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The map label for this gene is ada [H]

Identifier: 37523178

GI number: 37523178

Start: 3805009

End: 3806616

Strand: Direct

Name: ada [H]

Synonym: glr3609

Alternate gene names: 37523178

Gene position: 3805009-3806616 (Clockwise)

Preceding gene: 37523177

Following gene: 37523179

Centisome position: 81.67

GC content: 65.17

Gene sequence:

>1608_bases
ATGGATATCGACCACCTGGCCTGCTACCGGGCCGTTCTGGCGCGGGATGAGCGCTTCGACGGCCGCTTCTATACGGCGGT
GAAGACGACCGGCATCTACTGCCGACCCGTCTGCCCGACGCCGCCTCCCAAGGCGCACAACTGTATGTTCTTCGCGAGCG
CGGCGGCTGCACAGGCGGCCGGATTTCGGCCCTGTATCCGCTGTCGGCCGGAACTTGCCCCAGGCCATGCAGGCTGGAGC
GGCACGCACGAAACCCTGCGCCGAGCAATTTCGCTGATGGCCGAGGGAGCCCCCGAAACCGAAAACCTCCCGGACATCGC
CGCTGCCGTCGGTGTCGGCGAGCGACAACTGCGGCGCATTTTTCGCGAGCAAACGGGCGCCTCGGCGATCGAGTTTAAGA
CCGTACACCGCATCCTCTTTGCAAAAGCCCTGATCGTCGATACAGATCTGGCCATGGCGGAGATCGCTTTCGCTTCCGGT
TTCGGCAGCATCCGTCGATTCAATGCGGCTTTCCAGCAAATGTATGGTCGTCCGCCCCACACCCTGCGCAAGCAAGGATG
CATTGCCGGTGGCTGCGGCATTGTCCTGCGCCTGGGTTATCGCAAGCCGTTCAACTGGTCGGCGTTTCTCGCTTTTCTGG
CCCCCAGGGCGATCCGCGGGGTCGAAGCGGTAACCGGTGAAACCTATCGGCGCAGCCTGCGGGCGGCGGACGGTGCGGCC
CTCGTGACCGTTACCGATGATCCGCAGGCCGGGGTGCTGGTTGCGCGTGTACAGAGCGACCGGGTCGCAGCACTTTCGGC
CGTTGCCGCCCGACTGCGGCGCTTTTTCGACCTCGACGCCGATCCGGCCGCAATCGCGGCTGTCCTGGGTGCCGACCCAC
TTCTCGCTCCGTTGCTCGAAACCGTGCCAGGCCGACGGATACCGGGGACCATGGACAGCTTCGAGCTGGCGGTACGCGCC
ATCGTCGGGCAACAGGTGAGCGTCACGGGCGCCCGCACCATTGTGGGCCGTATCGCCGAGCGCTGGGGTGAGCCGCTCGA
CCTGCACCTGGGCGCGTTGCCGCCGGATGGGCCATTGCTGTTGTTTCCACAGGTGCAAGCCCTGGTGAACGCTCCTTTGG
AAGATGTCGGCGTCATGCCCGCCCGCGCCCGGGCGATCCGTGCACTTGCAGCGGCGCTGGTAGAAGATCCAGAACTGTTA
AATCCGGCGCCTCCCCCGGCACGGACGGTCGCAAGGCTCCTGCAACTGCCGGGCATCGGACCCTGGACGGCTCAGTACGT
GGCCATCAGGGCCTTGGGAGATCCCGACGCCTTTCCGGCAGGCGACCTTGGCCTGCTCAAAGCCACCTCGTCAGGCAGGC
CACACCTCACCCCGCGCGCGCTGGAACTGCGCTCCCAGGCTTGGCGGCCGTGGCGGGCCTACGCCGCAATCCACCTCTGG
GCATCCCAAGCGGCCACAACCGACAAGCACGAAGGGGAAGGAGAAGGGTCATGTCACAGACGCAATCCATCGACAGCACT
CTACAAGTCGGGAACATCCCAACACCGCTCGGAACCTTACGGTGTAAGGTCAACAGCGACGGTGCCCTCGTTCACCTCGA
CTTCATAG

Upstream 100 bases:

>100_bases
CGCCGGAGGTGACGCTCATCGAGCTGTCGCCTGCGGCCTGAACGCCGGTGGTGTCCGAAAACGGCCAGACATCGTCTTTT
TGGTCGATTAGGCTTGGCAT

Downstream 100 bases:

>100_bases
AAAAGAACGAACTGCAGGGTGTCCCGCGCCCGCTGGAGCGATACGAAACCGTGACCTTGCAACCTGAGGCGGTGGCAGCA
GTCGCCTCACAGCTTCAAGC

Product: AraC family transcription regulator

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MDIDHLACYRAVLARDERFDGRFYTAVKTTGIYCRPVCPTPPPKAHNCMFFASAAAAQAAGFRPCIRCRPELAPGHAGWS
GTHETLRRAISLMAEGAPETENLPDIAAAVGVGERQLRRIFREQTGASAIEFKTVHRILFAKALIVDTDLAMAEIAFASG
FGSIRRFNAAFQQMYGRPPHTLRKQGCIAGGCGIVLRLGYRKPFNWSAFLAFLAPRAIRGVEAVTGETYRRSLRAADGAA
LVTVTDDPQAGVLVARVQSDRVAALSAVAARLRRFFDLDADPAAIAAVLGADPLLAPLLETVPGRRIPGTMDSFELAVRA
IVGQQVSVTGARTIVGRIAERWGEPLDLHLGALPPDGPLLLFPQVQALVNAPLEDVGVMPARARAIRALAAALVEDPELL
NPAPPPARTVARLLQLPGIGPWTAQYVAIRALGDPDAFPAGDLGLLKATSSGRPHLTPRALELRSQAWRPWRAYAAIHLW
ASQAATTDKHEGEGEGSCHRRNPSTALYKSGTSQHRSEPYGVRSTATVPSFTSTS

Sequences:

>Translated_535_residues
MDIDHLACYRAVLARDERFDGRFYTAVKTTGIYCRPVCPTPPPKAHNCMFFASAAAAQAAGFRPCIRCRPELAPGHAGWS
GTHETLRRAISLMAEGAPETENLPDIAAAVGVGERQLRRIFREQTGASAIEFKTVHRILFAKALIVDTDLAMAEIAFASG
FGSIRRFNAAFQQMYGRPPHTLRKQGCIAGGCGIVLRLGYRKPFNWSAFLAFLAPRAIRGVEAVTGETYRRSLRAADGAA
LVTVTDDPQAGVLVARVQSDRVAALSAVAARLRRFFDLDADPAAIAAVLGADPLLAPLLETVPGRRIPGTMDSFELAVRA
IVGQQVSVTGARTIVGRIAERWGEPLDLHLGALPPDGPLLLFPQVQALVNAPLEDVGVMPARARAIRALAAALVEDPELL
NPAPPPARTVARLLQLPGIGPWTAQYVAIRALGDPDAFPAGDLGLLKATSSGRPHLTPRALELRSQAWRPWRAYAAIHLW
ASQAATTDKHEGEGEGSCHRRNPSTALYKSGTSQHRSEPYGVRSTATVPSFTSTS
>Mature_535_residues
MDIDHLACYRAVLARDERFDGRFYTAVKTTGIYCRPVCPTPPPKAHNCMFFASAAAAQAAGFRPCIRCRPELAPGHAGWS
GTHETLRRAISLMAEGAPETENLPDIAAAVGVGERQLRRIFREQTGASAIEFKTVHRILFAKALIVDTDLAMAEIAFASG
FGSIRRFNAAFQQMYGRPPHTLRKQGCIAGGCGIVLRLGYRKPFNWSAFLAFLAPRAIRGVEAVTGETYRRSLRAADGAA
LVTVTDDPQAGVLVARVQSDRVAALSAVAARLRRFFDLDADPAAIAAVLGADPLLAPLLETVPGRRIPGTMDSFELAVRA
IVGQQVSVTGARTIVGRIAERWGEPLDLHLGALPPDGPLLLFPQVQALVNAPLEDVGVMPARARAIRALAAALVEDPELL
NPAPPPARTVARLLQLPGIGPWTAQYVAIRALGDPDAFPAGDLGLLKATSSGRPHLTPRALELRSQAWRPWRAYAAIHLW
ASQAATTDKHEGEGEGSCHRRNPSTALYKSGTSQHRSEPYGVRSTATVPSFTSTS

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=296, Percent_Identity=33.1081081081081, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788542, Length=120, Percent_Identity=39.1666666666667, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 57435; Mature: 57435

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDHLACYRAVLARDERFDGRFYTAVKTTGIYCRPVCPTPPPKAHNCMFFASAAAAQAA
CCCHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEECCCCCCCCCCCCEEEEEHHHHHHHC
GFRPCIRCRPELAPGHAGWSGTHETLRRAISLMAEGAPETENLPDIAAAVGVGERQLRRI
CCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHH
FREQTGASAIEFKTVHRILFAKALIVDTDLAMAEIAFASGFGSIRRFNAAFQQMYGRPPH
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCH
TLRKQGCIAGGCGIVLRLGYRKPFNWSAFLAFLAPRAIRGVEAVTGETYRRSLRAADGAA
HHHHCCCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCE
LVTVTDDPQAGVLVARVQSDRVAALSAVAARLRRFFDLDADPAAIAAVLGADPLLAPLLE
EEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHH
TVPGRRIPGTMDSFELAVRAIVGQQVSVTGARTIVGRIAERWGEPLDLHLGALPPDGPLL
HCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEE
LFPQVQALVNAPLEDVGVMPARARAIRALAAALVEDPELLNPAPPPARTVARLLQLPGIG
ECHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHCCCCC
PWTAQYVAIRALGDPDAFPAGDLGLLKATSSGRPHLTPRALELRSQAWRPWRAYAAIHLW
CCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
ASQAATTDKHEGEGEGSCHRRNPSTALYKSGTSQHRSEPYGVRSTATVPSFTSTS
HHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDIDHLACYRAVLARDERFDGRFYTAVKTTGIYCRPVCPTPPPKAHNCMFFASAAAAQAA
CCCHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEECCCCCCCCCCCCEEEEEHHHHHHHC
GFRPCIRCRPELAPGHAGWSGTHETLRRAISLMAEGAPETENLPDIAAAVGVGERQLRRI
CCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHH
FREQTGASAIEFKTVHRILFAKALIVDTDLAMAEIAFASGFGSIRRFNAAFQQMYGRPPH
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCH
TLRKQGCIAGGCGIVLRLGYRKPFNWSAFLAFLAPRAIRGVEAVTGETYRRSLRAADGAA
HHHHCCCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCE
LVTVTDDPQAGVLVARVQSDRVAALSAVAARLRRFFDLDADPAAIAAVLGADPLLAPLLE
EEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHH
TVPGRRIPGTMDSFELAVRAIVGQQVSVTGARTIVGRIAERWGEPLDLHLGALPPDGPLL
HCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEE
LFPQVQALVNAPLEDVGVMPARARAIRALAAALVEDPELLNPAPPPARTVARLLQLPGIG
ECHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHCCCCC
PWTAQYVAIRALGDPDAFPAGDLGLLKATSSGRPHLTPRALELRSQAWRPWRAYAAIHLW
CCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
ASQAATTDKHEGEGEGSCHRRNPSTALYKSGTSQHRSEPYGVRSTATVPSFTSTS
HHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]