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The map label for this gene is ruvA

Identifier: 37522453

GI number: 37522453

Start: 3074872

End: 3075492

Strand: Direct

Name: ruvA

Synonym: gvip394

Alternate gene names: 37522453

Gene position: 3074872-3075492 (Clockwise)

Preceding gene: 37522452

Following gene: 37522455

Centisome position: 66.0

GC content: 68.44

Gene sequence:

>621_bases
GTGATCACTTTTGTGCGCGGCATGCTCGCGGAGGTGGGTCCGCGCAGTGGCCAGAGTTGGGCGACCGTGGATGTGGGCGG
TGTGGGTTACCGGGTGTGGACCCACGCGCGCACCGTCGGCAAATTGCCCCGCATCGGCGAAGAGGTCAAACTCTTCACCC
TGATGATCGTGCGCGAGGATGCCATGCAGCTGTTCGGCTTTTTGGAACCCGGCGAGCGCGAACTGTTCGGCCAGCTGGTC
TCTGTGAGCGGCATCGGACCGCGCATGGGCCTGGCGCTGCTGGAGACGCTCGCTCCGACCGAACTGGTGCAGGCGATTTT
GCAGGGCAACACCCGCGCCCTCGCCCTTGCCCCGGGCGTCGGTGCCAAGACCGCCCAGCGCCTGGCTCTGGAGTTGCGCT
CGCGCCTCTCGAAGTGGCGCGAGGAGTCGGGGTTGAGTGCTATGGGTGCCCGCGCCTCCTCGCGCGTCTACGAAGAAGTC
GAGCTGGCGCTGTTGGCCCTGGGCTTCGCGCCGGGCGAAGTCGTGCGCGCCCTCGATGCGGTCGCCCCGGCGATGGCGGG
CGAGGAGCAGACCGAAGCCTGGCTCAGGGCCGCCATCGCCTGGCTTTCGGAGCAGGGCTGA

Upstream 100 bases:

>100_bases
TGGCGACGCTCGCGACCGGCAATCTGGTGGTGCCGGTGGTGGCCCACGTGCTGGTCAACTGGCTCTCGTGCCTACTCTGG
CGTAAGGAGCCGAGTCGGGT

Downstream 100 bases:

>100_bases
ATCAGCGTCCCGGCACCAGATCGACGGCGAAACCGAGAAACTGGGTGAACTGGGTCTCGCTGAAGTTGTTGTCGCTCACG
AGGATCAAAGCCCGCCGCCC

Product: Holliday junction DNA helicase RuvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MITFVRGMLAEVGPRSGQSWATVDVGGVGYRVWTHARTVGKLPRIGEEVKLFTLMIVREDAMQLFGFLEPGERELFGQLV
SVSGIGPRMGLALLETLAPTELVQAILQGNTRALALAPGVGAKTAQRLALELRSRLSKWREESGLSAMGARASSRVYEEV
ELALLALGFAPGEVVRALDAVAPAMAGEEQTEAWLRAAIAWLSEQG

Sequences:

>Translated_206_residues
MITFVRGMLAEVGPRSGQSWATVDVGGVGYRVWTHARTVGKLPRIGEEVKLFTLMIVREDAMQLFGFLEPGERELFGQLV
SVSGIGPRMGLALLETLAPTELVQAILQGNTRALALAPGVGAKTAQRLALELRSRLSKWREESGLSAMGARASSRVYEEV
ELALLALGFAPGEVVRALDAVAPAMAGEEQTEAWLRAAIAWLSEQG
>Mature_206_residues
MITFVRGMLAEVGPRSGQSWATVDVGGVGYRVWTHARTVGKLPRIGEEVKLFTLMIVREDAMQLFGFLEPGERELFGQLV
SVSGIGPRMGLALLETLAPTELVQAILQGNTRALALAPGVGAKTAQRLALELRSRLSKWREESGLSAMGARASSRVYEEV
ELALLALGFAPGEVVRALDAVAPAMAGEEQTEAWLRAAIAWLSEQG

Specific function: The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday

COG id: COG0632

COG function: function code L; Holliday junction resolvasome, DNA-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvA family

Homologues:

Organism=Escherichia coli, GI1788168, Length=207, Percent_Identity=33.8164251207729, Blast_Score=112, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVA_GLOVI (Q7NCU2)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925830.1
- ProteinModelPortal:   Q7NCU2
- SMR:   Q7NCU2
- GeneID:   2601285
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2884
- HOGENOM:   HBG635309
- OMA:   IATKEVK
- ProtClustDB:   PRK00116
- BioCyc:   GVIO251221:GLR2884-MONOMER
- HAMAP:   MF_00031
- InterPro:   IPR011114
- InterPro:   IPR013849
- InterPro:   IPR003583
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR000085
- InterPro:   IPR010994
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00278
- TIGRFAMs:   TIGR00084

Pfam domain/function: PF07499 RuvA_C; PF01330 RuvA_N; SSF50249 Nucleic_acid_OB; SSF47781 RuvA_2_like; SSF46929 RuvA_C-like

EC number: =3.6.4.12

Molecular weight: Translated: 22129; Mature: 22129

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITFVRGMLAEVGPRSGQSWATVDVGGVGYRVWTHARTVGKLPRIGEEVKLFTLMIVRED
CHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AMQLFGFLEPGERELFGQLVSVSGIGPRMGLALLETLAPTELVQAILQGNTRALALAPGV
HHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEECCC
GAKTAQRLALELRSRLSKWREESGLSAMGARASSRVYEEVELALLALGFAPGEVVRALDA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VAPAMAGEEQTEAWLRAAIAWLSEQG
HHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITFVRGMLAEVGPRSGQSWATVDVGGVGYRVWTHARTVGKLPRIGEEVKLFTLMIVRED
CHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AMQLFGFLEPGERELFGQLVSVSGIGPRMGLALLETLAPTELVQAILQGNTRALALAPGV
HHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEECCC
GAKTAQRLALELRSRLSKWREESGLSAMGARASSRVYEEVELALLALGFAPGEVVRALDA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VAPAMAGEEQTEAWLRAAIAWLSEQG
HHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292