Click here to switch to the map view.

The map label for this gene is atpI

Identifier: 37522479

GI number: 37522479

Start: 3104880

End: 3105620

Strand: Reverse

Name: atpI

Synonym: gvip403

Alternate gene names: 37522479

Gene position: 3105620-3104880 (Counterclockwise)

Preceding gene: 37522480

Following gene: 37522478

Centisome position: 66.66

GC content: 56.01

Gene sequence:

>741_bases
ATGGAGTTAGCGTTGGCAACCTTGGGCAATCAGCCTCTCATCGCGGCGGTGGAAGTCGGCAAGCATCTGACCTGGCAACT
CGGTCCGCTCAGCGTACACGGCCAGACGATGATCACCACCTGGGTGGTCATGCTCCTGCTTATCGGGCTGACCTTCATCG
GCACCCGCAAGTTGCAGAGGGTGCCCTCCGGTCTGCAAAACTTTCTGGAATACGCCTACGACTTGCTCGCCAGCATCGCC
CGCAACCAGATAGGTGAGAAGCAGTACCGCTCCTGGGTACCGCTCATCGGAACGATTTTTCTGTTCGTGTTGTTTGCCAA
CTGGCTCGGTCAGTTGCCTCTGCGGCTTTTTCATATTCCAGAAGGCGAATTGGCTTCGCCGACCAACGACATCAACACGA
CCGTGGCACTGTCCCTGATCGCTCTGGTTTCCTACATCTATGCAGGCTTGCGCAAGTCGGGTTTCGGTTACTTCAAGCAT
TACTTCGAATCACCGATTTTGGCGGCGGTGTGGGTACTCGAATTTTTCACCCGTCCCCTGTCCCTCAGCATTCGACTTTT
CGGCAACATCCTGGCTGAGGAGTTGGTGGTGGCGGTGTTGATTTTGCTGGTACCGATTCTGGTGCCTGTGCCCCTGATGA
TCCTGTTTTTGCTGACAGGTGCGATTCAGGCGCTGGTGTTTTCGACGCTCACCGCGTCCTATGTCGGTGAAGCGGTCGAG
GACCACGACGACCACCATTAG

Upstream 100 bases:

>100_bases
TTTCTTTGGTTTTTTGACCATCAAGGCGGCGATCCTGGTCGACACTTTGCGGACGCTGTTCGGTGACGTTTAGACGGGTT
GGCACTTGGAGGATGGTTGG

Downstream 100 bases:

>100_bases
TCCGACGGTGGTCTCAATACACAATGGACGTTTTATTAGGAGTGTCGCAATGAACGATATTACTGCTGCTGCTTCGGTGA
TCGCTGCCGCCCTCGCGGTC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MELALATLGNQPLIAAVEVGKHLTWQLGPLSVHGQTMITTWVVMLLLIGLTFIGTRKLQRVPSGLQNFLEYAYDLLASIA
RNQIGEKQYRSWVPLIGTIFLFVLFANWLGQLPLRLFHIPEGELASPTNDINTTVALSLIALVSYIYAGLRKSGFGYFKH
YFESPILAAVWVLEFFTRPLSLSIRLFGNILAEELVVAVLILLVPILVPVPLMILFLLTGAIQALVFSTLTASYVGEAVE
DHDDHH

Sequences:

>Translated_246_residues
MELALATLGNQPLIAAVEVGKHLTWQLGPLSVHGQTMITTWVVMLLLIGLTFIGTRKLQRVPSGLQNFLEYAYDLLASIA
RNQIGEKQYRSWVPLIGTIFLFVLFANWLGQLPLRLFHIPEGELASPTNDINTTVALSLIALVSYIYAGLRKSGFGYFKH
YFESPILAAVWVLEFFTRPLSLSIRLFGNILAEELVVAVLILLVPILVPVPLMILFLLTGAIQALVFSTLTASYVGEAVE
DHDDHH
>Mature_246_residues
MELALATLGNQPLIAAVEVGKHLTWQLGPLSVHGQTMITTWVVMLLLIGLTFIGTRKLQRVPSGLQNFLEYAYDLLASIA
RNQIGEKQYRSWVPLIGTIFLFVLFANWLGQLPLRLFHIPEGELASPTNDINTTVALSLIALVSYIYAGLRKSGFGYFKH
YFESPILAAVWVLEFFTRPLSLSIRLFGNILAEELVVAVLILLVPILVPVPLMILFLLTGAIQALVFSTLTASYVGEAVE
DHDDHH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=210, Percent_Identity=25.7142857142857, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6226527, Length=196, Percent_Identity=27.5510204081633, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_GLOVI (Q7NCR8)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925856.1
- ProteinModelPortal:   Q7NCR8
- SMR:   Q7NCR8
- GeneID:   2601311
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2910
- HOGENOM:   HBG734175
- OMA:   LHGQVFL
- ProtClustDB:   PRK05815
- BioCyc:   GVIO251221:GLL2910-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 27297; Mature: 27297

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x106deee8)-; HASH(0x1058e620)-; HASH(0x1076d5b8)-; HASH(0x15e8d04c)-; HASH(0x105d6d5c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELALATLGNQPLIAAVEVGKHLTWQLGPLSVHGQTMITTWVVMLLLIGLTFIGTRKLQR
CCCHHHHCCCCCHHHHHHHCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VPSGLQNFLEYAYDLLASIARNQIGEKQYRSWVPLIGTIFLFVLFANWLGQLPLRLFHIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECC
EGELASPTNDINTTVALSLIALVSYIYAGLRKSGFGYFKHYFESPILAAVWVLEFFTRPL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCH
SLSIRLFGNILAEELVVAVLILLVPILVPVPLMILFLLTGAIQALVFSTLTASYVGEAVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DHDDHH
CCCCCH
>Mature Secondary Structure
MELALATLGNQPLIAAVEVGKHLTWQLGPLSVHGQTMITTWVVMLLLIGLTFIGTRKLQR
CCCHHHHCCCCCHHHHHHHCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VPSGLQNFLEYAYDLLASIARNQIGEKQYRSWVPLIGTIFLFVLFANWLGQLPLRLFHIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECC
EGELASPTNDINTTVALSLIALVSYIYAGLRKSGFGYFKHYFESPILAAVWVLEFFTRPL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCH
SLSIRLFGNILAEELVVAVLILLVPILVPVPLMILFLLTGAIQALVFSTLTASYVGEAVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DHDDHH
CCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14621292