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The map label for this gene is 37522660

Identifier: 37522660

GI number: 37522660

Start: 3295372

End: 3296406

Strand: Direct

Name: 37522660

Synonym: glr3091

Alternate gene names: NA

Gene position: 3295372-3296406 (Clockwise)

Preceding gene: 37522659

Following gene: 37522661

Centisome position: 70.73

GC content: 63.57

Gene sequence:

>1035_bases
ATGCTGCTGGGGTTCGCCTGGATGGAGTTGTTCGTCGAGTCGGCACAGGCGAGCGCCAATCGCCTCTGCGCCCAGATGGG
CTTTACCCCGGTGGGCTGCTTCGAGGATTGTAATACTTTTAGTCTTGCGATACGCAATGGCGGTGCGCTGCTGGTGGTGA
GCGAGGCGCTTGGAGCGACCGGTCCGGTGCAGCGGTACCTCGATGGCCACCCCCAGGGGATCGCCGATGTCGCTTTTTGG
ACGGAAGCGTTTCCGGGTGGCCCCGGCGCTCTCCCCGGTCGCCTGCCCGCCACCGGACAAATCGTGGGGCCGGCGGGGAT
CACCCATACGTTCGCGCCTCCCCAGCCGGGCGATCTGCCGCCGGGTTTTCTTCCCCTGCCGGGCGCCGCGCTGCGCCGCG
AGCTGGCTGGGATCGACCACGTCGTGCTCAACCTCGGCACCGAAGCCTTCGAGCCTGCCATCCACTGGTACCGGCAGGTG
CTTGGGCTCGAAGCGAGCCGCTACTTTGAAATTTCCACCCCCCACTCGGCCCTCAAAAGCTGGGTACTCACCGACTCTGC
CCATCGCGTGCGCCTGCCGCTGAATGCCCCGCTGACTGCCAACTCCCAGGTGAGCGAATTTCTGGAGGCCAACGGTGGCC
CGGGAGTGCAGCATATTGCCCTACGCACGACGAATATTGCCCACACGGTCGACCACCTGCGCACCCTGGGGGTGGAATTT
CTCGACGCCCCGGCTACCTACTTCGAGCGCCTTGGAGATCGCGTCGATCTGGCCGGTCTGGACATGGAGACCTTGCGCCG
ATTGCACATCCTCGTCGACCAGGACGAAAGCGAAGGACGAATCTTGCAAATATTTACCCGACCGCTGTTCGCGGAGCCGA
CCTTGTTCTTCGAATTTATCGAGCGCCAGGGAACAGCCCTCGGCTTCGGCGAAGGTAACTTTCAGTCGCTTTTTGAAGCA
ATCGAACGGGAGCAGCAGTCGCGCGGCACCCTGGAGGCAGAGCGCAAACCCGCCTTCGTGCAGGACGCGCTATAG

Upstream 100 bases:

>100_bases
CGGTAATCAAAGGCGCGCTCGCCATGCAGTTGATGCGGCGCAGCTACGCGCGGGGGCTGGTGCGCTTCGGCGTGTTCGCG
GCCCAAAAGGCGGAGGGATA

Downstream 100 bases:

>100_bases
AAATCTGGGGTAAGAGTGTCGCTGCCGCTACACAAGCTGAAATCACTGTGCCGACGGTCGACGGCTTGATCACCGCAACA
GCCGCCCGCCACGGTCTGGC

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLLGFAWMELFVESAQASANRLCAQMGFTPVGCFEDCNTFSLAIRNGGALLVVSEALGATGPVQRYLDGHPQGIADVAFW
TEAFPGGPGALPGRLPATGQIVGPAGITHTFAPPQPGDLPPGFLPLPGAALRRELAGIDHVVLNLGTEAFEPAIHWYRQV
LGLEASRYFEISTPHSALKSWVLTDSAHRVRLPLNAPLTANSQVSEFLEANGGPGVQHIALRTTNIAHTVDHLRTLGVEF
LDAPATYFERLGDRVDLAGLDMETLRRLHILVDQDESEGRILQIFTRPLFAEPTLFFEFIERQGTALGFGEGNFQSLFEA
IEREQQSRGTLEAERKPAFVQDAL

Sequences:

>Translated_344_residues
MLLGFAWMELFVESAQASANRLCAQMGFTPVGCFEDCNTFSLAIRNGGALLVVSEALGATGPVQRYLDGHPQGIADVAFW
TEAFPGGPGALPGRLPATGQIVGPAGITHTFAPPQPGDLPPGFLPLPGAALRRELAGIDHVVLNLGTEAFEPAIHWYRQV
LGLEASRYFEISTPHSALKSWVLTDSAHRVRLPLNAPLTANSQVSEFLEANGGPGVQHIALRTTNIAHTVDHLRTLGVEF
LDAPATYFERLGDRVDLAGLDMETLRRLHILVDQDESEGRILQIFTRPLFAEPTLFFEFIERQGTALGFGEGNFQSLFEA
IEREQQSRGTLEAERKPAFVQDAL
>Mature_344_residues
MLLGFAWMELFVESAQASANRLCAQMGFTPVGCFEDCNTFSLAIRNGGALLVVSEALGATGPVQRYLDGHPQGIADVAFW
TEAFPGGPGALPGRLPATGQIVGPAGITHTFAPPQPGDLPPGFLPLPGAALRRELAGIDHVVLNLGTEAFEPAIHWYRQV
LGLEASRYFEISTPHSALKSWVLTDSAHRVRLPLNAPLTANSQVSEFLEANGGPGVQHIALRTTNIAHTVDHLRTLGVEF
LDAPATYFERLGDRVDLAGLDMETLRRLHILVDQDESEGRILQIFTRPLFAEPTLFFEFIERQGTALGFGEGNFQSLFEA
IEREQQSRGTLEAERKPAFVQDAL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=371, Percent_Identity=33.6927223719677, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI285002264, Length=347, Percent_Identity=34.2939481268012, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI14249394, Length=372, Percent_Identity=28.494623655914, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17555220, Length=373, Percent_Identity=33.7801608579088, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17550752, Length=359, Percent_Identity=30.9192200557103, Blast_Score=158, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24667510, Length=370, Percent_Identity=33.7837837837838, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21356105, Length=242, Percent_Identity=40.9090909090909, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 37392; Mature: 37392

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLGFAWMELFVESAQASANRLCAQMGFTPVGCFEDCNTFSLAIRNGGALLVVSEALGAT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCEEEEEEHHHCCC
GPVQRYLDGHPQGIADVAFWTEAFPGGPGALPGRLPATGQIVGPAGITHTFAPPQPGDLP
CCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCC
PGFLPLPGAALRRELAGIDHVVLNLGTEAFEPAIHWYRQVLGLEASRYFEISTPHSALKS
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHH
WVLTDSAHRVRLPLNAPLTANSQVSEFLEANGGPGVQHIALRTTNIAHTVDHLRTLGVEF
HHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHH
LDAPATYFERLGDRVDLAGLDMETLRRLHILVDQDESEGRILQIFTRPLFAEPTLFFEFI
HCCHHHHHHHCCCCEEECCCCHHHHHHHHHEECCCCCCCCEEEEECCCCCCCHHHHHHHH
ERQGTALGFGEGNFQSLFEAIEREQQSRGTLEAERKPAFVQDAL
HHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MLLGFAWMELFVESAQASANRLCAQMGFTPVGCFEDCNTFSLAIRNGGALLVVSEALGAT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCEEEEEEHHHCCC
GPVQRYLDGHPQGIADVAFWTEAFPGGPGALPGRLPATGQIVGPAGITHTFAPPQPGDLP
CCHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCC
PGFLPLPGAALRRELAGIDHVVLNLGTEAFEPAIHWYRQVLGLEASRYFEISTPHSALKS
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHEEEECCCHHHHHH
WVLTDSAHRVRLPLNAPLTANSQVSEFLEANGGPGVQHIALRTTNIAHTVDHLRTLGVEF
HHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHH
LDAPATYFERLGDRVDLAGLDMETLRRLHILVDQDESEGRILQIFTRPLFAEPTLFFEFI
HCCHHHHHHHCCCCEEECCCCHHHHHHHHHEECCCCCCCCEEEEECCCCCCCHHHHHHHH
ERQGTALGFGEGNFQSLFEAIEREQQSRGTLEAERKPAFVQDAL
HHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]