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The map label for this gene is ilvG [H]

Identifier: 37522848

GI number: 37522848

Start: 3483872

End: 3485662

Strand: Direct

Name: ilvG [H]

Synonym: gvip452

Alternate gene names: 37522848

Gene position: 3483872-3485662 (Clockwise)

Preceding gene: 37522846

Following gene: 37522849

Centisome position: 74.78

GC content: 64.71

Gene sequence:

>1791_bases
ATGCAAGCCACCGGAGCCTTCGCCGTCGTCGATAGTCTGTGCTGCCAGGGCGTCCGGCACATCTTCGGTTACCCCGGTGG
GGCCATTTTGCCGGTCTACGACGAGATTTACAAGGCCGAGGCCGAAGGGCGGTTTCAGCACTTTCTGGTGCGCCACGAGC
AGGGGGCGGCCCACGCCGCCGACGGCTACGCCCGGGCGACCGGCCGGGTGGGCGTCTGTGTGGCCACCTCCGGTCCCGGG
GCGACGAATCTGGTGACGGGCATCGCCACGGCCCACATGGATTCGGTGCCGATGGTGGCGATTACCGGTCAGGTGCCGCG
CCGGTCGATCGGTTCCGACGCCTTTCAAGAAGCCGATATTCTGGGCATCACCCTGCCCATCGTCAAGCACTCCTACGTCA
TCCGCAACACTGGGGACATCGGCCGCATCTTCAGCGAAGCCTTCCATATCGCAAGCAGCGGCCGGCCCGGCCCGGTGCTC
ATCGACGTTCCCAAGGACGTGGGCCAAGAAAGCTTCGAGTACACGCCGGTCCAGACGACGCCCAAAATTCCCGGGTACCG
CCCAACCACACGGGGCAATCCCCGCCAGGTGGCGGCGGCGGCGAAGCTCATCCTCGAAGCGGACCGGCCTCTGCTTTATG
TGGGTGGCGGCGCCATCTCCGCCGGGGCGCACGCCGAACTGATGCGCCTCGCGGAGCTGGGTTTGATCCCGACCACCACC
ACCTTGATGGGCAAGGGGGCCTTCCCTGAAGATCATCCGCTGGCCGTGGGCATGCTCGGCATGCACGGCACCGCCTACGC
CAATTTCGCCGTCACCGAGTGCGATTTGCTCATCGCCGTGGGGGCGCGCTTCGACGACCGGGTGACCGGCAAACTGGATG
AATTTGCCGCCCGCGCCCGCGTCATCCACATCGATATCGATCCGGCAGAGGTGGGCAAGAACCGGGGGCCGGAGGTGCCC
ATCGTGGGCGACGTCAAACTGGTGCTGCAGGATCTGATTAAAAAGCTCATCGAATTTCAGCCGCGCACCCGGGCGTGGCT
GGAGCGCATCGAGCGCTGGAAAGCCGAGTATCCGCTGGAGGTGCCGAGCGATGGCACCCGGCTGTACCCACAGGAAGTGA
TGGTCGCCTTTCGCGAACTGGCTACCGACGCCTACTACACCACCGACGTCGGCCAGCACCAGATGTGGGCGGCGCAGTTT
CTCAAAAACGGCCCCCGGCGCTGGATTTCCTCAGGCGGCCTCGGCACGATGGGCTACGGCTTTCCGGCGGCCATCGGCGT
GCAGGTGGCACTGCCTGACGAAGACGTCGTGTGCATCTCCGGCGACGCCAGCTTTCAGATGAACCTACAAGAAATCGGCA
CGGCGGTGCAGTACGACCTGCCGGTCAAGGCCGCCATCGTCAACAACGGCTGGCAGGGCATGGTCCGCCAGTGGCAAGAA
TTTTTCTACGACCGCCGCTTCTCCCACTCCCACATGAAGCCCTCGATGCCCGACTTCGTCAAACTCGCTGAAGCGTTCGG
GGCGGAGGGCATGGTCATCGATCACCCCGACCAGCTCAAAGAAGGCATCGAGGCGCTGATGGAGCGCGACCGGCCGGTGA
TTTGCGACTTTCATGTCGTCCCCGACGCCAACTGCTACCCGATGGTGCCCCCGGGCAAGGCCAACCACCAGATGGTCGGG
CTGCCCAGGCCGTTGCCGATGCAGCCGCTCGAACTCATCTACTGCCCCAACTGCGGCACCAAAAATACCACCGCCAACCG
CTTCTGCCCCGAGTGCGGCACCAAGCTTTAG

Upstream 100 bases:

>100_bases
TCGTATCGCGCCTGTGGGAAAAACGGGGCTCCCGCCGCTACGGGACTGATGTAGAGTAAGTGGTTACAGGGAACCGTTAT
ATTCGCTACAGGTTAAGTCT

Downstream 100 bases:

>100_bases
CCGGGCACTTTCTGCCTGCTCAGGAGGGTTGTGGCTACGTCCCAAGCTGTGGCAAACAGATAGCTCATCGGGTTGTGAAT
TAATGTTGACGGAGCGATCC

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MQATGAFAVVDSLCCQGVRHIFGYPGGAILPVYDEIYKAEAEGRFQHFLVRHEQGAAHAADGYARATGRVGVCVATSGPG
ATNLVTGIATAHMDSVPMVAITGQVPRRSIGSDAFQEADILGITLPIVKHSYVIRNTGDIGRIFSEAFHIASSGRPGPVL
IDVPKDVGQESFEYTPVQTTPKIPGYRPTTRGNPRQVAAAAKLILEADRPLLYVGGGAISAGAHAELMRLAELGLIPTTT
TLMGKGAFPEDHPLAVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDEFAARARVIHIDIDPAEVGKNRGPEVP
IVGDVKLVLQDLIKKLIEFQPRTRAWLERIERWKAEYPLEVPSDGTRLYPQEVMVAFRELATDAYYTTDVGQHQMWAAQF
LKNGPRRWISSGGLGTMGYGFPAAIGVQVALPDEDVVCISGDASFQMNLQEIGTAVQYDLPVKAAIVNNGWQGMVRQWQE
FFYDRRFSHSHMKPSMPDFVKLAEAFGAEGMVIDHPDQLKEGIEALMERDRPVICDFHVVPDANCYPMVPPGKANHQMVG
LPRPLPMQPLELIYCPNCGTKNTTANRFCPECGTKL

Sequences:

>Translated_596_residues
MQATGAFAVVDSLCCQGVRHIFGYPGGAILPVYDEIYKAEAEGRFQHFLVRHEQGAAHAADGYARATGRVGVCVATSGPG
ATNLVTGIATAHMDSVPMVAITGQVPRRSIGSDAFQEADILGITLPIVKHSYVIRNTGDIGRIFSEAFHIASSGRPGPVL
IDVPKDVGQESFEYTPVQTTPKIPGYRPTTRGNPRQVAAAAKLILEADRPLLYVGGGAISAGAHAELMRLAELGLIPTTT
TLMGKGAFPEDHPLAVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDEFAARARVIHIDIDPAEVGKNRGPEVP
IVGDVKLVLQDLIKKLIEFQPRTRAWLERIERWKAEYPLEVPSDGTRLYPQEVMVAFRELATDAYYTTDVGQHQMWAAQF
LKNGPRRWISSGGLGTMGYGFPAAIGVQVALPDEDVVCISGDASFQMNLQEIGTAVQYDLPVKAAIVNNGWQGMVRQWQE
FFYDRRFSHSHMKPSMPDFVKLAEAFGAEGMVIDHPDQLKEGIEALMERDRPVICDFHVVPDANCYPMVPPGKANHQMVG
LPRPLPMQPLELIYCPNCGTKNTTANRFCPECGTKL
>Mature_596_residues
MQATGAFAVVDSLCCQGVRHIFGYPGGAILPVYDEIYKAEAEGRFQHFLVRHEQGAAHAADGYARATGRVGVCVATSGPG
ATNLVTGIATAHMDSVPMVAITGQVPRRSIGSDAFQEADILGITLPIVKHSYVIRNTGDIGRIFSEAFHIASSGRPGPVL
IDVPKDVGQESFEYTPVQTTPKIPGYRPTTRGNPRQVAAAAKLILEADRPLLYVGGGAISAGAHAELMRLAELGLIPTTT
TLMGKGAFPEDHPLAVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDEFAARARVIHIDIDPAEVGKNRGPEVP
IVGDVKLVLQDLIKKLIEFQPRTRAWLERIERWKAEYPLEVPSDGTRLYPQEVMVAFRELATDAYYTTDVGQHQMWAAQF
LKNGPRRWISSGGLGTMGYGFPAAIGVQVALPDEDVVCISGDASFQMNLQEIGTAVQYDLPVKAAIVNNGWQGMVRQWQE
FFYDRRFSHSHMKPSMPDFVKLAEAFGAEGMVIDHPDQLKEGIEALMERDRPVICDFHVVPDANCYPMVPPGKANHQMVG
LPRPLPMQPLELIYCPNCGTKNTTANRFCPECGTKL

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=571, Percent_Identity=26.7950963222417, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI21361361, Length=567, Percent_Identity=27.336860670194, Blast_Score=156, Evalue=5e-38,
Organism=Escherichia coli, GI87081685, Length=566, Percent_Identity=47.5265017667844, Blast_Score=527, Evalue=1e-151,
Organism=Escherichia coli, GI1790104, Length=560, Percent_Identity=45.1785714285714, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI1786717, Length=542, Percent_Identity=35.239852398524, Blast_Score=332, Evalue=5e-92,
Organism=Escherichia coli, GI1787096, Length=558, Percent_Identity=28.1362007168459, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788716, Length=557, Percent_Identity=28.3662477558348, Blast_Score=175, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17531299, Length=562, Percent_Identity=26.1565836298932, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17531301, Length=562, Percent_Identity=26.1565836298932, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17542570, Length=570, Percent_Identity=24.5614035087719, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323755, Length=595, Percent_Identity=42.3529411764706, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6320816, Length=478, Percent_Identity=26.3598326359833, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323073, Length=489, Percent_Identity=24.3353783231084, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321524, Length=491, Percent_Identity=24.4399185336049, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922626, Length=567, Percent_Identity=25.5731922398589, Blast_Score=163, Evalue=4e-40,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 64877; Mature: 64877

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQATGAFAVVDSLCCQGVRHIFGYPGGAILPVYDEIYKAEAEGRFQHFLVRHEQGAAHAA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCHHHHHEECCCCCCCCC
DGYARATGRVGVCVATSGPGATNLVTGIATAHMDSVPMVAITGQVPRRSIGSDAFQEADI
CCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCE
LGITLPIVKHSYVIRNTGDIGRIFSEAFHIASSGRPGPVLIDVPKDVGQESFEYTPVQTT
EEEEEHHHHCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEECCHHCCCCCCCCCCCCCC
PKIPGYRPTTRGNPRQVAAAAKLILEADRPLLYVGGGAISAGAHAELMRLAELGLIPTTT
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCH
TLMGKGAFPEDHPLAVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDEFAARAR
HHEECCCCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEECCCCCCCCCCCHHHHHHCEE
VIHIDIDPAEVGKNRGPEVPIVGDVKLVLQDLIKKLIEFQPRTRAWLERIERWKAEYPLE
EEEEECCHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
VPSDGTRLYPQEVMVAFRELATDAYYTTDVGQHQMWAAQFLKNGPRRWISSGGLGTMGYG
CCCCCCEECHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCC
FPAAIGVQVALPDEDVVCISGDASFQMNLQEIGTAVQYDLPVKAAIVNNGWQGMVRQWQE
CCHHEEEEEECCCCCEEEEECCCCEEEEHHHHCCEEEECCCEEEEEECCCHHHHHHHHHH
FFYDRRFSHSHMKPSMPDFVKLAEAFGAEGMVIDHPDQLKEGIEALMERDRPVICDFHVV
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCEEEEEEEC
PDANCYPMVPPGKANHQMVGLPRPLPMQPLELIYCPNCGTKNTTANRFCPECGTKL
CCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQATGAFAVVDSLCCQGVRHIFGYPGGAILPVYDEIYKAEAEGRFQHFLVRHEQGAAHAA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCHHHHHEECCCCCCCCC
DGYARATGRVGVCVATSGPGATNLVTGIATAHMDSVPMVAITGQVPRRSIGSDAFQEADI
CCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCE
LGITLPIVKHSYVIRNTGDIGRIFSEAFHIASSGRPGPVLIDVPKDVGQESFEYTPVQTT
EEEEEHHHHCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEECCHHCCCCCCCCCCCCCC
PKIPGYRPTTRGNPRQVAAAAKLILEADRPLLYVGGGAISAGAHAELMRLAELGLIPTTT
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCH
TLMGKGAFPEDHPLAVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDEFAARAR
HHEECCCCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEECCCCCCCCCCCHHHHHHCEE
VIHIDIDPAEVGKNRGPEVPIVGDVKLVLQDLIKKLIEFQPRTRAWLERIERWKAEYPLE
EEEEECCHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
VPSDGTRLYPQEVMVAFRELATDAYYTTDVGQHQMWAAQFLKNGPRRWISSGGLGTMGYG
CCCCCCEECHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCC
FPAAIGVQVALPDEDVVCISGDASFQMNLQEIGTAVQYDLPVKAAIVNNGWQGMVRQWQE
CCHHEEEEEECCCCCEEEEECCCCEEEEHHHHCCEEEECCCEEEEEECCCHHHHHHHHHH
FFYDRRFSHSHMKPSMPDFVKLAEAFGAEGMVIDHPDQLKEGIEALMERDRPVICDFHVV
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCEEEEEEEC
PDANCYPMVPPGKANHQMVGLPRPLPMQPLELIYCPNCGTKNTTANRFCPECGTKL
CCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]