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The map label for this gene is clpP

Identifier: 37523335

GI number: 37523335

Start: 3974093

End: 3974686

Strand: Reverse

Name: clpP

Synonym: gvip508

Alternate gene names: 37523335

Gene position: 3974686-3974093 (Counterclockwise)

Preceding gene: 37523336

Following gene: 37523334

Centisome position: 85.31

GC content: 61.62

Gene sequence:

>594_bases
ATGCCCATCGGTATTCCCAAAGTTCCCTACCGCCTGCCGGGTGGCCAGAGCCAGTGGATTGACATTTTTAACCGTCTGGC
CCTCGATCGGATCATCTTTTTGGGCCGCGAGGTCGACGACGAAATCGCCAATGCGATCATCGCCTCGATGCTCTACCTCG
ACTCCGAAGACCCCGAAAAGGACATCTTCCTCTACATCAACAGCCCCGGCGGTTCGGTGTCGGCGGGGTTGGCCATCTAT
GACACCATGCAGCACGTGCGCGCCGACGTTGCCACCATGTGCGTGGGTCTTGCGGCGAGCATGGGTTCCTTTTTGCTCAC
CGCAGGCGCCAAGGGCAAGCGCACCAGCCTGCCCCACTCGCGCATCATGATCCACCAGCCCCTGGGCGGCGCCCAGGGCC
AGGCCACCGACATCGGCATCCAGGCCAAAGAGATCCTGTACACCAAAGATCGCCTCAACCAGATTCTCTCCGAACGGACC
GGCCAGCCTCTCGAGCGCATCGAGCGCGACACCGATCGCGACTTTTTCATGTCCGCCGAGGATGCCAAGCAGTACGGCCT
GATCGATCAGGTCGTCCAGCACCGCCCGGTCTGA

Upstream 100 bases:

>100_bases
CCTGATCGACAAGGTGCTCGAACCGAGTGCGAACAAGCTCGCCAAGCTCAAAGCGGTCGGCGCCCCGGTCTAGTTGAAGC
CACCTCAAAGGAGATTTGCC

Downstream 100 bases:

>100_bases
ATCTGTGTGGCAGTTGATTGAAGATGGACCGTGGAGCCGCTGGCAGTGCAATTTGCTCTGCGATTGGCCCCACGGTTTTT
TCACGCGCCACGCCCGGGGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MPIGIPKVPYRLPGGQSQWIDIFNRLALDRIIFLGREVDDEIANAIIASMLYLDSEDPEKDIFLYINSPGGSVSAGLAIY
DTMQHVRADVATMCVGLAASMGSFLLTAGAKGKRTSLPHSRIMIHQPLGGAQGQATDIGIQAKEILYTKDRLNQILSERT
GQPLERIERDTDRDFFMSAEDAKQYGLIDQVVQHRPV

Sequences:

>Translated_197_residues
MPIGIPKVPYRLPGGQSQWIDIFNRLALDRIIFLGREVDDEIANAIIASMLYLDSEDPEKDIFLYINSPGGSVSAGLAIY
DTMQHVRADVATMCVGLAASMGSFLLTAGAKGKRTSLPHSRIMIHQPLGGAQGQATDIGIQAKEILYTKDRLNQILSERT
GQPLERIERDTDRDFFMSAEDAKQYGLIDQVVQHRPV
>Mature_196_residues
PIGIPKVPYRLPGGQSQWIDIFNRLALDRIIFLGREVDDEIANAIIASMLYLDSEDPEKDIFLYINSPGGSVSAGLAIYD
TMQHVRADVATMCVGLAASMGSFLLTAGAKGKRTSLPHSRIMIHQPLGGAQGQATDIGIQAKEILYTKDRLNQILSERTG
QPLERIERDTDRDFFMSAEDAKQYGLIDQVVQHRPV

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=176, Percent_Identity=53.4090909090909, Blast_Score=194, Evalue=6e-50,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=58.6387434554974, Blast_Score=242, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=53.6458333333333, Blast_Score=198, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=52.0833333333333, Blast_Score=193, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_GLOVI (Q7NEW2)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926712.1
- ProteinModelPortal:   Q7NEW2
- SMR:   Q7NEW2
- MEROPS:   S14.001
- GeneID:   2602170
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3766
- HOGENOM:   HBG558421
- OMA:   ANKLCAQ
- ProtClustDB:   PRK00277
- BioCyc:   GVIO251221:GLL3766-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21757; Mature: 21626

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 100-100 ACT_SITE 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIGIPKVPYRLPGGQSQWIDIFNRLALDRIIFLGREVDDEIANAIIASMLYLDSEDPEK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
DIFLYINSPGGSVSAGLAIYDTMQHVRADVATMCVGLAASMGSFLLTAGAKGKRTSLPHS
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RIMIHQPLGGAQGQATDIGIQAKEILYTKDRLNQILSERTGQPLERIERDTDRDFFMSAE
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHEECHH
DAKQYGLIDQVVQHRPV
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PIGIPKVPYRLPGGQSQWIDIFNRLALDRIIFLGREVDDEIANAIIASMLYLDSEDPEK
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
DIFLYINSPGGSVSAGLAIYDTMQHVRADVATMCVGLAASMGSFLLTAGAKGKRTSLPHS
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RIMIHQPLGGAQGQATDIGIQAKEILYTKDRLNQILSERTGQPLERIERDTDRDFFMSAE
EEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHEECHH
DAKQYGLIDQVVQHRPV
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292