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The map label for this gene is mdmC [H]

Identifier: 37522385

GI number: 37522385

Start: 2995015

End: 2995695

Strand: Direct

Name: mdmC [H]

Synonym: glr2816

Alternate gene names: 37522385

Gene position: 2995015-2995695 (Clockwise)

Preceding gene: 37522384

Following gene: 37522386

Centisome position: 64.28

GC content: 64.17

Gene sequence:

>681_bases
ATGGCCGACGACGACTCGCGCACCGGTAGAGCCCACTACGCAAGCCCAGCCATCCGGGCTTACCTCGACGGGCTTTACCT
TCCCCCGGATCCGGATTTGGCCCACGCGGTGGCTGAACTTGACCGCGTAGGGATGCCGCGCATCCAGGTCTCCGCCACCG
AGGGCAAGATTCTCTACCTGCTTGTGCAGATGATCCGGGCGCGCAGGGTGGTTGAATTCGGTACCCTCTCCGGCTACTCG
GGTCTGTGGATACTCAAGGCCATGGGCCGGGACGGCCATCTGTGGACCTGCGAGTACAACCCCGAGCACGCCCGGGTGGC
GCGGGGAGTCTTCGAGCGGGCGGGCTACGGCCCGCAGGTGAGCATTTTCGAGGGACCGGGCCTGGCAAGCCTCGACAAGC
TTGCCCACTTCGCTCCCTTTGACGCGGTCTTCCTGGATGCCGACAAATCCGGCTATGCCCGCTACGCCCGCTGGGCCTTC
GAGCACCTCAGGCCGGGAGGCCTGATTATCGGCGACAACACCTATCTGTTTGGCTATCTGGCCGGGCGCGAACCCGACAA
TCAGTGGAATGCGCAGGCCATCGAGACGATGCGCGACTTTCATGCCTTTGTCGCTTCCCACTGCACCGCCGTCAGTCTAC
CCACCCCCGACGGCCTCACCGTCGGCATGAAACCTTACTGA

Upstream 100 bases:

>100_bases
GCGGACCGCCGGTTCTCTTTGCCAACCACGAGCTTCGATTACTTGCGCAGCTTTGCATCTCTGGGTTAGCCTGCCGGGAT
AGTCTGACTGCAGTTACACA

Downstream 100 bases:

>100_bases
GCAGTGCCGATGATAAAATTGGTTCTGTCGATCTGCCTTCAACAGTGGCTGCGATGGAACCTGTGAATAACCAAGCAGTC
CCCAAGCGGACTTGCGGTCA

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MADDDSRTGRAHYASPAIRAYLDGLYLPPDPDLAHAVAELDRVGMPRIQVSATEGKILYLLVQMIRARRVVEFGTLSGYS
GLWILKAMGRDGHLWTCEYNPEHARVARGVFERAGYGPQVSIFEGPGLASLDKLAHFAPFDAVFLDADKSGYARYARWAF
EHLRPGGLIIGDNTYLFGYLAGREPDNQWNAQAIETMRDFHAFVASHCTAVSLPTPDGLTVGMKPY

Sequences:

>Translated_226_residues
MADDDSRTGRAHYASPAIRAYLDGLYLPPDPDLAHAVAELDRVGMPRIQVSATEGKILYLLVQMIRARRVVEFGTLSGYS
GLWILKAMGRDGHLWTCEYNPEHARVARGVFERAGYGPQVSIFEGPGLASLDKLAHFAPFDAVFLDADKSGYARYARWAF
EHLRPGGLIIGDNTYLFGYLAGREPDNQWNAQAIETMRDFHAFVASHCTAVSLPTPDGLTVGMKPY
>Mature_225_residues
ADDDSRTGRAHYASPAIRAYLDGLYLPPDPDLAHAVAELDRVGMPRIQVSATEGKILYLLVQMIRARRVVEFGTLSGYSG
LWILKAMGRDGHLWTCEYNPEHARVARGVFERAGYGPQVSIFEGPGLASLDKLAHFAPFDAVFLDADKSGYARYARWAFE
HLRPGGLIIGDNTYLFGYLAGREPDNQWNAQAIETMRDFHAFVASHCTAVSLPTPDGLTVGMKPY

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=183, Percent_Identity=25.6830601092896, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24992; Mature: 24860

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDDSRTGRAHYASPAIRAYLDGLYLPPDPDLAHAVAELDRVGMPRIQVSATEGKILYL
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHH
LVQMIRARRVVEFGTLSGYSGLWILKAMGRDGHLWTCEYNPEHARVARGVFERAGYGPQV
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEE
SIFEGPGLASLDKLAHFAPFDAVFLDADKSGYARYARWAFEHLRPGGLIIGDNTYLFGYL
EEECCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCEEEEEE
AGREPDNQWNAQAIETMRDFHAFVASHCTAVSLPTPDGLTVGMKPY
ECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCEECCCCC
>Mature Secondary Structure 
ADDDSRTGRAHYASPAIRAYLDGLYLPPDPDLAHAVAELDRVGMPRIQVSATEGKILYL
CCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHH
LVQMIRARRVVEFGTLSGYSGLWILKAMGRDGHLWTCEYNPEHARVARGVFERAGYGPQV
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEE
SIFEGPGLASLDKLAHFAPFDAVFLDADKSGYARYARWAFEHLRPGGLIIGDNTYLFGYL
EEECCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEECCCCEEEEEE
AGREPDNQWNAQAIETMRDFHAFVASHCTAVSLPTPDGLTVGMKPY
ECCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]