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The map label for this gene is argG

Identifier: 37522502

GI number: 37522502

Start: 3128724

End: 3129920

Strand: Direct

Name: argG

Synonym: gvip407

Alternate gene names: 37522502

Gene position: 3128724-3129920 (Clockwise)

Preceding gene: 37522498

Following gene: 37522504

Centisome position: 67.15

GC content: 65.5

Gene sequence:

>1197_bases
ATGCGGGCGAAGAAAGTCGTACTGGCCTACTCGGGCGGCGTGGACACCAGCGTGTGCATTCCTTATCTAAAGCACGAATG
GGGTGTGGAGCAGGTGGTGGCCCTGGCGGCCGATCTGGGCCAGGGTGAAGATCTCGAAGCCGTCCGCCAGAAGGCCCTCG
CCTCCGGCGCCGACCAGGCAATCGTCCAGGATGCCCGCGAAGATTTTGTCTACGACTACGCCTTTGCGGCCCTGCAGGCC
AACGCCCTCTACGAGGGGCGCTACCCGCTCGCCACCGCCCTCGCCCGGCCACTCATCGCCCGGATCCTCGTCAAGTGCGC
CCAGGCGGTAGGGGCCGACGCCGTCGCCCACGGCTGCACGGGCAAGGGCAACGACCAGGTGCGCTTCGACGTGTCTATCG
GCGCGCTCGACCCGAAACTGAAAGTGCTCGCCCCCGCCCGCGAGTGGGGCATGTCCCGCGAGGAGACGATCGCCTATGGC
GAGCGCTACGGCATCCCCGCCCCGGTCAAGAAAAAATCGCCCTACTCGATCGACTTCAACCTGCTGGGCCGCTCCGTCGA
GTGCGGCGTCCTCGAAGATCCCTGGGCGGAACCGCCCGAGGAGGTCTACGCGATGACCAAATGCGTGGCGGACACCCCCG
ACCAGCCCACCTACATCGAACTGGAGTTCGAGCGCGGCGTGCCGGTGGCTTTGAATGGAGCGTCCTTGGGCGGGGTGAAG
CTGGTGGGCGAACTCAACCGCCTGGCCGGGGAGAACGGCGTCGGGCGCATCGACATGGTCGAAAATCGCCTGGTCGGGAT
TAAATCGCGCGAAATTTACGAATGCCCGGCCGGGGTGGTGCTGGTCCTGGCGCACCAGGCCCTCGAAGCGCTCACCCTGC
CCCGGGAGGTGACCGCCTACAAGCGCGGTGTCGAGGACACCTACGCCCAACTGGTCTACAACGGTCTGTGGTACAGTCCG
CTGCGCGGCGCCCTCGACGGGTTCATCGACTTCACCCAGCAACGGGCGAGCGGTGTGGTGCGCGTGCGCCTGCACAAAGG
AACCGCCACCGTCGTGGGCCGCAAAAGTCCCTATTCGCTCTACGACGTGGAGCTGGCCACCTACTCCGAAGGGGACAGCT
TCGATCACAAAGCCGCCGAGGGCTTTATTTATGTCTGGGGCCTGCCCACGCGCATTTATGCGCAGGTGCGCAAATAA

Upstream 100 bases:

>100_bases
AGGCCATGCGCTGAACATCTGTAACCGGCTGTTCCCATCCAAGGCAAAGCGACCCGCGCGTTAAGATGGCTGCGGACAGA
TATTCAACAAGCAGGTTGCG

Downstream 100 bases:

>100_bases
GTTCCCTAACCTCCCCGCGGCGCTCCAAGGCTAATTTCTGGGCGAGCTGACTCCTCCGCTCGGGCAGCCGCTTCCTGTAG
CGGAGCTGTCCACTTGCGCG

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRAKKVVLAYSGGVDTSVCIPYLKHEWGVEQVVALAADLGQGEDLEAVRQKALASGADQAIVQDAREDFVYDYAFAALQA
NALYEGRYPLATALARPLIARILVKCAQAVGADAVAHGCTGKGNDQVRFDVSIGALDPKLKVLAPAREWGMSREETIAYG
ERYGIPAPVKKKSPYSIDFNLLGRSVECGVLEDPWAEPPEEVYAMTKCVADTPDQPTYIELEFERGVPVALNGASLGGVK
LVGELNRLAGENGVGRIDMVENRLVGIKSREIYECPAGVVLVLAHQALEALTLPREVTAYKRGVEDTYAQLVYNGLWYSP
LRGALDGFIDFTQQRASGVVRVRLHKGTATVVGRKSPYSLYDVELATYSEGDSFDHKAAEGFIYVWGLPTRIYAQVRK

Sequences:

>Translated_398_residues
MRAKKVVLAYSGGVDTSVCIPYLKHEWGVEQVVALAADLGQGEDLEAVRQKALASGADQAIVQDAREDFVYDYAFAALQA
NALYEGRYPLATALARPLIARILVKCAQAVGADAVAHGCTGKGNDQVRFDVSIGALDPKLKVLAPAREWGMSREETIAYG
ERYGIPAPVKKKSPYSIDFNLLGRSVECGVLEDPWAEPPEEVYAMTKCVADTPDQPTYIELEFERGVPVALNGASLGGVK
LVGELNRLAGENGVGRIDMVENRLVGIKSREIYECPAGVVLVLAHQALEALTLPREVTAYKRGVEDTYAQLVYNGLWYSP
LRGALDGFIDFTQQRASGVVRVRLHKGTATVVGRKSPYSLYDVELATYSEGDSFDHKAAEGFIYVWGLPTRIYAQVRK
>Mature_398_residues
MRAKKVVLAYSGGVDTSVCIPYLKHEWGVEQVVALAADLGQGEDLEAVRQKALASGADQAIVQDAREDFVYDYAFAALQA
NALYEGRYPLATALARPLIARILVKCAQAVGADAVAHGCTGKGNDQVRFDVSIGALDPKLKVLAPAREWGMSREETIAYG
ERYGIPAPVKKKSPYSIDFNLLGRSVECGVLEDPWAEPPEEVYAMTKCVADTPDQPTYIELEFERGVPVALNGASLGGVK
LVGELNRLAGENGVGRIDMVENRLVGIKSREIYECPAGVVLVLAHQALEALTLPREVTAYKRGVEDTYAQLVYNGLWYSP
LRGALDGFIDFTQQRASGVVRVRLHKGTATVVGRKSPYSLYDVELATYSEGDSFDHKAAEGFIYVWGLPTRIYAQVRK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=405, Percent_Identity=43.4567901234568, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI16950633, Length=405, Percent_Identity=43.4567901234568, Blast_Score=309, Evalue=3e-84,
Organism=Escherichia coli, GI1789563, Length=390, Percent_Identity=27.4358974358974, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6324514, Length=414, Percent_Identity=40.3381642512077, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI21358151, Length=411, Percent_Identity=40.3892944038929, Blast_Score=281, Evalue=7e-76,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_GLOVI (Q7NCP5)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925879.1
- ProteinModelPortal:   Q7NCP5
- SMR:   Q7NCP5
- GeneID:   2601334
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2933
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- BioCyc:   GVIO251221:GLR2933-MONOMER
- BRENDA:   6.3.4.5
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 43363; Mature: 43363

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 37-37 BINDING 88-88 BINDING 118-118 BINDING 120-120 BINDING 124-124 BINDING 124-124 BINDING 125-125 BINDING 128-128 BINDING 176-176 BINDING 185-185 BINDING 261-261 BINDING 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKKVVLAYSGGVDTSVCIPYLKHEWGVEQVVALAADLGQGEDLEAVRQKALASGADQA
CCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHH
IVQDAREDFVYDYAFAALQANALYEGRYPLATALARPLIARILVKCAQAVGADAVAHGCT
HHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
GKGNDQVRFDVSIGALDPKLKVLAPAREWGMSREETIAYGERYGIPAPVKKKSPYSIDFN
CCCCCEEEEEEEECCCCCCEEEEECHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEHE
LLGRSVECGVLEDPWAEPPEEVYAMTKCVADTPDQPTYIELEFERGVPVALNGASLGGVK
ECCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEECCCCCCCCH
LVGELNRLAGENGVGRIDMVENRLVGIKSREIYECPAGVVLVLAHQALEALTLPREVTAY
HHHHHHHHCCCCCCCEEEEHHCCEECCCCCCCEECCCHHHHHHHHHHHHHHCCCHHHHHH
KRGVEDTYAQLVYNGLWYSPLRGALDGFIDFTQQRASGVVRVRLHKGTATVVGRKSPYSL
HCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCEE
YDVELATYSEGDSFDHKAAEGFIYVWGLPTRIYAQVRK
EEEEEEECCCCCCCCCHHCCCEEEEECCCHHHHHHHCC
>Mature Secondary Structure
MRAKKVVLAYSGGVDTSVCIPYLKHEWGVEQVVALAADLGQGEDLEAVRQKALASGADQA
CCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHH
IVQDAREDFVYDYAFAALQANALYEGRYPLATALARPLIARILVKCAQAVGADAVAHGCT
HHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
GKGNDQVRFDVSIGALDPKLKVLAPAREWGMSREETIAYGERYGIPAPVKKKSPYSIDFN
CCCCCEEEEEEEECCCCCCEEEEECHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEHE
LLGRSVECGVLEDPWAEPPEEVYAMTKCVADTPDQPTYIELEFERGVPVALNGASLGGVK
ECCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEECCCCCCCCH
LVGELNRLAGENGVGRIDMVENRLVGIKSREIYECPAGVVLVLAHQALEALTLPREVTAY
HHHHHHHHCCCCCCCEEEEHHCCEECCCCCCCEECCCHHHHHHHHHHHHHHCCCHHHHHH
KRGVEDTYAQLVYNGLWYSPLRGALDGFIDFTQQRASGVVRVRLHKGTATVVGRKSPYSL
HCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCEE
YDVELATYSEGDSFDHKAAEGFIYVWGLPTRIYAQVRK
EEEEEEECCCCCCCCCHHCCCEEEEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292