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The map label for this gene is yhcY [H]

Identifier: 37523555

GI number: 37523555

Start: 4187531

End: 4189498

Strand: Direct

Name: yhcY [H]

Synonym: glr3986

Alternate gene names: 37523555

Gene position: 4187531-4189498 (Clockwise)

Preceding gene: 37523554

Following gene: 37523556

Centisome position: 89.88

GC content: 67.02

Gene sequence:

>1968_bases
GTGCTTGTGGGTAGGGTACCGGGGTCGCTAGATTATGGTAGACAAAGCTACCCAGCGTCGAACTGTATGTTTGTCAGACA
GGATCCGGTTGCCGATACGCCCTTGCGACTGGTGCTCGACGCTGCCCCCGCGCCCATTTTCAGCGTCGATCGCCGCGGGC
GGTGCACCTATATCAACCGGGCGGCGGCTGAGCTGTTCGGCTACCCCCCCCATCTGCTGGCGGGCCAATTTATCGCCCGG
CTCATCCTGGGGGTGAGCGATTGGCGCGAATGCCCGTTCTGCCCGCCGCCTGGACTGCAGGAGCCACCGGCCGTCGCCCG
GTTTATCCGCGGCGACGGCAGCACCTTTGCCGCCCGCTACACCCGCGCGCCGCTCGTCGATGGCGATTGGGCCAGGGGCA
CCGTCGTCACCCTCGAAGTGCTCCCCGAGGCTGCCGCTCCGCAGGCCCGCCTCGATCGCTTCTTCGCGCAGTCGCCTTTG
AGCATGGTGCTCTACGCCCTCGACGGCCGGGTGCTGAGTGTGAACGACGCCTTCAGGCGCATGTGGGGTTTCGATCGCAT
CGACGGCGACTACTCGGTGCTGCGCGATCCGCAGCTCATCCAGCTTGGCGTCATGCCCTACGTCGAGCGGGCCTTTGCCG
GCGAATCGACGCTGATGCCGCCCATCTGTTACAACGCCGCCGCGTTGCATCCGGCGGGCCAGGAGCACTGGGCGCAGGCA
TTTTTGTATCCGATCAAAGATGCCGACGGCACCGTGCGGGAGGTGGCCCTCATCCACCAGGACGTCAGCGACCTCAAGCG
CGCCGAGTTGCTGGCCCGCGGCCAGATCGAGGCTCTGGTCGATACTTTGGGGGCGCTGGCGGCGGAGCCGATGCTCGATA
GCTTTCTAGGCCAGGTGCTCACCACCATCGCCACCCAGTTGGGGGTGCCCCTGGCGGAATTCTGGCTCACGGATTTCGAG
GACGACCTGTCGGTGATGCACATGACGTCCTGGCACGGCCGCATTTTGATGGGAGCCGATCAGCCCGATCATCCCGGCGC
CTGCGGCAAACCGCTGAGCGAGGCGCGCGACTGCGAAGTCTACCAGCAGGTCTACCTGCACCGGCGCTGCCTGGTGCTCG
AGGACGTTCCCAACAACCCGGTCAGTGTGCCGTTTCGGGAGTGGGCGGCGGCGCGCGGCGGCATCCAGACCATGTTGATT
GTGCCGCTGGTGTTGGCGGACCGGGTAATCGGCTCCTTCAGCGTCTGCAGCACCGAGAAACGGGTATTTTTAAGCCAGGA
GATCGAGCTGGCCCAGGCCCTTGCCCACCAGGCCACCCTGGCGGTGCAATTGACGCGATTGGCCGAGCAAGGCCGCCGAT
CGGCGGTGCTCGAAGAGCGCAACCGCATGGCCCGCGAACTGCACGACACACTCATGCAGGGACTGGCGGGCATCGTCGTC
CAACTGCAGGCGGCCACCGACGCAGGTGTCGCCGATCCGCTCGACGGGCGCGATCACATCGATCGCGCCCGCACCCTGGC
GCGCCGGAGCCTGGCGGAGGCGCGCCGCTCCGTGCGCGCCCTGCGGCCCCAACTGCTCGAACAGGGCGATCTGGGTCAGG
CCCTGGCTGACCTGCTGCAGCAAAGCATCTACGACAACCACACCGAGGCCCGCTGCGAGGTGCGCGGCACCCCCTTCGCC
CTCCCGGCGGAGGCCGAAAACCAGCTGTTGCGCATTGCCGGGGAGGCCCTCTCCAACGCCCTGCGCCACGCCCGGGCAAA
TCGCGTGCACGTCGAACTCGATTACGAGCGTCCCCAGGTGCGTCTGGTGGTGGCCGACGACGGTCGGGGGTTCGACCCCG
ATCGCGTCGGTACCGATCGCTTCGGTCTGGTCGGCATGCGCGAGCGCGCCGAGCGGATCGGCGCCGACCTGCGGCTTGAA
AGTGTCCCCGGGCAGGGTACTCGGGTGGCGGTCACTTTGGTAAGTTGA

Upstream 100 bases:

>100_bases
CGAAGCTTTGCGCGTCGAGGGCGAGAAGACCGTCACCCTCTACCCGAGCGGTTTGTTTGATCCCGGTTGTGCCCTGCTCT
TGGCTGAAAAGACCTGAGCA

Downstream 100 bases:

>100_bases
TCGAAGCTGCACAGCTGCGACGATGGGCTTGGCGGGCCTGTATCTATTGAAAGGCATAGGCTGCCGCTGACCAATTGGCC
GGGGGCAAGTTCAACGCTCG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MLVGRVPGSLDYGRQSYPASNCMFVRQDPVADTPLRLVLDAAPAPIFSVDRRGRCTYINRAAAELFGYPPHLLAGQFIAR
LILGVSDWRECPFCPPPGLQEPPAVARFIRGDGSTFAARYTRAPLVDGDWARGTVVTLEVLPEAAAPQARLDRFFAQSPL
SMVLYALDGRVLSVNDAFRRMWGFDRIDGDYSVLRDPQLIQLGVMPYVERAFAGESTLMPPICYNAAALHPAGQEHWAQA
FLYPIKDADGTVREVALIHQDVSDLKRAELLARGQIEALVDTLGALAAEPMLDSFLGQVLTTIATQLGVPLAEFWLTDFE
DDLSVMHMTSWHGRILMGADQPDHPGACGKPLSEARDCEVYQQVYLHRRCLVLEDVPNNPVSVPFREWAAARGGIQTMLI
VPLVLADRVIGSFSVCSTEKRVFLSQEIELAQALAHQATLAVQLTRLAEQGRRSAVLEERNRMARELHDTLMQGLAGIVV
QLQAATDAGVADPLDGRDHIDRARTLARRSLAEARRSVRALRPQLLEQGDLGQALADLLQQSIYDNHTEARCEVRGTPFA
LPAEAENQLLRIAGEALSNALRHARANRVHVELDYERPQVRLVVADDGRGFDPDRVGTDRFGLVGMRERAERIGADLRLE
SVPGQGTRVAVTLVS

Sequences:

>Translated_655_residues
MLVGRVPGSLDYGRQSYPASNCMFVRQDPVADTPLRLVLDAAPAPIFSVDRRGRCTYINRAAAELFGYPPHLLAGQFIAR
LILGVSDWRECPFCPPPGLQEPPAVARFIRGDGSTFAARYTRAPLVDGDWARGTVVTLEVLPEAAAPQARLDRFFAQSPL
SMVLYALDGRVLSVNDAFRRMWGFDRIDGDYSVLRDPQLIQLGVMPYVERAFAGESTLMPPICYNAAALHPAGQEHWAQA
FLYPIKDADGTVREVALIHQDVSDLKRAELLARGQIEALVDTLGALAAEPMLDSFLGQVLTTIATQLGVPLAEFWLTDFE
DDLSVMHMTSWHGRILMGADQPDHPGACGKPLSEARDCEVYQQVYLHRRCLVLEDVPNNPVSVPFREWAAARGGIQTMLI
VPLVLADRVIGSFSVCSTEKRVFLSQEIELAQALAHQATLAVQLTRLAEQGRRSAVLEERNRMARELHDTLMQGLAGIVV
QLQAATDAGVADPLDGRDHIDRARTLARRSLAEARRSVRALRPQLLEQGDLGQALADLLQQSIYDNHTEARCEVRGTPFA
LPAEAENQLLRIAGEALSNALRHARANRVHVELDYERPQVRLVVADDGRGFDPDRVGTDRFGLVGMRERAERIGADLRLE
SVPGQGTRVAVTLVS
>Mature_655_residues
MLVGRVPGSLDYGRQSYPASNCMFVRQDPVADTPLRLVLDAAPAPIFSVDRRGRCTYINRAAAELFGYPPHLLAGQFIAR
LILGVSDWRECPFCPPPGLQEPPAVARFIRGDGSTFAARYTRAPLVDGDWARGTVVTLEVLPEAAAPQARLDRFFAQSPL
SMVLYALDGRVLSVNDAFRRMWGFDRIDGDYSVLRDPQLIQLGVMPYVERAFAGESTLMPPICYNAAALHPAGQEHWAQA
FLYPIKDADGTVREVALIHQDVSDLKRAELLARGQIEALVDTLGALAAEPMLDSFLGQVLTTIATQLGVPLAEFWLTDFE
DDLSVMHMTSWHGRILMGADQPDHPGACGKPLSEARDCEVYQQVYLHRRCLVLEDVPNNPVSVPFREWAAARGGIQTMLI
VPLVLADRVIGSFSVCSTEKRVFLSQEIELAQALAHQATLAVQLTRLAEQGRRSAVLEERNRMARELHDTLMQGLAGIVV
QLQAATDAGVADPLDGRDHIDRARTLARRSLAEARRSVRALRPQLLEQGDLGQALADLLQQSIYDNHTEARCEVRGTPFA
LPAEAENQLLRIAGEALSNALRHARANRVHVELDYERPQVRLVVADDGRGFDPDRVGTDRFGLVGMRERAERIGADLRLE
SVPGQGTRVAVTLVS

Specific function: Member of the two-component regulatory system yhcY/yhcZ. Probably activates yhcZ by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=239, Percent_Identity=32.2175732217573, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788812, Length=206, Percent_Identity=31.0679611650485, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082311, Length=249, Percent_Identity=30.9236947791165, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 72153; Mature: 72153

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVGRVPGSLDYGRQSYPASNCMFVRQDPVADTPLRLVLDAAPAPIFSVDRRGRCTYINR
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHEEEECCCCCEEECCCCCCEEHHHH
AAAELFGYPPHLLAGQFIARLILGVSDWRECPFCPPPGLQEPPAVARFIRGDGSTFAARY
HHHHHHCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEHHH
TRAPLVDGDWARGTVVTLEVLPEAAAPQARLDRFFAQSPLSMVLYALDGRVLSVNDAFRR
CCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHCCCEEEECHHHHH
MWGFDRIDGDYSVLRDPQLIQLGVMPYVERAFAGESTLMPPICYNAAALHPAGQEHWAQA
HCCCCCCCCCHHHHCCCCEEEECCHHHHHHHHCCCCCCCCCHHCCCHHCCCCCHHHHHHH
FLYPIKDADGTVREVALIHQDVSDLKRAELLARGQIEALVDTLGALAAEPMLDSFLGQVL
HHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TTIATQLGVPLAEFWLTDFEDDLSVMHMTSWHGRILMGADQPDHPGACGKPLSEARDCEV
HHHHHHHCCCHHHHHHHCCCCCHHEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHH
YQQVYLHRRCLVLEDVPNNPVSVPFREWAAARGGIQTMLIVPLVLADRVIGSFSVCSTEK
HHHHHHHHHHEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCHH
RVFLSQEIELAQALAHQATLAVQLTRLAEQGRRSAVLEERNRMARELHDTLMQGLAGIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
QLQAATDAGVADPLDGRDHIDRARTLARRSLAEARRSVRALRPQLLEQGDLGQALADLLQ
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QSIYDNHTEARCEVRGTPFALPAEAENQLLRIAGEALSNALRHARANRVHVELDYERPQV
HHHHCCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEE
RLVVADDGRGFDPDRVGTDRFGLVGMRERAERIGADLRLESVPGQGTRVAVTLVS
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCEEEEEEEC
>Mature Secondary Structure
MLVGRVPGSLDYGRQSYPASNCMFVRQDPVADTPLRLVLDAAPAPIFSVDRRGRCTYINR
CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHEEEECCCCCEEECCCCCCEEHHHH
AAAELFGYPPHLLAGQFIARLILGVSDWRECPFCPPPGLQEPPAVARFIRGDGSTFAARY
HHHHHHCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEHHH
TRAPLVDGDWARGTVVTLEVLPEAAAPQARLDRFFAQSPLSMVLYALDGRVLSVNDAFRR
CCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHCCCEEEECHHHHH
MWGFDRIDGDYSVLRDPQLIQLGVMPYVERAFAGESTLMPPICYNAAALHPAGQEHWAQA
HCCCCCCCCCHHHHCCCCEEEECCHHHHHHHHCCCCCCCCCHHCCCHHCCCCCHHHHHHH
FLYPIKDADGTVREVALIHQDVSDLKRAELLARGQIEALVDTLGALAAEPMLDSFLGQVL
HHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TTIATQLGVPLAEFWLTDFEDDLSVMHMTSWHGRILMGADQPDHPGACGKPLSEARDCEV
HHHHHHHCCCHHHHHHHCCCCCHHEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHH
YQQVYLHRRCLVLEDVPNNPVSVPFREWAAARGGIQTMLIVPLVLADRVIGSFSVCSTEK
HHHHHHHHHHEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCHH
RVFLSQEIELAQALAHQATLAVQLTRLAEQGRRSAVLEERNRMARELHDTLMQGLAGIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
QLQAATDAGVADPLDGRDHIDRARTLARRSLAEARRSVRALRPQLLEQGDLGQALADLLQ
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QSIYDNHTEARCEVRGTPFALPAEAENQLLRIAGEALSNALRHARANRVHVELDYERPQV
HHHHCCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCEE
RLVVADDGRGFDPDRVGTDRFGLVGMRERAERIGADLRLESVPGQGTRVAVTLVS
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]