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The map label for this gene is trpC

Identifier: 37522125

GI number: 37522125

Start: 2709500

End: 2710387

Strand: Reverse

Name: trpC

Synonym: gvip350

Alternate gene names: 37522125

Gene position: 2710387-2709500 (Counterclockwise)

Preceding gene: 37522126

Following gene: 37522124

Centisome position: 58.18

GC content: 63.74

Gene sequence:

>888_bases
GTGAAGATTCGTCGCCGTCCCGAACAGCCGCCGGTCGCCGTGGGTCCGCTGCAGTTTCAGCTGCAGGGTGCCGATGTCGA
ACCGGGCAACATCCTCGAAAAAATTGTCTGGGCCAAAGAGCAGGAACTGGACCGCTGGCGAGAGCGCTTGCCCCTTGCCA
AGCTGCGGGCCCGCACCGCAAGCGCCCCGGAGGTGCGCAATTTTTTGGGTGCGCTGCGCCGATCTCCCCATCCGGTCGCC
GTGATCGCCGAGGTCAAAAAAGCCTCCCCGAGCCGTGGAGTGCTCAGAAGCGATTTTGATCCGGTGGCCCTTGCCCAGGC
TTACACCCGCGGCGGTGCGGACGCCATCTCCGTGCTCACCGACGAAGCCTTTTTTCAAGGCAGTTTCACCAACCTCAGCC
GTATCCGTGAGCAGGTGCCGCTGCCTTTGCTGTGCAAAGAATTTATCCTCGGCCCTTACCAGATTTATCTGGCCCGCGCC
CACGGGGCCGACGCCGTATTGCTGATCGCCGCCATTTTGAGCGATACCGACCTGGCCTACTTGATGCGGGTGGCCGACCA
GCTGGGGATGGCAGCCCTGGTCGAAGTGCACGATCTCGAAGAACTCGACCGCGTTCTGGCTCTGGAAGGAGTGGCGCTGG
TGGGCATCAACAACCGCAACCTGCTCGACTTCGAAGTGCACCTGGAGACTACCGAAACGCTTCTGACCGAGCGGGGCGAA
CGGCTCGCCGAGTGGGGCATCACCGTGGTGAGCGAATCGGGCATTTACCAGGGTGCGGATCTGGCGCGCGTGCGCAAGGC
GGGGGCGCGCGCGGTGCTGGTCGGTGAATCTCTATTGCGCGAAGCGGACCCGGCCCAGGCCGTCGGTCGGCTGGTGGAGG
GCGTATGA

Upstream 100 bases:

>100_bases
GCAGGACAGCTGATCGCCGGGCGTCTGCGCTCCTGAGTGGTCGCCTGTACGCTGGTGCGCGGTGGTGTCAGAATATGTGG
GCACCTCCATGTGTCGCACT

Downstream 100 bases:

>100_bases
TGCAGATTCCTGTACCCGCCCATATCCACTACGAGACCCTCCTGCGCGTCCTGGAGCGACAGACCGCCGCCGCAGTGATC
CAGGTCGATCACGCCAGTCT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKIRRRPEQPPVAVGPLQFQLQGADVEPGNILEKIVWAKEQELDRWRERLPLAKLRARTASAPEVRNFLGALRRSPHPVA
VIAEVKKASPSRGVLRSDFDPVALAQAYTRGGADAISVLTDEAFFQGSFTNLSRIREQVPLPLLCKEFILGPYQIYLARA
HGADAVLLIAAILSDTDLAYLMRVADQLGMAALVEVHDLEELDRVLALEGVALVGINNRNLLDFEVHLETTETLLTERGE
RLAEWGITVVSESGIYQGADLARVRKAGARAVLVGESLLREADPAQAVGRLVEGV

Sequences:

>Translated_295_residues
MKIRRRPEQPPVAVGPLQFQLQGADVEPGNILEKIVWAKEQELDRWRERLPLAKLRARTASAPEVRNFLGALRRSPHPVA
VIAEVKKASPSRGVLRSDFDPVALAQAYTRGGADAISVLTDEAFFQGSFTNLSRIREQVPLPLLCKEFILGPYQIYLARA
HGADAVLLIAAILSDTDLAYLMRVADQLGMAALVEVHDLEELDRVLALEGVALVGINNRNLLDFEVHLETTETLLTERGE
RLAEWGITVVSESGIYQGADLARVRKAGARAVLVGESLLREADPAQAVGRLVEGV
>Mature_295_residues
MKIRRRPEQPPVAVGPLQFQLQGADVEPGNILEKIVWAKEQELDRWRERLPLAKLRARTASAPEVRNFLGALRRSPHPVA
VIAEVKKASPSRGVLRSDFDPVALAQAYTRGGADAISVLTDEAFFQGSFTNLSRIREQVPLPLLCKEFILGPYQIYLARA
HGADAVLLIAAILSDTDLAYLMRVADQLGMAALVEVHDLEELDRVLALEGVALVGINNRNLLDFEVHLETTETLLTERGE
RLAEWGITVVSESGIYQGADLARVRKAGARAVLVGESLLREADPAQAVGRLVEGV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=267, Percent_Identity=42.3220973782771, Blast_Score=173, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322638, Length=242, Percent_Identity=38.8429752066116, Blast_Score=132, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_GLOVI (Q7NHI0)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925502.1
- HSSP:   P00909
- ProteinModelPortal:   Q7NHI0
- SMR:   Q7NHI0
- GeneID:   2600957
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2556
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   GVIO251221:GLL2556-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 32333; Mature: 32333

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRRRPEQPPVAVGPLQFQLQGADVEPGNILEKIVWAKEQELDRWRERLPLAKLRARTA
CCCCCCCCCCCEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
SAPEVRNFLGALRRSPHPVAVIAEVKKASPSRGVLRSDFDPVALAQAYTRGGADAISVLT
CCHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCHHCCCCHHHHHHHHHCCCCHHHHHHH
DEAFFQGSFTNLSRIREQVPLPLLCKEFILGPYQIYLARAHGADAVLLIAAILSDTDLAY
HHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHH
LMRVADQLGMAALVEVHDLEELDRVLALEGVALVGINNRNLLDFEVHLETTETLLTERGE
HHHHHHHHCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECHHHHHHHHHHH
RLAEWGITVVSESGIYQGADLARVRKAGARAVLVGESLLREADPAQAVGRLVEGV
HHHHCCCEEEECCCCCCCCHHHHHHHCCCCEEEECHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKIRRRPEQPPVAVGPLQFQLQGADVEPGNILEKIVWAKEQELDRWRERLPLAKLRARTA
CCCCCCCCCCCEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
SAPEVRNFLGALRRSPHPVAVIAEVKKASPSRGVLRSDFDPVALAQAYTRGGADAISVLT
CCHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCHHCCCCHHHHHHHHHCCCCHHHHHHH
DEAFFQGSFTNLSRIREQVPLPLLCKEFILGPYQIYLARAHGADAVLLIAAILSDTDLAY
HHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHH
LMRVADQLGMAALVEVHDLEELDRVLALEGVALVGINNRNLLDFEVHLETTETLLTERGE
HHHHHHHHCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECHHHHHHHHHHH
RLAEWGITVVSESGIYQGADLARVRKAGARAVLVGESLLREADPAQAVGRLVEGV
HHHHCCCEEEECCCCCCCCHHHHHHHCCCCEEEECHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292