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The map label for this gene is cobS [H]

Identifier: 37523296

GI number: 37523296

Start: 3938660

End: 3939388

Strand: Reverse

Name: cobS [H]

Synonym: gvip504

Alternate gene names: 37523296

Gene position: 3939388-3938660 (Counterclockwise)

Preceding gene: 37523300

Following gene: 37523294

Centisome position: 84.55

GC content: 70.23

Gene sequence:

>729_bases
ATGCGCGACTGGCTTGCCGCTTTGTTGTTCTATACCGCTTTACCATTGCCCCTGGGCCCGGTGTCCTTCGATCGCATCGC
CCGCTGGCTGCCGGCGGTGGGCCTGGTGGTGGGCGGCCTGAACGCCGGGGTGTACGCGCTGCTGTTGGCGCTGGGGTTTG
CAGCCCACCTGGCCGCGCTGCTTGCGGTCGTGGCGGGGTTGTGGATCACCGGCGGGCTGCACCTCGACGGGCTCATCGAC
ACCGCCGACGGTTGGGCCGCAGGCCCCGAGCGGCGTCTTGCCGCCATGGCCGACAGCGCCGTGGGTGCCTTCGGGGTGAT
GGCCGCCGTTGCCCTGTTGGCCGCCAAGACCTCTGCCCTGGCCGATCTGGCCGGTGCTGCCGCCCCCGCGGCCCTGGTGC
TCGCGGCGGTCTCCGCCCGCTGGGGACAACTGGTCACCATCGGTTGGTTTCCCTATCTCAAAAGCGAAGGCAAGGGCAAG
TTCTTGAAGGACAACACCCACTGGCCCGCCGACGGCTGGTTCGGTACTGCCTGGTGGCTGGCGAGCCTGATCGCCCTGGG
GAGCGTGTACCCGGCGGTGGCCCTTGCCGCCGGAATCGGAGGGGCACTCGGTGCCCTGCTGGGCGGAGCGCTCGTCGCCC
GCCGCTTCGGCGGCCACACCGGCGACACCTACGGAGCGGTGATCGAAGTGGGGGAGGCGGTGGCGCTGGTGCTTGCCACC
CTCGTCTAA

Upstream 100 bases:

>100_bases
TCCAAAGGGCGCCACCAGAGAATATTTACCCAATTTTACCGCCCGGTAGTCGAACGGGCCTGCACAGGAGACACTGTAAC
CTGACCTTTGCCCTGATCCA

Downstream 100 bases:

>100_bases
CCGACCTGGGACAATCCCGCCAACGCCCTGAGTTTGCGTTCGCTGCGCGCAGTGGTGACGTGACCCGTCGCTGCGAACCC
GGTAGAGAAGAGCGGTTCAT

Product: cobalamin synthase

Products: GMP; adenosylcobalamin

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MRDWLAALLFYTALPLPLGPVSFDRIARWLPAVGLVVGGLNAGVYALLLALGFAAHLAALLAVVAGLWITGGLHLDGLID
TADGWAAGPERRLAAMADSAVGAFGVMAAVALLAAKTSALADLAGAAAPAALVLAAVSARWGQLVTIGWFPYLKSEGKGK
FLKDNTHWPADGWFGTAWWLASLIALGSVYPAVALAAGIGGALGALLGGALVARRFGGHTGDTYGAVIEVGEAVALVLAT
LV

Sequences:

>Translated_242_residues
MRDWLAALLFYTALPLPLGPVSFDRIARWLPAVGLVVGGLNAGVYALLLALGFAAHLAALLAVVAGLWITGGLHLDGLID
TADGWAAGPERRLAAMADSAVGAFGVMAAVALLAAKTSALADLAGAAAPAALVLAAVSARWGQLVTIGWFPYLKSEGKGK
FLKDNTHWPADGWFGTAWWLASLIALGSVYPAVALAAGIGGALGALLGGALVARRFGGHTGDTYGAVIEVGEAVALVLAT
LV
>Mature_242_residues
MRDWLAALLFYTALPLPLGPVSFDRIARWLPAVGLVVGGLNAGVYALLLALGFAAHLAALLAVVAGLWITGGLHLDGLID
TADGWAAGPERRLAAMADSAVGAFGVMAAVALLAAKTSALADLAGAAAPAALVLAAVSARWGQLVTIGWFPYLKSEGKGK
FLKDNTHWPADGWFGTAWWLASLIALGSVYPAVALAAGIGGALGALLGGALVARRFGGHTGDTYGAVIEVGEAVALVLAT
LV

Specific function: Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) [H]

COG id: COG0368

COG function: function code H; Cobalamin-5-phosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobS family [H]

Homologues:

Organism=Escherichia coli, GI1788301, Length=248, Percent_Identity=33.0645161290323, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003805 [H]

Pfam domain/function: PF02654 CobS [H]

EC number: 2.7.8.26

Molecular weight: Translated: 24459; Mature: 24459

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDWLAALLFYTALPLPLGPVSFDRIARWLPAVGLVVGGLNAGVYALLLALGFAAHLAAL
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LAVVAGLWITGGLHLDGLIDTADGWAAGPERRLAAMADSAVGAFGVMAAVALLAAKTSAL
HHHHHHHHHHCCCEECCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLAGAAAPAALVLAAVSARWGQLVTIGWFPYLKSEGKGKFLKDNTHWPADGWFGTAWWL
HHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCEECCCCCCCCCCCCHHHHHH
ASLIALGSVYPAVALAAGIGGALGALLGGALVARRFGGHTGDTYGAVIEVGEAVALVLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LV
HC
>Mature Secondary Structure
MRDWLAALLFYTALPLPLGPVSFDRIARWLPAVGLVVGGLNAGVYALLLALGFAAHLAAL
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LAVVAGLWITGGLHLDGLIDTADGWAAGPERRLAAMADSAVGAFGVMAAVALLAAKTSAL
HHHHHHHHHHCCCEECCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLAGAAAPAALVLAAVSARWGQLVTIGWFPYLKSEGKGKFLKDNTHWPADGWFGTAWWL
HHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCEECCCCCCCCCCCCHHHHHH
ASLIALGSVYPAVALAAGIGGALGALLGGALVARRFGGHTGDTYGAVIEVGEAVALVLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LV
HC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: adenosylcobinamide-GDP; alpha-ribazole

Specific reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA