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The map label for this gene is clpP

Identifier: 37523336

GI number: 37523336

Start: 3974714

End: 3975370

Strand: Reverse

Name: clpP

Synonym: gvip508.1

Alternate gene names: 37523336

Gene position: 3975370-3974714 (Counterclockwise)

Preceding gene: 37523337

Following gene: 37523335

Centisome position: 85.33

GC content: 62.1

Gene sequence:

>657_bases
ATGAGCGAACTTGCCAACTACGGGCCTGGTGCGATCCGGGCCGCTTACTCCGGGGACTACGGCTTTCGCACGCCTCCCCC
GGACCTGCCCTCTTTGCTGCTCAACGAGCGCATCGTCTATCTCGGCACCCCGATTAACGACGTGGTGGCCGAACTATTGA
TTGCCCAGCTGCTCTATCTCGAGTCGGAGGACAACGCCAAACCGATCGAGATTTACATCAACAGCCCCGGCGTGGCCGGC
TTCGAGACCAGCGCCTTCGCGGTCTACGACACGATGCGCCACGTGCGCATGCCGATCAAGACCATCTGCTTGGGCCTGGC
GGGCGGCTTCTCGGCGCTGCTGATGGCGGCGGGCACCAAGGGTCAGCGCATGAGCCTGCCCAATTCACGCATCATTCTTT
ACCAACCCTACGGCGGTGCGCGCGGCCAGGCCACCGACATCAACATCCGCGCCCAGGAACTCCTCACCACCAAGCGCACC
CTCAACCAGCTGCTGAGTATCCATACCGGCAAGACCGTCGAGCAGATCGACAAGGACACTGAGCGCCTTTTTTACATGTC
CCCGCAGGAAGCCGTTTCCTACGGCCTGATCGACAAGGTGCTCGAACCGAGTGCGAACAAGCTCGCCAAGCTCAAAGCGG
TCGGCGCCCCGGTCTAG

Upstream 100 bases:

>100_bases
TATCCGGAGTAAGTCCCAGGGGACTGTCAAGGGCGGATCTCCGCACCTGCGGGGGTCCAGCCCAGCTGTTATATTGGCAA
AAAAGGCTGGGGAGTCACCA

Downstream 100 bases:

>100_bases
TTGAAGCCACCTCAAAGGAGATTTGCCATGCCCATCGGTATTCCCAAAGTTCCCTACCGCCTGCCGGGTGGCCAGAGCCA
GTGGATTGACATTTTTAACC

Product: ATP-dependent Clp protease-like protein

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSELANYGPGAIRAAYSGDYGFRTPPPDLPSLLLNERIVYLGTPINDVVAELLIAQLLYLESEDNAKPIEIYINSPGVAG
FETSAFAVYDTMRHVRMPIKTICLGLAGGFSALLMAAGTKGQRMSLPNSRIILYQPYGGARGQATDINIRAQELLTTKRT
LNQLLSIHTGKTVEQIDKDTERLFYMSPQEAVSYGLIDKVLEPSANKLAKLKAVGAPV

Sequences:

>Translated_218_residues
MSELANYGPGAIRAAYSGDYGFRTPPPDLPSLLLNERIVYLGTPINDVVAELLIAQLLYLESEDNAKPIEIYINSPGVAG
FETSAFAVYDTMRHVRMPIKTICLGLAGGFSALLMAAGTKGQRMSLPNSRIILYQPYGGARGQATDINIRAQELLTTKRT
LNQLLSIHTGKTVEQIDKDTERLFYMSPQEAVSYGLIDKVLEPSANKLAKLKAVGAPV
>Mature_217_residues
SELANYGPGAIRAAYSGDYGFRTPPPDLPSLLLNERIVYLGTPINDVVAELLIAQLLYLESEDNAKPIEIYINSPGVAGF
ETSAFAVYDTMRHVRMPIKTICLGLAGGFSALLMAAGTKGQRMSLPNSRIILYQPYGGARGQATDINIRAQELLTTKRTL
NQLLSIHTGKTVEQIDKDTERLFYMSPQEAVSYGLIDKVLEPSANKLAKLKAVGAPV

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=174, Percent_Identity=53.448275862069, Blast_Score=186, Evalue=2e-47,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=45.0777202072539, Blast_Score=182, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17538017, Length=173, Percent_Identity=47.3988439306358, Blast_Score=170, Evalue=6e-43,
Organism=Drosophila melanogaster, GI20129427, Length=175, Percent_Identity=48.5714285714286, Blast_Score=168, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_GLOVI (Q7NEW1)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926713.1
- HSSP:   Q16740
- ProteinModelPortal:   Q7NEW1
- GeneID:   3167814
- GenomeReviews:   BA000045_GR
- HOGENOM:   HBG558421
- ProtClustDB:   PRK12552
- BioCyc:   GVIO251221:GLL3767-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23704; Mature: 23572

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELANYGPGAIRAAYSGDYGFRTPPPDLPSLLLNERIVYLGTPINDVVAELLIAQLLYL
CCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHH
ESEDNAKPIEIYINSPGVAGFETSAFAVYDTMRHVRMPIKTICLGLAGGFSALLMAAGTK
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHCCCC
GQRMSLPNSRIILYQPYGGARGQATDINIRAQELLTTKRTLNQLLSIHTGKTVEQIDKDT
CCEEECCCCEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHH
ERLFYMSPQEAVSYGLIDKVLEPSANKLAKLKAVGAPV
HHEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SELANYGPGAIRAAYSGDYGFRTPPPDLPSLLLNERIVYLGTPINDVVAELLIAQLLYL
CCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHH
ESEDNAKPIEIYINSPGVAGFETSAFAVYDTMRHVRMPIKTICLGLAGGFSALLMAAGTK
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHCCCC
GQRMSLPNSRIILYQPYGGARGQATDINIRAQELLTTKRTLNQLLSIHTGKTVEQIDKDT
CCEEECCCCEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHH
ERLFYMSPQEAVSYGLIDKVLEPSANKLAKLKAVGAPV
HHEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292