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The map label for this gene is ddc [H]

Identifier: 37522239

GI number: 37522239

Start: 2832026

End: 2833510

Strand: Reverse

Name: ddc [H]

Synonym: gll2670

Alternate gene names: 37522239

Gene position: 2833510-2832026 (Counterclockwise)

Preceding gene: 37522240

Following gene: 37522236

Centisome position: 60.82

GC content: 64.58

Gene sequence:

>1485_bases
GTGCCTGTCCAGGGTCCGTCCATAACCTGCTCGCCTCAACAGGGCACCACAAGCACTGACGAAGCGTTTGCGGCGTCCGC
TGCGATTTTGGGCAGGACGGCCGAGTTGGCGGCCAAATACGTTGCCAGCCTCGCGCAGCGGCCGGTCGGCAAGCCGGTAT
CGGTTGTGCAACTGGCCGCTGCCCTGGAGGAACCGCTGCCGGAGCAGGGCACGCCGCCGGCTGCCGCAGTCGAAGAGTGG
TTGAGCCGGGCCGAACCGGGCATTGTTGCCTCTGCTGGACCACGTTACTTTGGCTTTGTGATCGGTGGAACCACAGCTGC
TGCCCTGGCCGGGGACTGGCTGGCCTCCGCCATTGACCAGAACGCTTGTCTGTGGGCAACCAGCCCGGCTGCCGTTCAAA
CCGAGCTGGTCGTGATGCGGTGGCTGAAAGAACTATTTCAGTTGCCCGCCGACTGGGTAGGAGCGCTGACCAGCGGCACT
TCAAACGCTCATCTTATCGGTCTGGCGGCTGCCCGCCAGTGGGTCGGTGCACAGCTGGGCTTCGATCCGGCCCGCGACGG
GCTGAGCGGCTTCGAGCCGGTGCCGGTCGTCTGCAGCACGGCAACGCACGTCAGTACTACAAAGGCGCTTGCCACTCTGG
GATTGGGCCGCAGCACAGTGCGCCAGGTGCCTGCGCCCGGCGGGGTGATCGATCTCGGTGCGCTCGCGGCAACGCTGCAG
ACCATCGGTGGTCCTGCCATCGTGATCGCCAACGCCGGCGAGGTCAACACCGGTGCTTTCGATCCGCTCGACAAGATCGC
CGATCTGTGTCAGTTCCATCCTGGGGGTGCCTGGCTCCACGTGGATGGTGCCTTCGGTCTTTGCGCCCGGCTTTGCGATC
GTCTTGCGCCCCTGGTGCAGGGTGTGGAGCGGGCCGACTCGCTCGCGTCCGACGGGCACAAGTGGTTGAATTTGCCCTAC
GACTGCGGCTTTGTCTTCGTGCGCAACCCGGAGGCACTGCGCTCGGCCTTCAGTGCCGACGCCGCGTATATCGCTCCGGA
GCCCGATGCGGGCTGGGACCCCACCAGCCACATGCCCGAACTCTCGCGCCGCTTTCGGGGGCTTGCTGCCTGGTGCGCCA
TCAAAGCTTACGGCCGGATTGGTTACCGGGCGCTGGTGGAGCGGTGCGTCGGCTGGGCCGACGAGTTCGGGCGGTGGGTG
CAAACGACGCGCAGCCTCGAACTTGTAGCCCCCGTTTCGCTCAACATCGTATGCTTTCGGTATATCCGGGCCGGCCTCAG
TACCGTCGAACTCAACGCTCTCAATCGTGCGGCCGACGCCGCGCTGCGGGAGGATGGTCGGGTCTTTCTCAGCAGCACCG
TCTGGCAGGAAAAAGTCGCTTTGCGGGCGGCTTTCAACAACTGGGCCACAGGCCCCGAAGACCTCGCACTTTTGAAAGCC
GCTGTGCAGAGTGTGGCGCGAAATCTAGAAATCTGTAATGACTAA

Upstream 100 bases:

>100_bases
GCCGACGTGCACCTCGAGCACTTTCGGTTGCCCATCCTGGTTGAGTCGCCGCACATCGCGGGGGTAGCAATCAAGCATGG
GTAATGCACCGTCGGAAAAT

Downstream 100 bases:

>100_bases
TTCGTTGCAGAAGTGACAGTTGCCGGGTTCGCCCGGCAACTGAGCAATGGCGCTATTCTTTGGGTTCGGTGATGCGCTGG
AACAGATAGCCGGTGCCGCG

Product: amino acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MPVQGPSITCSPQQGTTSTDEAFAASAAILGRTAELAAKYVASLAQRPVGKPVSVVQLAAALEEPLPEQGTPPAAAVEEW
LSRAEPGIVASAGPRYFGFVIGGTTAAALAGDWLASAIDQNACLWATSPAAVQTELVVMRWLKELFQLPADWVGALTSGT
SNAHLIGLAAARQWVGAQLGFDPARDGLSGFEPVPVVCSTATHVSTTKALATLGLGRSTVRQVPAPGGVIDLGALAATLQ
TIGGPAIVIANAGEVNTGAFDPLDKIADLCQFHPGGAWLHVDGAFGLCARLCDRLAPLVQGVERADSLASDGHKWLNLPY
DCGFVFVRNPEALRSAFSADAAYIAPEPDAGWDPTSHMPELSRRFRGLAAWCAIKAYGRIGYRALVERCVGWADEFGRWV
QTTRSLELVAPVSLNIVCFRYIRAGLSTVELNALNRAADAALREDGRVFLSSTVWQEKVALRAAFNNWATGPEDLALLKA
AVQSVARNLEICND

Sequences:

>Translated_494_residues
MPVQGPSITCSPQQGTTSTDEAFAASAAILGRTAELAAKYVASLAQRPVGKPVSVVQLAAALEEPLPEQGTPPAAAVEEW
LSRAEPGIVASAGPRYFGFVIGGTTAAALAGDWLASAIDQNACLWATSPAAVQTELVVMRWLKELFQLPADWVGALTSGT
SNAHLIGLAAARQWVGAQLGFDPARDGLSGFEPVPVVCSTATHVSTTKALATLGLGRSTVRQVPAPGGVIDLGALAATLQ
TIGGPAIVIANAGEVNTGAFDPLDKIADLCQFHPGGAWLHVDGAFGLCARLCDRLAPLVQGVERADSLASDGHKWLNLPY
DCGFVFVRNPEALRSAFSADAAYIAPEPDAGWDPTSHMPELSRRFRGLAAWCAIKAYGRIGYRALVERCVGWADEFGRWV
QTTRSLELVAPVSLNIVCFRYIRAGLSTVELNALNRAADAALREDGRVFLSSTVWQEKVALRAAFNNWATGPEDLALLKA
AVQSVARNLEICND
>Mature_493_residues
PVQGPSITCSPQQGTTSTDEAFAASAAILGRTAELAAKYVASLAQRPVGKPVSVVQLAAALEEPLPEQGTPPAAAVEEWL
SRAEPGIVASAGPRYFGFVIGGTTAAALAGDWLASAIDQNACLWATSPAAVQTELVVMRWLKELFQLPADWVGALTSGTS
NAHLIGLAAARQWVGAQLGFDPARDGLSGFEPVPVVCSTATHVSTTKALATLGLGRSTVRQVPAPGGVIDLGALAATLQT
IGGPAIVIANAGEVNTGAFDPLDKIADLCQFHPGGAWLHVDGAFGLCARLCDRLAPLVQGVERADSLASDGHKWLNLPYD
CGFVFVRNPEALRSAFSADAAYIAPEPDAGWDPTSHMPELSRRFRGLAAWCAIKAYGRIGYRALVERCVGWADEFGRWVQ
TTRSLELVAPVSLNIVCFRYIRAGLSTVELNALNRAADAALREDGRVFLSSTVWQEKVALRAAFNNWATGPEDLALLKAA
VQSVARNLEICND

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=397, Percent_Identity=28.2115869017632, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI132814448, Length=397, Percent_Identity=28.2115869017632, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI92110055, Length=454, Percent_Identity=27.0925110132159, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI197276620, Length=422, Percent_Identity=25.8293838862559, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4503875, Length=422, Percent_Identity=25.8293838862559, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI197383062, Length=452, Percent_Identity=25.2212389380531, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI194294551, Length=344, Percent_Identity=28.4883720930233, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI58331246, Length=422, Percent_Identity=24.1706161137441, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17534819, Length=403, Percent_Identity=25.8064516129032, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17534817, Length=403, Percent_Identity=25.8064516129032, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17555682, Length=503, Percent_Identity=24.2544731610338, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71993062, Length=424, Percent_Identity=25.4716981132075, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI133931025, Length=432, Percent_Identity=23.3796296296296, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71981211, Length=451, Percent_Identity=23.9467849223947, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71981217, Length=460, Percent_Identity=23.4782608695652, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71993058, Length=412, Percent_Identity=24.7572815533981, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551992, Length=513, Percent_Identity=21.0526315789474, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585139, Length=471, Percent_Identity=24.6284501061571, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI221476190, Length=471, Percent_Identity=24.6284501061571, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24585143, Length=471, Percent_Identity=24.6284501061571, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28573972, Length=437, Percent_Identity=25.629290617849, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24652373, Length=423, Percent_Identity=29.5508274231678, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24586044, Length=433, Percent_Identity=26.5588914549654, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17136190, Length=356, Percent_Identity=26.685393258427, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24585135, Length=408, Percent_Identity=25.2450980392157, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136594, Length=454, Percent_Identity=24.8898678414097, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356415, Length=377, Percent_Identity=25.4641909814324, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24657193, Length=392, Percent_Identity=25, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24657185, Length=392, Percent_Identity=25, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24657188, Length=392, Percent_Identity=25, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 52047; Mature: 51915

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVQGPSITCSPQQGTTSTDEAFAASAAILGRTAELAAKYVASLAQRPVGKPVSVVQLAA
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALEEPLPEQGTPPAAAVEEWLSRAEPGIVASAGPRYFGFVIGGTTAAALAGDWLASAIDQ
HHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHHCC
NACLWATSPAAVQTELVVMRWLKELFQLPADWVGALTSGTSNAHLIGLAAARQWVGAQLG
CCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCC
FDPARDGLSGFEPVPVVCSTATHVSTTKALATLGLGRSTVRQVPAPGGVIDLGALAATLQ
CCHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCHHHHHHCCCCCCEEHHHHHHHHHH
TIGGPAIVIANAGEVNTGAFDPLDKIADLCQFHPGGAWLHVDGAFGLCARLCDRLAPLVQ
HCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
GVERADSLASDGHKWLNLPYDCGFVFVRNPEALRSAFSADAAYIAPEPDAGWDPTSHMPE
HHHHHHHHHHCCCCEECCCCCCCEEEEECHHHHHHHHCCCCEEECCCCCCCCCCCCCCHH
LSRRFRGLAAWCAIKAYGRIGYRALVERCVGWADEFGRWVQTTRSLELVAPVSLNIVCFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
YIRAGLSTVELNALNRAADAALREDGRVFLSSTVWQEKVALRAAFNNWATGPEDLALLKA
HHHCCCCEEEHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AVQSVARNLEICND
HHHHHHHHHCCCCC
>Mature Secondary Structure 
PVQGPSITCSPQQGTTSTDEAFAASAAILGRTAELAAKYVASLAQRPVGKPVSVVQLAA
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
ALEEPLPEQGTPPAAAVEEWLSRAEPGIVASAGPRYFGFVIGGTTAAALAGDWLASAIDQ
HHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHHCC
NACLWATSPAAVQTELVVMRWLKELFQLPADWVGALTSGTSNAHLIGLAAARQWVGAQLG
CCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCC
FDPARDGLSGFEPVPVVCSTATHVSTTKALATLGLGRSTVRQVPAPGGVIDLGALAATLQ
CCHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHCCCHHHHHHCCCCCCEEHHHHHHHHHH
TIGGPAIVIANAGEVNTGAFDPLDKIADLCQFHPGGAWLHVDGAFGLCARLCDRLAPLVQ
HCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
GVERADSLASDGHKWLNLPYDCGFVFVRNPEALRSAFSADAAYIAPEPDAGWDPTSHMPE
HHHHHHHHHHCCCCEECCCCCCCEEEEECHHHHHHHHCCCCEEECCCCCCCCCCCCCCHH
LSRRFRGLAAWCAIKAYGRIGYRALVERCVGWADEFGRWVQTTRSLELVAPVSLNIVCFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
YIRAGLSTVELNALNRAADAALREDGRVFLSSTVWQEKVALRAAFNNWATGPEDLALLKA
HHHCCCCEEEHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AVQSVARNLEICND
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]