Click here to switch to the map view.

The map label for this gene is ptrB [C]

Identifier: 37522840

GI number: 37522840

Start: 3474002

End: 3476113

Strand: Direct

Name: ptrB [C]

Synonym: glr3271

Alternate gene names: 37522840

Gene position: 3474002-3476113 (Clockwise)

Preceding gene: 37522839

Following gene: 37522843

Centisome position: 74.57

GC content: 67.76

Gene sequence:

>2112_bases
ATGGGCAGTTTCAGGCTGATGGGGACGGGCGCATGGCCGGGAGCGCTTTTCGCGCTGGTGCTGATCCTATCGGGCGGCGG
GGTGCTTGCCACCGACTCGGTGACGCCACCGCCTGCCGCCCGCACCGCACCAGCGACCGGCACCTACGGCGCGGTCAAGG
TGGAAGACCCTTACCGGTGGTTGGAAAAAGCCGCTTCCCCCGAGGTTCAGGGCTGGATCGACGCCCAGAACGCTTACGCC
GAAAAGGTGCTCAGCCGCTACCCAGGCCGGGAGAAAATGGCCGCGCGCGTGCGCGAACTTTCGCTCACCTCCGAGCAACG
CTCCAAACCGCACCTCGCGGGCGGACGGCTGTTTTATTTGCGTCTGACCCCGCCCCAGGAGCAGCCGGTTCTCATCTCCC
AGTCCTGGCCCACCGGTACTGCGCGGGTGCTGGTCGATCCCAACCGTGCAGGCGGCCTTACCGCCGTCACCGAATTTTGG
CCGTCGCCCAGCGGTCGCTACGTGGCCTACGGCACCGCCGACAAAGGCACCGAAGACACGGTGATCCGGGTGGTCGATGC
GCGCACGGGCCGCCCGCTGCCGGAGGTGCTCCGGCGGGCGGGCGGGGGCACCACGCCCTCGGCCCTCGCCTGGGACGCCG
ATGAAAAAGGTTTTATCTACACGCGCTTCCCGGTGGACAGCGTCGCTCCGTTCAACGTGGCGCTCTTTCACCACCGCCTG
GGCACTCCCGCCTCCCAGGACAAGTTGCACTTCGGCGCGGGTCTTTCGCCCTACGCCGAATACGCACTGATCGCCTCCAA
AGACCACAAATACGTCGCGGCCCTGGTGATGGCCGGCGACGGCGAACCCCAATCGCTCTACGTGCGCGAGGCGGGCGAGT
GGCTGCCGCTGCTCAAGCCGCGCGAAGGAGTAATTGCCGGCACTTTCCTGGGGGAACGCATTCTGGTGATTGCCACCGGC
GGCTCGCCGCGCGGCCGGGTGGTCGTCGTCGAAGGGGGCACCTTCCGGACGCTGGTGCGCGAGGGCGACTGGGCGATGCG
CGACATCGCCCCGCTCAGGGAGGGCTTTTTGGTCACTGAGGTCTGGGGAGCCGACTGGCGGGTGCGCCAGTTCGACAAAG
ACGGCCGGTTCGTGCGCGCGCTCCCGCTCCCGGCAAGCGGCATCGGCATCGATGCGGTTGCCTCGGACGAGCGCTCGTCC
GAGGCGATCGTGGCCTACTCGGGCTGGAGCGAGCCGGGCCGCTGGATGCGCTACGACGGTGCCACCGGCAAGTCGAACGA
AATTTTTGCCCTCAAGGCGGCGGCGGACTACGCCGGTGTAGAGGCCACCAAAATCGAAGCGCTTTCTAAAGACGGCACCC
GCGTGCCGGTGACAGTGTTGGCCCGTCGCGGCACGATCCCCGACGGCACCGCCCCGGCCATTCTTTACGGCTACGGCGGC
TACGGCATCAGTGTGCGGCCGACATTTTCGGGGGCGAATCTGGCCTGGATCGAGCGGGGCGGCGTCTACGCGGTGGCCAA
TCTGCGCGGCGGCGGCGAATTTGGCGAACAGTGGCACCTGGACGGCCGGCTCACCCGCAAGCAAAACGTCTTCGACGATT
TTGTCGCGGCGGCCGAGGCGCTGGTGCAGACGCGCTGGGTTGCCCCCAACAAATTGGGCATCCTGGGCGGCAGCAACGGC
GGCTTATTGGTGGGAGCGGCCCTCACCCAGCGGCCCGAACTGTTTCGAGCAGCGGTCGGCCAGGTGGGCATCTACGACAT
GCTGCGCGTCGAGTTGCACCCGAACGGCGCTTTCAACGTCACCGAGTTTGGGACGGTCGAAAATCCCGACCAGTTCGCCG
CCCTGTACGCCTACTCGCCTTTGCACCGGGTCAAAGACGGCACCGCCTACCCGGCTGTGCTGCTGCTGACCGGCGAGAAC
GACCCGCGCGTGGACGCTTACCAGTCGCGCAAGATGGCCGCGCGGCTGCAGGCGGCCACCCGCTCGGACCACCCGGTGGC
GCTGATTACCCGCCGCGCCGCAGGCCATGGCGTCGGTGCGTCATTTAGCCAGCGCACCGGCGACCGCGCCGCTGCGCTGA
TCTTCTTTGCGGGCGAACTGGGGCTACCGTGA

Upstream 100 bases:

>100_bases
GGGGTGCCGCCGAGGTCGAAGCGACGGTCACTTTGCAAATTAGCTATTGAATACGCTCGGAAGCTGCCAGAATAACTAGC
GGTTGTGTTGCAAGGAAGAT

Downstream 100 bases:

>100_bases
GCTTTCTTCAGACGGCTGTTCAAAGATGCCGGGGTTCGGCTGGAAAATCCAGTTGCAGTGCCTCCCAGTCGGCCAAGGCA
AATTGCCCGGCTACAGCGCT

Product: prolyl endopeptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MGSFRLMGTGAWPGALFALVLILSGGGVLATDSVTPPPAARTAPATGTYGAVKVEDPYRWLEKAASPEVQGWIDAQNAYA
EKVLSRYPGREKMAARVRELSLTSEQRSKPHLAGGRLFYLRLTPPQEQPVLISQSWPTGTARVLVDPNRAGGLTAVTEFW
PSPSGRYVAYGTADKGTEDTVIRVVDARTGRPLPEVLRRAGGGTTPSALAWDADEKGFIYTRFPVDSVAPFNVALFHHRL
GTPASQDKLHFGAGLSPYAEYALIASKDHKYVAALVMAGDGEPQSLYVREAGEWLPLLKPREGVIAGTFLGERILVIATG
GSPRGRVVVVEGGTFRTLVREGDWAMRDIAPLREGFLVTEVWGADWRVRQFDKDGRFVRALPLPASGIGIDAVASDERSS
EAIVAYSGWSEPGRWMRYDGATGKSNEIFALKAAADYAGVEATKIEALSKDGTRVPVTVLARRGTIPDGTAPAILYGYGG
YGISVRPTFSGANLAWIERGGVYAVANLRGGGEFGEQWHLDGRLTRKQNVFDDFVAAAEALVQTRWVAPNKLGILGGSNG
GLLVGAALTQRPELFRAAVGQVGIYDMLRVELHPNGAFNVTEFGTVENPDQFAALYAYSPLHRVKDGTAYPAVLLLTGEN
DPRVDAYQSRKMAARLQAATRSDHPVALITRRAAGHGVGASFSQRTGDRAAALIFFAGELGLP

Sequences:

>Translated_703_residues
MGSFRLMGTGAWPGALFALVLILSGGGVLATDSVTPPPAARTAPATGTYGAVKVEDPYRWLEKAASPEVQGWIDAQNAYA
EKVLSRYPGREKMAARVRELSLTSEQRSKPHLAGGRLFYLRLTPPQEQPVLISQSWPTGTARVLVDPNRAGGLTAVTEFW
PSPSGRYVAYGTADKGTEDTVIRVVDARTGRPLPEVLRRAGGGTTPSALAWDADEKGFIYTRFPVDSVAPFNVALFHHRL
GTPASQDKLHFGAGLSPYAEYALIASKDHKYVAALVMAGDGEPQSLYVREAGEWLPLLKPREGVIAGTFLGERILVIATG
GSPRGRVVVVEGGTFRTLVREGDWAMRDIAPLREGFLVTEVWGADWRVRQFDKDGRFVRALPLPASGIGIDAVASDERSS
EAIVAYSGWSEPGRWMRYDGATGKSNEIFALKAAADYAGVEATKIEALSKDGTRVPVTVLARRGTIPDGTAPAILYGYGG
YGISVRPTFSGANLAWIERGGVYAVANLRGGGEFGEQWHLDGRLTRKQNVFDDFVAAAEALVQTRWVAPNKLGILGGSNG
GLLVGAALTQRPELFRAAVGQVGIYDMLRVELHPNGAFNVTEFGTVENPDQFAALYAYSPLHRVKDGTAYPAVLLLTGEN
DPRVDAYQSRKMAARLQAATRSDHPVALITRRAAGHGVGASFSQRTGDRAAALIFFAGELGLP
>Mature_702_residues
GSFRLMGTGAWPGALFALVLILSGGGVLATDSVTPPPAARTAPATGTYGAVKVEDPYRWLEKAASPEVQGWIDAQNAYAE
KVLSRYPGREKMAARVRELSLTSEQRSKPHLAGGRLFYLRLTPPQEQPVLISQSWPTGTARVLVDPNRAGGLTAVTEFWP
SPSGRYVAYGTADKGTEDTVIRVVDARTGRPLPEVLRRAGGGTTPSALAWDADEKGFIYTRFPVDSVAPFNVALFHHRLG
TPASQDKLHFGAGLSPYAEYALIASKDHKYVAALVMAGDGEPQSLYVREAGEWLPLLKPREGVIAGTFLGERILVIATGG
SPRGRVVVVEGGTFRTLVREGDWAMRDIAPLREGFLVTEVWGADWRVRQFDKDGRFVRALPLPASGIGIDAVASDERSSE
AIVAYSGWSEPGRWMRYDGATGKSNEIFALKAAADYAGVEATKIEALSKDGTRVPVTVLARRGTIPDGTAPAILYGYGGY
GISVRPTFSGANLAWIERGGVYAVANLRGGGEFGEQWHLDGRLTRKQNVFDDFVAAAEALVQTRWVAPNKLGILGGSNGG
LLVGAALTQRPELFRAAVGQVGIYDMLRVELHPNGAFNVTEFGTVENPDQFAALYAYSPLHRVKDGTAYPAVLLLTGEND
PRVDAYQSRKMAARLQAATRSDHPVALITRRAAGHGVGASFSQRTGDRAAALIFFAGELGLP

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=712, Percent_Identity=31.1797752808989, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI284172438, Length=275, Percent_Identity=29.8181818181818, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI284172431, Length=275, Percent_Identity=29.8181818181818, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI284172420, Length=275, Percent_Identity=29.8181818181818, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI284172413, Length=275, Percent_Identity=29.8181818181818, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI70778815, Length=275, Percent_Identity=29.8181818181818, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI108860686, Length=239, Percent_Identity=30.5439330543933, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI108860692, Length=199, Percent_Identity=31.6582914572864, Blast_Score=96, Evalue=9e-20,
Organism=Escherichia coli, GI1788150, Length=681, Percent_Identity=27.4596182085169, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24583414, Length=716, Percent_Identity=31.4245810055866, Blast_Score=305, Evalue=8e-83,
Organism=Drosophila melanogaster, GI221510989, Length=700, Percent_Identity=29.2857142857143, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 75430; Mature: 75299

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSFRLMGTGAWPGALFALVLILSGGGVLATDSVTPPPAARTAPATGTYGAVKVEDPYRW
CCCEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCHHHH
LEKAASPEVQGWIDAQNAYAEKVLSRYPGREKMAARVRELSLTSEQRSKPHLAGGRLFYL
HHHHCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEE
RLTPPQEQPVLISQSWPTGTARVLVDPNRAGGLTAVTEFWPSPSGRYVAYGTADKGTEDT
EECCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEHHHCCCCCCCEEEEECCCCCCCCE
VIRVVDARTGRPLPEVLRRAGGGTTPSALAWDADEKGFIYTRFPVDSVAPFNVALFHHRL
EEEEEECCCCCCHHHHHHHCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCEEEEEEHHC
GTPASQDKLHFGAGLSPYAEYALIASKDHKYVAALVMAGDGEPQSLYVREAGEWLPLLKP
CCCCCCCCEEECCCCCHHHCEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCC
REGVIAGTFLGERILVIATGGSPRGRVVVVEGGTFRTLVREGDWAMRDIAPLREGFLVTE
CCCEEEEEECCCEEEEEEECCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCEEEEE
VWGADWRVRQFDKDGRFVRALPLPASGIGIDAVASDERSSEAIVAYSGWSEPGRWMRYDG
ECCCCCEEEEECCCCCEEEEECCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCEEEECC
ATGKSNEIFALKAAADYAGVEATKIEALSKDGTRVPVTVLARRGTIPDGTAPAILYGYGG
CCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEECC
YGISVRPTFSGANLAWIERGGVYAVANLRGGGEFGEQWHLDGRLTRKQNVFDDFVAAAEA
CEEEEEECCCCCCEEEEECCCEEEEEEECCCCCCCCEEECCCEECCHHHHHHHHHHHHHH
LVQTRWVAPNKLGILGGSNGGLLVGAALTQRPELFRAAVGQVGIYDMLRVELHPNGAFNV
HHHHHCCCCCCEEEEECCCCCEEEEEHHHCCHHHHHHHHCCCCCEEEEEEEECCCCCCCE
TEFGTVENPDQFAALYAYSPLHRVKDGTAYPAVLLLTGENDPRVDAYQSRKMAARLQAAT
EECCCCCCCHHEEEEEEECCHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHC
RSDHPVALITRRAAGHGVGASFSQRTGDRAAALIFFAGELGLP
CCCCCEEEEEECCCCCCCCCCHHHCCCCCEEEEEEEECCCCCC
>Mature Secondary Structure 
GSFRLMGTGAWPGALFALVLILSGGGVLATDSVTPPPAARTAPATGTYGAVKVEDPYRW
CCEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCHHHH
LEKAASPEVQGWIDAQNAYAEKVLSRYPGREKMAARVRELSLTSEQRSKPHLAGGRLFYL
HHHHCCCCCEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEE
RLTPPQEQPVLISQSWPTGTARVLVDPNRAGGLTAVTEFWPSPSGRYVAYGTADKGTEDT
EECCCCCCCEEEECCCCCCCEEEEECCCCCCCCEEEHHHCCCCCCCEEEEECCCCCCCCE
VIRVVDARTGRPLPEVLRRAGGGTTPSALAWDADEKGFIYTRFPVDSVAPFNVALFHHRL
EEEEEECCCCCCHHHHHHHCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCEEEEEEHHC
GTPASQDKLHFGAGLSPYAEYALIASKDHKYVAALVMAGDGEPQSLYVREAGEWLPLLKP
CCCCCCCCEEECCCCCHHHCEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCC
REGVIAGTFLGERILVIATGGSPRGRVVVVEGGTFRTLVREGDWAMRDIAPLREGFLVTE
CCCEEEEEECCCEEEEEEECCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCEEEEE
VWGADWRVRQFDKDGRFVRALPLPASGIGIDAVASDERSSEAIVAYSGWSEPGRWMRYDG
ECCCCCEEEEECCCCCEEEEECCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCEEEECC
ATGKSNEIFALKAAADYAGVEATKIEALSKDGTRVPVTVLARRGTIPDGTAPAILYGYGG
CCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEECC
YGISVRPTFSGANLAWIERGGVYAVANLRGGGEFGEQWHLDGRLTRKQNVFDDFVAAAEA
CEEEEEECCCCCCEEEEECCCEEEEEEECCCCCCCCEEECCCEECCHHHHHHHHHHHHHH
LVQTRWVAPNKLGILGGSNGGLLVGAALTQRPELFRAAVGQVGIYDMLRVELHPNGAFNV
HHHHHCCCCCCEEEEECCCCCEEEEEHHHCCHHHHHHHHCCCCCEEEEEEEECCCCCCCE
TEFGTVENPDQFAALYAYSPLHRVKDGTAYPAVLLLTGENDPRVDAYQSRKMAARLQAAT
EECCCCCCCHHEEEEEEECCHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHC
RSDHPVALITRRAAGHGVGASFSQRTGDRAAALIFFAGELGLP
CCCCCEEEEEECCCCCCCCCCHHHCCCCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]