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The map label for this gene is hemF

Identifier: 37523445

GI number: 37523445

Start: 4082299

End: 4083168

Strand: Reverse

Name: hemF

Synonym: gvip515

Alternate gene names: 37523445

Gene position: 4083168-4082299 (Counterclockwise)

Preceding gene: 37523446

Following gene: 37523442

Centisome position: 87.64

GC content: 62.64

Gene sequence:

>870_bases
ATGCAGTCGCTCCAGGACAACATCACCAGCCGCCTTGAAGCGGTCGATGGAGAAGGGCGCTTTGTTGAAGATCTCTGGGA
GCGCGAGGAAGGGGGCGGGGGCCGCTCGCGAATACTCACCGAGGGCCGCGTCTTCGAGCGCGCTGGGATCGGTTTTTCGG
AAGTGCACGGCTCCCACCTGCCCCCCTCGATCCTCCAACAGCGCCCGGAGGCCGAAGGGCACCCTTTTTATGTGACCGGC
ACCTCGATGGTGCTCCACCCGCGCAATCCCTACGTCCCGACGGTGCACCTCAACTACCGCTACTTCGAGGCGGGGCCGGT
CTGGTGGTTCGGGGGCGGTGCGGATCTGACGCCCTACTACGGCTTTGTTGAGGATGCGGCCCACTTTCACGCCACCCTCA
AGGCCGCCTGCGACGCCCACGACCCCGAGTACTATCCGCGCTTCAAAAAGTGGTGCGACGAGTACTTTTATCTCAAACAC
CGCCAGGAGCCGCGCGGGGTGGGAGGGATCTTCTTCGATTACGTGCAGGGCGATTGGGAAAAAATCTTCGCCTTTGCCCA
GTCCTGCGGCAACGCCTTTTTGCCCGCCTACCTGCCGATTGTCGAGCGGCGCCACACCCTGCCCTACGCAGAGCGCGAGC
GAAACTTTCAGCTCTACCGCCGCGGACGTTACGTCGAATTCAACCTTGTCTGGGATCGCGGCACCATCTTCGGTCTGCAG
ACCAACGGCCGGATCGAATCGATCTTGATGTCGATGCCGCCGCTGGTGCGCTGGGAGTATAATTACCGCCCCGAGCCCGG
TACAGCGGAGGCTGAACTGTACGAAGTGTTCCTGGTGCCCCAGGATTGGGCCAGCCAGGCGAAGCGCTGA

Upstream 100 bases:

>100_bases
ACAATGCTCGATTCTTCTTTGAGACCGTCAAATCCCTCGCCCCAGTGAGCGCCCGATGACCGCCGTTATGACCGACCGGC
GCGCACGCGTGCGCGTCTTC

Downstream 100 bases:

>100_bases
GATCGATCAGGTGCCGGTCCAGTCCTCCCAGATGAGACCGGGTACGCGGGCAAACTCCACAACGTTGGCGGTTACAAGTG
TTGCGCTGTGCCGCTGCGCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MQSLQDNITSRLEAVDGEGRFVEDLWEREEGGGGRSRILTEGRVFERAGIGFSEVHGSHLPPSILQQRPEAEGHPFYVTG
TSMVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYYGFVEDAAHFHATLKAACDAHDPEYYPRFKKWCDEYFYLKH
RQEPRGVGGIFFDYVQGDWEKIFAFAQSCGNAFLPAYLPIVERRHTLPYAERERNFQLYRRGRYVEFNLVWDRGTIFGLQ
TNGRIESILMSMPPLVRWEYNYRPEPGTAEAELYEVFLVPQDWASQAKR

Sequences:

>Translated_289_residues
MQSLQDNITSRLEAVDGEGRFVEDLWEREEGGGGRSRILTEGRVFERAGIGFSEVHGSHLPPSILQQRPEAEGHPFYVTG
TSMVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYYGFVEDAAHFHATLKAACDAHDPEYYPRFKKWCDEYFYLKH
RQEPRGVGGIFFDYVQGDWEKIFAFAQSCGNAFLPAYLPIVERRHTLPYAERERNFQLYRRGRYVEFNLVWDRGTIFGLQ
TNGRIESILMSMPPLVRWEYNYRPEPGTAEAELYEVFLVPQDWASQAKR
>Mature_289_residues
MQSLQDNITSRLEAVDGEGRFVEDLWEREEGGGGRSRILTEGRVFERAGIGFSEVHGSHLPPSILQQRPEAEGHPFYVTG
TSMVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYYGFVEDAAHFHATLKAACDAHDPEYYPRFKKWCDEYFYLKH
RQEPRGVGGIFFDYVQGDWEKIFAFAQSCGNAFLPAYLPIVERRHTLPYAERERNFQLYRRGRYVEFNLVWDRGTIFGLQ
TNGRIESILMSMPPLVRWEYNYRPEPGTAEAELYEVFLVPQDWASQAKR

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family

Homologues:

Organism=Homo sapiens, GI41393599, Length=293, Percent_Identity=50.1706484641638, Blast_Score=293, Evalue=1e-79,
Organism=Escherichia coli, GI1788777, Length=290, Percent_Identity=61.0344827586207, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320249, Length=306, Percent_Identity=48.0392156862745, Blast_Score=284, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17864388, Length=299, Percent_Identity=51.8394648829431, Blast_Score=309, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM6_GLOVI (Q7NEK3)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926822.1
- ProteinModelPortal:   Q7NEK3
- SMR:   Q7NEK3
- GeneID:   2602279
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3876
- HOGENOM:   HBG631180
- OMA:   HMNTRFV
- ProtClustDB:   PRK05330
- BioCyc:   GVIO251221:GLL3876-MONOMER
- BRENDA:   1.3.3.3
- GO:   GO:0005737
- HAMAP:   MF_00333
- InterPro:   IPR001260
- InterPro:   IPR018375
- Gene3D:   G3DSA:3.40.1500.10
- PANTHER:   PTHR10755
- PIRSF:   PIRSF000166
- PRINTS:   PR00073

Pfam domain/function: PF01218 Coprogen_oxidas; SSF102886 Coprogen_oxidas

EC number: =1.3.3.3

Molecular weight: Translated: 33577; Mature: 33577

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: ACT_SITE 96-96 BINDING 82-82

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLQDNITSRLEAVDGEGRFVEDLWEREEGGGGRSRILTEGRVFERAGIGFSEVHGSHL
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHEEEECCCCHHHHCCCHHHCCCCCC
PPSILQQRPEAEGHPFYVTGTSMVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYY
CHHHHHCCCCCCCCCEEEECCEEEEECCCCCCCEEEEEEEEEECCCEEEECCCCCCCCCH
GFVEDAAHFHATLKAACDAHDPEYYPRFKKWCDEYFYLKHRQEPRGVGGIFFDYVQGDWE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHCCCHH
KIFAFAQSCGNAFLPAYLPIVERRHTLPYAERERNFQLYRRGRYVEFNLVWDRGTIFGLQ
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHCCCCEECCCCEEEEEEEECCCEEEEEE
TNGRIESILMSMPPLVRWEYNYRPEPGTAEAELYEVFLVPQDWASQAKR
CCCHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEECCHHHHHCCC
>Mature Secondary Structure
MQSLQDNITSRLEAVDGEGRFVEDLWEREEGGGGRSRILTEGRVFERAGIGFSEVHGSHL
CCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHEEEECCCCHHHHCCCHHHCCCCCC
PPSILQQRPEAEGHPFYVTGTSMVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYY
CHHHHHCCCCCCCCCEEEECCEEEEECCCCCCCEEEEEEEEEECCCEEEECCCCCCCCCH
GFVEDAAHFHATLKAACDAHDPEYYPRFKKWCDEYFYLKHRQEPRGVGGIFFDYVQGDWE
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHCCCHH
KIFAFAQSCGNAFLPAYLPIVERRHTLPYAERERNFQLYRRGRYVEFNLVWDRGTIFGLQ
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHCCCCEECCCCEEEEEEEECCCEEEEEE
TNGRIESILMSMPPLVRWEYNYRPEPGTAEAELYEVFLVPQDWASQAKR
CCCHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292