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The map label for this gene is icd [H]

Identifier: 37522657

GI number: 37522657

Start: 3292173

End: 3293252

Strand: Reverse

Name: icd [H]

Synonym: gvip428

Alternate gene names: 37522657

Gene position: 3293252-3292173 (Counterclockwise)

Preceding gene: 37522666

Following gene: 37522654

Centisome position: 70.69

GC content: 65.09

Gene sequence:

>1080_bases
GTGTCCCCATATCGTGTCACACTGATCCGCGGCGATGGGATCGGCCCGGAAGTGACGCAGGCAGCCCGGATCGTGCTCGA
CGCCACCGGGATCGACTTTGAGTGGGTCGTGGTCGATGCCGGCGCCGAGGTGATGGAGAAGTCCGGCACACCCCTTCCGG
CCCCAGTGATCGAAGCGGTGCGCGCGAGCGACGCCGCCATCAAAGGCCCGATCACCACCCCCGCAGGTTCGGGCATCCGT
TCGGTCAACGTCGCCTTGCGTCGGGCCCTCGACTTGTACGCCAACCTGCGCCCGGCCCGCACCCTGCCCGGGGTGCACTC
GCGCTACGACAATATCGATCTGGTGGTCGTGCGCGAAAATACCGAGGACCTCTACAGCGGCATCGAGTTTGAAAAAAATT
CTCCCCAGGCTCTTGAAGTAATCGAGATGCTCATGCGCCTGGGCGGCAAAAAAATCTTTCCAAGATCCGGCCTTGCGGTC
AAACCAATCTCCAGCGAGGCGAGCGAGCGGATCGCCCGCTTCGCCTTCGAGTACGCCCGCCGCCACGCCCGCCGCAAAGT
TACCGCCGTCCACAAGGCGAATATCTTGAAGCACACCGACGGTCTGTTTCTGGAGGCTGCCCGCCAGGTGGCTTCGGAGT
ATCCGGATGTCGAGTTTGAAGATCGGATCGTGGACAACCTTTGCATGCAACTCGTCCAGAGGCCGGAATCCTACGACGTC
CTGGTGCTGCCCAACCTCTATGGCGATATCGTCTCGGATCTGACCGCCGGGCTGGTGGGCGGTCTCGGGGTGGCGCCGGG
GGCCAATATCGGCGATCGCAGCGCCGTCTTCGAAGCGATCCACGGCTCGGCGCCGCGCTACGCCGGTCAGAACAAGGTCA
ATCCCTCGGCACTCATCCTGAGCGGCGCGCTGTTGCTTCGGCACCTGGGCGAGCAGGAGGCCGCCGTGCGCGTCGAGCAG
GCCGTGGCCGCCGTGATCGCCGAAGGCCGCAGCGTTACCTACGACCTGGCCCCGGCGGGAGCGACCCCCGCCGGTACCCG
CCAGATGGCCGAGGCGATTGCCCAGAAGGTAGCGGGCTGA

Upstream 100 bases:

>100_bases
CGGGGTTGAAAAATGCCGCCCCCTGGGACTGCCGGGTCATCTTCAGGAGCGGTATCGTATGGGGGCGTTCTTAACTCTGT
AGAATTGCGGGAGTTCGTCC

Downstream 100 bases:

>100_bases
GGAGGGTCAGCGGGCGATCCGCAGGGAGTCGGTCTGGGAGGCGAGCGGATTGTCCGGCAACACAAAGAGCAGCCCCGCAT
CCGAGGGGGAGGCTCCGGCA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSPYRVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRASDAAIKGPITTPAGSGIR
SVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTEDLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAV
KPISSEASERIARFAFEYARRHARRKVTAVHKANILKHTDGLFLEAARQVASEYPDVEFEDRIVDNLCMQLVQRPESYDV
LVLPNLYGDIVSDLTAGLVGGLGVAPGANIGDRSAVFEAIHGSAPRYAGQNKVNPSALILSGALLLRHLGEQEAAVRVEQ
AVAAVIAEGRSVTYDLAPAGATPAGTRQMAEAIAQKVAG

Sequences:

>Translated_359_residues
MSPYRVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRASDAAIKGPITTPAGSGIR
SVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTEDLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAV
KPISSEASERIARFAFEYARRHARRKVTAVHKANILKHTDGLFLEAARQVASEYPDVEFEDRIVDNLCMQLVQRPESYDV
LVLPNLYGDIVSDLTAGLVGGLGVAPGANIGDRSAVFEAIHGSAPRYAGQNKVNPSALILSGALLLRHLGEQEAAVRVEQ
AVAAVIAEGRSVTYDLAPAGATPAGTRQMAEAIAQKVAG
>Mature_358_residues
SPYRVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAVRASDAAIKGPITTPAGSGIRS
VNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVRENTEDLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVK
PISSEASERIARFAFEYARRHARRKVTAVHKANILKHTDGLFLEAARQVASEYPDVEFEDRIVDNLCMQLVQRPESYDVL
VLPNLYGDIVSDLTAGLVGGLGVAPGANIGDRSAVFEAIHGSAPRYAGQNKVNPSALILSGALLLRHLGEQEAAVRVEQA
VAAVIAEGRSVTYDLAPAGATPAGTRQMAEAIAQKVAG

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=332, Percent_Identity=43.0722891566265, Blast_Score=285, Evalue=5e-77,
Organism=Homo sapiens, GI28178821, Length=311, Percent_Identity=42.443729903537, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI28178816, Length=311, Percent_Identity=42.443729903537, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI4758582, Length=344, Percent_Identity=40.9883720930233, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI28178838, Length=326, Percent_Identity=42.0245398773006, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI28178819, Length=153, Percent_Identity=53.5947712418301, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1787381, Length=366, Percent_Identity=42.0765027322404, Blast_Score=262, Evalue=2e-71,
Organism=Escherichia coli, GI87081683, Length=376, Percent_Identity=35.6382978723404, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1788101, Length=383, Percent_Identity=33.6814621409922, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71986051, Length=343, Percent_Identity=46.9387755102041, Blast_Score=317, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI25144293, Length=339, Percent_Identity=41.0029498525074, Blast_Score=237, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17550882, Length=346, Percent_Identity=39.5953757225434, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17505779, Length=337, Percent_Identity=39.7626112759644, Blast_Score=221, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6324709, Length=358, Percent_Identity=40.2234636871508, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6324291, Length=356, Percent_Identity=39.6067415730337, Blast_Score=245, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6322097, Length=352, Percent_Identity=37.5, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319830, Length=387, Percent_Identity=29.1989664082687, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24643270, Length=332, Percent_Identity=43.6746987951807, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24643268, Length=332, Percent_Identity=43.6746987951807, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24661184, Length=341, Percent_Identity=39.2961876832845, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI161078635, Length=347, Percent_Identity=37.463976945245, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI161078633, Length=347, Percent_Identity=37.463976945245, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24650122, Length=347, Percent_Identity=37.463976945245, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI161078637, Length=347, Percent_Identity=37.463976945245, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI281362242, Length=349, Percent_Identity=39.8280802292264, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24648872, Length=349, Percent_Identity=39.8280802292264, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI161078639, Length=343, Percent_Identity=37.3177842565598, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI20130355, Length=325, Percent_Identity=30.4615384615385, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45550436, Length=229, Percent_Identity=24.4541484716157, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 38390; Mature: 38259

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPYRVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAV
CCCEEEEEEECCCCCHHHHHHHHHEEEECCCCEEEEEEECCHHHHHCCCCCCCHHHHHHH
RASDAAIKGPITTPAGSGIRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVREN
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEEECC
TEDLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVKPISSEASERIARFAFEYAR
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCEECCCCHHHHHHHHHHHHHHHH
RHARRKVTAVHKANILKHTDGLFLEAARQVASEYPDVEFEDRIVDNLCMQLVQRPESYDV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCE
LVLPNLYGDIVSDLTAGLVGGLGVAPGANIGDRSAVFEAIHGSAPRYAGQNKVNPSALIL
EECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
SGALLLRHLGEQEAAVRVEQAVAAVIAEGRSVTYDLAPAGATPAGTRQMAEAIAQKVAG
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPYRVTLIRGDGIGPEVTQAARIVLDATGIDFEWVVVDAGAEVMEKSGTPLPAPVIEAV
CCEEEEEEECCCCCHHHHHHHHHEEEECCCCEEEEEEECCHHHHHCCCCCCCHHHHHHH
RASDAAIKGPITTPAGSGIRSVNVALRRALDLYANLRPARTLPGVHSRYDNIDLVVVREN
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEEECC
TEDLYSGIEFEKNSPQALEVIEMLMRLGGKKIFPRSGLAVKPISSEASERIARFAFEYAR
HHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCEECCCCHHHHHHHHHHHHHHHH
RHARRKVTAVHKANILKHTDGLFLEAARQVASEYPDVEFEDRIVDNLCMQLVQRPESYDV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCE
LVLPNLYGDIVSDLTAGLVGGLGVAPGANIGDRSAVFEAIHGSAPRYAGQNKVNPSALIL
EECCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
SGALLLRHLGEQEAAVRVEQAVAAVIAEGRSVTYDLAPAGATPAGTRQMAEAIAQKVAG
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9325430; 9389475 [H]