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The map label for this gene is glmU [H]

Identifier: 37523272

GI number: 37523272

Start: 3910305

End: 3911288

Strand: Reverse

Name: glmU [H]

Synonym: gll3703

Alternate gene names: 37523272

Gene position: 3911288-3910305 (Counterclockwise)

Preceding gene: 37523273

Following gene: 37523271

Centisome position: 83.95

GC content: 63.62

Gene sequence:

>984_bases
ATGAAAGCATTCGTGCTCGCCGCCGGCAAGGGTACGCGCCTGCGCCCCTTCACCGACGCCCTGCCCAAGCCGCTGATGCC
CGTGATGAACAAGCCCGTCATGGCCCACATCCTGGGACTGTGCCGCAAGCACGGCCTCGACCAGGTCGTTGCGAACCTGC
ACTACAAAGGCGAAAAGATCAGCGAGTATTTCGGCAACGGCTCCCAATACCAGGTGTCGCTGGGCTACTCCCGCGAGGAG
CAACTGTTGGGCACCGCGGGCGGTGTGCGCCGCCAGGCGGACTTTTTGGCCGGCGGCCCCTTTCTGGTCATCTCCGGCGA
CGTGATGACCGATTTGGATCTGACCGCCCTGCTGCAGTTCCACAAACAATCCGGCGCCGTGGCCACCATGGCCGTCAAAG
AAGTCGGAGACCCGAGCCGCTTCGGGGTTGTGGTGAGCGACAGTCACGGCAAAGTCGAAAGTTTCCAAGAAAAACCCATC
CGGGGCACCGAGCGCTCGCGGTGGGCCAACACCGGCATCTATGTGCTGGAGCCGGAGGTGTTCAATTACATCCCCGAGGC
GACCTTCTTCGACTTCGGCAACGACCTGTTTCCGATGCTGGTGGCCGAGGGAGCACCGGTCTTTGCGATGCGCACAGGAG
CCTACTGGTCGGATGTCGGTACCCTGGCGCAGTATCTGTACACGCACTGGGAATTGTTGACCCATCCCGAGATTGTCCAG
CGCATCGGCGAAGGGACGGTCGTCGAACCGGGGGCGGTGATCTCCGACCAGGCGCTCATCGGCCGCCACTGCACCATCGA
AAAAGGGGCGCGGGTGCTGGGCTACAGCTGCGTGAGCGACGGGTGCGTGATTCGTGCCGGCTCGGTCGTGGTCGACAGTG
TGATGTGGACGAGTGAGCAGCTGGGCGAGCGGCTCAGCGGCGACCTGGTGCGCTCGATCTGGGGCGACGGCAAGCACGTC
TGCCTCGGCATCCCCAACCTCTAG

Upstream 100 bases:

>100_bases
ACACCCGATAGCCACAGCATTTCTGTTCTGTTTCCCACTGTCCTGCGAGATTGGCATCGTTTTTGCTTTGTCTACCCGTC
AAACATCCTGGAGGAAACCG

Downstream 100 bases:

>100_bases
TCGCTGCGAAGTGGGCGCTGCGCCCGACCCCGATCCTCCCTTGCCGCCAAATTACGGTATATCTGGTAAGGCTCCAGCTG
TAAATGCACACAGGGGAAAG

Product: mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKAFVLAAGKGTRLRPFTDALPKPLMPVMNKPVMAHILGLCRKHGLDQVVANLHYKGEKISEYFGNGSQYQVSLGYSREE
QLLGTAGGVRRQADFLAGGPFLVISGDVMTDLDLTALLQFHKQSGAVATMAVKEVGDPSRFGVVVSDSHGKVESFQEKPI
RGTERSRWANTGIYVLEPEVFNYIPEATFFDFGNDLFPMLVAEGAPVFAMRTGAYWSDVGTLAQYLYTHWELLTHPEIVQ
RIGEGTVVEPGAVISDQALIGRHCTIEKGARVLGYSCVSDGCVIRAGSVVVDSVMWTSEQLGERLSGDLVRSIWGDGKHV
CLGIPNL

Sequences:

>Translated_327_residues
MKAFVLAAGKGTRLRPFTDALPKPLMPVMNKPVMAHILGLCRKHGLDQVVANLHYKGEKISEYFGNGSQYQVSLGYSREE
QLLGTAGGVRRQADFLAGGPFLVISGDVMTDLDLTALLQFHKQSGAVATMAVKEVGDPSRFGVVVSDSHGKVESFQEKPI
RGTERSRWANTGIYVLEPEVFNYIPEATFFDFGNDLFPMLVAEGAPVFAMRTGAYWSDVGTLAQYLYTHWELLTHPEIVQ
RIGEGTVVEPGAVISDQALIGRHCTIEKGARVLGYSCVSDGCVIRAGSVVVDSVMWTSEQLGERLSGDLVRSIWGDGKHV
CLGIPNL
>Mature_327_residues
MKAFVLAAGKGTRLRPFTDALPKPLMPVMNKPVMAHILGLCRKHGLDQVVANLHYKGEKISEYFGNGSQYQVSLGYSREE
QLLGTAGGVRRQADFLAGGPFLVISGDVMTDLDLTALLQFHKQSGAVATMAVKEVGDPSRFGVVVSDSHGKVESFQEKPI
RGTERSRWANTGIYVLEPEVFNYIPEATFFDFGNDLFPMLVAEGAPVFAMRTGAYWSDVGTLAQYLYTHWELLTHPEIVQ
RIGEGTVVEPGAVISDQALIGRHCTIEKGARVLGYSCVSDGCVIRAGSVVVDSVMWTSEQLGERLSGDLVRSIWGDGKHV
CLGIPNL

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=302, Percent_Identity=31.1258278145695, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI11761619, Length=302, Percent_Identity=31.1258278145695, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI31881779, Length=349, Percent_Identity=26.9340974212034, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI45447090, Length=349, Percent_Identity=26.9340974212034, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1788351, Length=229, Percent_Identity=30.5676855895196, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790224, Length=231, Percent_Identity=29.004329004329, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789837, Length=363, Percent_Identity=24.7933884297521, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=307, Percent_Identity=31.9218241042345, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17509979, Length=327, Percent_Identity=31.1926605504587, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17509981, Length=316, Percent_Identity=30.379746835443, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320148, Length=328, Percent_Identity=29.8780487804878, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6320417, Length=395, Percent_Identity=22.0253164556962, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355443, Length=312, Percent_Identity=31.7307692307692, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24644084, Length=312, Percent_Identity=31.7307692307692, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653912, Length=334, Percent_Identity=26.6467065868263, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 35620; Mature: 35620

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFVLAAGKGTRLRPFTDALPKPLMPVMNKPVMAHILGLCRKHGLDQVVANLHYKGEKI
CCEEEEECCCCCCCCCHHHHCCCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHH
SEYFGNGSQYQVSLGYSREEQLLGTAGGVRRQADFLAGGPFLVISGDVMTDLDLTALLQF
HHHHCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
HKQSGAVATMAVKEVGDPSRFGVVVSDSHGKVESFQEKPIRGTERSRWANTGIYVLEPEV
HHHCCCEEEEEHHHCCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCHHCCCCEEEECHHH
FNYIPEATFFDFGNDLFPMLVAEGAPVFAMRTGAYWSDVGTLAQYLYTHWELLTHPEIVQ
HHHCCCCHHHHCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHH
RIGEGTVVEPGAVISDQALIGRHCTIEKGARVLGYSCVSDGCVIRAGSVVVDSVMWTSEQ
HCCCCCEECCCCEECCCHHHCCCCCHHHCCCEEEEHHHCCCEEEEECHHHHHHHHHHHHH
LGERLSGDLVRSIWGDGKHVCLGIPNL
HHHHHHHHHHHHHHCCCCEEEEECCCC
>Mature Secondary Structure
MKAFVLAAGKGTRLRPFTDALPKPLMPVMNKPVMAHILGLCRKHGLDQVVANLHYKGEKI
CCEEEEECCCCCCCCCHHHHCCCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCHH
SEYFGNGSQYQVSLGYSREEQLLGTAGGVRRQADFLAGGPFLVISGDVMTDLDLTALLQF
HHHHCCCCEEEEEECCCHHHHHHHCCCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
HKQSGAVATMAVKEVGDPSRFGVVVSDSHGKVESFQEKPIRGTERSRWANTGIYVLEPEV
HHHCCCEEEEEHHHCCCCCCEEEEEECCCCCHHHHHCCCCCCCCCCHHCCCCEEEECHHH
FNYIPEATFFDFGNDLFPMLVAEGAPVFAMRTGAYWSDVGTLAQYLYTHWELLTHPEIVQ
HHHCCCCHHHHCCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHH
RIGEGTVVEPGAVISDQALIGRHCTIEKGARVLGYSCVSDGCVIRAGSVVVDSVMWTSEQ
HCCCCCEECCCCEECCCHHHCCCCCHHHCCCEEEEHHHCCCEEEEECHHHHHHHHHHHHH
LGERLSGDLVRSIWGDGKHVCLGIPNL
HHHHHHHHHHHHHHCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]