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The map label for this gene is hutH

Identifier: 37522635

GI number: 37522635

Start: 3261206

End: 3262750

Strand: Direct

Name: hutH

Synonym: glr3066

Alternate gene names: 37522635

Gene position: 3261206-3262750 (Clockwise)

Preceding gene: 37522630

Following gene: 37522637

Centisome position: 70.0

GC content: 64.85

Gene sequence:

>1545_bases
ATGAAACTATTGACCGATTGGTTGGTGCTCGACGGTTGTTCTCTTGCTGTCGATGATCTCGTCGCCGTTGCCCGTGGCGG
TGTACCGGTGAGGCTCTCGCCTGCCAGCCTGGAATTGGTCCGCCGCTCGCGCGCCTTTGTCGAAGCGTTGCTTGAAGGCG
ATGAGATTGTTTACGGGATCACCACCGGCTTCGGCTACTTCAAGAACCGGCGCATCCCCCGCTCGGCGGTCGAGCAGTTG
CAGCAAAATTTGCTGATGAGCAGTGCCGCCGGGTTGGGGGAACCCTTCGGCCGCGAAGTGGTGCGGGCCATGCTGCTGCT
GCGGGCCAACACCCTGGCGCAGGGGTATTCGGGGGTACGCCCCGAGACTTTGCAACTGCTCGTGGCGATGCTCAACCGGG
GGGTGCACCCGGTGGTGCCCTGCCGGGGATCGGTGGGGGCGAGCGGCGATCTGGCTCCTTTGGCCCACTTGGCGTTGGTG
CTCACCGGTGAAGGGGAGGCGGAGGTAGGGGGCGAGGTGCTTCCCGGGGCAGCAGCCCTGGCCCGCGCCGGTCTCGAACC
GATTCGGTTGGGAGCCAAGGAAGGCCTGGCGCTTATCAACGGCACCCAGGCGATGAGCGCCCTCGGGGCGCTCACCGTCC
ACCGCGCCCAGCGGCTTGCCAAACTCGCGGATCTTGCCTGTGCGATGACCCTGGAGGCTACCCTCGGGTCGCGCTCGGCC
TTTTTGCCCCATTTCCACCGCCTGAGGCCCCATCCCGGCCAGCAGTCGAGTGCGCGCAATTTGCTGGTGCTCACCGAAGA
CAGCGCTCTGATTGCTTCCCACGCGGGCTGCGACCGGGTACAGGACGCCTATTCGCTGCGCTGCGCGCCCCAGGTGCACG
GGGCGAGTCTGGATGCCATCAGCTACGCCGCCGGGGTGATCGCAATCGAAATCAACTCGGTCACCGACAATCCCCTTATC
TTTGCCGACACTGGCCAGGTGGTGACCGGCGGTCACTTCCATGGCCAGCCCGTCGCCATGGCCTCGGATGTGCTCGCGAT
TGCCCTCGCGGAACTGGCCGACATCTCCGAGCGGCGCACCGAGCGGCTGGTCAACGCCGATTACTCCAACGGTCTGCCGA
TGTTTCTCACCGAGGCAGGCGGTTTGCACTCGGGCTATATGGTCGCTCAATACACTGCCGCCTCGCTGGTCTCCGAGAAC
AAAGTGCTTGCCCACCCCGCCTGCGTCGACTCGATCCCGACTTCCGCTGGTCAGGAAGATCATGTGAGCATGGGGCTCAC
CGCCGCCCGCAAAGCGGTCACCGTCTGCGACAACTGCGAGCGGGTGATCGCTATCGAACTGATGTGTGCTGCCCAAGCAC
TCGATTTGCGCGGCAAACTCACCCCCGGCCGCGGCAGCCGGGTGGGTCTGGAGGTGATTCGCGCGGCCGTGCCGCACCTG
GAATCCGACCGCATCGTCAGCCGCGATATCGAAAAAGTGGTTGAACTGATGGCCGACGGCCACTTGCTTGAAGCGGTCGA
AGCGGCATGCGGCCGGCTCGATTAA

Upstream 100 bases:

>100_bases
GCACAGTATCGGCGGGTTTGCGAACGATCGTTGCGCCGACCGTCAGCGGCGGGGGGTAGTTGATTAGCATGGCGAATGGG
TAGAGCCACAAAGGCGAACG

Downstream 100 bases:

>100_bases
TCCTGGAGGGTCCAGCTGCTCCTGCCTGGAAGCCTGTTTTCACCCTGGCACTTGGCATCTGGCGGTTGGTTTTGCACGCG
AGTTTGTGGAGCGAGAGGCG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MKLLTDWLVLDGCSLAVDDLVAVARGGVPVRLSPASLELVRRSRAFVEALLEGDEIVYGITTGFGYFKNRRIPRSAVEQL
QQNLLMSSAAGLGEPFGREVVRAMLLLRANTLAQGYSGVRPETLQLLVAMLNRGVHPVVPCRGSVGASGDLAPLAHLALV
LTGEGEAEVGGEVLPGAAALARAGLEPIRLGAKEGLALINGTQAMSALGALTVHRAQRLAKLADLACAMTLEATLGSRSA
FLPHFHRLRPHPGQQSSARNLLVLTEDSALIASHAGCDRVQDAYSLRCAPQVHGASLDAISYAAGVIAIEINSVTDNPLI
FADTGQVVTGGHFHGQPVAMASDVLAIALAELADISERRTERLVNADYSNGLPMFLTEAGGLHSGYMVAQYTAASLVSEN
KVLAHPACVDSIPTSAGQEDHVSMGLTAARKAVTVCDNCERVIAIELMCAAQALDLRGKLTPGRGSRVGLEVIRAAVPHL
ESDRIVSRDIEKVVELMADGHLLEAVEAACGRLD

Sequences:

>Translated_514_residues
MKLLTDWLVLDGCSLAVDDLVAVARGGVPVRLSPASLELVRRSRAFVEALLEGDEIVYGITTGFGYFKNRRIPRSAVEQL
QQNLLMSSAAGLGEPFGREVVRAMLLLRANTLAQGYSGVRPETLQLLVAMLNRGVHPVVPCRGSVGASGDLAPLAHLALV
LTGEGEAEVGGEVLPGAAALARAGLEPIRLGAKEGLALINGTQAMSALGALTVHRAQRLAKLADLACAMTLEATLGSRSA
FLPHFHRLRPHPGQQSSARNLLVLTEDSALIASHAGCDRVQDAYSLRCAPQVHGASLDAISYAAGVIAIEINSVTDNPLI
FADTGQVVTGGHFHGQPVAMASDVLAIALAELADISERRTERLVNADYSNGLPMFLTEAGGLHSGYMVAQYTAASLVSEN
KVLAHPACVDSIPTSAGQEDHVSMGLTAARKAVTVCDNCERVIAIELMCAAQALDLRGKLTPGRGSRVGLEVIRAAVPHL
ESDRIVSRDIEKVVELMADGHLLEAVEAACGRLD
>Mature_514_residues
MKLLTDWLVLDGCSLAVDDLVAVARGGVPVRLSPASLELVRRSRAFVEALLEGDEIVYGITTGFGYFKNRRIPRSAVEQL
QQNLLMSSAAGLGEPFGREVVRAMLLLRANTLAQGYSGVRPETLQLLVAMLNRGVHPVVPCRGSVGASGDLAPLAHLALV
LTGEGEAEVGGEVLPGAAALARAGLEPIRLGAKEGLALINGTQAMSALGALTVHRAQRLAKLADLACAMTLEATLGSRSA
FLPHFHRLRPHPGQQSSARNLLVLTEDSALIASHAGCDRVQDAYSLRCAPQVHGASLDAISYAAGVIAIEINSVTDNPLI
FADTGQVVTGGHFHGQPVAMASDVLAIALAELADISERRTERLVNADYSNGLPMFLTEAGGLHSGYMVAQYTAASLVSEN
KVLAHPACVDSIPTSAGQEDHVSMGLTAARKAVTVCDNCERVIAIELMCAAQALDLRGKLTPGRGSRVGLEVIRAAVPHL
ESDRIVSRDIEKVVELMADGHLLEAVEAACGRLD

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=503, Percent_Identity=46.3220675944334, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567831, Length=509, Percent_Identity=47.5442043222004, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_GLOVI (Q7NCB3)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_926012.1
- ProteinModelPortal:   Q7NCB3
- SMR:   Q7NCB3
- GeneID:   2601467
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr3066
- NMPDR:   fig|251221.1.peg.3066
- HOGENOM:   HBG510887
- OMA:   CKPDDTI
- BioCyc:   GVIO251221:GLR3066-MONOMER
- BRENDA:   4.3.1.3
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 54038; Mature: 54038

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLTDWLVLDGCSLAVDDLVAVARGGVPVRLSPASLELVRRSRAFVEALLEGDEIVYGI
CCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEE
TTGFGYFKNRRIPRSAVEQLQQNLLMSSAAGLGEPFGREVVRAMLLLRANTLAQGYSGVR
ECCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
PETLQLLVAMLNRGVHPVVPCRGSVGASGDLAPLAHLALVLTGEGEAEVGGEVLPGAAAL
HHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHEEEEEECCCCCCCCCCCCCCHHHH
ARAGLEPIRLGAKEGLALINGTQAMSALGALTVHRAQRLAKLADLACAMTLEATLGSRSA
HHCCCCHHHCCHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
FLPHFHRLRPHPGQQSSARNLLVLTEDSALIASHAGCDRVQDAYSLRCAPQVHGASLDAI
HCCHHHHCCCCCCCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHHEECCCCCCCCCCHHH
SYAAGVIAIEINSVTDNPLIFADTGQVVTGGHFHGQPVAMASDVLAIALAELADISERRT
HHHCEEEEEEEECCCCCCEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ERLVNADYSNGLPMFLTEAGGLHSGYMVAQYTAASLVSENKVLAHPACVDSIPTSAGQED
HHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCHHHHCCCCCCCCCC
HVSMGLTAARKAVTVCDNCERVIAIELMCAAQALDLRGKLTPGRGSRVGLEVIRAAVPHL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
ESDRIVSRDIEKVVELMADGHLLEAVEAACGRLD
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLLTDWLVLDGCSLAVDDLVAVARGGVPVRLSPASLELVRRSRAFVEALLEGDEIVYGI
CCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEE
TTGFGYFKNRRIPRSAVEQLQQNLLMSSAAGLGEPFGREVVRAMLLLRANTLAQGYSGVR
ECCCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
PETLQLLVAMLNRGVHPVVPCRGSVGASGDLAPLAHLALVLTGEGEAEVGGEVLPGAAAL
HHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHEEEEEECCCCCCCCCCCCCCHHHH
ARAGLEPIRLGAKEGLALINGTQAMSALGALTVHRAQRLAKLADLACAMTLEATLGSRSA
HHCCCCHHHCCHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
FLPHFHRLRPHPGQQSSARNLLVLTEDSALIASHAGCDRVQDAYSLRCAPQVHGASLDAI
HCCHHHHCCCCCCCCCCCCEEEEEECCCHHHHHCCCHHHHHHHHHEECCCCCCCCCCHHH
SYAAGVIAIEINSVTDNPLIFADTGQVVTGGHFHGQPVAMASDVLAIALAELADISERRT
HHHCEEEEEEEECCCCCCEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ERLVNADYSNGLPMFLTEAGGLHSGYMVAQYTAASLVSENKVLAHPACVDSIPTSAGQED
HHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCHHHHCCCCCCCCCC
HVSMGLTAARKAVTVCDNCERVIAIELMCAAQALDLRGKLTPGRGSRVGLEVIRAAVPHL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
ESDRIVSRDIEKVVELMADGHLLEAVEAACGRLD
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292