCCGATCGCC
AGTCGCGCCTTTCAAATCTGCGCTTTCAAAAAAGGCAGTTCGACAGCTACACCCAGTTGGGCACCGAAGGCGCTGTCAGC
CAGATCACGGTCGATCAATACCGGGACAGCTACGAGACGGCCAAAGCGAACGTCGATGCCATCGATTCGCAAATCAAAGC
CCAGCAGGCCCAAGTTGCCCGCGCCAGAAGCGGCCTCAAGCAGGCCGAAGCGAGTCTGCGCCAACAGCAGGTGCAGGCGC
AGTTCTACGCCATCCAGGCCCCCTTTGCCGGCGCTGTGGGCGATATCCCGGTCAAAGTGGGCGATTATGTCGGGACGGAC
ACCCGGCTTTTGACGGTGACCGAGAACCGGCCCCTGGAGGTGAACGTCGCCATTCCCCAGGAGCGGGCGGTGCAGTTGCG
CAAGGGAATGAGCATCGAATTGCTCGATAACCAGGGCAAAGTCGTGGGCAACGGCCGTATCTTTTTTATCGCCCCCAACA
TCGACACCGGCAACCAGGCGGTACTGGTCAAGGCACTCTACGACAACCCCCAGGGCCAGTTGCGCGCCGATCAGACCGTG
CAGTCGCGGGTGATCTGGAACAAGCAGCCCGGGGTATTGGTGCCGGCCACCGCCATTTCGCGGGTGGCGGGCCAGAACTT
CGTCTTTGTCGCCCAGGCGCCGGAGGCGGGCAAGCTGGTGGCCCGCCAGCGTCCCGTCGTCCTTGGCGACATCCAGGGCA
ACGACTACCAGGTCAAATCGGGCCTCAAAGCCAACGAACGCATTGTCGTATCCGGAACGTTGAAGCTGACCGACGGCGCC
CCCATCGTCGCCCAGCCCTGA

Upstream 100 bases:

>100_bases
GCCAGTATTTCCGGGGAGCCTGTTTTTATCGAAAACTTAGAAGATGTAGCAGCAAAGTCCAATCAAGTCGGGTGCTGGAG
CACCCAATAGGGGAGGCAGG

Downstream 100 bases:

>100_bases
TCCCACGAACCCGTCGCCAAGGAGCCAGGTATGTTCGTCGATTTTTTCATCCGTCGGCCAATTTTCGCCGGGGTGTGCGC
CGTCATCATCTTGCTGGCCG

Product: hypothetical protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MKHTGLQFATGVLLIATLGGCGGGGESQAQQGPPPQGVPVQVATVNSATVVDSTNYVATLISRRSVTMQPRVAGQVTNIY
VRAGAAVAAGTPLVQIDAREQQANVSSFEAAQRSARAELDSAEQTLRSNQADRQSRLSNLRFQKRQFDSYTQLGTEGAVS
QITVDQYRDSYETAKANVDAIDSQIKAQQAQVARARSGLKQAEASLRQQQVQAQFYAIQAPFAGAVGDIPVKVGDYVGTD
TRLLTVTENRPLEVNVAIPQERAVQLRKGMSIELLDNQGKVVGNGRIFFIAPNIDTGNQAVLVKALYDNPQGQLRADQTV
QSRVIWNKQPGVLVPATAISRVAGQNFVFVAQAPEAGKLVARQRPVVLGDIQGNDYQVKSGLKANERIVVSGTLKLTDGA
PIVAQP

Sequences:

>Translated_406_residues
MKHTGLQFATGVLLIATLGGCGGGGESQAQQGPPPQGVPVQVATVNSATVVDSTNYVATLISRRSVTMQPRVAGQVTNIY
VRAGAAVAAGTPLVQIDAREQQANVSSFEAAQRSARAELDSAEQTLRSNQADRQSRLSNLRFQKRQFDSYTQLGTEGAVS
QITVDQYRDSYETAKANVDAIDSQIKAQQAQVARARSGLKQAEASLRQQQVQAQFYAIQAPFAGAVGDIPVKVGDYVGTD
TRLLTVTENRPLEVNVAIPQERAVQLRKGMSIELLDNQGKVVGNGRIFFIAPNIDTGNQAVLVKALYDNPQGQLRADQTV
QSRVIWNKQPGVLVPATAISRVAGQNFVFVAQAPEAGKLVARQRPVVLGDIQGNDYQVKSGLKANERIVVSGTLKLTDGA
PIVAQP
>Mature_406_residues
MKHTGLQFATGVLLIATLGGCGGGGESQAQQGPPPQGVPVQVATVNSATVVDSTNYVATLISRRSVTMQPRVAGQVTNIY
VRAGAAVAAGTPLVQIDAREQQANVSSFEAAQRSARAELDSAEQTLRSNQADRQSRLSNLRFQKRQFDSYTQLGTEGAVS
QITVDQYRDSYETAKANVDAIDSQIKAQQAQVARARSGLKQAEASLRQQQVQAQFYAIQAPFAGAVGDIPVKVGDYVGTD
TRLLTVTENRPLEVNVAIPQERAVQLRKGMSIELLDNQGKVVGNGRIFFIAPNIDTGNQAVLVKALYDNPQGQLRADQTV
QSRVIWNKQPGVLVPATAISRVAGQNFVFVAQAPEAGKLVARQRPVVLGDIQGNDYQVKSGLKANERIVVSGTLKLTDGA
PIVAQP

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=397, Percent_Identity=25.6926952141058, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789665, Length=422, Percent_Identity=25.1184834123223, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786668, Length=422, Percent_Identity=24.6445497630332, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081796, Length=339, Percent_Identity=23.8938053097345, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43353; Mature: 43353

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTGLQFATGVLLIATLGGCGGGGESQAQQGPPPQGVPVQVATVNSATVVDSTNYVATL
CCCCCCHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCHHHHH
ISRRSVTMQPRVAGQVTNIYVRAGAAVAAGTPLVQIDAREQQANVSSFEAAQRSARAELD
HHCCCEEECCCCCCEEEEEEEEECCEEECCCCEEEEECCHHHCCCHHHHHHHHHHHHHHH
SAEQTLRSNQADRQSRLSNLRFQKRQFDSYTQLGTEGAVSQITVDQYRDSYETAKANVDA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEHHHHHCCHHHHHCCHHH
IDSQIKAQQAQVARARSGLKQAEASLRQQQVQAQFYAIQAPFAGAVGDIPVKVGDYVGTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCEEECCCCCCC
TRLLTVTENRPLEVNVAIPQERAVQLRKGMSIELLDNQGKVVGNGRIFFIAPNIDTGNQA
CEEEEEECCCCEEEEEECCHHHHHHHHCCCEEEEECCCCEEEECCEEEEEECCCCCCCCE
VLVKALYDNPQGQLRADQTVQSRVIWNKQPGVLVPATAISRVAGQNFVFVAQAPEAGKLV
EEEEEEECCCCCCEECCHHHHHHEEECCCCCEEECHHHHHHHCCCCEEEEEECCCCCCHH
ARQRPVVLGDIQGNDYQVKSGLKANERIVVSGTLKLTDGAPIVAQP
HCCCCEEEEECCCCCEEECCCCCCCCEEEEEEEEEEECCCCEEECC
>Mature Secondary Structure
MKHTGLQFATGVLLIATLGGCGGGGESQAQQGPPPQGVPVQVATVNSATVVDSTNYVATL
CCCCCCHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCHHHHH
ISRRSVTMQPRVAGQVTNIYVRAGAAVAAGTPLVQIDAREQQANVSSFEAAQRSARAELD
HHCCCEEECCCCCCEEEEEEEEECCEEECCCCEEEEECCHHHCCCHHHHHHHHHHHHHHH
SAEQTLRSNQADRQSRLSNLRFQKRQFDSYTQLGTEGAVSQITVDQYRDSYETAKANVDA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEHHHHHCCHHHHHCCHHH
IDSQIKAQQAQVARARSGLKQAEASLRQQQVQAQFYAIQAPFAGAVGDIPVKVGDYVGTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCEEECCCCCCC
TRLLTVTENRPLEVNVAIPQERAVQLRKGMSIELLDNQGKVVGNGRIFFIAPNIDTGNQA
CEEEEEECCCCEEEEEECCHHHHHHHHCCCEEEEECCCCEEEECCEEEEEECCCCCCCCE
VLVKALYDNPQGQLRADQTVQSRVIWNKQPGVLVPATAISRVAGQNFVFVAQAPEAGKLV
EEEEEEECCCCCCEECCHHHHHHEEECCCCCEEECHHHHHHHCCCCEEEEEECCCCCCHH
ARQRPVVLGDIQGNDYQVKSGLKANERIVVSGTLKLTDGAPIVAQP
HCCCCEEEEECCCCCEEECCCCCCCCEEEEEEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA