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The map label for this gene is hemE

Identifier: 37523446

GI number: 37523446

Start: 4083210

End: 4084253

Strand: Reverse

Name: hemE

Synonym: gvip516

Alternate gene names: 37523446

Gene position: 4084253-4083210 (Counterclockwise)

Preceding gene: 37523447

Following gene: 37523445

Centisome position: 87.66

GC content: 62.36

Gene sequence:

>1044_bases
GTGACCCAATCGCTGTTGCTCGACGCCGCCCGCAGTAAACCTGTGGCTCGGCCTCCCGTCTGGATGATGCGCCAGGCGGG
CCGCTATATGGCCGAGTACCGCGCCCTGCGCGATAAGTACGGCTTTAAAGAGCGCTGCGAAAATCCGGATCTGGCCGTCG
AGATTTCGCTGCAACCTTTTCGGGCCTTCAGGCCCGATGGGGTGATCATGTTCTCCGATATCCTCACGCCCTTCGATGGG
ATGGGTATTCCCTTTGAACTGGTGGAAAGCCGCGGCCCGGTGATCGATCCGCCGATTCGCACCCGCGAGCAGGTCGAGGC
GGTGCGGCCCCTCGATCCGGAGGCGTCGCTGGCTTTTGTACGCACGATCTTGCAGACGCTGCGCCGCGAGGTGGGCGAAG
CGGCGACGGTGCTCGGGTTTGTGGGAGCGCCCTGGACGCTGGCTGCTTACGCGGTCGAGGGCAAAAGCTCCAAAGATTAT
GCCCTCATCAAGCAGATGGCCTTCAGCGAGCCGGACTTGCTGCACGCGCTACTCACCAAGTTCGCCGATGCGATCGCCCG
CTATGTGATCTTTCAGATCGACTCGGGAGCGCAGGCGGTGCAGCTGTTCGACACCTGGGCGGGGCAACTCAATCCCGCCG
ATTATCGGGCGTTTGCGCTGCCTTACGAGCGGCGCATCGTCGAGCAGGTGCGCCAGGTGCACCCCGAGACACCGTTGATT
CTGTACATCAATCACTCCGCCGGGTTGCTGCGGCACGTCGGCGAGAGCGGCGTCGATGTGATGAGCCTGGACTGGACAGT
TGATATGGCGGAGGCGCGGGCGATCCTGGGACCGGATATGGCGGTTCAGGGCAACCTCGACCCGTGCGTGCTGCTGGGAG
ATCAAGCCCAGATTCGCTCCCGCATCCTCGATATTGTCGAGAAAGCCGGTCCCACCGGTCACATCATGAACCTGGGCCAC
GGCATTCTGCCTTCGACACCCGAAGACAATGCTCGATTCTTCTTTGAGACCGTCAAATCCCTCGCCCCAGTGAGCGCCCG
ATGA

Upstream 100 bases:

>100_bases
CGGGAGGGCTCGTTGCCTCGCCCTCCCGCTTGATGCTGTGGGTGGGATCGGGGTGGGGGCTATAATCGGTGGCGCGAATC
GATGAGAGGATGAACTGGCT

Downstream 100 bases:

>100_bases
CCGCCGTTATGACCGACCGGCGCGCACGCGTGCGCGTCTTCATGCAGTCGCTCCAGGACAACATCACCAGCCGCCTTGAA
GCGGTCGATGGAGAAGGGCG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTQSLLLDAARSKPVARPPVWMMRQAGRYMAEYRALRDKYGFKERCENPDLAVEISLQPFRAFRPDGVIMFSDILTPFDG
MGIPFELVESRGPVIDPPIRTREQVEAVRPLDPEASLAFVRTILQTLRREVGEAATVLGFVGAPWTLAAYAVEGKSSKDY
ALIKQMAFSEPDLLHALLTKFADAIARYVIFQIDSGAQAVQLFDTWAGQLNPADYRAFALPYERRIVEQVRQVHPETPLI
LYINHSAGLLRHVGESGVDVMSLDWTVDMAEARAILGPDMAVQGNLDPCVLLGDQAQIRSRILDIVEKAGPTGHIMNLGH
GILPSTPEDNARFFFETVKSLAPVSAR

Sequences:

>Translated_347_residues
MTQSLLLDAARSKPVARPPVWMMRQAGRYMAEYRALRDKYGFKERCENPDLAVEISLQPFRAFRPDGVIMFSDILTPFDG
MGIPFELVESRGPVIDPPIRTREQVEAVRPLDPEASLAFVRTILQTLRREVGEAATVLGFVGAPWTLAAYAVEGKSSKDY
ALIKQMAFSEPDLLHALLTKFADAIARYVIFQIDSGAQAVQLFDTWAGQLNPADYRAFALPYERRIVEQVRQVHPETPLI
LYINHSAGLLRHVGESGVDVMSLDWTVDMAEARAILGPDMAVQGNLDPCVLLGDQAQIRSRILDIVEKAGPTGHIMNLGH
GILPSTPEDNARFFFETVKSLAPVSAR
>Mature_346_residues
TQSLLLDAARSKPVARPPVWMMRQAGRYMAEYRALRDKYGFKERCENPDLAVEISLQPFRAFRPDGVIMFSDILTPFDGM
GIPFELVESRGPVIDPPIRTREQVEAVRPLDPEASLAFVRTILQTLRREVGEAATVLGFVGAPWTLAAYAVEGKSSKDYA
LIKQMAFSEPDLLHALLTKFADAIARYVIFQIDSGAQAVQLFDTWAGQLNPADYRAFALPYERRIVEQVRQVHPETPLIL
YINHSAGLLRHVGESGVDVMSLDWTVDMAEARAILGPDMAVQGNLDPCVLLGDQAQIRSRILDIVEKAGPTGHIMNLGHG
ILPSTPEDNARFFFETVKSLAPVSAR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=35.0574712643678, Blast_Score=224, Evalue=8e-59,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=41.4705882352941, Blast_Score=268, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6320252, Length=352, Percent_Identity=34.6590909090909, Blast_Score=223, Evalue=4e-59,
Organism=Drosophila melanogaster, GI19921920, Length=338, Percent_Identity=36.3905325443787, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI221330099, Length=338, Percent_Identity=36.3905325443787, Blast_Score=231, Evalue=8e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_GLOVI (Q7NEK2)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926823.1
- ProteinModelPortal:   Q7NEK2
- SMR:   Q7NEK2
- GeneID:   2602280
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3877
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   GVIO251221:GLL3877-MONOMER
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 38531; Mature: 38400

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 42-42 BINDING 73-73 BINDING 150-150 BINDING 205-205 BINDING 320-320

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSLLLDAARSKPVARPPVWMMRQAGRYMAEYRALRDKYGFKERCENPDLAVEISLQPF
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECHH
RAFRPDGVIMFSDILTPFDGMGIPFELVESRGPVIDPPIRTREQVEAVRPLDPEASLAFV
HHCCCCCEEEEHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHH
RTILQTLRREVGEAATVLGFVGAPWTLAAYAVEGKSSKDYALIKQMAFSEPDLLHALLTK
HHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHH
FADAIARYVIFQIDSGAQAVQLFDTWAGQLNPADYRAFALPYERRIVEQVRQVHPETPLI
HHHHHHHHEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEE
LYINHSAGLLRHVGESGVDVMSLDWTVDMAEARAILGPDMAVQGNLDPCVLLGDQAQIRS
EEEECCCHHHHHCCCCCCEEEEECCEEEHHHHHHHHCCCEEEECCCCCEEEECCHHHHHH
RILDIVEKAGPTGHIMNLGHGILPSTPEDNARFFFETVKSLAPVSAR
HHHHHHHHCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TQSLLLDAARSKPVARPPVWMMRQAGRYMAEYRALRDKYGFKERCENPDLAVEISLQPF
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEEECHH
RAFRPDGVIMFSDILTPFDGMGIPFELVESRGPVIDPPIRTREQVEAVRPLDPEASLAFV
HHCCCCCEEEEHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHH
RTILQTLRREVGEAATVLGFVGAPWTLAAYAVEGKSSKDYALIKQMAFSEPDLLHALLTK
HHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHH
FADAIARYVIFQIDSGAQAVQLFDTWAGQLNPADYRAFALPYERRIVEQVRQVHPETPLI
HHHHHHHHEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEE
LYINHSAGLLRHVGESGVDVMSLDWTVDMAEARAILGPDMAVQGNLDPCVLLGDQAQIRS
EEEECCCHHHHHCCCCCCEEEEECCEEEHHHHHHHHCCCEEEECCCCCEEEECCHHHHHH
RILDIVEKAGPTGHIMNLGHGILPSTPEDNARFFFETVKSLAPVSAR
HHHHHHHHCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292