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The map label for this gene is ogt [H]

Identifier: 37523179

GI number: 37523179

Start: 3806667

End: 3807041

Strand: Direct

Name: ogt [H]

Synonym: glr3610

Alternate gene names: 37523179

Gene position: 3806667-3807041 (Clockwise)

Preceding gene: 37523178

Following gene: 37523182

Centisome position: 81.71

GC content: 67.47

Gene sequence:

>375_bases
GTGACCTTGCAACCTGAGGCGGTGGCAGCAGTCGCCTCACAGCTTCAAGCGTATTTTGCAGGGGAGCGCCGAAGCTTCGA
TTTGGCCCTGGCGCCGGTCGGCAATGCCTTCCAGCAAACCGTCTGGAGGCAACTGTGCCGGATTCCCTACGGGGTCACGA
TCACCTACGGCGAACTCGCCGGCCGCATCGGCAATCCGAGCGCGGCCCGGGCGGTCGGCCGGGCCAACGCCCTCAATCCG
ATTGCGATCGTTGTACCCTGCCACCGGGTGATCGGTTCGGACGGCAGCCTGACGGGCTACGCGGGCGGCCTGGCGCGCAA
GGCCGCCCTGCTGGCGCTCGAAGGGACAACGCTCAACCTGGGGTGGTCCCCCTGA

Upstream 100 bases:

>100_bases
ACGGTGTAAGGTCAACAGCGACGGTGCCCTCGTTCACCTCGACTTCATAGAAAAGAACGAACTGCAGGGTGTCCCGCGCC
CGCTGGAGCGATACGAAACC

Downstream 100 bases:

>100_bases
CGCGTCACTGTTTGCTCGCCTGGCTCGCTTCGAATTGTTCGTAGGCTTCGACGATGCGCTGCACGAGCGGGTGGCGCACG
ACATCTTCGCGGCCGAACTC

Product: methylated-DNA--protein-cysteine S-methyltransferase

Products: NA

Alternate protein names: 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase [H]

Number of amino acids: Translated: 124; Mature: 123

Protein sequence:

>124_residues
MTLQPEAVAAVASQLQAYFAGERRSFDLALAPVGNAFQQTVWRQLCRIPYGVTITYGELAGRIGNPSAARAVGRANALNP
IAIVVPCHRVIGSDGSLTGYAGGLARKAALLALEGTTLNLGWSP

Sequences:

>Translated_124_residues
MTLQPEAVAAVASQLQAYFAGERRSFDLALAPVGNAFQQTVWRQLCRIPYGVTITYGELAGRIGNPSAARAVGRANALNP
IAIVVPCHRVIGSDGSLTGYAGGLARKAALLALEGTTLNLGWSP
>Mature_123_residues
TLQPEAVAAVASQLQAYFAGERRSFDLALAPVGNAFQQTVWRQLCRIPYGVTITYGELAGRIGNPSAARAVGRANALNPI
AIVVPCHRVIGSDGSLTGYAGGLARKAALLALEGTTLNLGWSP

Specific function: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a sui

COG id: COG0350

COG function: function code L; Methylated DNA-protein cysteine methyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MGMT family [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=121, Percent_Identity=39.6694214876033, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787596, Length=109, Percent_Identity=53.2110091743119, Blast_Score=109, Evalue=4e-26,
Organism=Escherichia coli, GI1788542, Length=88, Percent_Identity=52.2727272727273, Blast_Score=93, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI115533070, Length=85, Percent_Identity=50.5882352941176, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533068, Length=85, Percent_Identity=50.5882352941176, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320001, Length=81, Percent_Identity=48.1481481481481, Blast_Score=89, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137554, Length=111, Percent_Identity=41.4414414414414, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01035 DNA_binding_1; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 12936; Mature: 12805

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQPEAVAAVASQLQAYFAGERRSFDLALAPVGNAFQQTVWRQLCRIPYGVTITYGELA
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEHHHHC
GRIGNPSAARAVGRANALNPIAIVVPCHRVIGSDGSLTGYAGGLARKAALLALEGTTLNL
CCCCCCHHHHHHHCCCCCCCEEEEEECHHHHCCCCCCCCCCCHHHHHEEEEEECCCEEEC
GWSP
CCCC
>Mature Secondary Structure 
TLQPEAVAAVASQLQAYFAGERRSFDLALAPVGNAFQQTVWRQLCRIPYGVTITYGELA
CCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEHHHHC
GRIGNPSAARAVGRANALNPIAIVVPCHRVIGSDGSLTGYAGGLARKAALLALEGTTLNL
CCCCCCHHHHHHHCCCCCCCEEEEEECHHHHCCCCCCCCCCCHHHHHEEEEEECCCEEEC
GWSP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]