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The map label for this gene is thrS

Identifier: 37522455

GI number: 37522455

Start: 3076742

End: 3078625

Strand: Direct

Name: thrS

Synonym: gvip395

Alternate gene names: 37522455

Gene position: 3076742-3078625 (Clockwise)

Preceding gene: 37522453

Following gene: 37522456

Centisome position: 66.04

GC content: 61.52

Gene sequence:

>1884_bases
GTGACTTTTCGGCAGCCTGCGCGGAGGACTTTGTCCGGCCGCTTTGGCGCTTTGAAATGCCACAATGGCGGTTGCAGTTG
CGACTCGAAGGCTATGGAAAACGACATTCTCCGGCAAAGCGACCCCGAAAAACTGCACCGGATCCGCCACAGCACCAGCC
ACATCCTGGCGATGGCGGTCCAGAAGCTTTTCCCGGAGACCAAGGTAACCATCGGCCCGGCCATCGAGAACGGCTTCTAC
TACGACTTCGACCGGCCGACTCCCTTCACCCCCGAAGATCTCAAAAAGATCGAAAAAGAGATGCGCCGCATCGTGCAGCA
GAAATTGCCGCTGGTGCGCGAGGAAGTGCCGCGCGAGGCGATGCGCGAGCGCCTCGAAGCGCTGGGGGAGCCCTACAAAC
TGGAACTCTTTGAAGGCTTCGACCACGACGCGCCGGTGAGCCTCTACCGCACCGGCGACTGGTGGGATCTGTGCGCCGGT
CCCCACGTCGAATCGACCGCCGAGATCCACCCGAACGCCTTCAAATTGCGCTCGGTGGCAGGGGCTTACTGGCGCGGCGA
CGAGAAGCGCGCCCAACTGCAGCGCATCTACGGCACCGCCTGGGAGACCCCCGAGCAACTCGAAGAATTTTTGCGCCGCG
AGGAGGAGGCCAAAAAGCGCGACCACCGCAAACTCGGCCGCGAATTGGGACTGTTTGTCTTCTCGGATCTGGTCGGGCCG
GGTCTACCGCTGTGGACCCCCAAAGGAGCCCTGCTGCGCTATATCCTCGAAGAATTCCTGCGCAAGGAGCAGGTCAAGCG
CGGCTACCAGCAGGTAGTCACCCCCCACATCGCCCGCGTGGACCTGTTCAAAACCAGCGGCCACTGGTTCAAGTACAAAG
ACGACATGTTTCCGCTGATGGCCACAAGCGAGGAGGAAGGGGCCGAAGAAGGCTTCGTGATGAAGCCGATGAACTGTCCT
TTCCATATCCAGATCTACAAGTCGGAGTTACACTCCTACCGGGAGCTGCCGATCCGCCTCGCCGAATTCGGGACGGTGTA
CCGCTACGAGCAGTCGGGCGAGTTGGGCGGCCTGACGCGCGTGCGCGGCTTTACGGTCGACGACTCGCACCTGTTTGTGA
CGCCCGAACAACTGGACGACGAATTTAAAAAAGTCGTCGATTTGATCCAGTTCGTCTTCCGCTCGCTGCAGTTGGGCGAC
GGTTTTTCCGCCCGCCTCTCCTTTCGCGACCCGACCTCAGACAAATACATCGGCTCCGACGCAGCCTGGGAAAAAGCCCA
GGCAGCTATCCTCAAAGCATCCCAAGACTTGGGTCTCAAGTACTTCGTGGCCGAAGGGGAAGCGGCATTTTACGGCCCCA
AGCTCGACTTTATCTTCCGAGATGCCCTCGGCCGCGAGTGGCAACTGGGCACCGTCCAGGTCGATTACATCCTGCCGGAG
CGCTTCGAGTTGGAGTACGTCGCCGAGGACGGCTCCCGCCGCCGCCCGGTGATGATCCACCGCGCCCCCTTCGGTTCGCT
CGAACGGTTCATCGCCATCCTCATTGAGCACTTTGCGGGCGATTTTCCGCTCTGGCTCGCCCCTGAGCAGGTACGGATTT
TGCCCGTCACCGACCAGTTCGTGGGCTATGCCGAGTCGGTCAAAGATCGCCTCGTGTCCCTGGAGATGCGCGCCGAGGTC
GACGCGAGCAGCGAACGGCTGGGCAAGAAGATCCGCAACGGCGAGACCGCCAAGGTGCCGGTGCTGCTGGTGGTGGGTGA
AAGTGAGGCGAATAGCGGCACGGTGGCGGTCCGCACCCGCGTCGAGGGCGAAAAGGACAAAGGTACCCTACCCGTTGAGG
AGGCCATCGCCTACCTGCAGGAGCGCCTCGCAAAGCGTACCTGA

Upstream 100 bases:

>100_bases
ATTTGAAACTGAACATCTGCTTGCCCTCCGTACCCAGCAATACGCAAACGCATTGCATCGTAGTGGAGTGACATTAAACG
CCCATTAAGCCGCGCTCGCC

Downstream 100 bases:

>100_bases
GGCGGGGGATTTTGCCGTAGTTTTTCGCCGGGAATTGTGGTAGATATTTCTAGCATCTCTTCCCCAAATTCCAGTGAAAT
ACGCGCTTGGGCTGCTTCTG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MTFRQPARRTLSGRFGALKCHNGGCSCDSKAMENDILRQSDPEKLHRIRHSTSHILAMAVQKLFPETKVTIGPAIENGFY
YDFDRPTPFTPEDLKKIEKEMRRIVQQKLPLVREEVPREAMRERLEALGEPYKLELFEGFDHDAPVSLYRTGDWWDLCAG
PHVESTAEIHPNAFKLRSVAGAYWRGDEKRAQLQRIYGTAWETPEQLEEFLRREEEAKKRDHRKLGRELGLFVFSDLVGP
GLPLWTPKGALLRYILEEFLRKEQVKRGYQQVVTPHIARVDLFKTSGHWFKYKDDMFPLMATSEEEGAEEGFVMKPMNCP
FHIQIYKSELHSYRELPIRLAEFGTVYRYEQSGELGGLTRVRGFTVDDSHLFVTPEQLDDEFKKVVDLIQFVFRSLQLGD
GFSARLSFRDPTSDKYIGSDAAWEKAQAAILKASQDLGLKYFVAEGEAAFYGPKLDFIFRDALGREWQLGTVQVDYILPE
RFELEYVAEDGSRRRPVMIHRAPFGSLERFIAILIEHFAGDFPLWLAPEQVRILPVTDQFVGYAESVKDRLVSLEMRAEV
DASSERLGKKIRNGETAKVPVLLVVGESEANSGTVAVRTRVEGEKDKGTLPVEEAIAYLQERLAKRT

Sequences:

>Translated_627_residues
MTFRQPARRTLSGRFGALKCHNGGCSCDSKAMENDILRQSDPEKLHRIRHSTSHILAMAVQKLFPETKVTIGPAIENGFY
YDFDRPTPFTPEDLKKIEKEMRRIVQQKLPLVREEVPREAMRERLEALGEPYKLELFEGFDHDAPVSLYRTGDWWDLCAG
PHVESTAEIHPNAFKLRSVAGAYWRGDEKRAQLQRIYGTAWETPEQLEEFLRREEEAKKRDHRKLGRELGLFVFSDLVGP
GLPLWTPKGALLRYILEEFLRKEQVKRGYQQVVTPHIARVDLFKTSGHWFKYKDDMFPLMATSEEEGAEEGFVMKPMNCP
FHIQIYKSELHSYRELPIRLAEFGTVYRYEQSGELGGLTRVRGFTVDDSHLFVTPEQLDDEFKKVVDLIQFVFRSLQLGD
GFSARLSFRDPTSDKYIGSDAAWEKAQAAILKASQDLGLKYFVAEGEAAFYGPKLDFIFRDALGREWQLGTVQVDYILPE
RFELEYVAEDGSRRRPVMIHRAPFGSLERFIAILIEHFAGDFPLWLAPEQVRILPVTDQFVGYAESVKDRLVSLEMRAEV
DASSERLGKKIRNGETAKVPVLLVVGESEANSGTVAVRTRVEGEKDKGTLPVEEAIAYLQERLAKRT
>Mature_626_residues
TFRQPARRTLSGRFGALKCHNGGCSCDSKAMENDILRQSDPEKLHRIRHSTSHILAMAVQKLFPETKVTIGPAIENGFYY
DFDRPTPFTPEDLKKIEKEMRRIVQQKLPLVREEVPREAMRERLEALGEPYKLELFEGFDHDAPVSLYRTGDWWDLCAGP
HVESTAEIHPNAFKLRSVAGAYWRGDEKRAQLQRIYGTAWETPEQLEEFLRREEEAKKRDHRKLGRELGLFVFSDLVGPG
LPLWTPKGALLRYILEEFLRKEQVKRGYQQVVTPHIARVDLFKTSGHWFKYKDDMFPLMATSEEEGAEEGFVMKPMNCPF
HIQIYKSELHSYRELPIRLAEFGTVYRYEQSGELGGLTRVRGFTVDDSHLFVTPEQLDDEFKKVVDLIQFVFRSLQLGDG
FSARLSFRDPTSDKYIGSDAAWEKAQAAILKASQDLGLKYFVAEGEAAFYGPKLDFIFRDALGREWQLGTVQVDYILPER
FELEYVAEDGSRRRPVMIHRAPFGSLERFIAILIEHFAGDFPLWLAPEQVRILPVTDQFVGYAESVKDRLVSLEMRAEVD
ASSERLGKKIRNGETAKVPVLLVVGESEANSGTVAVRTRVEGEKDKGTLPVEEAIAYLQERLAKRT

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=590, Percent_Identity=38.8135593220339, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI38570111, Length=581, Percent_Identity=38.382099827883, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI20070344, Length=595, Percent_Identity=34.9579831932773, Blast_Score=338, Evalue=6e-93,
Organism=Escherichia coli, GI1788013, Length=607, Percent_Identity=42.504118616145, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71984184, Length=575, Percent_Identity=37.2173913043478, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71984192, Length=568, Percent_Identity=37.1478873239437, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322112, Length=589, Percent_Identity=37.5212224108659, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322654, Length=389, Percent_Identity=35.4755784061697, Blast_Score=247, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24583842, Length=588, Percent_Identity=39.2857142857143, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI28574141, Length=588, Percent_Identity=39.2857142857143, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24583839, Length=588, Percent_Identity=39.2857142857143, Blast_Score=423, Evalue=1e-118,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_GLOVI (Q7NCU0)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925832.1
- ProteinModelPortal:   Q7NCU0
- SMR:   Q7NCU0
- GeneID:   2601287
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2886
- HOGENOM:   HBG352811
- OMA:   NDETMST
- ProtClustDB:   PRK12305
- BioCyc:   GVIO251221:GLR2886-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 71921; Mature: 71790

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFRQPARRTLSGRFGALKCHNGGCSCDSKAMENDILRQSDPEKLHRIRHSTSHILAMAV
CCCCCHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QKLFPETKVTIGPAIENGFYYDFDRPTPFTPEDLKKIEKEMRRIVQQKLPLVREEVPREA
HHHCCCCCEEECCEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHH
MRERLEALGEPYKLELFEGFDHDAPVSLYRTGDWWDLCAGPHVESTAEIHPNAFKLRSVA
HHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCHHHHHHHH
GAYWRGDEKRAQLQRIYGTAWETPEQLEEFLRREEEAKKRDHRKLGRELGLFVFSDLVGP
HHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLPLWTPKGALLRYILEEFLRKEQVKRGYQQVVTPHIARVDLFKTSGHWFKYKDDMFPLM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCEEEECCCCCCEE
ATSEEEGAEEGFVMKPMNCPFHIQIYKSELHSYRELPIRLAEFGTVYRYEQSGELGGLTR
ECCCCCCCCCCCEECCCCCCEEEEEEHHHHHHHHHCCHHHHHCCCEEEECCCCCCCCCCE
VRGFTVDDSHLFVTPEQLDDEFKKVVDLIQFVFRSLQLGDGFSARLSFRDPTSDKYIGSD
EEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCC
AAWEKAQAAILKASQDLGLKYFVAEGEAAFYGPKLDFIFRDALGREWQLGTVQVDYILPE
HHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHHHHHHCCCCEEECEEEEEEECCC
RFELEYVAEDGSRRRPVMIHRAPFGSLERFIAILIEHFAGDFPLWLAPEQVRILPVTDQF
CEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECHHH
VGYAESVKDRLVSLEMRAEVDASSERLGKKIRNGETAKVPVLLVVGESEANSGTVAVRTR
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEEE
VEGEKDKGTLPVEEAIAYLQERLAKRT
ECCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFRQPARRTLSGRFGALKCHNGGCSCDSKAMENDILRQSDPEKLHRIRHSTSHILAMAV
CCCCHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QKLFPETKVTIGPAIENGFYYDFDRPTPFTPEDLKKIEKEMRRIVQQKLPLVREEVPREA
HHHCCCCCEEECCEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHH
MRERLEALGEPYKLELFEGFDHDAPVSLYRTGDWWDLCAGPHVESTAEIHPNAFKLRSVA
HHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCHHHHHHHH
GAYWRGDEKRAQLQRIYGTAWETPEQLEEFLRREEEAKKRDHRKLGRELGLFVFSDLVGP
HHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLPLWTPKGALLRYILEEFLRKEQVKRGYQQVVTPHIARVDLFKTSGHWFKYKDDMFPLM
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCEEEECCCCCCEE
ATSEEEGAEEGFVMKPMNCPFHIQIYKSELHSYRELPIRLAEFGTVYRYEQSGELGGLTR
ECCCCCCCCCCCEECCCCCCEEEEEEHHHHHHHHHCCHHHHHCCCEEEECCCCCCCCCCE
VRGFTVDDSHLFVTPEQLDDEFKKVVDLIQFVFRSLQLGDGFSARLSFRDPTSDKYIGSD
EEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCC
AAWEKAQAAILKASQDLGLKYFVAEGEAAFYGPKLDFIFRDALGREWQLGTVQVDYILPE
HHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCHHHHHHHHCCCCEEECEEEEEEECCC
RFELEYVAEDGSRRRPVMIHRAPFGSLERFIAILIEHFAGDFPLWLAPEQVRILPVTDQF
CEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCCEEEEEECHHH
VGYAESVKDRLVSLEMRAEVDASSERLGKKIRNGETAKVPVLLVVGESEANSGTVAVRTR
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEEE
VEGEKDKGTLPVEEAIAYLQERLAKRT
ECCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292