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The map label for this gene is argF

Identifier: 37522670

GI number: 37522670

Start: 3302357

End: 3303298

Strand: Reverse

Name: argF

Synonym: gvip429

Alternate gene names: 37522670

Gene position: 3303298-3302357 (Counterclockwise)

Preceding gene: 37522671

Following gene: 37522669

Centisome position: 70.9

GC content: 66.35

Gene sequence:

>942_bases
ATGAGCGCGAGTCTGGGTGCGACGCGCTTCAGGCCGGATCTGCTGAGTCTCGACGACCTCGACGAAGCGCAATTGCACGC
GCTTCTGACCCTCGCCCACCAGCTCAAGCGCGGCGAGCGGGTGGCGAACCTGCACGGCAAAGTGCTGGGGTTGGTGTTTC
TCAAAGCCTCCACCCGCACCCGCGTCTCGTTTACGGTCGCGATGTACCAGTTGGGTGGCCAGGTGATCGACCTCAGTCCC
AGCAACACCCAGGTGGGCCGGGGCGAACCGGTGCGCGACACCGCCCGCGTCCTGGGCCGCTATGTCGACGGTCTCGCCAT
TCGCACCTTCGCCCAGACGGAACTGGAGGAGTACGCCCACTACGCGGGGATCCCGGTCATCAACGCCCTCACCGACCACG
AGCACCCCTGCCAGGTCGTGGCGGACCTGCTCACTATCCGCGAGAATTTTGGGCGGCTTGCCGGGCTCAAGCTCGCCTAC
GTGGGCGACGGCAACAATGTCGCCCACTCGCTGCTGTTGGGTTGCGCCAAGGTGGGCATGTCGATCGCGGTCGCCACTCC
CGAGGGTTTTACCCCTGACCCGGCCGTGAGTGCGCGCGCCAGTGAAATTGCTGGGCGCACCGGTGCCGAGGTGCAGATCC
TGCGCGACCCGTTCGAGGCGGCCCGGGGGGCGCACATCCTCTATACCGACGTCTGGACGAGTATGGGCCAGGAGGCCGAG
ACCCAGCACCGGTTGCAATTATTCGAGCAATACCAGATCAACGCGGCGCTGCTGAACTGCGCCGCAGCGGAGGCGATCGT
GCTGCACTGCCTGCCTGCCCACCGGGGTGAGGAGATCACCGACGAAGTCATGGAAGGCCCCCGCTCGCGCATCTGGGATG
AGGCCGAAAACCGGCTGCACGCCCAGAAGGCGGTACTCGCAGCGCTGATGGGCGGCCGGTAG

Upstream 100 bases:

>100_bases
CCGGGATGCCCGTCGAGCAGGTGGTGGCGGCGGCCGGCAAACCTTTCCCTGCCGAGCGCCAGCCGGTGGCCGCCGAGAAC
CAGACGCCGGTGGCGACGCC

Downstream 100 bases:

>100_bases
TTGCAGGCAAGCGGATGAGTGATGTGGACGGCACGGCGATTGTCATTTGCGACGGCCTCTATGCCACCGGCAGCGGCAAG
ACGGCCCACGGCCTGGTGCG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSASLGATRFRPDLLSLDDLDEAQLHALLTLAHQLKRGERVANLHGKVLGLVFLKASTRTRVSFTVAMYQLGGQVIDLSP
SNTQVGRGEPVRDTARVLGRYVDGLAIRTFAQTELEEYAHYAGIPVINALTDHEHPCQVVADLLTIRENFGRLAGLKLAY
VGDGNNVAHSLLLGCAKVGMSIAVATPEGFTPDPAVSARASEIAGRTGAEVQILRDPFEAARGAHILYTDVWTSMGQEAE
TQHRLQLFEQYQINAALLNCAAAEAIVLHCLPAHRGEEITDEVMEGPRSRIWDEAENRLHAQKAVLAALMGGR

Sequences:

>Translated_313_residues
MSASLGATRFRPDLLSLDDLDEAQLHALLTLAHQLKRGERVANLHGKVLGLVFLKASTRTRVSFTVAMYQLGGQVIDLSP
SNTQVGRGEPVRDTARVLGRYVDGLAIRTFAQTELEEYAHYAGIPVINALTDHEHPCQVVADLLTIRENFGRLAGLKLAY
VGDGNNVAHSLLLGCAKVGMSIAVATPEGFTPDPAVSARASEIAGRTGAEVQILRDPFEAARGAHILYTDVWTSMGQEAE
TQHRLQLFEQYQINAALLNCAAAEAIVLHCLPAHRGEEITDEVMEGPRSRIWDEAENRLHAQKAVLAALMGGR
>Mature_312_residues
SASLGATRFRPDLLSLDDLDEAQLHALLTLAHQLKRGERVANLHGKVLGLVFLKASTRTRVSFTVAMYQLGGQVIDLSPS
NTQVGRGEPVRDTARVLGRYVDGLAIRTFAQTELEEYAHYAGIPVINALTDHEHPCQVVADLLTIRENFGRLAGLKLAYV
GDGNNVAHSLLLGCAKVGMSIAVATPEGFTPDPAVSARASEIAGRTGAEVQILRDPFEAARGAHILYTDVWTSMGQEAET
QHRLQLFEQYQINAALLNCAAAEAIVLHCLPAHRGEEITDEVMEGPRSRIWDEAENRLHAQKAVLAALMGGR

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=303, Percent_Identity=41.2541254125413, Blast_Score=248, Evalue=4e-66,
Organism=Homo sapiens, GI18105007, Length=308, Percent_Identity=31.1688311688312, Blast_Score=118, Evalue=6e-27,
Organism=Escherichia coli, GI1786469, Length=329, Percent_Identity=39.209726443769, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1790703, Length=328, Percent_Identity=38.4146341463415, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI2367364, Length=311, Percent_Identity=31.1897106109325, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI48994908, Length=347, Percent_Identity=27.0893371757925, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193204318, Length=325, Percent_Identity=29.8461538461538, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322373, Length=319, Percent_Identity=32.6018808777429, Blast_Score=197, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6322331, Length=310, Percent_Identity=30.6451612903226, Blast_Score=109, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24642586, Length=316, Percent_Identity=30.379746835443, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_GLOVI (Q7NGR7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926047.1
- PDB:   3GD5
- PDBsum:   3GD5
- ProteinModelPortal:   Q7NGR7
- SMR:   Q7NGR7
- GeneID:   2601502
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.3101
- HOGENOM:   HBG579429
- OMA:   FTVAMYQ
- ProtClustDB:   PRK00779
- BioCyc:   GVIO251221:GLL3101-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 33958; Mature: 33827

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 108-108 BINDING 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASLGATRFRPDLLSLDDLDEAQLHALLTLAHQLKRGERVANLHGKVLGLVFLKASTRT
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHEEHHEEECCCCC
RVSFTVAMYQLGGQVIDLSPSNTQVGRGEPVRDTARVLGRYVDGLAIRTFAQTELEEYAH
EEHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAGIPVINALTDHEHPCQVVADLLTIRENFGRLAGLKLAYVGDGNNVAHSLLLGCAKVGM
HCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHCC
SIAVATPEGFTPDPAVSARASEIAGRTGAEVQILRDPFEAARGAHILYTDVWTSMGQEAE
EEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHCCCEEEEEHHHHHCCCHHH
TQHRLQLFEQYQINAALLNCAAAEAIVLHCLPAHRGEEITDEVMEGPRSRIWDEAENRLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHH
AQKAVLAALMGGR
HHHHHHHHHHCCC
>Mature Secondary Structure 
SASLGATRFRPDLLSLDDLDEAQLHALLTLAHQLKRGERVANLHGKVLGLVFLKASTRT
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHEEHHEEECCCCC
RVSFTVAMYQLGGQVIDLSPSNTQVGRGEPVRDTARVLGRYVDGLAIRTFAQTELEEYAH
EEHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAGIPVINALTDHEHPCQVVADLLTIRENFGRLAGLKLAYVGDGNNVAHSLLLGCAKVGM
HCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHCC
SIAVATPEGFTPDPAVSARASEIAGRTGAEVQILRDPFEAARGAHILYTDVWTSMGQEAE
EEEEECCCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHHHHCCCEEEEEHHHHHCCCHHH
TQHRLQLFEQYQINAALLNCAAAEAIVLHCLPAHRGEEITDEVMEGPRSRIWDEAENRLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHH
AQKAVLAALMGGR
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292